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Name _____________________ Date _______________ Period ______ # _____ The Cell Cycle Virtual Lesson http://www.hippocampus.org/homeworkhelp/Biology/The%20Reproduction%20of%20Cells_The%20Cell%20Cycle%20&%20Mitosis%20Overview.html 1. Cell division is required for the _____________ and _______________ of all multicellular organisms. It is also used to replace and repair tissue and even for reproduction in organisms (meiosis). 2. Cell division is best described as a _____________ and goes through two major phases _________________ (G1, S, and G2) and _______________ (M phase). 3. In humans, cell division must _________________ and _____________ since it occurs in spirts. 4. What hormone in humans tells cells to rest or continue in the cell cycle? 5. The part of the cell cycle where the cell is said to be in its “resting stage” (interphase) is further divided into G1 ________________, G2 _______________, and S ______________________ in which proteins are synthesized and cell organelles are duplicated in preparation for mitosis. 6. Which part of interphase is responsible for chromosome duplication as DNA synthesis occurs? 7. Cell Cycle Regulation If the cell at G1 checkpoint fails, it will exit the cell cycle and enter a nondividing resting state called _____________ (non-dividing). Nerve cell (neurons) never reenter the cell cycle while cells found in organs such as the liver may remain here for ___________ and may reenter the cycle if the organ has been ___________ so that these cells may be replenished. If the proper _____________ are available, there are not too many cells already cycling (density-dependent inhibition forces cells to leave the cycle), and growth factors are present, then a cell may reenter the cell cycle at the end of G1 and begin the S phase. Through recombinant DNA technology, scientists can make __________ in the lab for use in patients who have a deficiency in this hormone to restore more normal growth patterns. 8. Why does a eukaryotic cell have to undergo mitosis? 9. Eukaryotic chromosomes are made up of chromatin which consist of ______ wrapped around histone protein. In interphase the DNA is called chromatin and looks like a ball of yarn. Early in mitosis, the chromatin condenses and forms chromosomes. The two identical copies of the visible chromosomes are called ____________ chromatids and are linked at the centromere. Inside the centromere is a kinetochore which will help make the mitotic spindle (spindle fibers). The mitotic spindle is responsible for the __________ distribution of chromosomes to each of the daughter cells. The _______________ is responsible for organizing the mitotic spindle. Name _____________________ Date _______________ Period ______ # _____ 10. The four phases of mitosis (M) phase also known as “nuclear division” are __________________(P), ________________(M), ___________________(A), and _________________(T). 11. ___________________ (“cell splitting”) occurs after the stages of mitosis. 12. Prophase (P): (Early) Chromatin condenses into _________________, the ______________ disappears, the ___________ fibers are formed. (Late) Spindle fibers attach to chromosomes and the nuclear envelope disappears. 13. Metaphase (M): Chromosomes line up on the ___________ __________ (middle). Sister chromatids separate. 15. Anaphase (A): The poles move apart, lengthening of the cell occurs, and spindle fibers ___________ pulling the sister chromatids away from each other to opposite poles. 16. Telophase (T): A nuclear envelope forms around each set of chromosomes and _____________ reappear. The __________ apparatus is disassembled. 17. Cytokinesis is the division of the ____________. In animal cell cytokinesis a contractile ring forms around the daughter cells which forms a ______________ _____________ which deepens until the cell is pinched into two new ________________ cells each with one nucleus and an identical sets of chromosomes. In plant cell cytokinesis a _________ __________ is formed due to the extra outer layer- the cell wall. 18. How much time does a cell spend in each phase of cell division? Number of Cells Field 1 Field 2 Field 3 Total Percent of Total Cells Counted (%) Interphase Prophase Metaphase Anaphase Telophase Total Cells Counted Highlight those items that were emphasized in summary section 5. Time in Each Stage (% x 1440 minutes) I P M A T C