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TOPIC 12 SCHIZOPHRENIA AND OTHER PSYCHOTIC DISORDER 1 Schizophrenia is a chronic psychotic disorder characterized by disturbed behavior, thinking, emotions and perceptions Acute episode of schizophrenia are characterized by delusions, hallucinations, illogical thinking, incoherent speech and bizarre behavior Major diagnostic features of schizophrenia; A. Two or more of the following must be present for a significant portion of time over the course of a 1-month period: - delusions - hallucinations - speech that is either incoherent or characterized by marked loosing associations - disorganized or catatonic behavior - negative features (e.g. flattened affect) B. Dysfunctions in work, interpersonal relations or self-care Sign of disturbance for at least 6 months, with at least 1 month of symptoms listed. 4 Disorganized type Catatonic type Undifferentiated type Residual type 5 SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIFORM DISORDER DELUSIONAL DISORDER BRIEF PSYCHOTIC DISORDER SHARED PSYCHOTIC DISORDER 6 GENETIC ASPECTS PRENATAL EXPOSURES GENES AND ENVIRONMENT A NEURODEVELOPMENTAL PERSPECTIVE BIOLOGICAL ASPECTS NEUROCOGNITION PSYCHOSOCIAL AND CULTURAL ASPECTS 7 PHARMACOLOGICAL APPROACHES First-Generation Antipsychotics Second-Generation Antipsychotics PSYCHOSOCIAL APPROACHES Family Therapy Case Management Social-skills training Cognitive-Behavioral therapy Individual treatment 8