Download Pathology and Physiopathology

Pathology and Physiopathology
Academic/Subject Sector
Year
Semester
Med/04- General Pathology
III
Total number of credits
1 and 2
22
Integrated Course coordinator
Prof. Columbano A.([email protected])
Integrated Course lecturers
Even student numbers
Atzori L. ([email protected])
Muntoni S. ([email protected])
Columbano A. ([email protected]),
Locci F. ([email protected]).
Odd student numbers
Batetta B.([email protected])
Dessì S.( [email protected])
Laconi E.( [email protected])
Pani P.([email protected])
Aims of the course
The aim of the integrated course is to initiate students in the study of pathological
processes and clinical conditions.
It is specifically intended to provide students with the basic pathological principles by
relating basic science with main pathogenetic and physiophatologic mechanisms. General
topics include genetic diseases, cell death, inflammation, neoplasia and cardiovascular
diseases.
At the end of the course students should have a sound knowledge of the fundamental
biological and pathological defence mechanisms of the immune system. Emphasis will be
also placed on the applications of molecular biology and their relevance in the
understanding of the origin of diseases.
Syllabus
General Pathology: Cellular injury and cellular death, Cellular growth and differentiation,
Normal regulation and adaptation, Acute and chronic inflammation, Tissue repair and fibrosis,
Genetic disorders, Non-inherited congenital disorders, Environmental, occupational and
nutritional diseases, Drug biotransformation, Ageing.
Immunology and Immunopathology: Cells of the immune system, Structure and function
of histocompatibility antigens, Mechanisms of immunologic tissue injury (hypersensitivity
reactions), Autoimmune diseases, Immunologic deficiency syndromes, Amyloidosis.
Oncology: Epidemiology: Definition and terminology, Biology of tumor growth
(angiogenesis, progression and heterogeneity, invasion and metastasis), Carcinogenic agents
and their cellular interaction, DNA damage and repair, Molecular basis of cancer (Oncogenes,
cancer suppressor genes, molecular basis of multistep carcinogenesis).
Pathophysiology: Thermoregulation, Diabetes, Gout, Atherosclerosis, Thrombosis, Embolism,
Fatty liver, Liver failure. Heart failure and hypertension, Respiratory failure, Qualitative and
quantitative blood cells alterations, Non-inflammatory edema, Osteoporosis, Obesity and
malnutrition, Altered production, transmission, and transduction of hormone signalling
General Pathology: Cell injury and stress, adaptive cellular changes, cell death - Necrosis and
apoptosis -Acute inflammation - Chronic inflammation - Repair, regeneration and fibrillation -Cell
proliferation and differentiation- Molecular basis of genetic diseases: genic punctiform mutations in
coding and non-coding sequences: deletions and insertions - Autosomal recessive and x-linked
dominant genetic diseases - Chromosomal diseases - Non-hereditary congenital diseases - Extrinsic
causes of diseases: physical agents-induced lesions (radiations) Metabolic medicine system.
Environmental and occupational pathology, smoking, alcohol, organic and non-organic chemical
agents-induced lesions. Aging.
Immunology and Immunopathology: Characteristics of the immune system - Innate and
specific immune response - Antigens and immunogenicity - Antibodies - Major histocompatibility
complex (MHC)- Tissues and cells of the immune system - Lynphocites B - Lynphocites TSpecific humoral and cell-mediated humoral response - Cytokines - Tolerance - Active and passive
immunity - Hypersensitivity reactions - Erythrocyte antigenic systems- Immunodeficiency- Selfimmunity.
Oncology: Principles of tumors epidemiology - Definition. Terminology. Characteristics of
benign and malignant tumors - Culture characteristics of tumor cells - metastatization process Biochemical atypias - Etiological agents: Physical and viral chemical agents - Mechanism of action
of cancerogenic and DNA-repair systems - Molecular basis of tumors - Biology of tumor growth Models of cancerogenesis.
Physiopathology: Thermoregulation: Diabetes- Gout - Atherosclerosis, thrombosis, embolism Hepatic failure and steatosis - Heart failure and arterial hypertension- Respiratory failure - Hematic
cells: Qualitative and quantitative alterations. Noninflammatory oedema. Osteoporosis. Obesity and
malnutrition. Altered production, transmission, and transduction of hormone signalling.
Reference texts
General pathology and physiopathology:
Pathologic Basis of Disease (R. S. Cotran, V. Kumar, S. L. Robbins);
Patologia Generale (Pontieri);
Pathology (Stevens & Lowe)
Immunology and immunopathology:
Abbas et al.- Cellular and Molecular Immunology (Abbas et al);
Roitt et al – Immunologia
Teaching methods
Assessment
Requirements to take the exam
4 self-assessment tests at the end of each series of
lectures:
1. Molecular, cellular, genetic and general
pathology
2. Immunology and Immunopathology
3. Oncology
4. Pathophysiology
At the end of the Integrated Course students will take
a comprehensive final oral examination
Students must have taken the Human Anatomy and
Physiology exams first.
Language of instruction
Where we are
Interactive teaching centre:
Even student numbers: Sezione di Oncologia e Patologia Molecolare of the Dipartimento di
Tossicologia. Istituti Biologici Via Porcell, 1st floor, Phone: 070-675 8346.
Odd student numbers: Sezione di Patologia Sperimentale del Dipartimento di Scienze
Biomediche e Biotecnologie. Istituti Biologici Via Porcell, 2nd floor.
Further information