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866 JACC: CARDIOVASCULAR IMAGING, VOL. 8, NO. 7, 2015 Letters to the Editor JULY 2015:863–9 Please note: Dr. Miglioranza has received a post-graduate grant from CAPES, a ila has Brazilian governmental agency for post-graduate support. Dr. Miha received a research grant from the European Association of Cardiovascular Imaging. Drs. Muraru and Badano have received equipment grants from and served on the speakers bureau for GE Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. artery origin and proximal left anterior descending artery from the pulmonary artery were 8.7 mm and 11.9 mm, respectively. Coronary artery relational anatomy was felt to be favorable for intervention with combined transcatheter aortic ViV and TPVI (Figure 1A). REFERENCES Using standard techniques, a 26-mm transcatheter 1. Vahanian A, Alfieri O, Andreotti F, et al. Guidelines on the management of valvular heart disease (version 2012): Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology, European Association for Cardio-Thoracic Surgery. Eur Heart J 2012;33: 2451–96. 2. Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;63:e57–185. 3. Cohen GI, White M, Sochowski RA, et al. Reference values for normal adult transesophageal echocardiographic measurements. J Am Soc Echocardiogr 1995;8:221–30. 4. Colombo T, Russo C, Ciliberto GR, et al. Tricuspid regurgitation secondary to mitral valve disease: tricuspid annulus function as guide to tricuspid valve repair. Cardiovasc Surg 2001;9:369–77. 5. Chopra HK, Nanda NC, Fan P, et al. Can two-dimensional echocardiography and Doppler color flow mapping identify the need for tricuspid valve repair? J Am Coll Cardiol 1989;14:1266–74. aortic valve replacement (Sapien-XT, Edwards Lifesciences) was successfully undertaken within the aortic prosthesis. Post-deployment echocardiographic assessment demonstrated normal valve function. A noncontrast rotational angiogram of the cardiac and vascular structures was then performed, and images were matched with previously performed CT reconstructions of the pulmonary conduit. Coregistration using known skeletal landmarks enabled overlay of 3D images onto live fluoroscopy to guide transcatheter pulmonary valve placement. An exchangelength stiff guidewire was placed in the left lower lobe pulmonary artery using a balloon wedge catheter, and serial balloon dilations of the pulmonary conduit were performed using 18- and 22-mm balloons with simultaneous left coronary angiography demonstrating no coronary–conduit interaction. A 22-mm A Combined Transcatheter Aortic diameter balloon-in-balloon “BIB” catheter (NuMed, Valve-in-Valve and Pulmonary Valve Hopkinton, New Jersey) with a mounted stent (Pal- Implantation maz-XL-4010, Cordis, Bridgewater, New Jersey) was delivered via a 14-Fr Mullins sheath into the pulmonary conduit. This was used to expand the homograft Patients with surgically treated congenital cardiac conduit and prepare a landing zone to minimize future disease increasingly survive into adulthood and face risk of transcatheter pulmonary valve stent fracture. the need for repeat sternotomies for senescent pros- Fluoroscopic and 3D CT overlay facilitated accurate thetic valves and conduits. This poses increased risk positioning and deployment of the stent. The stent was of chest re-entry injury, and alternatives to redo then post-dilated using a 22-mm balloon, and no stent median sternotomy are important. Although trans- recoil was noted. A 22-mm transcatheter pulmonary catheter aortic valve-in-valve (ViV) and transcatheter valve was then successfully deployed using a 22-mm pulmonary valve implantation (TPVI) (Melody valve, delivery system (Ensemble delivery system, Med- Medtronic, Minneapolis, Minnesota) have both been tronic) within the landing zone created by the stent separately described (1–3), we describe a combination (Figures 1B and 1C). The peak-to-peak catheter right of aortic ViV and TPVI