Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Biol 2511: Genetics Fall 2006 page 1 of 6 Biol 2511: Genetics Fall 2006 Syllabus page 1 of 7 Instructor: Selene Nikaido, Ph.D. Office: WCM 315A Contact: 660-543-4324 (voice) 660-543-4355 (fax) [email protected] (email) Office hours: Mondays 2-5 p.m., Wednesday 2-3 p.m., Fridays 9:30-10:30 a.m. and 1:30-2:30 p.m. or by appointment Course hours: MWF noon-1 p.m. in WCM 322 (lecture) and Thursdays 10-11:50 a.m. or 2–3:50 p.m. in WCM 315 (laboratory) Course textbook: Pierce, B.A. (2005) Genetics: A Conceptual Approach, 2nd Edition. New York: W.H. Freeman and Company. Laboratory Manual: Instructions will be posted weekly on Blackboard. Blackboard: http://courses.ucmo.edu or http://www.ucmo.edu (Click on Current Students and Click on Blackboard) Course Objectives Learn concepts of transmission, molecular and population genetics Relate genetics concepts to an understanding of other complex biological concepts Understand how related concepts are similar and different (learn to compare and contrast concepts) Understand the nature of science and the scientific method Learn the proper use of common laboratory equipment Course features Blackboard In addition to lectures, laboratories and your textbook, course materials will be provided on Blackboard. You may access Blackboard from any computer that has Internet capabilities. The easiest way to access Blackboard is to go to the UCM website (www.ucmo.edu) and click on “Current Students” in the menu bar near the top. Click on “Blackboard” on the new page. If you have never used Blackboard or if you experience difficulties using Blackboard, call the Blackboard hotline, 1-866-337-9179. You may find the following features useful. You will want to check “Course Documents” for weekly laboratory exercises. Here you will find information about the week’s laboratory. Occasionally, important announcements for the course will be provided through Blackboard. Grades may be viewed in Blackboard as well. I will post grades only through Blackboard. You will see a course listing for the lecture and for the laboratory. On the laboratory course listing, you will be able to view your lab scores. Nothing else is posted on the laboratory course listing. All course materials will be posted on the lecture course listing only. Shortcuts to course material can be found on the left menu bar on the Genetics lecture homepage. Guide to Studying Genetics Success in Genetics will require a fair amount of work on your part. The amount of work required will depend on a number of factors including your previous experience, your skill in learning, and your goals for the course. I will provide many resources for you to achieve your goals, but ultimately, you will be responsible for your success. How to use your textbook Your textbook is an essential resource for information that I want you to learn. The following steps are suggestions guiding you to use your textbook efficiently. Biol 2511: Genetics Fall 2006 page 2 of 6 1. Read the assigned pages. I chose this textbook because I find it readable. I hope you do so, too. 2. All unfamiliar words or words in bold should be treated as vocabulary words. Make note cards with these vocabulary words and begin to memorize their definitions. You must know the meaning of words before you can begin to place them in their proper context with other concepts. 3. At the end of the chapter, you will find a summary of the concepts and new vocabulary presented in the chapter. Make sure you understand the concepts and vocabulary. 4. Try to group and place vocabulary words in context with other vocabulary words and concepts. If you make note cards of words, you can use the note cards to test your ability to group words according to their relationships. 5. Use your lecture notes to guide you to what I think is important. Lectures serve as one of several resources through which you can obtain information you need to know. The lecture is not all encompassing so you will want to use your textbook as a reference to fill-in the gaps within your lecture notes. 6. When writing your vocabulary note cards and when organizing your lecture notes, ask yourself, “Do I really understand what I am writing?” If not, you need to ask someone for help. It is better to start studying weeks before your examination, and not only during the weekend or night (!) before an examination. 7. The textbook has an accompanying website with supplemental information. The address to this site is www.whfreeman.com/pierce. You may want to visit this website for additional presentations of the course material. Questions and problems An excellent way of gauging whether you understand the concepts is to do the problems and answer the questions at the end of each chapter we cover. The answers to problems with asterisks (*) have answers at the end of the textbook. Genetics is challenging because it is a logical, analytical area of biology. To fully understand genetics, problems are presented for you to solve. View these as mysteries or puzzles. Be tenacious and don’t make excuses like “I cannot think logically,” or “It’s too hard and I’ll learn it later.” By doing problems, you will improve your logical skills. Consider forming a study group, not so much to have other people to learn