Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Slide 1 - AccessPharmacy
Transcript
Routes of SN-38 transport and exposure to intestinal epithelial cells. SN-38 is transported into the bile following glucuronidation by liver UGT1A1 and extrahepatic UGT1A7. Following cleavage of luminal SN-38 glucuronide (SN-38G) by bacterial β-glucuronidase, reabsorption into epithelial cells can occur by passive diffusion (indicated by the dashed arrows entering the cell) as well as by apical transporters. Movement into epithelial cells may also occur from the blood by basolateral transporters. Intestinal SN-38 can efflux into the lumen through P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2) and into the blood by means of MRP1. Excessive accumulation of the SN-38 in intestinal epithelial cells and bone marrow, resulting from reduced glucuronidation, can lead to the cellular damage and toxicity depicted in Figure 6-8 (Reproduced with permission from Tukey RH et al. Pharmacogenetics Source: Drug Metabolism, Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e of human UDP-glucuronosyltransferases and irinotecan toxicity. Mol Pharmacol, 2002, 62:446–450. Copyright © 2002 The American Society for Citation: Brunton LL,Therapeutics.). Chabner BA, Knollmann BC. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e; 2011 Available at: Pharmacology and Experimental http://mhmedical.com/ Accessed: August 03, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
