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Dr. Ahmed Hassan Elshafeey Ahmed H. Elshafeey, Ph.D. [email protected] Professional Experience July2007-Present 1. Associate Professor of Pharmaceutics and industrial pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt. January 2007 - Present 2. Pharma and study director in Genuine research center (GRC), Cairo, Egypt.( http://grc-me.com/ May 2004 -Present 3. Research member in Bio Center of Applied Research and Advanced Studies (BIOCARAS), Faculty of Pharmacy, Cairo University. July 1998- June 2004 Assistant Lecturer of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt. September 2001- 2003 Doctoral Research Fellow, College of Pharmacy, University of Rhode Island, U.S.A. December 1991- June 1998. Teaching Assistant of Pharmaceutics, Faculty of Pharmacy, Cairo University, Egypt. Education 2009 Associate Professor of Pharmaceutics and industrial pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt. 1999-2004 Doctor of Philosophy in Pharmaceutical Sciences, Faculty of Pharmacy, Cairo University, June 2004. The practical work was done through a channel in the College of Pharmacy, university of Rhode Island, USA from (20012003) under the supervision of Prof. H.Zia. 1992-1998 Master of Pharmaceutical Sciences, Faculty of Pharmacy, Cairo University, July 1998. 1986-1991 Bachelor of Pharmaceutical Sciences, Faculty of Pharmacy, 1 Dr. Ahmed Hassan Elshafeey Cairo University, May 1991. Egypt. Grade: Excellent with Honors. Qualifications and Experience: More than 20 years experience in PK/PD teaching and research. Study director and pharmacokinetic analysis in Genuine Research center (CRO for bioequivalence and clinical trials). Perform different BE study designs such as cross over, parallel, partial replicate and replicate design, reference Scaled average bioequivalence. Pharmacokinetic and statistical calculations using Kinetica 2000 and Winnonlin. Familiarity with SAS Formulation of drugs for nasal, ocular and transdermal delivery Microencapsulation of peptides and proteins as injectable and intranasal delivery products Nanotechnology and drug delivery. Small particle formation and microencapsulation; the kinetics and mechanisms of drug release from small particle systems, emulsions, multiple emulsions, vesicles, biocompatible matrices and liquid crystals. Pharmacokinetics and bioavailability of different drug products using HPLC-UV and LC-MS/MS Method development and validation using LC-MS/MS (API 3200, 4000 and Waters TQD). Memberships - The American Association of Pharmaceutical Scientists (AAPS) The Egyptian Syndicate of Pharmacists, Cairo, Egypt The Egyptian Pharmaceutical Society, Cairo, Egypt Peer Reviewer In - International journal of Pharmaceutics Pharmaceutical Research. Journal of bioavailability and Bioequivalence. Drug Development and Industrial Pharmacy. - Asian Journal of Pharmaceutics Training Courses 2 Dr. Ahmed Hassan Elshafeey 1- "Liquid chromatography mass spectroscopy (LC-MS/MS)" at Executive Technology Forum, Milford, Massachusetts, USA, Septemper-2009. 2- "Basic LC/MS Training 4000 Q TRAP®", Dramstadt, Germany, October- 2008. 3- "New trends in Tablet coating", Faculty of Pharmacy, Cairo University, February- 2008. 4- "Stability Testing to Support Pharmaceutical Industry in Egypt", Faculty of Pharmacy, Cairo University, October- 2007. 5- "New Trends in Teaching", Faculty and Leadership Project (FLDP) – Cairo University- May - 2007. 6- "Handling and Use of Experimental Animals", University of Rhode Island, USA, 2002. 