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2 0 1 4 / 2 0 1 5 Product Catalog ENZYMES dia g nos t ic rea g ents blood cu l tu re p l a tes immu nochemi str y ap p l i ca t i ons bi osen sor s u ri na l y s is poi nt-of-care E NZ YME S PRODUCT CATA LOG Sekisui Diagnostics has been a leader in the manufacturing of high quality enzymes and specialist biochemicals to the global healthcare market for over 40 years. We have worked with many global partners to supply high quality materials for a variety of applications, including enzymes for biotherapeutic manufacture, pharmaceutical production, clinical chemistry and biosensors. From enzyme discovery through to commercialization, we commit to excellence in quality, attention to detail and customer service. Our flexibility of scale, from small R&D quantities to full scale manufacturing, allows us to support you every step of the way from concept to product launch. Key elements for success lie within the way we work and the systems that are in place. • Working closely with our partners and disciplined project management ensures a focused and timely delivery of your product. • Our accreditation to ISO 9001, plus manufacturing systems that exceed this benchmark, guarantees high standards, consistency, and reliability of product supply. • Our accreditations to ISO 14001 (Environmental Management System), OHSAS 18001 (Safety Management System) and knowledge of CTPAT (security), provide assurance of responsible manufacturing and supply. By utilizing our fully integrated, multi-functional teams and accredited quality management systems we are able to offer the complete solution, tailored to your requirements. DIAGNOSTIC ENZYMES PRODUCT SOURCE PART NO. 1-5-Anhydroglucitol-6-Phosphate Dehydrogenase Escherichia coli T-95 Acyl-CoA Oxidase Arthrobacter sp. T-17 Acyl-CoA Synthetase Pseudomonas fragi T-16 Alcohol Oxidase Candida sp. T-38 Alkaline Phosphatase Escherichia coli T-08 Ascorbate Oxidase Zucchini 70-6141-20 Ascorbate Oxidase Acremonium sp. T-53 Ascorbate Oxidase Acremonium sp. (R) T-187 Bilirubin Oxidase Myrothecium sp. BIOX-70-1021 Bilirubin Oxidase Bacillus subtilis T-188 Catalase Aspergillus sp. (L) CATA-70-4004 Cholesterol Dehydrogenase Nocardia sp. CHDE-70-1241 Cholesterol Esterase NEW Microbial (R) CHES-70-1821 Cholesterol Esterase Candida rugosa 70-6551-03 Cholesterol Esterase Pseudomonas sp. CHES-70-1041 Cholesterol Esterase Pseudomonas sp. T-18 Cholesterol Esterase Microorganism T-98 Cholesterol Esterase Candida rugosa 70-6201-01 Cholesterol Oxidase Nocardia sp. CHOX-70-1101 Cholesterol Oxidase Microorganism T-101 Cholesterol Oxidase Microorganism (L) T-84 Cholesterol Oxidase Microbial (R) RECO-70-1229 Cholesterol Oxidase Streptomyces lividans (R) RECO-70-1221 Choline Oxidase Arthrobacter globiformis T-05 Colipase Porcine pancreas (L) 70-6254-01 Diacentinase Bacillus subtilis (L) 70-6304-01 Diaphorase (NADH) Bacillus megaterium T-06 Diaphorase (NADPH) Bacillus megaterium T-10 DNASE B Escherichia coli (L) (R) 70-6174-01 Glucoamylase Rhizopus sp. GLUC-70-6881 Glucose Dehydrogenase NAD Dependent Bacillus sp. GLDE-70-1191 Glucose Dehydrogenase FAD Dependent Aspergillus sp. GLDE-70-1192 Glucose Oxidase HPS150 Aspergillus