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Water & the Minerals Fluids      Females 50-55% water Males 55-60% Less water in older adults More in children More in persons who exercise Fluids  Main functions  Shape and structure to cells  normal turgor  Aids in digestion and absorption of nutrients  Transports/ lubricates  Solvent/ chemical reactions  Stabilizes body temperature Fluids    Adults metabolize 2.5-3 liters water/day Excrete 500-600 ml/day to get rid of body wastes 7-9 liters secreted into GI tract each day almost all reabsorbed Approximate Total Volume of Digestive Secretions Produced in 24 Hours by Adult of Average Size Secretion Amount Saliva Gastric Bile Pancreatic Intestinal TOTAL 1500 ml 2500 500 700 3000 8200 ml Fluids     Normal losses 2.5 liters/day Obligatory Facultative Thirst-not always accurate diminished in elderly infants can’t tell you watch color of urine Fluids      ECF water outside cell 1/3 body H20 blood plasma interstitial fluids     ICF water inside cells 2/3 body H20 site of basic metabolic activity Dehydration      Fluid volume deficient or hypovolemia Output exceeds water intake Shift of water from ECF to ICF Lower blood volume Cellular edema Dehydration  Hypovolemia symptoms  intense thirst  dry mucous membranes  weak and rapid pulse  orthostatic hypotension  vomiting and confusion  concentrated urine  life threatening -10% weight loss Signs of dehydration        Headache/ lightheadness Fatigue Loss of appetite Flushed skin Heat intolerance Dry mouth and eyes Dark, scanty urine Fluid overload      Fluid volume excess or hypervolemia Fluid intoxication muscle cramps and low BP excessive water intake renal failure or CHF water shifts from cell to ECF Fluid overload     Peripheral edema Rapid, bounding pulse Distended neck veins Pulmonary edema/SOB Fluids    Adequate water intake 30 ml/kg or 1-1.5 ml/1 kcalorie energy expenditure Urine should be pale yellow Minerals   Inorganic elements Classified as macro and trace elements by amount by need Functions      Structure Fluid Balance Vitamin, enzyme, and hormone activity Nerve cell transmission Muscle contraction Acid -Base balance     Determined by pH Water regulates pH Normal pH 7.35-7.45 Acid base buffers carbonic acid sodium bicarbonate Acid -Base Balance  Disturbances  respiratory acidosis  chronic lung disease  metabolic acidosis  ketosis  respiratory alkalosis  hyperventalating  metabolic alkalosis  vomiting Mineral salts       NaCl in body water Movement directed by cells Water follows salt Separate into ions in solution Conduct electricity Called electrolytes Electrolytes    Cations-NA+, K+ Anions-ClUsually balanced Sodium        Principle electrolyte in ECF Primary regulator ECF volume Maintains acid base balance Muscular irritability Nerve impulse transmission Intestinal secretions 35-40% skeleton Sodium      1 gram sodium in 1/5 t. of NaCl Salt is 39% sodium Use less with HTN, CHF, and Kidney Failure Adjust depending on climate and physical activity Suggested intake 2400 mg or 1000mg/1000 kcalories Sodium   Increased losses with vomiting and diarrhea Replace both Na+ and water Potassium      Principle cation in ICF Maintains cell integrity Keeps heart beat steady Deaths from severe diarrhea or dieresis Assists in CHO and protein metabolism Potassium    High K foods associated with decreased risk of stroke and lower blood pressure Hypokalemia too low=death Hyperkalemia too high =death Lower Sodium Diet      Reduce sodium gradually Learn to read the food labels and compare brands Fresh is best Balance high and low sodium foods Experiment with herbs,etc. Chloride   Principle anion of ECF Not usually treated separately from sodium problems Calcium     Most abundant 99% bone and teeth 1% serum Bound with P04-3 and Mg++ Calcium   Bones replete serum Serum Ca++  bone and teeth formation  controls muscle contractions  transmits nerve impulses  blood clotting  secretion of hormones Calcium    Calcium Regulated very tightly 30-40% dietary calcium absorbed  bound to oxalates & phytates in plant foods  New recommendations Calcium    Serum levels kept constant Vitamin D and parathyroid hormone raises Ca++ levels PRN Calcium travels with Albumin in blood-need to do corrected Ca++ calculation if Albumin low Calcium Deficiencies  Means less bone density  Osteoporosis- thin, white or Asian women most at risk  Rickets- malabsorption of Ca++ Calcium Deficiencies   Sedentary lifestyle less absorption Low calcium diet increased blood pressure ETOH and smoking increases losses Calcium Supplements     Carbonate Citrate Acetate NO oyster shell Supplements No more than 2500mg per day Count amounts from food Smaller divided doses Do not take iron and calcium at the same time Plenty of fluids Calcium Excesses   Constipation Kidney Stones Calcium Sources       Milk Cheese Yogurt Soy & other legumes Whole grains Green Leafy Vegetables Phosphorous     Combined with Ca++ in bone and teeth 85% in bones Major body buffer Important in energy transfers-ATP Phosphorous    Absorption regulated by parathyroid hormone Excesses excreted in urine Renal insufficiency = high serum levels Phosphorous Deficiencies    Malnutrition ETOH abuse Starvation Phosphorous Sources        Meats Poultry Fish Eggs Legumes Milk and Dairy Products Soft drinks Magnesium      Small amount in body Critical to operation of hundreds of enzymes Smooth muscle relaxation Necessary for release of energy Holds calcium in tooth enamel Magnesium Deficiency      Vomiting and diarrhea ETOH abuse Protein malnutrition Causes hallucinations in ETOH withdrawal Prolonged muscle contractions Magnesium Sources      Green leafy vegetables Nuts Legumes Whole grains Seafood Iron      3-5 g stored in body 2/3 as heme in hemoglobin 1/3 as ferritin RBC carries O2 to tissues Needed for new cells Iron    10-15% dietary iron absorbed Amount increases in deficiency Nonheme Fe+++ ferric  plant  source Nonheme and heme Fe++ ferrous  animal source Iron Toxicity     Repeated transfusions Polycystic disease Iron poisoning Symptoms N&V shock convulsions and coma Iron Deficiencies       Most deficient nutrient in US Nutritional Anemias Hemorrhagic Anemias Postgastrectomy anemia Malabsorption anemia Chronic disease anemia Iron Deficiencies  Symptoms  weakness and fatigue  headaches  apathy  Pica-eating of non-nutrient substances  ice, clay, paste, starch, kaolin Iron Deficiency Anemia      Increase food sources Include iron fortified cereals Know heme iron sources Add sources of Vitamin C Drink coffee & tea between meals, not with meals Cook in iron pots Iron Sources     Liver Lean meat Dried beans Fortified cereals Iodine   Major source is iodized salt Thyroid hormones body temperature metabolic rate reproduction/growth nerve and muscle functions Zinc     Picked up by albumin for transport Energy job Healing job Immune function Zinc Deficiencies      Mental disorders Abnormal dark adaptation in vision Skin lesions Hair loss Strict vegetarians at risk Iodine Deficiencies     Goiter Weight gain Birth defects Cretinism Selenium     Antioxidant Sparing effect on Vitamin C Research area Toxicity  hair & nail loss  skin lesions  diarrhea Selenium  Rare deficiency in long term parenteral nutrition Other Trace Minerals  Copper  wound healing  hemoglobin  help cells use FE++  sheaths around nerve fibers  Deficiency dementia, liver failure Other Trace Minerals    Manganese Fluoride excess can mottle teeth Chromium CHO/lipid metabolism works with insulin