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Office: University of Illinois Medical Center, Section of Respiratory, Critical Care, and Sleep Medicine , 840 S. Wood St., Chicago, IL 60612 312-413-0936 or 312-996-8040 Fax: 312413-0503 [email protected] James J. Herdegen, M.D. Educational Experience University of Illinois (Champaign-Urbana) B.S. 1978-1982 Biochemistry University of Chicago, Chicago, Illinois M.D. 1982-1986 Medicine University of Iowa Hospitals and Clinics Iowa City, Iowa Internship 1986- Internal Medicine University of Iowa Hospitals and Clinics Iowa City, Iowa Residency 1987-89 Internal Medicine Rush-Presbyterian-St. Luke’s Medical Center Chicago, Illinois Fellowship 1990-93 Pulmonary/Critical Care Medicine Rush-Presbyterian-St. Luke’s Medical Center Chicago, Illinois Fellowship 1995-96 Sleep Medicine Board Certifications 1989 1992 1993 1997 Internal Medicine Pulmonary Medicine (recertified 2002) Critical Care Medicine (recertified 2002) Sleep Medicine Professional Memberships American College of Physicians Fellow, American College of Chest Physicians American Thoracic Society American Academy of Sleep Medicine Professional Experience 1989-90 Attending Physician and Medical Supervisor, Medical Residency Unit of the Cook County Jail 1993-2004 1998-2002 1998-2004 1998-2004 1998-Present 1998-2004 1999-2004 2001-Present 2002-Present 2004-Present 2004-Present Assistant Professor of Medicine, Section of Pulmonary and Critical Care Medicine Rush-Presbyterian-St. Luke’s Medical Center Medical Director, Sleep Disorder Service Rush-Presbyterian-St. Luke’s Medical Center Co-Director, Sleep Medicine Training Program Rush-Presbyterian-St. Luke’s Medical Center Assistant Director, Department of Respiratory Therapy, Rush University Medical Center Reviewer: Critical Care Medicine Voluntary Attending, Cook County Hospital Director, Sleep Disorder Service Cook County Hospital Reviewer: Chest Adjunct Assistant Professor, University of Illinois College of Engineering Bioengineering Medical Director, Center for Sleep and Ventilatory Disorders, University of Illinois Medical Center Associate Professor of Clinical Medicine, University of Illinois at Chicago Research Awards 1982 1983-84 1992 1993 1999 2000 Visiting Research Biochemist: Development of a cDNA Dot Hybridization Assay for the Quantitation of Specific mRNA. University of Illinois, Champaign-Urbana, Illinois Kraft Nutrition Fellowship: Analysis of Apolipoprotein-E mRNA expression in Various Tissue and Cell Types. University of Chicago, Chicago, Illinois Cecile Lehman Mayer Award Finalist, American College of Chest Physicians International Meeting Recipient, Glaxo Educational Grant Recipient, Clinical Investigator Award, ResMed Corporation Recipient, Clinical Investigator Award, Respironics, Inc. Selected Publications Abstracts Herdegen JJ, Casey LC, Mazzone T. coordinate induction of cytokines and alpha-2macroglobulin by LPS in THP-1 cells (abstract). Chest 1992;102:88S. Herrera P, Herdegen JJ, Itokazu G, Jasek J, Weinstein RA. Impact of infectious disease (ID) consultation of PCP prophylaxis for hospitalized HIV infected patients. (abstract-poster) Infectious Diseases Society of America 1996 Herdegen JJ, Clark LJ, Stepanski EJ, Cartwright RD. Use of a CPAP support service to enhance and predict CPAP use AJRCCM 2000;161:A361. Herdegen JJ, Clark LJ, Stepanski EJ, Stevens DR, Proske AE, Cartwright RD. Treating sleepdisordered breathing: A longitudinal analysis of patient characteristics and positive airway pressure compliance Sleep 2000;23:A82. Abraham L and Herdegen JJ. Sleep-disordered breathing (SDB) in Asian-Indians. AJRCCM 2001;163:A635. Herdegen, JJ and Clark LC. Comparison of PSG and PAP (positive airway pressure) compliance characteristics among patients from an urban public