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Cancer Unit Jeopardy Review Normal Mitosis 10 One situation in which normal mitosis occurs (hyperplasia, metaplasia, growth, repair, replace) 20 Two situations in which normal mitosis occurs 30 When the same type of cells and the same number of cells are produced (replacement) 40 When one cell becomes two, two become four, four become eight (growth) 50 The production of wbcs when a bacterial infection occurs (hyperplasia) 60 Metaplasia, beyond the definition scarring (replacement of a specialized cell with a less specialized cell) 70 Hyperplasia (the mitosis of cells only when there is a physiological need) 80 When normal cells appear abnormal to a pathologist (dysplastic) Abnormal Mitosis 10 20 30 40 50 60 70 80 An abnormal mass of cells (neoplasm) A solid-filled growth (tumor) Innocent (benign) A fluid-filled neoplasm (cyst) Cancer (malignant) Malignancy found all over the body (diffuse) Benign tumor that may become malignant (polyp) Two types of diffuse cancer (leukemia, lymphoma) Cancer Characteristics 10 Two nuclear characteristics of cancer cell (extra chromatin, two nuclei, enlarged nuclei) 20 Ratio of nucleus size to cytoplasm (1:1) 30 Two differences between benign tumors and malignant tumors (non-invasive, normal cells, localized) 40 Spreading of cancer cells (metastasis) 50 The reason that cancer cell nuclei stain dark (extra chromatin) 60 Most common path by which cancer cells travel and survive (lymph system) 70 Lack of cellular adhesion and loss of contact inhibition (reasons cancer cells metastasize) 80 Two substances that keep normal cells anchored (fibronectin, mucopolysaccharide) Treatments and Staging 10 20 30 40 50 The number one treatment for most cancers (surgery) Nausea, vomiting, hair loss (side effects of chemotherapy) Two types of radiation (beamed, capsule) The N in TNM staging system (lymph node involvement) Using a patient’s own cells to fight cancer (immunotherapy) 60 The stage in which cancer has seeded in secondary organs (Stage 4) 70 Blocks the effects of estrogen or progesterone (hormone therapy) Misc. 10 20 30 40 50 60 70 80 90 Cancer that arises in the pigment producing cells (melanoma) Causes cancer (carcinogen) Inorganic material usually found in lung cancer patients (tar) Virus that can cause cancer (HPV) An imbalance of these can lead to cancer (hormones) The first stage of neoplastic transformation (activation) P53 is one type of this defense mechanism (tumor suppressor gene) Releases anti-oxidants in the cells (peroxisomes) Chemotherapy used before surgery (neoadjuvant)