from as to have a motivation to do the exercises and to make learning genetics more fun. Laboratory class Laboratory class is a required component of the course. It is not a separate class. Even if you have taken Genetics during a previous semester, you must attend and participate in laboratory class for 25% of your grade. Prior to coming to class, you should read the background description of the laboratory for the week. You will find the reading assignment for the week’s laboratory in Blackboard under Course Documents. You want to read the assigned background material before coming to class so you will understand the laboratory exercise and be able to complete the exercise within the two-hour period. You will be tested on the content of the laboratories through two examinations. Attendance and courteous behavior Attendance is required on days when lecture examinations and quizzes are scheduled. Attendance is required for all laboratory classes. Failure to attend class will probably result in a lower grade than you wish to obtain for this class. Attendance will be taken at every lecture class, and regular attendance may be required if you are on federally sponsored financial aid. If you arrive to class after I have already begun to talk, do not walk in front of the class. Take a seat in the back or along the same side of the classroom as the door you enter. When you walk in front of the class while I am lecturing, you are being discourteous Biol 2511: Genetics Fall 2006 page 3 of 6 to the students who arrived on time. Please turn off your cell phone when you attend class to participate in a lecture, and to take an examination and quiz. Assessment of performance in the course You will be evaluated according to the following types of assessments. ➤ Examinations (4) 40% (400 points) ➤ Final examination 20% (200 points) ➤ Homework/In-class exercises 15% (150 points) ➤ Laboratory 25% (250 points) Examinations: During the semester you will be given four 100-point examinations, which are tentatively scheduled for the following dates: Exam 1 – Wednesday, September 13 Exam 2 – Wednesday, October 4 Exam 3 – Wednesday, November 1 Exam 4 – Monday, November 20 The 200-point final examination will be given during finals week. The final must be given at the time scheduled by the university. No exceptions are allowed unless you have two other finals scheduled for that day. Only then can an arrangement be made to take the final at another time. The final examination will be comprehensive with emphasis on topics since the fourth exam and the last three laboratory classes. No examinations will be given outside of the regularly scheduled time when the class takes the exam unless you are absent due to a regularly scheduled university event (you must notify me prior to the test) or in case of medical emergency or death in the family (you must provide documentation). If you have a conflict due to a regularly scheduled university event, you must arrange to take the exam prior to the scheduled day of the exam. If you miss an exam due to an unforeseen event, you may petition for a make-up exam. It will be your responsibility to petition for a make-up examination. It is my discretion to grant you the opportunity to make-up an examination. It is also my discretion to alter the make-up examination from the regularly scheduled examination so that a makeup examination taken after the class has taken the regularly scheduled examination may be more difficult than the regularly scheduled examination. No make-up final exams will be given. The final exam for this class is scheduled for the last day of finals. Please do not assume you can make-up the final exam because you have travel plans and will not be in Warrensburg that day. Make your travel plans with the taking of the final exam at its regularly scheduled time in mind. In-class exercises and homework: In-class exercises will be announced only on the day of the exercise is given. Part of the role of in-class exercises is to provide you with group and hands-on learning experiences. For this reason, I will not allow you to makeup in-class exercises. You may ask for a copy of the exercise, but I will not give you credit for the work. If you miss an in-class exercise because of a UCM-sponsored event, you must see me and bring a signed letter indicating why you were gone. I will also give homework assignments. Homework assignments will be announced in lecture class only. If you miss class, check with me to see if a homework assignment was given. Homework assignments will have a deadline. Generally, homework will not be accepted for grading after the deadline. Deadlines are created to help you learn the value of being on time. Much success in business or a career depends on being able to meet deadlines. Laboratory: Laboratory performance will comprise 25% of your course grade. You will be assessed in laboratory through the following: 1) one exam on September 28, 2006, 2) two reports – due on October 26 and on November 16 3) three in-class exercises on November 16, November 30 and December 7 Biol 2511: Genetics Fall 2006 page 4 of 6 The exam will be worth 50 points. The reports will be worth 70 points each (140 points total), and the in-class exercises will be worth 20 points each (60 points total). Missed