Download Division of Chemical Biology

Division of Chemical Biology
Protein folding, metal ion
transport pathways,
amyloid mechanisms and
modulation
Pernilla Wittung Stafshede
Head of Division
Nanofluidic tools for
single DNA molecule
biophysics
Fredrik Westerlund
How and why do
biomolecules
(mis)function in their
cellular milieus?
Molecular basis of
disease
Diagnostics for
Antibiotic Resistance
Genes
Protein aggregation in
neurodegenerative disease,
Cell models and
bioimaging, RNA drug
delivery
Elin Esbjörner
Drug delivery
Pernilla Wittung Stafshede
Going from metalloprotein folding to...
How?
• Purified proteins and
engineered variants
• A range of biophysical
(spectroscopic,
calorimetric) in vitro
methods
...metal delivery by metal ...protein misfolding
and amyloid diseases
transport proteins
(Copper ion transport)
(Parkinsons disease)
...protein folding in
crowded cell milieu
(excluded volume, membranes)
Fredrik Westerlund
Nano-tools for DNA analysis
Optical DNA mapping - antibiotic resistance
Fredrik Westerlund
Protein-DNA interactions
Elin Esbjörner
protein aggregation in the test tube…
…and in living cells
Cell’s treated with Alzheimer’s disease peptide Aβ
Alzheimer’s disease
ALS
Parkinson’s disease
Methods: Live Cell Imaging, Flow Cytometry,
Mammalian Cell Culture, Fluorescence, Biophysical
Chemistry
Courses
•
Biophysical Chemistry (MSc level)
•
Protein Folding and Function (MSc level)