Download NIAID Weekly Tuberculosis News Digest (10/02/2007)

NIAID Weekly Tuberculosis News Digest (07/22/2008)
Kathleen Collins, MSc, Office of Global Research (OGR), NIAID, NIH
Rebecca Prevots, PhD, MPH, Laboratory of Clinical Infectious Diseases (LCID), NIAID, NIH
**Scientific Journal Articles and/or reports chosen for the Digest must have an e-publication which is timely for the week
of the digest unless a significant amount of news surrounds the paper publication of an article previously e-published.**
INTERNATIONAL TB NEWS
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NIAID Release: Anti-TB Drug Fails to Benefit HIV-Exposed Infants who were Unexposed to
TB at Study Enrollment Click link
Six-thousand year old bones excavated in Jericho may help a joint Israeli-PalestinianGerman-British research group combat tuberculosis Press Release Click link BBC
WHO praises China for reaching all targets set for detection of TB Click link and the
implementation of their TB control program Click link
US: Door to door TB control advocacy in Mississippi Click link
UK: TB rates were dropping and now they are on the rise; one man’s nagging cough proved to
be worse than at first suspected Click link
Literature Highlights:
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BMJ: Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults
being treated for tuberculosis: randomised clinical trial Click link Researchers show that
Cotrimoxazole prophylaxis cuts risk of death for HIV+ patients with TB in Zambia News
 JAMA:
o Opportunities and Challenges for HIV Care in Overlapping HIV and TB
Epidemics Click link Researchers urge integration of HIV treatment and TB prevention
Press Release Press Release 2
o Tuberculosis Among Foreign-Born Persons in the United States Click link Press
Release More
o
 PLoS Med:
o International Monetary Fund Programs and Tuberculosis Outcomes in PostCommunist Countries Click link New research links IMF loans with higher death rates
from tuberculosis Press Release Click link
o Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review
of 13 Observational Studies Click link News More
 Nature Med: A membrane protein preserves intrabacterial pH in intraphagosomal
Mycobacterium tuberculosis Click link
MDR-TB / XDR-TB
WHO XDR-TB news and archives Click link WHO MDR-TB Click link STOP TB Work Group
CDC XDR-TB Click link WHO Weekly Epi Record Click link
XDR-TB surveillance updated June 08 2008: 49 countries with XDR-TB June 2008 MAP
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Most Recent WHO XDR-TB Newsletter Feb 2008 Click link
WHO’s latest XDR-TB Fact Sheet which includes epi, funding, progress, future plans as of
Nov. 2007 Click link is now out of date but should be updated soon
WHO FAQ about drug resistant and MDR-TB Click link
WHO urges Asian nations to tackle TB, especially drug-resistance AP Click link More
Interested in signing up for a drug resistance newsletter? Click link
Botswana: Local health authorities have 6 MDR-TB cases on record Click link
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South Africa:
o After years of silence one Sister finally speaks out about severe staff shortages, flawed
isolation procedures, and lack of infection control which cause major problems in one
South African hospital Click link
o One family tries to come to grips with their son’s suicide in a TB treatment facility Click
Literature Highlights:
 Ann Int Med: Initial drug resistance and tuberculosis treatment outcomes: systematic
review and meta-analysis Click link
 PLoS Med: Scaling Up Programmatic Management of Drug-Resistant Tuberculosis: A
Prioritized Research Agenda Click link Researchers highlight the need to massively increase
drug-resistant TB research News More
 CID: Cost-effectiveness analysis of introduction of rapid, alternative methods to identify
multidrug-resistant tuberculosis in middle-income countries Click link
 J Med Microbiol:
o Rapid detection of multidrug-resistant Mycobacterium tuberculosis in Cotonou
(Benin) using two low-cost colorimetric methods: resazurin and nitrate reductase
assays Click link
o An overview of the phenotypic and genotypic characteristics of multidrug-resistant
Mycobacterium tuberculosis isolates from four Asian countries Click link
 Chest: Case series report of a linezolid-containing regimen for extensively drug-resistant
tuberculosis Click link
 J Microbiol Methods: Rapid culture-based methods for drug-resistance detection in
Mycobacterium tuberculosis Click link
PHARMACEUTICALS
Anti-bacterial Drugs