7- "Safe Chemical handling", University of Rhode Island, USA, 2001 Scientific Activities Contribution in Editing a book chapter: Marine Derived Polysaccharides as Drug Delivery Systems, In: “Polysaccharides: Development, Properties and Applications” of Nova Science Publishers, Inc., New York, USA. Prizes and Awards Prize for the best scientific research article in 2009 from Arab Company for Drug Industries and Medical Appliances (ACDIMA) Amman, Jordan. Research article: Utility of Nanosized Microemulsion for Transdermal Delivery of Tolterodine Tartrate: Ex-Vivo Permeation and In-Vivo Pharmacokinetic Studies. Pharmaceutical Research. 2009 Nov; 26(11):244653. Conferences 1- "Bioequivalence Study of Two Rizatriptan Formulations after Single-dose Administration to Healthy Male Volunteers using Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)". FIP Pharmaceutical Sciences World Congress 2010 in association with the AAPS Annual Meeting and Exposition in New Orleans, Louisiana, USA, November-2010. 2- "Effect of Acrylic Colloidal Nanoparticle Suspensions on Enhancement of Acyclovir Oral Bioavailability". The Third International Conference of Pharmaceutical and Drug Industries Division, National Research Center, Cairo, Egypt. 2009. 3 Dr. Ahmed Hassan Elshafeey 3- "Formulation and Bioavailability of Orodispersable Famotidine Tablets. The Egyptian Pharmaceutical Society XXXI, Cairo, Egypt. December, 2008. 4- “Formulation, in vitro and in vivo evaluation of spray coated and Pulsatile capsules for colon targeting of budesonide". AAPS Annual Meeting and Exposition in Georgia World congress center, Atlanta, Georgia USA, November-2008. 5- Facilitating Clinical Trials in MENA Region. Amman, Jordan, October2008. 6- “Formulation and In Vitro Evaluation of Compression Coated Tablets for Colonic Delivery of Budesonide". AAPS Annual Meeting and Exposition in San Diego Convention center, California, USA, November-2007. 7- "Intranasal delivery of Sildenafil Citrate in Rabbits". The Third International Conference of Pharmaceutical and Drug Industries Division, National Research Center, Cairo, Egypt. 2007. 8- "Rapid and Selective Assay of Clozapine in Human Plasma using High Performance Liquid Chromatography and Ultraviolet Detection". The 65th international Congress of FIP, Cairo, Egypt. Septemper-2005. 9- The development of a new method for the determination of Racecadotril in human plasma by high performance liquid chromatography. The 65th international Congress of FIP, Cairo, Egypt. Septemper-2005. 10- “Resealed Erythrocytes as a New Trend in Drug Targeting” presented in the Egyptian Pharmaceutical Society XXX held from 19-21, December, 2006 in Cairo, Egypt. Publications: 1. Rania M. Hathout, Ahmed H. Elshafeey, “Development and Characterisation of Colloidal Soft Nano-carriers for Transdermal Delivery and Bioavailability Enhancement of an Angiotensin II receptor Blocker”, European Journal of Pharmaceutics and Biopharmaceutics, 2012 Jul 20. [Epub ahead of print] 2. Soad A. Yehia, Ahmed H. Elshafeey, Aliaa ElMeshad, Hamoud A. Al-Bialey. A Pharmaceutical Study on Different Approaches for Itopride Hydrochloride 4 Dr. Ahmed Hassan Elshafeey Sustainment: In-vitro and in-vivo evaluation. J. Chem. Pharm. Res., 2012, 4(2):1398-1412. 3. Soad A. Yehia, Ahmed H. Elshafeey, Ibrahim Elsayed. Biodegradable donepezil lipospheres for depot injection optimization and in-vivo evaluation: Journal of Pharmacy & Pharmacology. Article first published online: 2 MAY 2012. DOI: 10.1111/j.2042-7158.2012.01530.x 4. Soad A. Yehia, Ahmed H. Elshafeey, Ibrahim Elsayed. A novel injectable in situ forming poly-DL-lactide and DL-lactide/glycolide implant containing lipospheres for controlled drug delivery. Journal of Liposome Research, Posted online on November 18, 2011. (doi:10.3109/08982104.2011.631141). 