Download Cornea: Window to Ocular Immunology

CORNEA: WINDOW TO
OCULAR IMMUNOLOGY
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Immune response
 Protection of host
 harmful or unpleasant effects (damage to innocent
bystander cells) d/t interaction of immunogen and host
defense
Immune privilege
Ocular Diseases related Immune Response
Dry eye disease
Graft rejection
Allergic conjunctivits
Th1, Th17 cell related
Th1 related
Th2 related
Fungal keratitis
Herpes stromal keratitis
VKH syndrome
- Neutrophil, Macrophages
- Type 4 hypersensitivity
- Type 2, 4 hypersensitivity
Cornea is the window to the eye and to
ocular immunity for clinic and research
 Regulating ocular inflammation is crucial for
preserving the clarity of the eye's window.
 Immune privilege is essential for the preservation
of vision.
 Understanding immunological pathogenesis is the
key of disease diagnosis and treatment.
Today`s topic
 Ocular Immunology and Inflammation
 Ocular surface immunology
 especially dry eye syndrome
 Ocular allergies
 Graft rejection in corneal transplantation
 Corneal neovascularization and lymphangiogenesis