Download Rajput, Ashwani BIOGRAPHICAL SKETCH Ashwani Rajput

Program Director/Principal Investigator (Last, First, Middle):
Rajput, Ashwani
BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
Ashwani Rajput
The Victor and Ruby Hansen Surface Professor eRA COMMONS USER NAME (credential, e.g., agency login)
RAJPUT
Chief, Division of Surgical Oncology
Associate Professor, Surgery
P30 Role:
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Miami University, Oxford, Ohio
Case Western Reserve University, Cleveland,
Ohio
AB
1985-1989
Zoology
MD
1989-1993
Medicine
A. Personal Statement
I am the inaugural Chief of the Division of Surgical Oncology and the Chief of Surgical Services for the UNM
Cancer Center. Since my recruitment in 2009 we have built a vibrant academic Division of Surgical Oncology
which is now comprised of 7 clinical faculty in general surgical oncology, 1 PhD basic science faculty, 5 midlevels and a number of support staff. I also assist in the programmatic development and multi-disciplinary
integration of sub-specialty surgical programs that include orthopedic oncology, head/neck surgery, urology,
plastics & reconstructive surgery, thoracic surgery and gynecologic oncology. As a physician scientist, my
laboratory has focused on key signal transduction pathways that control cancer metastases. In addition to
this basic science work, I partner with my colleagues in the population sciences to understand the patterns of
disease in New Mexico, the disparities that exist and how we may target them to impact change for better
health outcomes of our population. Thus, I am ideally suited to be a part of the UNM Cancer Center P30.
B. Positions and Honors
Positions and Employment
1993-94
Intern, General Surgery, Case Western Reserve University
1994-95, 97-99 Resident, General Surgery, Case Western Reserve University
1995-97
Dudley P. Allen Research Scholar, Case Western Reserve University, Department of Surgery
1996-99
Clinical Instructor, Case Western Reserve University, Department of Surgery
1999-00
Chief Resident, General Surgery, Case Western Reserve University
2000-02
Fellow, Surgical Oncology, Roswell Park Cancer Institute, Assistant Clinical Instructor,
Department of Surgery, State University of New York at Buffalo
2002-2009
Representative – National Comprehensive Cancer Network Colorectal Screening Panel
2002-2009
Attending Surgeon, Roswell Park Cancer Institute; Assistant Member, Pharmacology and
Therapeutics; Assistant Professor of Surgery, State University of New York at Buffalo
2008-2013
Editorial Board, Journal of Clinical Oncology
2008-2009
Chairman, Western New York Cancer Coalition
2008-present
Member, Death Review Committee for NCI sponsored Prostate, Lung, Colorectal, Ovarian
Cancer Screening Trial
2009-present
The Victor and Ruby Hansen Surface Professor, Chief, Division of Surgical Oncology ,
University of New Mexico, & Chief, Surgical Services, UNM Cancer Center
Honors
1989
Williams Award for Outstanding Undergraduate Research, Dept. of Zoology, Miami Univ.
1989
Summa Cum Laude Graduate Miami University; Oxford, OH (4.0 GPA)
1991
Rainbow Babies & Children’s Hospital Science Day Award for presentation of paper:
“Inguinal hernias in VLBW infants: Incidence and indication for operation”, June 7, 1991.
1995
Participant: American Association for Cancer Research, Molecular Biology in Clinical
Oncology Workshop; Aspen, CO
PHS 398/2590 (Rev. 06/09)
Biographical Sketch Format Page
Program Director/Principal Investigator (Last, First, Middle):
Rajput, Ashwani
2001
Berlex Oncology Fellow: Communications in Oncology Workshop; San Diego, CA
2001
Fellow: Berlex Oncology Foundation Clinical Epidemiology Workshop; Brewster, MA
2001
Fellow: Berlex Oncology Foundation Genetics in Oncology Workshop:Woodlands,TX
2001-2002
Administrative Fellow, Surgical Oncology, Roswell Park Cancer Institute
2002
Roswell Park Cancer Institute E. Douglas Holyoke, MD Award for Outstanding
Clinical/Scientific Achievement by a Surgical Oncology Fellow
2006-2009
Buswell Research Fellow; University at Buffalo, SUNY
2009
American Cancer Society Award of Appreciation
2010
Apple for the Teacher Award, University of New Mexico School of Medicine Excellence in
Teaching Award –Phase II (Third year clerkship)
2014
Hind Rattan Award 2014 for outstanding services, achievements and contributions from the
NRI Welfare Society of India
C. Selected Peer-reviewed Publications (Selected from 57 peer-reviewed publications)
Most relevant to the current application
1. Rajput A, Koterba AP, Kreisberg JI, Foster JM, Willson JKV, Brattain MG. A novel mechanism of
resistance to epidermal growth factor receptor antagonism in vivo. Cancer Res 67:665-673, 2007. (PMID
17234777)
2. Guo X+, Rajput A+, Rose R, Hauser J, Beko A, Kuropatwinski K, Levea C, Hoffman RM, Brattain MG,
Wang J. Mutant PIK3CA bearing colon cancer cells display increased metastasis in an orthotopic model.