5. Ahmed H. Elshafeey, Yassin E. Hamza, Soad Y. Amin, Hossein Zia. In vitro transdermal permeation of fenoterol hydrobromide, Journal of Advanced Research (2012) 3, 125– 132 6. A.H. Elshafeey1,2, Y.E. Hamza, S.Y. Amin, F. Akhlaghi and H. Zia. Enhanced Bioavailability of Fenoterol Transdermal Systems in Rabbits. Journal of Bioequivalence & Bioavailability, http://dx.doi.org/10.4172/jbb.1000067. 7. Aly A. Abdelbary, Ahmed H. Elshafeey, Mohamed El-Nabarawi, Abdelhalim Elassasy, Xiaoling Li and Bhaskara Jasti. Comparative In vivo Evaluation of Aripiprazole Coprecipitate, Nanoparticles and Marketed Tablets in Healthy Human Volunteers and In vitro-In vivo Correlation. Journal of Current Trends in Biotechnology and Pharmacy, Vol. 5 (4) 1397-1409 October 2011. 8. Soad A. Yehia, Ahmed H. Elshafeey, Ibrahim Elsayed, Pulsatile systems for colon targeting of budesonide: In vitro and in vivo evaluation. Journal of Drug Delivery November 2011, Vol. 18, No. 8, Pages 620-630. 9. Kamel Hassan, Amany O.; Elshafeey, Ahmed H. Nanosized particulate systems for dermal and transdermal delivery. Journal of Biomedical Nanotechnology, Volume 6, Number 6, December 2010, pp. 621-633(13) 10. Elshafeey AH, Kamel AO, Fathallah MM. Utility of Nanosized Microemulsion for Transdermal Delivery of Tolterodine Tartrate: Ex-Vivo Permeation and In-Vivo Pharmacokinetic Studies. Pharm Res. 2009 Aug 21. [Epub ahead of print] 11. Ahmed H. Elshafeey, Amany O. Kamel, Gehanne A.S. Awad. Ammonium Methacrylate Units Polymer Content and their effect on Acyclovir Colloidal Nanoparticles Properties and Bioavailability in Human Volunteers. Colloids and Surfaces B: Biointerfaces, In Press, Accepted Manuscript, Available online 6 September 2009. 12. A.H. Elshafeey , M. Elsherbiny, M.M Fathallah; A Single-Dose, A single-dose, randomized, two-way crossover study comparing two olanzapine tablet products in healthy adult male volunteers under fasting conditions Clinical Therapeutics,Vol 31, No 3, 2009. 13. Elshafeey, A.H., E.R. Bendas, and O.H. Mohamed, Intranasal microemulsion of sildenafil citrate: in vitro evaluation and in vivo pharmacokinetic study in rabbits. AAPS PharmSciTech. 2009;10(2):361-7. Epub 2009 Mar 31. 14. Abdelbary, A.H. Elshafeey, G. Zidan “Comparative effects of different cellulosic-based directly compressed orodispersable tablets on oral bioavailability of famotidine” Carbohydrate Polymers, Volume 77, Issue 4, 19 July 2009, Pages 799-806. 5 Dr. Ahmed Hassan Elshafeey 15. Elshafeey, A. H. and E. I. Sami (2008). " Preparation and in-vivo pharmacokinetic study of a novel extended release compression coated tablets of fenoterol hydrobromide.." AAPS PharmSciTech. 2008;9(3):1016-24. Epub 2008 Sep 3. 16. Yehia, S.A., A.H. Elshafeey, I. Sayed, and A.H. Shehata, Optimization of budesonide compression-coated tablets for colonic delivery. AAPS PharmSciTech, 2009. 10(1): p. 147-57. 17. Hamza, YE; Amin, SY; El-Shafeey, AH. Influence of Acrylic Resin and Ethylcellulose on the Sustainability of Indomethacin via Solid Dispersion. Pharmazeutische Industrie (Germany), Vol.62, (7), pp.551-555, 2000. 18. G.Abdelbary, A.H.Elshafeey, A.Abdelbary. The development of a new method for the determination of Racecadotril in human plasma by high performance liquid chromatography FIP Cairo, Egypt, 2005. 19. A.H.Elshafeey, G.Abdelbary, A.Abdelbary. Rapid and selective analysis of Clozapine in human plasma using high performance liquid chromatography and ultraviolet detection. FIP Cairo, Egypt, 2005. 6