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Kowsar Medical Journal
Vol. 16, No. 3, Fall 2011
Pages: 181-184
PhD
*
MSc
MSc
MSc
*
(BMI)
T4
TSH
BMI
SPSS 18
T
±
±
T4 TSH
±
.
BMI
BMI
Relationship between Visfatin hormone and thyroid dysfunction in patients
with hyperthyroidism and hypothyroidism
Farazandeh Mehr M.1 MSc, Shabani S.1 MSc, Hoghooghi Rad L.1 MSc, Hedayati M.* PhD
‫٭‬Obesity Research Center, Institute of Endocrinology & Metabolism Science,
Shahid Beheshti University of Medical Sciences, Tehran, Iran
1
Obesity Research Center, Institute of Endocrinology & Metabolism Science,
Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Aims: Adipokines are proteins secreted from adipose tissue that are involved in metabolism control. Visfatin is
one of the adipokines with different biological roles. Serum levels of Visfatin were found to be associated with
BMI, thyroid dysfunctions, and metabolic syndrome in several studies. The aim of this study was to assess
Visfatin’s association with thyroid dysfunction.
Materials & Methods: This case-control study was performed on patients who referred to the clinic of the
Research Institute for Endocrine Sciences of Shahid-Beheshti University in year 2009. 48 patients with
hypothyroidism, 34 patients with hyperthyroidism and 82 normal individuals as control group were selected by
easy given sampling method and then were studied. BMI and fasting Visfatin, TSH and T4 serum levels were
measured by enzyme immunoassay methods. Data were analyzed using independent t-test, Pearson correlation
coefficient and one-way ANOVA by SPSS 18 software.
Results: Visfatin serum levels in both groups of patients with hyperthyroidism and hypothyroidism (9.38±1.77
ng/ml and 6.70±1.35 ng/ml, respectively) were significantly higher than the control group (2.51±0.12 ng/ml).
There was no significant correlation between serum levels of TSH, T4 and BMI and Visfatin serum level in case
and control groups.
Conclusion: This study shows that the Visfatin level is independent of BMI changes in patients who have
thyroid dysfunction. The findings of this study suggest that changes in Visfatin levels may be considered as a
criterion for diagnosis of hypothyroidism and hyperthyroidism.
Keywords: Visfatin, Hypothyroidism, Hyperthyroidism, BMI
.‫ فزستبده شوند‬[email protected] ‫ تمبم درخواستهب ببید به نشبني‬.‫ مهدي هدایتي‬:‫نویسنده مسئول‬
00/4/13 :‫ پذیزش مقبله‬00/1/24 :‫دریبفت مقبله‬
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Kowsar Medical Journal
Vol. 16, No. 3, Fall 2011
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