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Synthesis of amino acid derivatives via enantio- and diastereoselective Pdcatalyzed allylic substitutions with a non-stabilized enolate as nucleophile
Thomas D. Weiß, Günter Helmchen,* Uli Kazmaier,
J. Chem. Soc. Chem. Commun. 2002, 1270-1271.
Diastereomer ratios of up to 95:5 and enantiomeric excess of up to 95 % were achieved in Pdcatalyzed asymmetric allylic substitutions with zinc enolates of glycine esters as nucleophiles;
a remarkable effect of the ligand on the diastereoselectivity of the substitution was found.