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Caná L. Ross, Ph.D. Positions 2013-2016 2009-2013 2001-2008 Education 2005-2008 2001-2004 Post-doctoral Fellow, PI: Tor Savidge, Ph.D. Department of Pathology Texas Children’s Microbiome Center Baylor College of Medicine Houston, TX, USA Post-doctoral Fellow, PI: Magnus Höök, Ph.D. Center for Inflammatory and Infectious Disease, Institute for Biosciences and Technology, Texas A&M Houston, TX, USA Graduate Research Assistant, PI: Theresa M. Koehler, Ph.D. Department of Microbiology and Molecular Genetics Graduate School of Biomedical Sciences University of Texas HSC – Houston Houston, TX USA Department of Microbiology & Molecular Genetics University of Texas – Health Science Center, Houston, TX Doctor of Philosophy (PI: Theresa M. Koehler, Ph.D.) Dissertation Title: “The molecular basis for beta-lactamase gene expression in B. anthracis, B. cereus and B. thuringiensis” Department of Microbiology & Molecular Genetics University of Texas – Health Science Center, Houston, TX Masters of Science (PI: Theresa M. Koehler, Ph.D.) Thesis Title: “plcR/papR-independent expression of anthrolysin O in B. anthracis.” Departments of Journalism and Department of Radio and Television Texas A&M University – Commerce (formerly East Texas State University) Commerce, TX Bachelor of Arts (double major) Journalism and Radio and Television. Teaching and Mentoring 2013-present Mentoring (Texas Children’s Hospital and Baylor College of Medicine) -undergraduate summer research students Preparation and design of research projects Instruction on experimental methods and interpretation of results. Data presentation and technical writing. All relevant laboratory training, including safety procedures, sterile technique, equipment use, proper handling of pathogens, and record-keeping. 2009-2013 Mentoring (Center for Inflammatory and Infectious Disease) undergraduate summer research students, masters students and medical students Preparation and design of research projects Instruction on experimental methods and interpretation of results. Manuscript writing and data presentation Guide MS students in the development of independent, hypothesis-driven projects. Discuss results and problem-solving with MS students. Oversee MS students in preparing research proposals and scientific manuscripts. All relevant laboratory training, including safety procedures, sterile technique, equipment use, proper handling of pathogens, and record-keeping. 2002-2008 Lecturing and Mentoring (Department of Microbiology and Molecular Genetics) Lectures – Graduate Student Seminar Series Mechanisms of transcriptional regulation and methods of investigation. Preparation of Research proposal Common tactics for troubleshooting Mentoring – undergraduate summer research students, junior graduate students and medical students. Preparation and design of research project Instruction on experimental methods. Manuscript writing and data presentation All relevant laboratory training, including safety procedures, sterile technique, equipment use, proper handling of pathogens, and record-keeping. 2000–2001 Teaching Assistant, Houston Baptist University (Houston, TX) Biology I (Dr. Betty Thompson) Biology II (Dr. Betty Thompson) Chemistry I (Dr. Treacy Woods) Prepare materials prior to class, including equipment, solutions and reagents. Provide assistance to students with experimental procedures. Answered questions regarding course material 1999-2001 Instructor, Mad Science of Houston: Teach after school science courses to elementary and junior high school students. Funding and Awards 2013 National Institute of Health; Pediatric GI Fellowship (T32-DK07664) “Microbial GABA and susceptibility to Clostridium difficile infection” Role: Post-doctoral Trainee 2012 Merck grant; “Pathomicrobiologic characteristics of Clostridium difficile recurrence” Role: co-Investigator (PI: K. Garey, PharmD) 2010 American Heart Association Post-doctoral Fellowship: “The role of collagen-binding MSCRAMMs in infectious endocarditis” (10POST4160090) Role: Principal Investigator 2007 Recipient, William W. and Pearl Wallis Knox Foundation Scholarship 2006 Second Place, GSEC Annual Research Poster Competition University of Texas- Health Science Center, Houston. 