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APPENDIX 1. The 19 articles selected for full-text reading 1. Rodrigues, D. C., Taba, M., Novaes, A. B., Souza, S. L., Grisi, M. F. (2003) Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. Journal of Periodontology 74,1361-1367. 2. Llambés, F., Silvestre, F. J., Hernández-Mijares, A., Guiha, R., Caffesse, R. (2005) Effect of non-surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients. Journal of Clinical Periodontology 32, 915-920. 3. Singh, S., Kumar, V., Kumar, S., Subbappa, A. (2008) The effect of periodontal therapy on the improvement of glycemic control in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. International Journal of Diabetes in Developing Countries 28, 38-44. 4. Llambés, F., Silvestre, F. J., Hernández-Mijares, A., Guiha, R., Caffesse, R. (2008) The effect of periodontal treatment on metabolic control of type 1 diabetes mellitus. Clinical Oral Investigations 12, 337-343. 5. Gaikwad, S. P., Gurav, A. N., Shete, A. R., Desarda, H. M. (2013) Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study. Journal of Periodontal and Implant Science 43, 79-86. 6. Tsalikis, L., Sakellari, D., Dagalis, P., Boura, P., Konstantinidis, A. (2014) Effects of doxycycline on clinical, microbiological and immunological parameters in well-controlled diabetes type-2 patients with periodontal disease: a randomized, controlled clinical trial. Journal of Clinical Periodontology 41, 972980. 7. Botero, J. E., Yepes, F. L., Ochoa, S. P., Hincapie, J. P., Roldan, N., Ospina, C. A., Castrillon, C. A., Becerra, M. A. (2013) Effects of periodontal non-surgical therapy plus azithromycin on glycemic control in patients with diabetes: a randomized clinical trial. Journal of Periodontal Research 48, 706-712. 8. O'Connell, P. A., Taba, M., Nomizo, A., Freitas, M. C. F., Suaid, F. A., Uyemura, S. A., Trevisan, G. L., Novaes, A. B., Souza, S. L., Palioto, D. B., Grisi, M. F. (2008) Effects of periodontal therapy on glycemic control and inflammatory markers. Journal of Periodontology 79, 774-783. 1 9. Gilowski, L., Kondzielnik, P., Wiench, R., Płocica, I., Strojek, K., Krzemiński, T. F. (2012) Efficacy of short-term adjunctive subantimicrobial dose doxycycline in diabetic patients - randomized study. Oral Diseases 18, 763-770. 10. Al-Nowaiser, A. M., Al-Zoman, H., Baskaradoss, J. K., Robert, A. A., Al-Zoman, K. H., Al-Sohail, A. M., Al-Suwyed, A. S., Ciancio, S. G., Al-Mubarak, S. A. (2014) Evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients. Saudi Medical Journal 35, 1203-1209. 11. Deo, V., Gupta, S., Bhongade, M. L., Jaiswal, R. (2010) Evaluation of subantimicrobial dose doxycycline as an adjunct to scaling and root planing in chronic periodontitis patients with diabetes: a randomized, placebo-controlled clinical trial. The Journal of Contemporary Dental Practice 11, 009-16. 12. Miranda, T. S., Feres, M., Perez-Chaparro, P. J., Faveri, M., Figueiredo, L. C., Tamashiro, N. S., Bastos, M. F., Duarte, P. M. (2014) Metronidazole and amoxicilina as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1- year outcomes of a randomized placebocontrolled trial. Journal of Clinical Periodontology 41, 890-899. 13. Al-Zahrani, M. S., Bamshmous, S. O., Alhassani, A. A., Al-Sherbini, M. M. (2009) Short-term effects of photodynamic therapy on periodontal status and glycemic control of patients with diabetes. Journal of Periodontology 80, 1568-1573. 14. Grossi, S. G., Skrepcinski, F. B., DeCaro, T., Robertson, D. C., Ho, A. W., Dunford, R. G., Genco, R. J. (1997) Treatment of periodontal disease in diabetics reduces glycated hemoglobin. Journal of Periodontology 68, 713-719. Excluded in final analysis due to not proper type of disease 15. López, N. J., Quintero, A., Llancaqueo, M., Jara, L. (2009) Effects of periodontal therapy on markers of systemic inflammation in patients with coronary heart disease risk. Revista Médica de Chile. 137, 1315-1322. 16. López, N. J., Quintero, A., Casanova, P. A., Ibieta, C. I., Baelum, V., López, R. (2012) Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial. Journal of Periodontology 83, 267-278. 2 Excluded in final analysis due to not truly random 17. Eickholz, P. (2007) Systemic doxycycline and nonsurgical periodontal treatment in diabetic patients. Evidence-Based Dental 8, 14. Excluded in final analysis due to no access to the full-text 18. Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population. ClinicalTrials.gov identifier: NCT01798225 19. A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus ("SLSRPD"). ClinicalTrials.gov identifier: NCT02263352 3