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Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation by Xiaojian Wang, Hongmei Li, Catherine Matte-Martone, Weiguo Cui, Ning Li, Hung Sheng Tan, Derry Roopenian, and Warren D. Shlomchik Blood Volume 118(24):6426-6437 December 8, 2011 ©2011 by American Society of Hematology LTFNYRNL derived from H60 is efficiently cross-presented. Xiaojian Wang et al. Blood 2011;118:6426-6437 ©2011 by American Society of Hematology CD8 cells are cross-primed whether antigen is restricted to hematopoietic or nonhematopoietic cells. Xiaojian Wang et al. Blood 2011;118:6426-6437 ©2011 by American Society of Hematology Widespread expression of Kb-LTFNYRNL, but not LTFNYRNL without Kb, blunts the accumulation of TetH60+ cells. Xiaojian Wang et al. Blood 2011;118:6426-6437 ©2011 by American Society of Hematology SIINFEKL-specific but not spontaneous memory T cells are restimulated by cross-presenting APCs. (A-B) Kb−/− and actOVA. Xiaojian Wang et al. Blood 2011;118:6426-6437 ©2011 by American Society of Hematology Optimal cross-presentation requires CD40L and type I IFN stimulation of conventional DCs. BALB/c or BALB/c-OVA mice were irradiated and reconstituted with B6 (CD45.2) BM, 106 CD8, and 105 CD4 cells from B6 CD45.1 mice. Xiaojian Wang et al. Blood 2011;118:6426-6437 ©2011 by American Society of Hematology Donor cells acquire host transmembrane proteins, including MHC class I-SIINFEKL complexes. Xiaojian Wang et al. Blood 2011;118:6426-6437 ©2011 by American Society of Hematology Hybrid DCs are effective APCs. B6actOVA mice were irradiated and reconstituted with BALB/c BM. As controls, B6 and BALB/c mice underwent syngeneic transplants. Xiaojian Wang et al. Blood 2011;118:6426-6437 ©2011 by American Society of Hematology
