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Managing blood glucose levels in people with Diabetes Mellitus: The MiniMed Paradigm Veo System (and other alternative technologies identified in scoping) Diabetes mellitus is a chronic metabolic disorder which causes a person’s blood glucose to become too high. To prevent this, insulin is often administered to reduce the blood glucose level but sometimes, this can cause blood glucose levels to become too low and lead to hypoglycaemia. Achieving good blood glucose control reduces the risk of diabetes-related complications such as diabetic eye and kidney diseases and diabetic-related cardiovascular events. The MiniMed Paradigm Veo System is an integrated continuous glucose monitoring and insulin pump system intended for use as an aid in managing blood glucose levels in people with diabetes. It produces alerts if glucose levels become too high or low, if levels are rapidly changing, or if the system predicts glucose levels will be too high or too low in the near future. The system can also suspend insulin delivery automatically if there is no response to a low glucose warning. This could be beneficial in reducing the incidence of nocturnal hypoglycaemia and associated anxiety. Other potential patient benefits of the technology include improved glucose control resulting in fewer diabetes-related complications, improved quality of life and easier adherence to treatment. Potential healthcare system benefits of the technology include cost and resource savings associated with a reduction in hospital admissions due to diabetes-related complications, and achieving optimum therapy more quickly. The NICE Diagnostics Assessment Programme will assess the clinical and cost-effectiveness of the MiniMed Paradigm Veo System (and other alternative technologies identified during scoping) in order to make recommendations on its use in the NHS.