niger (R) GLOX-70-6457 Glucose Oxidase HPS300 Aspergillus niger (R) GLOX-70-6456 Glucose Oxidase Aspergillus niger (L) 70-6644-01 Glucose Oxidase L150 Aspergillus niger (R) (L) GLOX-70-6599 (L) Liquid (R) Recombinant ENZ 1 E N Z YME S PR ODUCT CATA LOG DIAGNOSTIC ENZYMES DIAGNOSTIC ENZYMES PRODUCT SOURCE PART NO. PRODUCT SOURCE PART NO. Glucose-6-Phosphate Dehydrogenase Leuconostoc mesenteroides GLPD-70-1201 Purine Nucleoside Phosphorylase Bacillus sp. (L) T-69 Glucose-6-Phosphate Dehydrogenase Bacillus sp. T-51 Pyruvate Oxidase Aerococcus viridans T-45 Glycerol Kinase Flavobacterium meningosepticum T-64 Streptolysin O Escherichia coli (R) (L) 70-6844-01 Glycerol Kinase Cellulomonas sp. GLKI-70-6495 Sarcosine Oxidase Bacillus sp. T-46 Glycerol Kinase Escherichia coli 70-6741-01 Tyramine Oxidase Arthrobacter sp. T-25 Glycerol Phosphate Oxidase Pediococcus sp. 70-6051-01 Urease Jack bean UREA-70-1651 L-α-Glycerophosphate Oxidase Streptococcus sp. (R) T-107 Urease Jack bean (L) 70-6734-01 L-α-Glycerophosphate Oxidase Streptococcus sp. (R) 70-4875-01 Uricase Bacillus fastidiosus URIC-70-1701 L-α-Glycerophosphate Oxidase Aerococcus viridians T-15 Uricase Escherichia coli (R) URIC-70-1731 Glycerophosphorylcholine Phosphodiesterase Gliocladium roseum T-33 Uricase Arthrobacter globiformis (R) URIC-70-1721 Hexokinase Yeast HEXO-70-1351 Xanthine Dehydrogenase Microorganism (L) T-134 Hexokinase Bacillus sp. T-50 ANTIBIOTIC INACTIVATING ENZYMES Hexokinase Rhodothermus obamensis T-141 Hexokinase ADP Dependent Pyrococcus furiosus T-92 Hexokinase ADP Dependent 3 α-Hydroxysteroid Dehydrogenase Thermococcus litoralis T-93 Pseudomonas sp. T-58 12-α-Hydroxysteroid Dehydrogenase Bacillus spaericus T-190 3-Hydroxybutyrate Dehydrogenase Alcaligenes faecalis T-68 Lactate Dehydrogenase Microbial LADE-70-1411 Lactate Oxidase Aerococcus viridians (R) RELO-70-1381 Lipase Chromobacterium viscosum LIPA-70-1461 Lipase Chromobacterium viscosum and Bacillus sp. T-116 Lipase Microorganism T-63 Monoglyceride Lipase Bacillus sp. T-117 Lysophospholipase Vibrio sp. T-32 Malate Dehydrogenase Microbial MADE-70-1521 Maltase (α-Glucosidase) Yeast MALT-70-1235 NAD Synthetase Bacillus stearothermophilus T-67 SPECIALITY PRODUCTS Oxaloacetate Decarboxylase Pseudomonas sp. T-14 PRODUCT USAGE PART NO. Peroxidase RZ 2.0 Horseradish PERO-70-6915 Streptavidin Streptavidin is sourced from Streptomyces avidinii. Suitable for techniques such as ELISA, RIA, DNA probes, immunocytochemistry and protein blotting. STRE-70-4801 Phosphofructokinase Bacillus stearothermophilus T-142 Valinomycin Bacillus stearothermophilus T-120 Valinomycin is sourced from Streptomyces sp. Suitable as a potassium ionophore in electrodes or other devices for the measurement of potassium. VALI 997860 Phosphoglucose Isomerase Phospholipase A2 Streptomyces violaceoruber (L) T-194 Bacillus cereus T-11 CNPG3 Phospholipase D Streptomyces chromofuscus T-07 2-Chloro-4-nitrophenyl maltotrioside (CNPG3) is a proprietary substrate for the determination of pancreatic α-amylase. No requirement for auxillary enzymes as colour is directly released by α-amylase cleavage. CHNM-70-3821 Phospholipase C Phospholipase D Streptomyces sp. T-39 2 ENZ Sekisui Diagnostics is