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Imperial College London Job Description Job Title: Research Assistant/Associate (maternity cover) Section: Structural Biology Division: Experimental Medicine Department: Medicine Job Family and Level: Academic and Research, Level A or B Salary Range: Level A: £29,350 - £32,520 per annum Level B: £33,410 - £42,380 per annum Responsible To: Professors Paul Freemont and Xiaodong Zhang Works closely with: Research group Location: South Kensington Campus Funding: Cancer Research UK Duration: Full-time, fixed-term for 6 months Research Programme The multifunctional AAA ATPase p97 is involved in a myriad of cellular processes including cell cycle regulation, membrane traffic, protein quality control, DNA metabolism, signalling and apoptosis. Consequently mutations in p97 cause cell deaths or various disease. Furthermore, p97 has been shown to be a potential target for cancer treatment. The researcher will undertake structural and mechanistic studies of p97 and its key cofactors, especially those involved in cancer pathways. Job Summary This is a temporary post to cover maternity leave for 6 months. The post will carry out structural characterisations of p97 and its cofactors using cutting edge cryo-electron microscopy single particle analysis. Research Duties o o o o o Plan, execute and analyse experiments Maintaining an up-to-date detailed knowledge of relevant and recent research literature To maintain accurate and complete records of all findings To ensure the validity and reliability of data at all times Prepare and present findings to colleagues at seminars and lab meetings o o Prepare and present findings to other researchers through scientific publications and conferences To train and supervise students or other members of the laboratories or collaborators Other Duties To be actively involved in related research and scholarly activities essential for the project as a whole To be responsible for the general good practice of the laboratory and to carry out necessary tasks related to that (in agreement with supervisors) To undertake appropriate administration tasks To undertake limited teaching duties as required by the Department To comply with relevant College policies, including Financial Regulations, Equal Opportunities Policy, Promoting Race Equality Policy, Health and Safety Policy, Information Systems Security Policy and Intellectual Property Rights and Register of Interests Policies To undertake any necessary training and/or development To maintain safe workplace practice and procedures in accordance with the requirements of Health and Safety legislation; To maintain an up to date knowledge of relevant statutory Health and Safety legislation and recommendations and attend safety training as required. Any other duties commensurate with the grade of the post as directed by the supervisor Job descriptions cannot be exhaustive and so the post holder may be required to undertake other duties, which are broadly in line with the above key responsibilities. The post holder is expected to observe and comply with all College policies and regulations, for example Health and Safety, Data Protection etc. Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to adhere to the principles set out in our Equal Opportunities in Employment Policy, Promoting Race Equality Policy and Disability Policy and all other relevant guidance/practice frameworks. Person Specification Imperial Expectations These are the 7 principles that Imperial leaders, managers and supervisors are expected to follow: 1) Champion a positive approach to change and opportunity 2) Communicate regularly and effectively within, and across, teams 3) Consider the thoughts and expectations of others 4) Deliver positive outcomes 5) Encourage inclusive participation and eliminate discrimination 6) Support and develop staff to optimise talent 7) Work in a planned and managed way Qualifications PhD or equivalent in structural biology (or passed PhD viva with minor corrections) Knowledge / Experience Knowledge of research methods in structural biology Practical experience within a research environment carrying out electron microscopy single particle analysis Computer literate with a good knowledge of different computer programs with experience in data presentation and statistical analyses Skills and Abilities Demonstrated ability for innovative high quality structural biology research High levels of organisation and attention to detail High levels of initiative, innovation and problem solving skills Ability to rapidly learn new research methods Ability to undertake day-to-day supervision and training of other research team members Ability to conduct detailed reviews of research literature Ability to develop and apply new concepts Excellent verbal communication skills and the ability to deal with a wide range of people Excellent written communication skills and the ability to write clearly and succinctly for publication Ability to organise own work with minimal supervision Ability to meet deadlines and research objectives Advanced computer skills, especially electron microscopy image processing packages Personal Attributes Willingness to work as part of a team and to be open-minded and cooperative Flexible attitude towards work Discipline and regard for confidentiality and security at all times Willingness to undertake any necessary training for the role Willingness to travel both within the United Kingdom and abroad to conduct research and attend conferences