Download Title Times 14pt Bold

yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project

Document related concepts
no text concepts found
Nanotechnology for Oligonucleotide Based Drug delivery
Dal-Hee Min
Department of Chemistry and KI for the BioCentury, KAIST, Goosung-Dong 373-1, Yousung-Gu,
Daejeon, 305-701, Korea (ROK). E-mail: [email protected]; Fax:+82-42-350-2810; Tel:
Biotechnology is an emerging area of scientific and technological opportunity, which requires
multi-disciplinary efforts ranging from basic sciences to engineering and technological
development. A major theme of biotechnology includes development of micro/nanoscale tools for
studying biosystems.
Specific research fields include developing platforms to assay biological
and biochemical events—enzymatic activity assays and biomolecular interactions—for diagnostic
tools and/or drug screening. In another approach, nanoparticles such as qdots are actively
harnessed for biosensors, cancer imaging, and targeted drug delivery in the same realm. The talk
will cover applications of micro/nano-biotechnology in biomedical research area, emphasizing
development of multi-functional nanoparticles for oligonucleotide (siRNA, ASDNA, etc.) based
drug delivery.
(1) “Nanoparticle self-assembly directed by antagonistic enzyme triggers” Adv. Mater. 2007, 19(21),
(2) “Targeted quantum dot conjugates for siRNA delivery” Bioconjug. Chem. 2007, 18, 1391.
(3) “Label-free detection of protein-protein interactions on biochips” Angew. Chem. 2005, 44, 5480.
(4) “Profiling kinase activities using a peptide chip and mass spectrometry” Angew. Chem. 2004, 43,
(5) “Peptide arrays: towards routine implementation” Curr. Opin. Chem. Biol., 2004, 8, 554.
(6) “Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor” Nature
Biotechnol, 2004, 22, 717.