a prime manufacturer of both β-Lactamase and Penicillinase from Bacillus cereus, for inactivation of all classes of β-Lactam antibiotics; cephalosporins up to 5th generation, carbapenems and penicillins. PRODUCT FORMAT USAGE PART NO. β-Lactamase ES Bulk powder BELA-70-1491 β-Lactamase ES Specially developed for use when inactivation of more resistant cephalosporins such as Cefepime, Cefoxitin,Cefradine and Ceftazidime is required. Sterile vials (pack of 10) β-Lactamase Bulk powder β-Lactamase Sterile vials (pack of 10) Penicillinase Bulk powder Penicillinase is a freeze-dried product containing buffer salts that is active against penicillins only. PENI-70-1541 Penicillinase Sterile vials (pack of 10) Convenient format of Penicillinase (PENI-70-1541) in ready-to-use vials which have been sterilised by gamma-irradiation and require reconstitution. PENI-70-1545 BpNPG7 (L) Liquid (R) Recombinant Convenient format of β-Lactamase ES (BELA-70-1461) in ready-to-use vials which have been sterilised by gamma-irradiation and require reconstitution. A freeze-dried product containing buffer salts and zinc that has a range of activity against both penicillins (βI activity) and cephalosporins (βII activity). Convenient format of β-Lactamase (BELA-70-1401) in ready-to-use vials which have been sterilised by gamma-irradiation and require reconstitution. Blocked p-nitrophenyl-α-D-maltoheptaoside (BpNPG7 ) is a substrate for the determination of pancreatic α-amylase. Auxillary enzymes, Glucoamylase and Maltaseare required to release the chromogen. (L) Liquid (R) Recombinant BELA-70-1461 BELA-70-1431 BELA-70-1401 BLNM-70-3685 ENZ 3 N OTE S SEKISUI DIAGNOSTICS YOUR GLOBAL PARTNER FOR OVER 30 YEARS Sekisui Diagnostics was created in 2011 when Sekisui Medical acquired Genzyme Diagnostics. The new company brings together extensive products development capabilities and a broad global sales/distribution network for our comprehensive product lines: • • • • Clinical chemistry systems and reagents Coagulation systems and reagents Infectious disease rapid tests, line immunoassays, and ELISA Kits Enzymes and specialty biochemicals Sekisui Diagnostics is a diverse company with extensive product development capabilities, state of the art manufacturing facilities, and deep diagnostics expertise. We are Sekisui Diagnostics and we are dedicated to improving the lives of patients all around the world. 4 ENZ Locations Worldwide HQ Sekisui Diagnostics, LLC Lexington, MA, USA +1 781-652-7800 Sekisui Diagnostics, LLC San Diego, CA, USA +1 858-777-2600 Sekisui Diagnostics, LLC Exton, PA, USA +1 610-594-8590 Sekisui Diagnostics, LLC Stamford, CT, USA +1 203-602-7777 Sekisui Diagnostics (UK) Ltd. Kings Hill, West Malling Kent, UK +44-1732-220022 Sekisui Virotech GmbH Rüsselsheim, Germany +49-6142-6909-0 American Diagnostica GmbH Pfungstadt, Germany +49-6157-990899 Sekisui Medical Co., Ltd. Tokyo, Japan +81-3-3272-0671 Sekisui Medical Technology (China) Ltd. Shunyi District, Beijing, China +86-10-8048-6325 Sekisui Medical Technology (China) Ltd. Chaoyang District, Beijing, China +86-10-6269-2662 Sekisui Diagnostics P.E.I. Inc. Charlottetown, PEI, Canada +1 902-566-1396 www.sekisuidiagnostics.com 80-8228-00-00 10/14