2004 First Place, Research Day Poster Competition University of Texas-Health Science Center, Houston Publications Spinler JK, Ross CL, Savidge TC. Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for? Anaerobe. 2016 May 13. pii: S1075-9964(16)30060-9. doi: 10.1016/j.anaerobe.2016.05.007. [Epub ahead of print] Review. PubMed PMID: 27180657. Spinler JK, Brown A, Ross CL, Boonma P, Conner ME, Savidge TC. Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease. Anaerobe. 2016 Aug;40:54-7. doi: 10.1016/j.anaerobe.2016.05.008. Epub 2016 May 11. PubMed PMID: 27180007; PubMed Central PMCID: PMC4969211. Ross CL, Spinler JK, Savidge TC. Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection. Anaerobe. 2016 May 12. pii: S1075-9964(16)30059-2. doi: 10.1016/j.anaerobe.2016.05.006. [Epub ahead of print] PubMed PMID: 27180006. Kang M, Ko YP, Liang X, Ross CL, Liu Q, Murray BE, Höök M. Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway. J Biol Chem. 2013 Jul 12;288(28):20520-31. doi: 10.1074/jbc.M113.454462. Epub 2013 May 29. PubMed PMID: 23720782; PubMed Central PMCID: PMC3711317. Ross CL, Liang X, Liu Q, Murray BE, Höök M, Ganesh VK. Targeted protein engineering provides insights into binding mechanism and affinities of bacterial collagen adhesins. J Biol Chem. 2012 Oct 5;287(41):34856-65. doi: 10.1074/jbc.M112.371054. Epub 2012 Aug 3. PubMed PMID: 22865854; PubMed Central PMCID: PMC3464587. Ross CL, Thomason KS, Koehler TM. An extracytoplasmic function sigma factor controls beta-lactamase gene expression in Bacillus anthracis and other Bacillus cereus group species. J Bacteriol. 2009 Nov;191(21):6683-93. doi: 10.1128/JB.00691-09. Epub 2009 Aug 28. PubMed PMID: 19717606; PubMed Central PMCID: PMC2795285. Ross CL, Koehler TM. plcR papR-independent expression of anthrolysin O by Bacillus anthracis. J Bacteriol. 2006 Nov;188(22):7823-9. Epub 2006 Sep 15. PubMed PMID: 16980467; PubMed Central PMCID: PMC1636328. Shannon JG, Ross CL, Koehler TM, Rest RF. Characterization of anthrolysin O, the Bacillus anthracis cholesterol-dependent cytolysin. Infect Immun. 2003 Jun;71(6):3183-9. PubMed PMID: 12761097; PubMed Central PMCID: PMC155736. Pre-submission enquiry Dann SM, Aitken SL, Ross C, Nazli, Urvil, Oezguen N, Wagal N, Luna RA, Eaves-Pyles T, Loeffelholz M, Luna R, Koussoulas K, Bornstein J, Versalovic J, Pothoulakis C, Garey K, Savidge TC. “Stool GABA and zolpidem confer disease susceptibility to Clostridium difficile infection” (presubmission enquiry; NEJM). In Preparation Ross, C.L., Peniche-Trujillo, A., Spinler, J.K., Oezguen, N., Cope, J., Urvil, P., Gerritsen, J., Smidt, H., Kellermayer, R., Versalovic, J., Luna, R.A., Bennett, G. Koo, H.M., Garey, K., Dann, S. and Savidge, T.C. “Multi-omics reveals microbial GABA as a communitydefined susceptibility to Clostridium difficile infection” (targeting Cell) Ross, C.L., Boonma P., Oezguen, N., Urvil, P., Koo, H.M., and Savidge, T.C. “High stool GABA is predictive of fidaxomicin treatment success for pediatric Clostridium difficile infection” Ross, C.L., and Savidge, T.C., Decoding antimicrobial-induced susceptibility to Clostridium difficile infection. (Invited Review, Anaerobe) Spinler JK, Brown A, Ross CL, Auchtung J, Boonma P, Haag T, Luna RA, Runge J, Versalovic J, Goodman S, Britton RA, Savidge T. “Lactobacillus reuteri supplementation is a viable option for preventative treatment of Clostridium difficile-associated diarrhea.” Tessier, ME, Brown, A., Andersson, H., Ross, CL, Boonma, P., Peniche-Trujillo, A., Dann, S., Francis, M., Sorg, J., Thevananther, S., Conner, ME., Savidge, TC., “Obeticholic acid (INT-747) confers disease protection against Clostridium difficile infection” Patents 2012 Ross, C., Liang X., Ganesh, V. and Höök M. “An engineered collagenbinding MSCRAMM with enhanced affinity for collagen.” (2011) Presentations Oral. Ross, C.L., Peniche-Trujillo, A., Oezguen, N., Cope, J., Gerritsen, J., Smidt, H., Bennett, G. Koo, H.M., Garey, K., Dann, S. and Savidge, T.C. (January 2015) “Microbial GABA and Clostridium difficile infection” Pediatric Gastroenterology Research Workshop, Houston, TX Ross, C.L., Peniche-Trujillo, A., Oezguen, N., Cope, J., G. Koo, H.M., Garey, K., Dann, S. and Savidge, T.C (November 2014) “Microbial GABA and Clostridium difficile infection” Multidisciplinary Translational Team Meeting, UTMB, Galveston, TX Ross, C.L. and Savidge, T. (November 2014) “The