vs. academic hospital. Sleep 2001;24:A263. Herdegen JJ and Clark LJ Sleep-disordered breathing (SDB) and CPAP use in an urban, poor population: Analysis by gender Sleep 2002;25:A339. Garimella PS and Herdegen JJ Pattern of sleep disordered breathing (SDB) in diabetes AJRCCM 2002;165:A515. Babu AR, Herdegen J, Kannan CR, Fogelfeld L, Shott S, Mazzone T. Treatment of obstructive sleep apnea with continuous positive airway pressure improves 24 hour glucose control Diabetes 2002;51:A465. Herdegen JJ, Manikdiyil B, Clark LJ, Millikan KW, Madura J. Sleep-Disordered Breathing (SDB) and Pattern of Weight Loss After Bariatric Surgery Sleep 2003;26:A261. Herdegen JJ, Babu AR, Kannan CR, Fogelfeld L, Shott S, Mazzone T. CPAP Improves PostPrandial Glycemic Control in Diabetics with Sleep-Disordered Breathing (SDB) AJRCCM 2003;167:A15. Garimella P, Lo, K-M, Adabala, R Mokhlesi B, Herdegen JJ. The Effect of Treatment Adherence on Hypercapnia Associated with Sleep-Disordered Breathing (SDB) AJRCCM 2003;167:A328. Waldo B, Herdegen JJ, Mikolaitis SL, Madura J, DeMeo MT. Sleep Apnea and Liver Function Levels in Patients Undergoing Bariatric Surgery Diabetes Care 2003. Hassaballa HA, Clark L, Babu A, Mazzone T, Shott S, Herdegen JJ. The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea AJRCCM 2004;169:A759. Kim EH, Madura JA, Clark LJ, Shott S, Herdegen JJ. Respiratory and sleep measures in bariatric surgery patients: Assessing desaturation risk. AJRCCM 2004;169:A899. Herdegen JJ, Clark LJ, Joo M. Sleep apnea in an urban public hospital: assessment of prevalence, disease severity, and treatment adherence. AJRCCM 2006. Kutty RM, Holterman AX, Cotler SJ, Madura JA and Herdegen JJ. Metabolic, liver function, and sleep parameters in pediatric and adult bariatric surgery patients. AJRCCM 2007. Prasad Bharati and Herdegen James J. REMstar Pro M series detects Breathing Events comparable to attended Polysomnography. AJRCCM 2008 Book Chapters Herdegen JJ, Bone RC. Inflammatory mediators in the critically ill. In: Intensive Care: Developments and Controversies. Webster NR, Bedenham A, eds. Bailliere’s Clinical Anaesthesiology. Vol 6, Ch 8. W.B. Saunders. London 1991. Herdegen JJ, Bone RC. The role of anticholinergic drugs in COPD. In: Anticholinergic therapy in obstructive airways disease. Gross NJ, ed. Franklin Scientific Publications, London 1994. Herdegen JJ, Bone RC. Inflammatory mediators and the role of immunomodulation in sepsis. In: Pulmonary and Critical Care Medicine. Bone RC, Dantzker D, George R, Matthay R, Reynolds H, eds. Mosby-Year Book. Chicago. 1994. Herdegen JJ. Pulmonary Section Cases 11-1 to 11-12. In: Diagnostic strategies for Internal Medicine: A Case-Based Approach. Grodzin CJ, Schwartz SC, Bone RC, eds. MosbyYear Book. Chicago 1996. Herdegen JJ, Bone RCB. Immunomodulation in Sepsis: Lessons Learned. In: Pulmonary and Critical Care Medicine. Bone RC, Dantzker D, George R, Matthay R, Reynolds H, eds. Mosby-Year Book. Chicago 1996 Herdegen JJ and Bone RC. Pulmonary manifestations of extrapulmonary infection. In: Infectious Diseases Teaching Atlas. Mandell GL, et. al. ed. Current Medicine 1996. Herdegen JJ. Chronic Disease and Sleep Architecture: Pharmacotherapeutic Considerations In: Sleep and Sleep Disorders: A Neuropharmacological Approach. Lader M, Cardinali DP, Pandi-Perumal SR, eds. Landes Bioscience Georgetown, TX 2004 Herdegen JJ. Sleep Pharmacology Sleep Medicine Secrets Stevens, DR ed.Hanley & Belfus, Inc. Philadelphia, PA 2004 Prasad B and Herdegen JJ. Sleep and quality of life in obesity. In: Sleep and Quality of Life in Medical Illnesses Verster JC, Streiner D, Pandi-Perumal SR ed. 2007. Peer Reviewed Publications Herdegen JJ, Bone RC. Dyspnea of 2-weeks duration and left pleural effusion in a previously healthy 50-year-old woman. In: