Download ECE 538 - Office of the Provost

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ECE
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VS-IT&E
Siddhartha Sikdar
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Undergraduate
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ECE
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538
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Title:
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[email protected]
Year
2010
Current
Medical Imaging
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Corequisite(s):
Graduate Standing or permission of instructor; ECE
320 or equivalent; PHYS 262 or equivalent.
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Cross-list with ECE 538
Catalog Copy for NEW Courses Only (Consult University Catalog for models)
Description (No more than 60 words, use verb phrases and present tense)
Notes (List additional information for the course)
Provides an introduction to the physical,
mathematical and engineering foundations of
modern medical imaging systems, medical image
processing and analysis methods. In addition, this
course introduces engineering students to clinical
applications of medical imaging. The emphasis is
on diagnostic ultrasound and magnetic resonance
imaging methods, although several other
modalities are covered. The course also provides
an overview of recent developments and future
trends in the field of medical imaging, discusses
some of the challenges and controversies, and
involves hands-on experience applying the
methods learnt in class to real-world problems.
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3
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For Registrar Office’s Use Only: Banner_____________________________Catalog________________________________
revised 10/7/09
SCHOOL PROPOSAL TO THE GRADUATE COUNCIL
BY
SCHOOL OF INFORMATION TECHNOLOGY AND ENGINEERING
1. CATALOG DESCRIPTION
(a) ECE 538 (3:3:0) Medical Imaging
(b) Prerequisites: Graduate standing or permission of instructor; ECE 320 or equivalent; PHYS 262 or
equivalent.
(c) Catalog Description: Provides an introduction to the physical, mathematical and engineering foundations
of modern medical imaging systems, medical image processing and analysis methods. In addition, this
course introduces engineering students to clinical applications of medical imaging. The emphasis is on
diagnostic ultrasound and magnetic resonance imaging methods, although several other modalities are
covered. The course also provides an overview of recent developments and future trends in the field of
medical imaging, discusses some of the challenges and controversies, and involves hands-on experience
applying the methods learnt in class to real-world problems.
2. JUSTIFICATION
(a) Course Objectives: The course will provide an introduction to the physical, mathematical and engineering
foundations of modern medical imaging systems, medical image processing and analysis methods,
clinical applications of medical imaging, recent developments and future trends.
(b) Course Necessity: Industry, government, and academia increasingly seek individuals who can use their
engineering expertise to solve problems in biology and medicine. This is the motivation for the research
and education program in Bioengineering being developed within the Volgenau School. Medical Imaging
is a key discipline within Bioengineering. This course is designed to broadly appeal to graduate students
in the Volgenau School and as well as other academic units as a technical elective. This course will also
be available as a technical elective for advanced undergraduate seniors in the Bioengineering
concentration of the BS EE program. This course has already been taught as ECE 590/699 Special Topics
in Engineering and has been well received. This course proposal aims to convert this Special Topics
course into a regular course as it is expected to be offered every fall.
(c) Relationship to Existing Courses: Relevant courses in ECE include ECE-537 Image Processing and
ECE-535 Signal Processing. Other Special Topics courses have been taught, one of which, Biomedical
Signal Processing, is relevant to the current proposal, and will be the subject of a future course proposal.
These courses cover complementary topics and would be appropriate as a sequence in combination with
the proposed course for ECE graduate students who are pursuing an emphasis in Bioengineering.
3. APPROVAL HISTORY
ECE Department
Date: October 31st, 2009
IT&E Graduate Committee
Date:
IT&E Dean
Date:
4. SCHEDULING
It is intended to teach this course every fall. Proposed Instructors: Siddhartha Sikdar, Vasiliki Ikonomidou and
suitably qualified faculty and adjunct professors.
5. COURSE OUTLINE
(a) Syllabus
Week 1
Introduction to Medical Imaging – Course objectives; Historical perspective; Introduction to different
imaging modalities; Physics of electromagnetic and acoustic waves; Classification of medical imaging
modalities and applications; Anatomical vs. functional imaging; Challenges, controversies and recent trends;
Patient safety considerations.
Week 2
Medical Imaging Systems – Basic concepts of imaging systems; Sampling; Linear shift invariant systems;
2D Fourier transforms; Point spread functions; Contrast transfer functions; Imaging geometries.
Week 3
Medical Imaging Systems – Image acquisition, reconstruction, visualization; Image manipulation, point
processing, convolution; Image enhancement.
Week 4
Evaluation of Imaging Systems–Signal to noise, contrast, spatial and temporal resolution of different
imaging modalities; Clinical considerations; Sensitivity and specificity; Receiver operating characteristics.
Week 5
Principles of Ultrasound Imaging – Physics of acoustic wave propagation; Interaction of ultrasound with
tissue: transmission, reflection, attenuation; Ultrasound beam properties; Speckle formation. Historical
perspective and new trends;
Week 6
Ultrasound Transducers and Instrumentation –Single element and array transducers; Steering and
focusing of ultrasound beams; Beamforming, demodulation, and ultrasound image formation; Ultrasound
signal and image processing; Different imaging modes; 1D, 2D, 3D and 4D imaging.
Week 7
Principles of Doppler Ultrasound – The Doppler equation; Continuous-wave and pulsed-wave Doppler;
Signal processing methods for velocity estimation; Slow time and fast time; Doppler spectra; Autocorrelation;
Time delay estimation; Clutter filters; Analysis of Doppler signals using 2D FFT; Clinical applications;
Introduction to elasticity imaging.
Week 8
Midterm.
Week 9
Principles of Magnetic Resonance Imaging – Structure of matter; Spin physics; Precession and Larmor
frequency; Concept of nuclear magnetic resonance; T1 and T2 relaxation times.
Week 10
MRI Imaging Systems–MR signal and image formation; Gradients; RF coils; Signal acquisition and
reconstruction; k-space; Source of image contrast; Different imaging modes; Spatial and temporal resolution;
Historical perspective and new trends.
Week 11
Principles of X-ray and Nuclear Imaging – Review of atomic physics; Radiation, attenuation, scattering,
detection; X-ray and nuclear imaging instrumentation; Safety considerations;
Week 12
Computed Tomography – Reconstruction of tomographic slices; Backprojection; Fourier slice theorem;
Filtered backprojection; CT imaging instrumentation; 2D, 3D and 4D imaging.
Week 13
Image Analysis – Introduction to medical image segmentation and registration; Image enhancement; Manual
and automated analysis; Computer-aided detection; Opportunities, challenges and controversies.
Week 14
Final project presentations.
Week 15
Final exam
(b) Required Textbook: Medical Imaging Physics–William R. Hendee, E. Russel Ritenour. Wiley-Liss Inc; 4th
Edition, 2002.
Supplementary texts for reference:
(1) Diagnostic Ultrasound Imaging: Inside Out–Thomas Szabo. Elsevier Academic Press; 2004.
(2) Magnetic Resonance Imaging: Physical Principles and Applications–Vadim Kuperman. Academic
Press; 2000.
(3) Medical Image Analysis–Atam Dhawan. Wiley-IEEE Press; 2003.
(4) Handbook of Medical Imaging: Processing and Analysis–Isaac N. Bankman. Academic Press; 2000.
(c) Student Evaluation Criteria
Homeworks
Mid-term exam
Final exam
Course project
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