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Rapid Estrogen Receptor Signaling Is Essential for the Protective Effects of Estrogen Against Vascular InjuryClinical Perspective by Sophie J. Bernelot Moens, Gavin R. Schnitzler, Moriah Nickerson, Huiming Guo, Kazutaka Ueda, Qing Lu, Mark J. Aronovitz, Heather Nickerson, Wendy E. Baur, Ulla Hansen, Lakshmanan K. Iyer, and Richard H. Karas Circulation Volume 126(16):1993-2004 October 16, 2012 Copyright © American Heart Association, Inc. All rights reserved. Interactions between estrogen receptor (ER)α and striatin are blocked in a novel ERα176–253 disrupting peptide mouse (DPM). Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004 Copyright © American Heart Association, Inc. All rights reserved. Rapid signaling is lost in cells from the disrupting peptide mouse (DPM) and in primary and immortalized cells lacking striatin. Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004 Copyright © American Heart Association, Inc. All rights reserved. Rapid signaling through striatin is required for transcriptional upregulation of endothelial nitric oxide synthase (eNOS) by 17β-estradiol (E2). Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004 Copyright © American Heart Association, Inc. All rights reserved. Identification of differentially 17β-estradiol (E2)–responsive genes in disrupting peptide mouse (DPM) vs wild-type (WT) by expression microarray. Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004 Copyright © American Heart Association, Inc. All rights reserved. The estrogen receptor (ER)α176–253 striatin-blocking peptide eliminates the effect of 17βestradiol (E2) on smooth muscle cell growth and endothelial cell migration. Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004 Copyright © American Heart Association, Inc. All rights reserved. The ability of estrogen to protect against carotid arterial injury is lost in disrupting peptide mouse (DPM) mice. Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004 Copyright © American Heart Association, Inc. All rights reserved.