Pulmonary and Critical Care Pearls. Sahn SA, ed. Chest 1993;104:1264-65. Herdegen JJ, Casey LC. The role of tumor necrosis factor in infections: Pathophysiology and clinical implications. Infections In Medicine 1993;10:27-42. Herdegen, JJ. Sleep-associated breathing disorders. In: Hospital Physician Pulmonary Disease Board Review Manual 1996. Herrera P and Herdegen JJ. Infectious Complications of AIDS. In: Hospital Physician Pulmonary Disease Board Review Manual 1996. Herdegen JJ and Herrera P. Tuberculosis: A case-based approach. In: Hospital Physician Pulmonary Disease Board Review Manual. 1998. Ferrell S and Herdegen JJ. Central sleep apnea In: Neurobase Arbor Publishing, San Diego 1999. Stevens S and Herdegen JJ. Central sleep apnea In: Neurobase Arbor Publishing, San Diego 2000, 2001. Herdegen JJ. Sleep disorders associated with cardiac disorders In: Neurobase Arbor Publishing, San Diego 1999, 2000, 2001, 2003 Herdegen JJ. Central alveolar hypoventilation In: Neurobase Arbor Publishing, San Diego 1999, 2000, 2001, 2002, 2003 Herdegen JJ. Sleep disorders associated with chronic lung disorders In: Neurobase Arbor Publishing, San Diego 1999, 2000, 2001, 2002, 2003 Herdegen JJ. Noninvasive positive pressure ventilatory support in patients with chronic respiratory failure. Hospital Physician Pulmonary Disease Board Review Manual. 2000; Vol. 7, Part 4. Herdegen JJ. Intensive care unit sleep disruption: Can the cycle be restored? Critical Care Medicine 2002;30:709-710. Giri VV and Herdegen JJ Sleep disorders associated with cardiac disorders. In: Neurobase Arbor Publishing, San Diego 2002. Herdegen JJ Treating syndrome X in minority populations: Begin with the treatment of obesity and hypertension Ethnicity and Disease 2002;12:429-432. Babu AR, Herdegen J, Fogelfeld L, Shott S, Mazzone T. Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Int Med. 2005;165:447452. Hassaballa HA, Tulaimat A, Herdegen JJ, Mokhlesi B The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea. Sleep Breath 2005;9:176-180. Mokhlesi B, Tulaimat A, Evans AT, Wang Y, Hassaballa HA, Itani A-A, Herdegen JJ, Stepanski EJ. Impact of adherence with positive airway pressure therapy on hypercapnia in obstructive sleep apnea. Journal of Clinical Sleep Medicine 2006;2:57-62. Herdegen JJ. Inadequate sleep hygiene In: Neurobase Arbor Publishing, San Diego 2007. Joo MJ and Herdegen JJ. Sleep apnea in an urban public hospital: assessment of severity and treatment adherence. J Clin Sleep Med. 2007;3:285-288. Holterman AX, Browne A, Dillard BE 3rd, Tussing L, Gorodner V, Stahl C, Browne N, Labott S, Herdegen J, Guzman G, Rink A, Nwaffo I, Galvani C, Horgan S, Holterman M. Shortterm outcome in the first 10 morbidly obese adolescent patients in the FDA-approved trial for laparoscopic adjustable gastric banding. J Pediatr Gastroenterol Nutr. 2007;45(4):465-73. Kallwitz ER, Herdegen J, Madura J, Jakate S, Cotler SJ. Liver enzymes and histology in obese patients with obstructive sleep apnea. Journal of Clinical Gastroenterology 2007;41:918-921. Research Experience/Support. 1995 Investigator, Multinational COMET trial evaluating efficacy of DNase in COPD patients during acute exacerbations. 1999 Principal Investigator: Open-label, multi-center, six-month trial of XyremTM (sodium oxybate)oral solution for the treatment of narcolepsy in study drug naïve patients. Sponsor: Orphan Medical 1999 Principal Investigator: Long-term, open-label, multi-center extension trial for XyremTM (sodium oxybate) oral solution for the treatment of narcolepsy. Sponsor: Orphan Medical 1999 Principal Investigator: The influence of positive airway pressure (PAP) compliance on clinical outcome: Short and long-term follow-up. Sponsor: ResMed 1999 Principal Investigator: Positive airway pressure (PAP) compliance in an