utilizing 3-dimensional (3D) ventricular outflow tract (RVOT) gradient was reduced computed tomography (CT) fluoroscopic coregistra- to 5 mm Hg. Transesophageal echocardiography tion to aid procedural execution. A 24-year-old man showed normal valve function with mild regurgita- with congenital bicuspid aortic stenosis, prior Ross tion. The patient was dismissed from the hospital on procedure, re-replacement of the right ventricle– day 2 with a mean transaortic gradient of 21 mm Hg, pulmonary artery homograft, ascending aortic aneu- and 11 mm Hg across the RVOT, with no demonstrable rysm repair, and aortic valve replacement (25-mm regurgitation. Perimount bioprosthesis, Edwards Lifesciences, This presentation is unique in that this was a young Irvine, California) was referred for symptomatic adult with 3 previous median sternotomies within a aortic and pulmonary conduit stenoses. Aortic valve period of 6 years, and efforts to avoid a repeated me- mean gradient was 52 mm Hg, and mean pulmonary dian conduit gradient was 38 mm Hg. CT demonstrated assessment and 3D imaging were essential to proce- pulmonary conduit stenosis and an aortic annular dural planning and execution. Although annular area of 360 mm 2 (annular dimensions 21.9 mm calcification and radiographic signatures of prosthetic 21.5 mm). The distances of the right coronary valves can often serve as fluoroscopic markers and sternotomy were critical. Multidisciplinary JACC: CARDIOVASCULAR IMAGING, VOL. 8, NO. 7, 2015 Letters to the Editor JULY 2015:863–9 F I G U R E 1 Pre- and Post-Intervention 3D Surface-Rendered Images of Aortic and Pulmonary Outflow Tracts (A) Surface-rendered images of the aorta (Ao) and right ventricular outflow tract (RVOT) demonstrating favorable relational anatomy of reimplanted coronary buttons to the RVOT/main pulmonary artery (MPA). The inset shows a distance of w8.8 mm between the RVOT and right coronary artery. (B) Lateral projection with fluoroscopic overlay during inflation of the outer balloon for delivery of transcatheter pulmonary valve (red arrow); transcatheter aortic valve in aortic position (blue arrow). (C) Final surface 3-dimensional (3D) rendered image of the transcatheter aortic and pulmonary valves. PV ¼ pulmonary vein; RCA ¼ right coronary artery. assist with valve positioning and deployment during REFERENCES transcatheter valve–ViV implantation, these are not 1. Eggebrecht H, Schafer U, Treede H, et al. Valve-in-valve transcatheter always available or optimal for procedural guidance. The use of 3D CT fluoroscopic coregistration using skeletal landmarks can significantly improve the accuracy of valve positioning and procedural success. aortic valve implantation for degenerated bioprosthetic heart valves. J Am Coll Cardiol Intv 2011;4:1218–27. 2. Meadows JJ, Moore PM, Berman DP, et al. Use and performance of the Melody Transcatheter Pulmonary Valve in native and postsurgical, nonconduit right ventricular outflow tracts. Circ Cardiovasc Interv 2014;7: 374–80. Saurabh Sanon, MD Allison K. Cabalka, MD Rakesh M. Suri, MD Donald Hagler, MD Charanjit S. Rihal, MD* From Plaque Morphology to Ischemia: *Division of Cardiovascular Diseases Pushing the Limits of Spatial Resolution 3. Dvir D, Webb J, Brecker S, et al. Transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves: results from the global valve-invalve registry. Circulation 2012;126:2335–44. Mayo Clinic 200 First Street South West Rochester, Minnesota 55905 E-mail: [email protected] http://dx.doi.org/10.1016/j.jcmg.2015.05.002 Please note: Dr. Rihal has received research funding from Edwards Lifesciences. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. We read with interest the paper by Park et al. (1) concerning the association between certain atherosclerotic plaque characteristics (APCs), depicted by coronary computed tomography angiography (CTA) and the presence of ischemia by invasive fractional flow reserve (FFR). The study addressed the 867