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For approval of new courses and deletions or modifications to an existing course. Course Approval Form More information is located on page 2. Action Requested: Course Level: X Create new course Delete existing course Modify existing course (check all that apply) Title Prereq/coreq College/School: Submitted by: Credits Schedule Type Repeat Status Restrictions Number: ECE Grade Type Department: Ext: 3-1539 VS-IT&E Siddhartha Sikdar Subject Code: Undergraduate X Graduate ECE Email: Effective Term: 538 X (Do not list multiple codes or numbers. Each course proposal must have a separate form.) Title: Fall Spring Summer [email protected] Year 2010 Current Medical Imaging Banner (30 characters max including spaces) New Credits: X (check one) Grade Mode: Fixed Variable X 3 or to Repeat Status: Regular (A, B, C, etc.) Satisfactory/No Credit Special (A, B C, etc. +IP) (check one) X (check one) Not Repeatable (NR) Repeatable within degree (RD) Repeatable within term (RT) X Schedule Type Code(s): (check all that apply) Prerequisite(s): Lecture (LEC) Lab (LAB) Recitation (RCT) Internship (INT) Total repeatable credits allowed: Independent Study (IND) Seminar (SEM) Studio (STU) Corequisite(s): Graduate Standing or permission of instructor; ECE 320 or equivalent; PHYS 262 or equivalent. Special Instructions: (detailed description of modification, add restrictions for major, college, or degree; cross-listed courses; hard-coding; etc.) Cross-list with ECE 538 Catalog Copy for NEW Courses Only (Consult University Catalog for models) Description (No more than 60 words, use verb phrases and present tense) Notes (List additional information for the course) Provides an introduction to the physical, mathematical and engineering foundations of modern medical imaging systems, medical image processing and analysis methods. In addition, this course introduces engineering students to clinical applications of medical imaging. The emphasis is on diagnostic ultrasound and magnetic resonance imaging methods, although several other modalities are covered. The course also provides an overview of recent developments and future trends in the field of medical imaging, discusses some of the challenges and controversies, and involves hands-on experience applying the methods learnt in class to real-world problems. Indicate number of contact hours: When Offered: (check all that apply) X Hours of Lecture or Seminar per week: Fall Summer Spring 3 Hours of Lab or Studio: Approval Signatures Department Approval Date College/School Approval Date If this course includes subject matter currently dealt with by any other units, the originating department must circulate this proposal for review by those units and obtain the necessary signatures prior to submission. Failure to do so will delay action on this proposal. Unit Name Unit Approval Name Unit Approver’s Signature Date For Graduate Courses Only Graduate Council Member Provost Office Graduate Council Approval Date For Registrar Office’s Use Only: Banner_____________________________Catalog________________________________ revised 10/7/09 SCHOOL PROPOSAL TO THE GRADUATE COUNCIL BY SCHOOL OF INFORMATION TECHNOLOGY AND ENGINEERING 1. CATALOG DESCRIPTION (a) ECE 538 (3:3:0) Medical Imaging (b) Prerequisites: Graduate standing or permission of instructor; ECE 320 or equivalent; PHYS 262 or equivalent. (c) Catalog Description: Provides an introduction to the physical, mathematical and engineering foundations of modern medical imaging systems, medical image processing and analysis methods. In addition, this course introduces engineering students to clinical applications of medical imaging. The emphasis is on diagnostic ultrasound and magnetic resonance imaging methods, although several other modalities are covered. The course also provides an overview of recent developments and future trends in the field of medical imaging, discusses some of the challenges and controversies, and involves hands-on experience applying the methods learnt in class to real-world problems. 