urban, indigent population: Effect of an intensive PAP support service. Sponsor: Respironics, Inc. 2000 Investigator, Behavioral treatment for co-morbid geriatric insomnia NIH Grant, Department of Health and Human Services (PI=Bruce D. Rybarczyk, Ph.D.) 2000 Principal Investigator, A double-blind, placebo-controlled parallel randomized study of efficacy and safety of (S)-Zopiclone in the treatment of adult subjects with primary insomnia. Sponsor: Sepracore 2001 Principal Investigator, A phase 3, multicenter, randomized, double-blind, placebocontrolled, parallel-group study to evaluate the safety and efficacy of 12 weeks of 2 oral doses (200 mg and 400 mg once daily) of Provigil (Modafinil) as treatment for adults with excessive daytime sleepiness associated with obstructive sleep apnea/hypopnea syndrome followed by a 9-month open-label extension. Sponsor: Cephalon, Inc. 2001 Co-Principal Investigator, Prospective evaluation of the treatment of obstructive sleep apnea with continuous positive airway pressure, on glucose excursions and glycemic control in type 2 diabetes mellitus. Sponsor: Mini-mitter Medtronic 2001 Rush-Cook County Hospital Collaborative Research Award: Developing a predictive model of treatment adherence to continuous positive airway pressure. $10,000 2003 Rush University Committee on Research (UCR) Grant: Pattern and Change of SleepDisordered Breathing (SDB) in Patients Undergoing Bariatric Surgery $20,000 2003 ResMed Foundation Management of sleep-disordered breathing (SDB) in bariatric surgery patients using the Autoset Spirit. $46,938 2005 Institute for Health Research and Policy, University of Illinois at Chicago: Effect of CPAP on glucose control in minority type 2 diabetics. $49,993 2005 Respironics Validation of breathing event detection of the REMstar Pro II during clinical polysomnography. $15,444 2005 Investigator (David W. Carley PI for UIC) Organon Pharmaceuticals, Inc. A randomized, double-blind, placebo-controlled, multicenter, parallel group dose ranging clinical trial to assess the efficacy and safety of Org 4419-2 in the treatment of obstructive sleep apnea/hypopneas syndrome. $97,150.00 2005 NIH R01 (PI Eve van Cauter, University of Chicago, Investigator James J. Herdegen) Sleep disturbance as a non-traditional risk factor in CKD Direct Costs $2,311,867, UIC total direct costs $617,332 2005 Investigator (David W. Carley PI for UIC) British Technology Group Single-Blind, Placebo Controlled Study of the Efficacy and Safety of Ondansetron and Fluoxetine in Patients with Obstructive Sleep Apnea Syndrome Committees: 1997-2004: Rush Medical Center Student Judiciary Committee 2000-2004: Rush Medical Center Bariatric and Nutrition Committee Sleep Medicine Fellowship Trainees: Traditional Track Fellows Susan M. Ferrell, M.D. 1999 Suzanne Stevens, M.D. 2001 Visvanatha V. Giri, M.D. 2002 James Cygan, M.D. 2003 Bharati Prasad, M.D. 2009 Alternative Track Fellows Ahamed V. P. Kutty, M.D. 1999 Raju Zachariah Abraham, M.D. 1999 Kailash C. Sharma, M.D. 1999 Dawn M. Kennedy, D.O. 2000 Ladly Abraham, M.D. 2001 Nathaniel Mark Pascual, M.D. 2001 Ramesh Adabala, M.B., B.S. 2002 Kar-Ming Lo, M.D. 2002 Hussam Sakkajha, M.D. 2003 Manar Alshahrouri, M.D. 2003 Prasad Garimella, M.D. 2003 Kamran Mahmood, MD 2005 Gita Patel, DO 2005 Carolina See, MD 2006 Michael Bommarito, MD 2006 Invited Lectures: 1999 Upper Midwest Sleep Society Meeting, Chicago, IL Treatment Adherence in Sleep-Disordered Breathing 1999 Kankakee Sleep Symposium Sleep-Disordered Breathing 2000 International Conference on Hypertension, Chicago, IL Sleep-Disordered Breathing 2000 Loyola Medical Center Sleep Grand Rounds Health Consequences of Sleep-Disordered Breathing 2002 Loyola Medical Center Sleep Grand Rounds Obesity and the Lung 2003 NAPS Lecture Series, University of