Download RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES ,KARNATAKA,
BANGALORE
PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION
1. Name of the candidate
and address
:
DR. R. RAGHU RUSHI
DEPARTMENT OF RADIO- DIAGNOSIS
VYDEHI MEDICAL COLLEGE BANGALORE
2. Name of the institution
:
VYDEHI INSTITUTE OF MEDICAL SCIENCES
AND RESEARCH CENTRE, BANGALORE.
3. Course of study and subject :
MD RADIODIAGNOSIS
4. Date of admission to the
Course
:
7 MAY 2009
5. Title of the topic
:
RADIOLOGICAL CHANGES IN PANCREAS IN
DIABETES MELLITUS AND ITS COMPLICATIONS
6.
BRIEF RESUME OF INTENDED WORK:
6.1. NEED FOR STUDY:
Pancreas though anatomically a single organ, histologically and physiologically has two distinct functions.
Its role in normal glucose metabolism is vital to effective functioning of human body. The number of people with
diabetes in India is currently around 40.9 million
[1]
. The World Health Organisation predicts the number of
diabetics in India would go up to 40 million by 2010 and 74 million by 2025.
The morphologic changes in pancreas in patients with diabetes and the complications of the same haven’t
been much investigated in radiology. So this study would be dedicated to study radiological changes in pancreas in
diabetes mellitus and its complications.
6.2. REVIEW OF LITERATURE:
Diabetes is a endocrinal disorder with multiorgan involvement. Pancreas the epicentre of the disorder
undergoes certain changes that can be picked up radiologically.
Diabetic patients tended to have more lobulations in pancreas as compared to the non diabetics on CT[2]. The
thickness of head, body and tail appear to be reduced in diabetics but this reduction varied. This is seen maximum in
insulin dependent diabetes mellitus patients, moderate in non insulin dependent and insulin treated patients. The
reduction of size involved the body of the pancreas more than any other parts of the gland.
Pancreatic volume was decreased more in type I diabetes than type II diabetes in a study conducted by K.Goda
etal[3]
In a study done to compare fat content in pancreas based on age , obesity and type II diabetes, it was found
that pancreatic fat increases with aging and obesity which is not seen in type II diabetes[4].
6.3. OBJECTIVE OF STUDY:
To Detect the Morphologic Changes in Pancreas in Subjects with Diabetes Mellitus and its Complications
using Ultrasonography and Computed Tomography.
7. MATERIALS AND METHODS
7.1 SOURCE OF DATA:
A] Cases referred to department of radio diagnosis and imaging, Vydehi Institute Of Medical sciences, Bangalore.
B] Duration Of Study : 1 yr study
C] Sample Size
: minimum of 100 cases (minimum of 30 each for normal, diabetic without complications
and diabetic with complications)
D] Inclusion Criteria
:
Normal subjects (control)
Patients with type 1 and type 2 diabetes without complications
Patients with type 1 and type 2 diabetes with complications.
E] Exclusion Criteria
: non diabetic pancreatic disorders
Pregnancy induced diabetes
Endocrinal disorders like glucagonoma, etc
7.2. METHODS OF DATA COLLECTION:
This is a cross sectional study.
Statistics: The changes in pancreas among uncomplicated diabetics and complicated diabetics would be compared
with each other and also with control group (normal individuals).
Standard test used: proportion, mean and standard deviation, ‘t’ test and Z test.
7.3. Does the study require any investigations or interventions to be conducted on the patients or other
humans or animals?
Yes, all the patients will be subjected to
-
Ultrasonography(USG)
-
Computed Tomography (CT).
7.4. Has ethical clearance been obtained from your institution in case of 7.3?
Yes, copy enclosed.
8. REFERENCES:
1. Madras diabetic research foundation. Epidemiology of type II diabetes: Indian scenario. New delhi: ICMR; 2007
2. JP Gilbeau, V Poncelet , Libon. E, Deurue.G, Heller.F.R. The density, contour, and thickness of the pancreas in
diabetics CT findings . American Journal of Roentgenology 1992;159(3): 527-531.
3.K.Goda, E.Sasaki, K.Nagata, M.Fukai, N.Ohsawa and T.Hahafusa . pancreas volume in type I and type II diabetes
mellitus. acta diabetologica 2001; 38 : 145-49
4. Saisho.Y, Butler.A.E, Meier.J.J, Monchamp.T, Allen-Auerbach, Rizza.R.A et al. pancreas volumes in humans
from birth to age one hundred taking into account obesity and presence of type II diabetes. clin anat journal 2007;
20-8:933-42
9. Signature of the Candidate
:
10. Remarks of the Guide
: a feasible and useful study which is not
patient
11.1 Name and Designation
of the Guide
:
11.2 Signature
:
11.3 Co guide (if any)
:
DR .RAMPRAKASH
MBBS MDRD
PROFFESOR & HOD
DEPARTMENT OF RADIODIAGNOSIS
VIMS & RC, BANGALORE.
11.4 Signature
:
11.5 Head of the Department
: DR .RAMPRAKASH
MBBS MDRD
PROFFESOR & HOD
DEPARTMENT OF RADIODIAGNOSIS
VIMS BANGALORE
11.6 Signature
:
12.1 Remarks of the Principal
:
12.2 Signature
:
a burden on the