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Russia: The seek and treat program, “Sputnik” started by Partners in Health follows 28 patients
ensuring they receive and take their drugs Science
Anti-TB Drugs: Two old drugs take precedence as drug-resistance rises Click link
Curr HIV/AIDS Rep: Managing tuberculosis and HIV in sub-Sahara Africa Click link
Antimicrobial Agents Chem: The Efficacy of Quinoxaline-2-carboxylate 1,4-di-N-oxide
Derivatives in Experimental Tuberculosis Click link
PNAS: A synthetic mammalian gene circuit reveals antituberculosis compounds Click link
J Postgrad Med: Low-dose inhaled versus standard dose oral form of anti-tubercular
drugs: Concentrations in bronchial epithelial lining fluid, alveolar macrophage and
serum Click link
Vaccines:
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U. of Oxford and Emergent BioSolutions Inc. announced the dev. of a joint venture, The
Oxford-Emergent Tuberculosis Consortium Ltd., which aims to further develop MVA85A, the
world's most clinically advanced vaccine candidate for the prevention of tuberculosis Click link
 BMC Microbiol: Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a
natural recA mutant Click link
 JID: Vaccination with Bacille-Calmette Guérin Promotes Mycobacterial Control in
Guinea Pig Macrophages Infected In Vivo Click link
Diagnostics
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Am J Public Health: From Mosques to Classrooms: Mobilizing the Community to Enhance
Case Detection of Tuberculosis Click link
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Scand JID: Clinical evaluation for diagnosing active TB disease and transitional change of
two commercial blood tests Click link
Braz JID: Development of a clinical scoring system for the diagnosis of smear-negative
pulmonary tuberculosis Click link
Clin Vaccine Immunol: Diagnosis of Central Nervous System Tuberculosis by T-cell-based
Assays on Peripheral Blood and Cerebrospinal Fluid Mononuclear cells Click link
J Clin Microbiol: Molecular Beacon Based Real-Time PCR for Detection and
Quantification of Mycobacterium tuberculosis DNA in Clinical Samples Click link
PLoS One: Interferon-gamma release assay for the diagnosis of latent TB infection-analysis of discordant results, when compared to the tuberculin skin test Click link
MORE LITERATURE & REPORTS
 Biochem Soc Trans: Tuberculosis: a balanced diet of lipids and carbohydrates Click link
 Biochemistry: Structural Analysis of Substrate and Effector Binding in Mycobacterium
tuberculosis d-3-Phosphoglycerate Dehydrogenase Click link
 BMC Vet Res: Molecular characterisation of Mycobacterium bovis isolated from cattle
slaughtered at the Bamako abattoir in Mali Click link
 Indian J Chest Dis: Manifestations of pulmonary tuberculosis in the elderly: a prospective
observational study from north India Click link
 Infection: The Impact of Age on the Demographic, Clinical, Radiographic Characteristics
and Treatment Outcomes of Pulmonary Tuberculosis Patients in Taiwan Click link
 J Biol Chem: Diarylquinolines are bactericidal for dormant mycobacteria as a result of
disturbed ATP homeostasis Click link
 J Clin Microbiol: Efficacy of "Dry Mist of Hydrogen Peroxide" (DMHP) against
Mycobacterium tuberculosis and use as a method for routine decontamination of
biosafety level 3 laboratory Click link
 JID: Role of Nitric Oxide in Defense of the Central Nervous System against
Mycobacterium tuberculosis Click link
 J Immunology: CREB, ATF, and AP-1 transcription factors regulate IFN-gamma
secretion by human T cells in response to mycobacterial antigen Click link
 J Med Microbiol: An overview of the phenotypic and genotypic characteristics of
multidrug-resistant Mycobacterium tuberculosis isolates from four Asian countries Click
 Trans R Soc Trop Med Hyg: Tuberculous infection in Saharia, a primitive tribal
community of Central India Click link
 Trop Doct:
o Prevalence of opportunistic infections in AIDS patients in Mangalore, Karnataka
Click link
o World Health Organization Clinical Stage 3 disease conditions in HIV-infected
patients who start antiretroviral therapy in Malawi Click link
o Baseline assessment of collaborative tuberculosis/HIV activities in Kinshasa, the
Democratic Republic of Congo Click link
 Tuberculosis (EdinB):
o Role of M. tuberculosis RD-1 region encoded secretory proteins in protective
response and virulence Click
o Lack of alpha-1 integrin alters lesion morphology during pulmonary
Mycobacterium tuberculosis infection Click link
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