Download [Ganoderma spores may regulate the levels of mitochondria

Ganoderma. Os esporos do Ganoderma por via oral aumentam a expressão do pgc1-alfa
(peroxisome proliferator-activated recptor gama coactivator 1 alfa) regulador mestre da
biogênese mitocondrial
Lembrar que os esporos do0 Ganoderma são ricos em triterpenos
[Ganoderma spores may regulate the levels of mitochondriarelated molecular substances in hippocampus of young rats
birthed by rats with gestational hypertension].
[Article in Chinese]
Cheng JJ, Zeng YS, Xiong Y, Zhang W, Chen SJ, Zhong ZQ.
Zhong Xi Yi Jie He Xue Bao. 2007 May;5(3):322-7.
Source
Division of Neuroscience, Department of Histology and Embryology, Zhongshan Medical College, Sun Yatsen University, Guangzhou, Guangdong Province 510080, China.
Abstract
OBJECTIVE:
To investigate the effects of Ganoderma spores on mitochondria-related molecular substances in
hippocampus of young rats birthed by rats with gestational hypertension.
METHODS:
Nitric oxide synthase (NOS) inhibitor Nw-nitro-L-arginine methylester (L-NAME) was intraperitoneally
injected into pregnant rats to induce gestational hypertension, and Ganoderma spores were administered
orally. The effects of Ganoderma spores on levels of mitochondria-related molecular substances in
hippocampus of young rats birthed by the rats with gestational hypertension were evaluated with
immunoradiometric assay of cAMP, RT-PCR analysis of related genes, and detection of enzyme activity.
RESULTS:
In hippocampus of the new-born rats birthed by rats with gestational hypertension, the cAMP level,
mitochondrial DNA (mtDNA) level and adenosine triphosphatase (ATPase) activity were decreased, and
the expression level of peroxisome proliferator activated receptor gamma coactivator 1 alpha (pgc1 alpha)
was unchanged compared to the normal control group. The cAMP level, mtDNA level, ATPase activity and
pgc1 alpha expression level in hippocampus of 30-day post-natal rats were lower than those of the rats in
normal control group. After oral administration of Ganoderma spores, the cAMP and mtDNA levels in
hippocampus of the new-born rats and 30-day post-natal rats recovered almost to the levels of normal
control rats, and the ATPase activity and pgc1 alpha expression level were also increased significantly.
CONCLUSION:
Ganoderma spores may regulate the levels of mitochondria-related molecular substances in hippocampus
of young rats birthed by rats with gestational hypertension.
PMID:17498495