laboratory classes cannot be made-up. Attendance in laboratory class will also be taken. Grade: Your course grade will be determined according to the amount of points you earn throughout the semester. Grades will be assigned as follows: Percentage of earned scores Course grade 100-90% A 89-80% B 79-70% C 69-60% D <60% F An exception to the above scale will be made for students who engage in academic dishonesty (i.e., cheating or plagiarizing). Academic dishonesty includes the copying of another student’s answers, using resource materials such as cheat sheets during examinations, changing answers after graded exams have been returned, and asking for a better exam score, etc. Academic dishonesty will not be tolerated. It may result in an F grade for the course or more serious consequences. For further consequences of academic dishonesty, consult the UCM student handbook, p. 124. A note on plagiarism: Copying or paraphrasing other people’s writing without citing them is a form of cheating called plagiarism. If you do not give credit for the words of others, you are suggesting that the words are your own. It can be difficult sometimes to know whether the words you write are original or paraphrased so that the words are considered the same as another person’s. For examples of what constitutes plagiarism, consult this web site: http://www.indiana.edu/~wts/wts/plagiarism.html#wwwplagiarism. Students caught plagiarizing will be subject to the penalties for cheating. If you are a student with a documented disability and wish to seek academic accommodations, you should contact the Office of Accessibility Services, Union 20, (V) (TTY) 660-543-4421 as soon as possible. Academic accommodations cannot be provided without documentation from the Office of Accessibility Services. Tentative Lecture Schedule† Date Lecture Topic Textbook reference Transmission Genetics 8/23 Introduction; Mendel’s experiment Chapter 2 & 3 8/25 Principle of Segregation Chapter 3 8/28 Principle of Independent Assortment Chapter 3 8/30 Probability Theory – Addition/Multiplication Rules Chapter 3 9/1 Chi-square analysis Chapter 3 9/4 Labor Day – Class dismissed 9/6 Sex Determination – by environment & chromosomes Chapter 4 9/8 Sex Determination in humans – Y chromosome Chapter 4 9/11 Sex Determination in Drosophila Chapter 4 (p. 83) 9/13 Exam 1 – September 13, 2006 9/15 Morgan’s experiment Chapter 4 (p. 83) 9/18 Chromosomal Theory of Inheritance Chapter 4 9/20 Inheritance of genes on X Chapter 4 9/22 Dosage compensation Chapter 4 9/25 Issues of dominance and expression Chapter 5 Biol 2511: Genetics Fall 2006 page 9/27 ABO blood group inheritance/Pedigree analysis Chapter 5 & Chapter 6 9/29 Gene interaction – two genes, one phenotype Chapter 5 10/2 Gene interaction – epistasis Chapter 5 10/4 Gene interaction with environment Chapter 5 Exam 2 – October 4, 2006 Molecular Genetics: Chemical Nature of the Gene 10/6 Griffith and Avery et al. Experiments Chapter 10 10/9 Hershey and Chase Experiment Chapter 10 10/11 Structure of DNA Chapter 10 10/13 Watson & Crick’s model of DNA Chapter 10 10/16 DNA/RNA secondary, chromosome structure Chapter 10 & 11 10/18 Chromosome structure: Packaging Chapter 11 10/20 Fall Break – Class dismissed 10/23 Chromosome structure: Transposition Chapter 11 10/25 DNA Replication: Meselson & Stahl Experiment Chapter 12 10/27 DNA Replication: Mechanism Chapter 12 10/30 DNA Replication: Mechanism Chapter 12 11/1 Exam 3 – November 1, 2006 Molecular Genetics: Expression of the Gene 11/3 Transcription: RNA synthesis Chapter 13 11/6 Transcription: Mechanism Chapter 13 11/8 RNA processing Chapter 14 11/10 Beadle and Tatum Chapter 15 11/13 Proteins Chapter 15 11/15 Translation Chapter 15 11/17 Genetic Code Chapter 15 11/20 Exam 4 – November 20, 2006 11/22 Thanksgiving – Class dismissed 11/24 Thanksgiving – Class dismissed Population Genetics 11/27 Mutations Chapter 17 11/29 Mutations in genomes Chapter 17 12/1 Mutations resulting in disease Chapter 17 12/4 Hardy-Weinberg Law Chapter 23 12/6 Applications of Hardy-Weinberg Law Chapter 23 12/7 DNA variation and gene genealogies (phylogeny) Chapter 23 12/15 Final Exam, 8-10 a.m. †Use this schedule as a guide. This schedule may be subject to change. This schedule will be given to you through the lab syllabus as well. Lab Schedule Lab Date Laboratory Text Reference 1 8/24 Gene Hunters Chapter 1, p. 1-7 2 8/31 DNA Isolation 3 9/7 Gel electrophoresis & pipettor use Chapter 18, p. 514-516 4 9/14 Restriction enzyme mapping Chapter 18, p. 509-514 5 9/21 Linkage mapping Chapter 7, p.160-184 9/28 Lab Exam I 6 10/5 Harvest of Fear Chapter 18, p. 538-539 7 10/12 PCR: GMO Chapter 18, p. 530-532 8 10/19 GMO PCR analysis (report 1) Chapter 18, p. 545-546, http://www.pbs.org/wgbh/harvest 9 10/26 E. coli transformation with pGLO Chapter 8, p. 199-202, 213-215 5 of 6 Biol 2511: Genetics Fall 2006 page 6 of 6 10 11/2 GFP isolation Chapter 19, p. 571 11 11/9 Protein electrophoresis (report 2) 12 11/16 Population Genetics: Alu (in-class 1) Chapter 11, p. 302, 310-311, http://www.geneticorigins.org/geneticorigins/pv92/intro.html 13 11/23 Thanksgiving – No Laboratory Class 11/30 mtDNA analysis (in-class 2) Chapter 20, p. 587-596, Chapter 7, p. 184, Chapter 19, p. 564-565 14 12/7 Bioinformatics (in-class 3) Chapter 19, p. 566