role of GABA in susceptibility to Clostridium difficile infection” Texas Branch ASM Meeting, Houston, TX (abstract selected for oral presentation) Ross, C.L. and Savidge. T. (August 2014) “Microbes, metabolites and Clostridium difficile infection. Experimental Pathology. Houston, TX Ross C.L. and Savidge, T. (June 2014) “Multi-omic signatures of Clostridium difficile infection.” Clostridium difficile Gulf Coast Collaborative Meeting. Houston, TX Ross C.L., Liang, X, Ganesh, V.K. and Höök, M. (June 2013) “Surface adhesions of Clostridium difficile.” Clostridium difficile Gulf Coast Collaborative Meeting. Houston, TX Ross C.L., Thomason, K. and Koehler, T.M. (October 2008) “ß-lactamase gene expression in the Bacillus cereus group species.” Molecular Biology of Infectious Disease Meeting, Houston, TX. Ross C.L.. Chen Y, and Koehler T. M. (June 2008). “Regulation of ß-lactamase gene expression in the Bacillus cereus group species”. Center for Infectious and Inflammatory Disease, Institute for Biosciences and Technology – Texas A&M, Houston Texas. (Oral). Ross C.L.. Chen Y, and Koehler T. M. (May 2006). “An extra-cytoplasmic function sigma factor controls -lactamase gene expression in Bacillus anthracis”. Molecular Biology and Infectious Disease (MBID) Seminar Series, University of TX – Health Science Center, Houston Texas. Ross C.L.. Chen Y, and Koehler T. M. (September 2005). “An extra-cytoplasmic function sigma factor controls -lactamase gene expression in Bacillus anthracis”. Bacillus ACT05, Santa Fe, NM. (abstract selected for oral presentation) Ross C.L., Chen Y and Koehler T.M. (April 2005). “An extra-cytoplasmic function sigma factor controls -lactamase gene expression in Bacillus anthracis”. Microbiology Department Retreat, Navasota, TX. Poster Ross, C.L., Peniche-Trujillo, A., Spinler, J.K., Oezguen, N., Cope, J., Urvil, P., Gerritsen, J., Smidt, H., Kellermayer, R., Versalovic, J., Luna, R.A., Bennett, G. Koo, H.M., Garey, K., Dann, S. and Savidge, T.C. (July 26-31, 2015) “Multi-omics reveals microbial GABA as a community-defined susceptibility to Clostridium difficile infection” Gordon Research Conference, Microbial Adhesion and Signal Transduction Newport, RI Ross, C.L., Peniche-Trujillo, A., Loeffelholz, M., Aitken, S., Oezguen, N., Urvil, P., Pena, M., Bennett, G. Koo, H.M., Garey, K., Dann, S. and Savidge, T.C. (February 2015) “The role of GABA in susceptibility to Clostridium difficile infection” 6th Annual Frontiers in Digestive Diseases Symposium Houston, TX Ross, C.L, Liang, X, Liu, Q, Murray, B.E., Hook, M. and Ganesh, V.K. (May 2011). “The ligand affinity and specificity of the Staphylococcus aureus and Enterococcus faecalis collagen-binding proteins, Ace and Cna, is influenced by the inter-domain linker and inter-domain orientation” 111th General Meeting American Society for Microbiology Ross, C.L, Liang, X, Liu, Q, Murray, B.E., Hook, M. and Ganesh, V.K. (October 2010). “The sequence and length of the inter-domain linker influences ligand affinity and specificity of S. aureus and E. faecalis collagen-binding MSCRAMMs.” International Conference on Gram-positive Pathogens. Omaha, NE. Ross C.L.. Chen Y, and Koehler T. M. (February 2008). “An extra-cytoplasmic function sigma factor controls -lactamase gene expression in Bacillus anthracis”. ASM Biodefense and Emerging Diseases Research Meeting, Baltimore, MD. Ross C.L.. Chen Y, and Koehler T. M. (April 2006). “An extra-cytoplasmic function sigma factor controls -lactamase gene expression in Bacillus anthracis”. Graduate Student Executive Committee (GSEC) Poster Competition, University of TX - Houston. Ross C.L.. Chen Y, and Koehler T. M. (April 2006). “An extra-cytoplasmic function sigma factor controls -lactamase gene expression in Bacillus anthracis”. Bugs, Drugs and Vaccines. The Academy of Medicine, Engineering and Science of Texas and the University of Texas System. Galveston, Texas. (Poster). Ross C.L.., and Koehler T.M. (November 2004). “plcR/papR-independent expression of anthrolysin O in Bacillus anthracis.” Research Day, Houston, TX.. (Poster). Ross C.L.., and Koehler T.M. (November 2004). “plcR/papR-independent expression of anthrolysin O in Bacillus anthracis.” 2004 Texas Branch of ASM Conference. Houston, Texas. (Poster). Memberships 2006 – Present Member of the American Society for Microbiology.