Cancer Res 67: 5851-5858, 2007. (+equal contribution). (PMID 17575153)
3. Rajput A, Dominguez San Martin I, Rose R, Beko A, Levea C, Sharratt E, Mazurchuk R, Hoffman RM,
Brattain MG, Wang J. Characterization of HCT116 human colon cancer cells in an orthotopic model. J
Surg Res 147:276-281, 2008. (PMID 17961596)
4. Wang J+, Rajput A+, Kan JL, Rose R, Liu XQ, Kuropatwinski K, Hauser J, Beko A, Dominguez I, Sharratt
EA, Brattain L, Levea C, Sun FL, Keane DM, Gibson NW, Brattain MG. Knockdown of RON tyrosine
kinase leads to reduced metastasis in an orthotopic model of human colon carcinoma. J Biol Chem
284(16):10912-22, 2009. (+equal contribution). (PMID 19224914)
5. Leiphrakpam PD, Rajput A, Mathiesen M, Agarwal E, Lazenby AJ, Are C, Brattain MG, Chowdhury S.
Ezrin expression and cell survival regulation in colorectal cancer. Cellular Signal 22 Jan 2014 E pub
ahead of print. (PMID 24462708).
Additional recent publications of importance to the field (in chronological order)
1. Are C, Simms N, Rajput A, Brattain M. Transforming growth factor-beta dependent suppression of hepatic
metastasis from colon cancer. HPB (Oxford) 12:498-506, 2010. (PMID 20815859)
2. Chowdhury S, Howell GM, Rajput A, Teggart C, Brattain L, Weber HR, Chowdhury A, Brattain MG.
Identification of a Novel TGFβ/PKA signaling transduceome in mediating control of cell survival and
metastasis in colon cancer. PLoS One 6(5):e19335, 2011. (PMID 21559296)
3. Ongchin M, Sharratt E, Dominguez I, Simms N, Wang J, Cheney R, LeVea C, Brattain M, Rajput A. The
effects of epidermal growth factor receptor activation and attenuation of the TGFβ pathway in an orthotopic
model of colon cancer. J Surg Res 156:250-6, 2009. (PMID 19524264)
4. Jiang Y, Liu XQ, Rajput A, Geng L, Ongchin M, Zeng Q, Taylor GS, Wang J. Phosphatase PRL-3 is a
direct regulatory target of TGF-β in colon cancer metastasis. Cancer Res 71:234-244, 2011. (PMID
21084277)
5. Liu X-Q, Rajput A, Geng L, Ongchin M, Chaudhuri A, Wang J. Restoration of TGF-β type II receptor
expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. J Biol
Chem 28(18):16082-90, 2011. (PMID: 21454688)
6. Chowdhury S, Howell GM, Rajput A, Teggart C, Brattain L, Weber HR, Chowdhury A, Brattain MG.
Identification of a Novel TGFβ/PKA signaling transduceome in mediating control of cell survival and
metastasis in colon cancer. PLoS One 6(5):e19335, 2011.
7. Simms N, Rajput A, Sharratt EA, Ongchin M, Teggart CA, Wang J, Brattain MG. Transforming growth
factor-β suppresses metastasis in human colon carcinoma. BMC Cancer June 6; 12(1):221, 2012. (PMID
22672900)
Program Director/Principal Investigator (Last, First, Middle):
Rajput, Ashwani
8. Chowdhury S, Hu YP, Dominguez I, Sharratt E, Spernyak J, Brattain MG, Rajput A. Anti-tumor Activity of
IGF1R Kinase Inhibitors in Colon Cancer. Clin Exp Pharmacol S4:005. doi 10 4172/2161-1459 S4-005,
2013.
