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Nanotechnology for Oligonucleotide Based Drug delivery Dal-Hee Min Department of Chemistry and KI for the BioCentury, KAIST, Goosung-Dong 373-1, Yousung-Gu, Daejeon, 305-701, Korea (ROK). E-mail: [email protected]; Fax:+82-42-350-2810; Tel: +82-42-350-2848. Biotechnology is an emerging area of scientific and technological opportunity, which requires multi-disciplinary efforts ranging from basic sciences to engineering and technological development. A major theme of biotechnology includes development of micro/nanoscale tools for studying biosystems. Specific research fields include developing platforms to assay biological and biochemical events—enzymatic activity assays and biomolecular interactions—for diagnostic tools and/or drug screening. In another approach, nanoparticles such as qdots are actively harnessed for biosensors, cancer imaging, and targeted drug delivery in the same realm. The talk will cover applications of micro/nano-biotechnology in biomedical research area, emphasizing development of multi-functional nanoparticles for oligonucleotide (siRNA, ASDNA, etc.) based drug delivery. References (1) “Nanoparticle self-assembly directed by antagonistic enzyme triggers” Adv. Mater. 2007, 19(21), 3579. (2) “Targeted quantum dot conjugates for siRNA delivery” Bioconjug. Chem. 2007, 18, 1391. (3) “Label-free detection of protein-protein interactions on biochips” Angew. Chem. 2005, 44, 5480. (4) “Profiling kinase activities using a peptide chip and mass spectrometry” Angew. Chem. 2004, 43, 5973. (5) “Peptide arrays: towards routine implementation” Curr. Opin. Chem. Biol., 2004, 8, 554. (6) “Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor” Nature Biotechnol, 2004, 22, 717.