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Division of Chemical Biology Protein folding, metal ion transport pathways, amyloid mechanisms and modulation Pernilla Wittung Stafshede Head of Division Nanofluidic tools for single DNA molecule biophysics Fredrik Westerlund How and why do biomolecules (mis)function in their cellular milieus? Molecular basis of disease Diagnostics for Antibiotic Resistance Genes Protein aggregation in neurodegenerative disease, Cell models and bioimaging, RNA drug delivery Elin Esbjörner Drug delivery Pernilla Wittung Stafshede Going from metalloprotein folding to... How? • Purified proteins and engineered variants • A range of biophysical (spectroscopic, calorimetric) in vitro methods ...metal delivery by metal ...protein misfolding and amyloid diseases transport proteins (Copper ion transport) (Parkinsons disease) ...protein folding in crowded cell milieu (excluded volume, membranes) Fredrik Westerlund Nano-tools for DNA analysis Optical DNA mapping - antibiotic resistance Fredrik Westerlund Protein-DNA interactions Elin Esbjörner protein aggregation in the test tube… …and in living cells Cell’s treated with Alzheimer’s disease peptide Aβ Alzheimer’s disease ALS Parkinson’s disease Methods: Live Cell Imaging, Flow Cytometry, Mammalian Cell Culture, Fluorescence, Biophysical Chemistry Courses • Biophysical Chemistry (MSc level) • Protein Folding and Function (MSc level)