2. JUSTIFICATION (a) Course Objectives: The course will provide an introduction to the physical, mathematical and engineering foundations of modern medical imaging systems, medical image processing and analysis methods, clinical applications of medical imaging, recent developments and future trends. (b) Course Necessity: Industry, government, and academia increasingly seek individuals who can use their engineering expertise to solve problems in biology and medicine. This is the motivation for the research and education program in Bioengineering being developed within the Volgenau School. Medical Imaging is a key discipline within Bioengineering. This course is designed to broadly appeal to graduate students in the Volgenau School and as well as other academic units as a technical elective. This course will also be available as a technical elective for advanced undergraduate seniors in the Bioengineering concentration of the BS EE program. This course has already been taught as ECE 590/699 Special Topics in Engineering and has been well received. This course proposal aims to convert this Special Topics course into a regular course as it is expected to be offered every fall. (c) Relationship to Existing Courses: Relevant courses in ECE include ECE-537 Image Processing and ECE-535 Signal Processing. Other Special Topics courses have been taught, one of which, Biomedical Signal Processing, is relevant to the current proposal, and will be the subject of a future course proposal. These courses cover complementary topics and would be appropriate as a sequence in combination with the proposed course for ECE graduate students who are pursuing an emphasis in Bioengineering. 3. APPROVAL HISTORY ECE Department Date: October 31st, 2009 IT&E Graduate Committee Date: IT&E Dean Date: 4. SCHEDULING It is intended to teach this course every fall. Proposed Instructors: Siddhartha Sikdar, Vasiliki Ikonomidou and suitably qualified faculty and adjunct professors. 5. COURSE OUTLINE (a) Syllabus Week 1 Introduction to Medical Imaging – Course objectives; Historical perspective; Introduction to different imaging modalities; Physics of electromagnetic and acoustic waves; Classification of medical imaging modalities and applications; Anatomical vs. functional imaging; Challenges, controversies and recent trends; Patient safety considerations. Week 2 Medical Imaging Systems – Basic concepts of imaging systems; Sampling; Linear shift invariant systems; 2D Fourier transforms; Point spread functions; Contrast transfer functions; Imaging geometries. Week 3 Medical Imaging Systems – Image acquisition, reconstruction, visualization; Image manipulation, point processing, convolution; Image enhancement. Week 4 Evaluation of Imaging Systems–Signal to noise, contrast, spatial and temporal resolution of different imaging modalities; Clinical considerations; Sensitivity and specificity; Receiver operating characteristics. Week 5 Principles of Ultrasound Imaging – Physics of acoustic wave propagation; Interaction of ultrasound with tissue: transmission, reflection, attenuation; Ultrasound beam properties; Speckle formation. Historical perspective and new trends; Week 6 Ultrasound Transducers and Instrumentation –Single element and array transducers; Steering and focusing of ultrasound beams; Beamforming, demodulation, and ultrasound image formation; Ultrasound signal and image processing; Different imaging modes; 1D, 2D, 3D and 4D imaging. Week 7 Principles of Doppler Ultrasound – The Doppler equation; Continuous-wave and pulsed-wave Doppler; Signal processing methods for velocity estimation; Slow time and fast time; Doppler spectra; Autocorrelation; Time delay estimation; Clutter filters; Analysis of Doppler signals using 2D FFT; Clinical applications; Introduction to elasticity imaging. Week 8 Midterm. Week 9 Principles of Magnetic Resonance Imaging – Structure of matter; Spin physics; Precession and Larmor frequency; Concept of nuclear magnetic resonance; T1 and T2 relaxation times. Week 10 MRI Imaging Systems–MR signal and image formation; Gradients; RF coils; Signal acquisition and reconstruction; k-space; Source of image contrast; Different imaging modes; Spatial and temporal resolution; Historical perspective and new trends. Week 11 Principles of X-ray and Nuclear Imaging – Review of atomic physics; Radiation, attenuation, scattering, detection; X-ray and nuclear imaging instrumentation; Safety considerations; Week 12 Computed Tomography – Reconstruction of tomographic slices; Backprojection; Fourier slice theorem; Filtered backprojection; CT imaging instrumentation; 2D, 3D and 4D imaging. Week 13 Image Analysis – Introduction to medical image segmentation and registration; Image enhancement; Manual and automated analysis; Computer-aided detection; Opportunities, challenges and controversies. Week 14 Final project presentations. Week 15 Final exam (b) Required Textbook: Medical Imaging Physics–William R. Hendee, E. Russel Ritenour. Wiley-Liss Inc; 4th Edition, 2002. Supplementary texts for reference: (1) Diagnostic Ultrasound Imaging: Inside Out–Thomas Szabo. Elsevier Academic Press; 2004. (2) Magnetic Resonance Imaging: Physical Principles and Applications–Vadim Kuperman. Academic Press; 2000. (3) Medical Image Analysis–Atam Dhawan. Wiley-IEEE Press; 2003. (4) Handbook of Medical Imaging: Processing and Analysis–Isaac N. Bankman. Academic Press; 2000. (c) Student Evaluation Criteria Homeworks Mid-term exam Final exam Course project 25% 25% 25% 25%