Illinois Xyrem and Other Medications for Excessive Sleepiness 2003 ATS International Conference, Post Graduate Course: Nonpulmonary Disorders of Sleep: Evaluation, Diagnosis and Management Sleep Pharmacology 2003 ATS International Conference, Mini-Symposium Poster Presentation: Metabolic/Neurological Consequences of OSA and Hypoxia CPAP Improves Post-Prandial Glycemic Control in Diabetics with Sleep-Disordered Breathing (SDB) 2003 ISME Conference (Illinois Society for Respiratory Care), Chicago, IL Diagnosis and Treatment of Sleep-Disordered Breathing 2004 University of Illinois at Chicago College of Medicine New Resident Orientation Effects of Fatigue and Sleep Deprivation Marriott Hotel in the Medical District 8/2004 Medicine Grand Rounds, University of Illinois, Chicago Sleep-disordered breathing and metabolic dysfunction 9/2004 Pulmonary Grand Rounds Section of Pulmonary, Critical Care and Sleep Medicine University of Illinois, Chicago. The diagnosis and treatment of sleep-disordered breathing (SDB) 10/2004 Cermak Health Services Clinical Conference, Chicago, IL The diagnosis and treatment of sleep-disordered breathing (SDB) 1/2005 Program Project Grant Meeting: Alterations of sleep and circadian timing in aging. University of Chicago, Chicago, IL Obstructive sleep apnea and diabetes. 2/2005 ENT Grand Rounds, University of Illinois at Chicago The diagnosis and treatment of sleep-disordered breathing (SDB) 3/2005 The life of the sleepy person VI. University of Illinois at Chicago College of Medicine and College of Nursing. The co-morbidity of sleep-disordered breathing 10/2005 Psychiatry Grand Rounds, University of Illinois at Chicago Evaluation of Excessive Sleepiness 1/2006 Family Medicine Grand Rounds, University of Illinois at Chicago Evaluation of excessive Sleepiness 1/2006 Pulmonary Fellow Clinical Review, University of Chicago Overview of Sleep Pharmacology 5/19/2006 Institute for Health Research and Policy University of Illinois “Improving health outcomes in the midst of the obesity epidemic: the effect of sleep apnea therapy on glycemic control” 2007 (Various Dates: Chicago, Seattle, Pittsburgh) American Family Physician national CME meetings Insomnia Update 11/3/2007 Sierra Heart Institute Reno Nevada, 18th Annual Trends in Cardiovascular Medicine Conference Obesity, sleep apnea, and metabolic syndrome: Pulling it all together 4/2008 Multi-Disciplinary Program in Mental Health and Aging Continuing Education Institute of IL Overview of Sleep Disorders 5/2008 University of Illinois at Chicago, Life of the Sleepy Person Conference VII Q&A on Sleep Disordered-Breathing 6/2008 St. Mary and Elizabeth Medical Center, Chicago, IL Grand Rounds Update on Sleep-Disordered Breathing 10/1/2008 Multi-Disciplinary Program in Mental Health and Aging Continuing Education Institute of IL Overview of Sleep Disorders November 24, 2008 “Your health and sleep” Jewish United Fund/Jewish Federation of Metropolitan Chicago Links to recent interviews/talks : http://abcnews.go.com/http://abcnews.go.com/ interview date: 9/29/08 by Lauren Cox ABC News Medical Unit Health and You magazine, Fall 2008, circ: 1,400,000 “Wake up to sleep apnea’s threat” by Jeffrey Bramnick OccupationalHazards.com Combating workplace sleep deprivation By Laura Walter May 5, 2008 http://www.occupational hazards.com/News/Article/80170/Combating_workplace_Sleep_Deprivation.aspx Chicago Sun-Times, May 19, 2008 “Safety board wants truckers tested for sleep apnea” By Mary Wisniewski http://www.suntimes.com/news/transportation/957117,CST-NWS-ride19.article Medical Producer Katharin Czink at WGN-TV Interview : Sleep apnea and associated health problems. The story's estimated audience was 390,087. You can view the story by clicking here: http://www2.schwartz-pr.com/files/06.26.08_WGN-TV.zip