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Overview of included systematic reviews Author/Year QOAQ Database search Used quality assessment Search Population period intervention Type of study Outcome 1 Prevention Worthington et al. 7 Sutherland & 7 Browland McGuire et al. 6.5 Potting et al. 5 Cochrane Oral Allocation of Health Group treatment and Trials information on Register reasons for Cochrane withdrawal by trial Central Register Of Controlled Trials MEDLINE EMBASE CINAHL CANCERLITH SIGLE LILACS Medline. Embase. Randomization, Cinahl Cancerlit blinding, NCI dropouts PDQ database Medline A rating form and systematic determination of levels of evidence, based on the American Society of Clinical Oncology criteria Medline, Pubmed, Randomization, Cinahl, Psycinfo blinding, dropouts 1966April 2004 Anyone with Active cancer prophylactically who received agents: chemotherapy and/or radiotherapy. 1966June 2000 Randomised Mucositis (all controlled levels of trials (RCTs) severity) Patients Active treatment undergoing radiation treatment to the head and neck area Update Patients Basic oral care, 2002- receiving bland 2005 cancer therapy rinses, protocols and education, good clinical practices Randomized Oral mucositis trials. scores, proxy measures of oral mucositis 19922002 All Measurement of randomized the studies severity of mucositis Adult patients Mouthwashes with oral mucositis undergoing chemotherapy Clinical studies, review studies Oral condition, cultures of blood, incidence of mucositis, duration mucositis, oral mucositis pain. Overview of included systematic reviews Migliorati et al. 4.5 Medline Donnelly et al. 4 Medline Bensadoun et 4 al. Medline A rating form based on the papers by Hadorn* and Somerfield* to establish the adequacy of each study and then to combine all the studies to provide a level of evidence and grade of recommendation Randomization, blinding, dropouts A rating form based on the papers by Hadorn and Somerfield to establish the adequacy of each study and then to combine all the studies to provide a level of Update Not specified 2002- in the 2005 review, probably cancer patients 1964June 2002 Patients with oral mucositis Alternative/natural Not specified Mucositis (not agents, ice or laser further therapy specified) Antimicrobial agent Prospective Incidence of oral clinical trials mucositis, Severity of oral mucositis, duration of oral mucositis, oral pain Weight loss, type of oral mucositis assessment Update Patients Amifostine Published Mucositis 2002- receiving peer(complete 2005 cancer therapy reviewed alimentary tract, (all medical but kinds, but in literature in results split results into section split anatomic region into of chemo/radio the alimentary and tract: others oral mucositis, esophagitis, Overview of included systematic reviews evidence and grade of recommendation. proctitis, vaginitis) 2 Treatment Worthington et al 7 Cochrane Oral Health Group Trials Register Cochrane Central Register Of Controlled Trials MEDLINE EMBASE CINAHL CANCERLITH SIGLE LILACS Allocation of treatment, and information on reasons for withdrawal by trial group 1966- Anyone with Active agents August cancer 2003 who is receiving chemotherapy and/or radiotherapy and has oral mucositis. Randomised Mucositis at controlled different trials levels of severity, Days to heal (mean), Oral pain scores or categories Relief of dysphagia Incidence of systemic infection Amount of analgesia Days stay in hospital Cost of oral care Patient quality of life.