9. Chowdhury S, Ongchin M, Sharratt E, Dominguez I, Wang, J, Brattain M, Rajput A. Intra-tumoral
Heterogeneity in Metastatic Potential and Survival Signaling Between iso-clonal HCT116 and HCT 116b
Human Colon Carcinoma Cell Lines. PLoS One 8(4):e60299, 2013. (PMID 23560089)
10. Chowdhury S, Ongchin M, Wan G, Sharratt E, Rajput A. Restoration of PTEN Activity Decreases
Metastases in an Orthotopic Model of Colon Cancer. J Surg Res 184:755-60, 2013. (PMID 23623571)
D. Research Support
Ongoing Research Support
1. RFP S09-148
Bocklage (PI)
10/2010-10/2015
Annotated Human Solid Tumor and Blood Specimen Contract with NCI.
The goal of this study is to provide annotated specimen data to try and define optimal conditions for tissue
storage and processing for translational research.
Role: Co-Investigator
2. R25 CA 153825-01 Datye & Oliver (Co-PI’s)
This project is for Cancer Nanotechnology Training Centers.
10/2010-10/2015
3. P50 GM065794 Wilson (PI)
Spatio-Temporal Modeling Center
Role: Collaborator
2012-2014
4. Contract Millennium Pharmaceuticals/Takeda
Rajput (PI)
4/28/14-3/31/19
A Phase I, First in Human, Single Dose Open Label, Positron Emission Tomography (PET) Imaging study
of [68Ga] MLN 6907 in Patients with Metastatic Colorectal Carcinoma
Role: Principal Investigator
Completed Research Support
Foundation Grant Rajput (Co-PI)
2008-2009
The William B. Anderson and Juliet J. Anderson Rosch Charitable Foundation
Western New York Cancer Coalition
This grant provides funds for the implementation of Comprehensive Cancer Control at the local community
level.
Role: Co-PI
Foundation Grant
Rajput (Co-PI)
2008-2009
Eastern Tennessee State University Office of Rural and Community Health & Community Partnerships
Western New York Cancer Coalition Southern Tier Initiative
A comprehensive cancer control initiative for rural, impoverished counties in Western New York
Foundation Grant
Rajput (PI)
2006-2009
Buswell Fellowship, University at Buffalo; SUNY
Extending EGFR Efficacy
Goal: To identify and characterize molecular targets that contribute to colon cancer malignancy, to determine
the role of mutant PI3K in colon cancer invasion and metastasis, to determine the role of RON in colon cancer
invasion and metastasis and to determine if the inactivation of RON or PI3K can modulate EGFR inhibition
sensitivity.
Role: PI
Foundation Grant
Rajput (PI)
Potential Avenues for Extending EGFR Efficacy
2006-2008
Program Director/Principal Investigator (Last, First, Middle):
Rajput, Ashwani
Ralph Wilson Medical Research Foundation
Goal: To identify and characterize molecular targets that contribute to colon cancer malignancy & metastases
Role: PI
NCI R01 CA 054809-14
Brattain (PI)
7/1/2005-8/1/2007
Autocrine TGF alpha—Function and Control in Colon Cancer
Goal: The overall goals of this project are to determine whether endogenously activated EGFR sites are critical
for maintaining the malignant phenotype of colon cancer in vitro and in vivo, and to determine whether ErbB2
y1248 is critical to the maintenance of malignancy in colon cancer in vitro and in vivo.
Role: Co-Investigator
Foundation Grant
Rajput (PI)
7/1/2005-6/30/2006
The Role of the ErbB Family in Colon Cancer
Wendy Will Case Cancer Fund, Inc.
Goal: To identify and characterize molecular targets that contribute to colon cancer malignancy & metastases
Role: PI
NIH/NCI R21-CA101326-01A1
Rustum (PI)
9/2003-8/2005
Irinotecan in Combination with Celecoxib: A Phase I Study with Molecular and Pharmacokinetic Correlates
Role: Co-Investigator
Foundation Grant
Rajput (PI)
The Role of the ErbB Family in Colon Cancer Metastasis
American Cancer Society Institutional Review Grant #IRG-02-197-02
Goal: To develop and orthotopic model of metastases to study ErbB family signaling
Role: PI
2004
Foundation Grant
Rajput (Co-PI)
2003-2004
Patient Education
Roswell Park Alliance Foundation Quality of Life Grant
Goal: To improve the understanding and quality of life for surgical oncology patients with GI cancers
Role: Co-PI
Foundation Grant
Rajput (PI)
2002-2003
Gastrointestinal Surgery Patient Education
Roswell Park Alliance Foundation Quality of Life Grant
Goal: To improve the understanding and quality of life for surgical oncology patients with GI cancers
Role: PI