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Rapid Estrogen Receptor Signaling Is Essential for the
Protective Effects of Estrogen Against Vascular
InjuryClinical Perspective
by Sophie J. Bernelot Moens, Gavin R. Schnitzler, Moriah Nickerson, Huiming Guo,
Kazutaka Ueda, Qing Lu, Mark J. Aronovitz, Heather Nickerson, Wendy E. Baur, Ulla
Hansen, Lakshmanan K. Iyer, and Richard H. Karas
Circulation
Volume 126(16):1993-2004
October 16, 2012
Copyright © American Heart Association, Inc. All rights reserved.
Interactions between estrogen receptor (ER)α and striatin are blocked in a novel ERα176–253
disrupting peptide mouse (DPM).
Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004
Copyright © American Heart Association, Inc. All rights reserved.
Rapid signaling is lost in cells from the disrupting peptide mouse (DPM) and in primary and
immortalized cells lacking striatin.
Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004
Copyright © American Heart Association, Inc. All rights reserved.
Rapid signaling through striatin is required for transcriptional upregulation of endothelial nitric
oxide synthase (eNOS) by 17β-estradiol (E2).
Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004
Copyright © American Heart Association, Inc. All rights reserved.
Identification of differentially 17β-estradiol (E2)–responsive genes in disrupting peptide mouse
(DPM) vs wild-type (WT) by expression microarray.
Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004
Copyright © American Heart Association, Inc. All rights reserved.
The estrogen receptor (ER)α176–253 striatin-blocking peptide eliminates the effect of 17βestradiol (E2) on smooth muscle cell growth and endothelial cell migration.
Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004
Copyright © American Heart Association, Inc. All rights reserved.
The ability of estrogen to protect against carotid arterial injury is lost in disrupting peptide
mouse (DPM) mice.
Sophie J. Bernelot Moens et al. Circulation. 2012;126:19932004
Copyright © American Heart Association, Inc. All rights reserved.
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