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Biochemistry –CHEM 3500-01– Spring 2010-Scott Lecture: TR 9:00-10:40 AM Room 130 Sequoya Instructor: Dr. Tricia L. Scott Office: 218C Sequoya Hall Phone: 706-272-2494 Secretary: 706-272-4440 E-mail: [email protected] Office Hours: Monday: 9:00-10:40 AM and 12:15-1:30 PM Tuesday and Thursday: 10:40-12:15 AM Science Learning Center Hours (Seq 115): Tuesday: 1:30-3:30 PM Other hours available by appointment. Course Materials: Biochemistry: A Short Course by Tymoczko, Berg, and Stryer. A scientific calculator Student Learning Objectives: Upon completion of the course CHEM 3500 students should be able to: 1. Understand the biological environment including water, membranes, and buffered systems. 2. Know the main classes of biopolymers, their building blocks, and understand their three-dimensional structure. 3. Understand how enzymes work and what contributes to their activity, inhibition, and overall regulation. 4. Understand membranes and transport of molecules across membranes. 5. Understand the energetics and organization of metabolic pathways. 6. Know key steps and intermediates in common metabolic pathways such as glycolysis, TCA cycle, electron transport, and lipid metabolism. 7. Understand key steps in DNA replication and repair. 8. Understand key steps in the processes of transcription and translation. ASSESSMENT Exams (4 each) Quizzes/Homework Class Participation Final Exam 60 % 10% 10 % 20 % OBJECTIVES [1 – 8] [1 – 8] [1 – 8] [1 – 8] GRADING: Final letter grades will be based on four regular exams, a cumulative final exam, quizzes, homework, and class participation. Grading scale: 90% or better 80-89% 70-79% 60-69% 59% or below A B C D F I will NOT send grades by e-mail or phone. You must see me in person at my office to discuss any grades. Some grades such as the final exam grade and final course average will be posted on GeorgiaVIEW. ATTENDANCE POLICY: Attendance in lecture will be taken each day through a sign-in sheet. To earn credit for class participation you need to attend lectures and actively participate in class discussions. Please DO NOT sign the attendance sheet for someone else. If caught, both parties will receive a zero for class participation. If you miss a day and your absence causes you to miss an exam, quiz, or in-class assignment, you will receive a grade of zero for that exam, quiz, or in-class assignment. There will be NO makeup quizzes given. Only one lowest quiz score will be dropped. Makeup of missed in-class assignments may be allowed with a valid excuse. No assignments will be accepted after the instructor has graded and returned papers. There will be NO makeup exams. The final exam grade will be used to replace the lowest regular exam grade and therefore can be counted twice. If the final exam grade is the lowest exam grade, then the final exam grade will be counted once and no regular exam grade will be replaced. The final exam grade can be used to replace a zero for a missed exam. Only one missed exam score may be replaced by the final exam. All other missed exams will result in a grade of zero. Any alleged errors in the grading of any exam, quiz, or assignment must be brought to the attention of the instructor within one week of the return of that exam, quiz, or assignment. Academic Honesty: Acts which violate the academic integrity policy (e.g., cheating, plagiarism, etc.) of the college will not be tolerated and will result in a grade of “F” for the course and referral to the disciplinary committee. Calculators will be used in course work. If your calculator is programmable, the instructor may reserve the right to inspect or erase any and all programs prior to taking an exam or quiz. How To Do Well In This Course: 1. Meet the prerequisites (It is assumed that you know this material BEFORE taking this class): You need to be able to use logarithms and scientific notation; to rearrange and solve algebraic equations; to balance chemical equations; to understand atomic structure and reactivity; to calculate pH and use equilibrium constants; to identify and understand the properties of functional groups such as reactivity and polarity; to calculate concentrations; and to use various other skills learned in general and organic chemistry. 2. Read the textbook. Read the assigned chapters before coming to lecture (See Tentative Schedule) and then review class notes after lecture. Lecture time is limited, and we cannot possibly cover every detail of the book. Exam questions will come from both material covered in lecture and in the textbook. 3. Do the homework problems in the textbook. Really do them, do not just read the answers given in the back of the book. 4. Make a commitment to study. Don’t try to cram material the night before the exam. Keep up with your work and studying and try not to get behind. Study a couple of hours each day. There is a lot of material to learn! Biochemistry is a vast subject. This course will be challenging and demanding, but hopefully very rewarding. 5. Use flash cards, study groups, and other study strategies. 6. Get help early. Don’t wait too long to come see me. CELL PHONE AND ELECTRONIC DEVICE POLICY: The use of cell phones or any other electronic communication devices during any lecture or exam is prohibited. Cell phones must be turned off or switched to silent mode. If an emergency situation exists, cell phone use may be permitted only with prior permission from the instructor. The use of cell phones or other prohibited devices during class will be reason for dismissal from the class that day. Any exam, quiz, or assignment missed due to dismissal from class will result in a grade of zero. WITHDRAWAL FROM THE COURSE: The last day to drop this class without penalty is Monday, March 22, 2010. You will be assigned a grade of W. After this date, withdrawal without penalty is permitted only in cases of extreme hardship as determined by the Vice President for Academic Affairs; otherwise a grade of WF will be issued. The proper form for withdrawing from all classes at the college after the official drop/add period but before the published withdrawal date is the Schedule Adjustment Form. Students who are assigned to the Academic Advising Center for advisement must meet with an advisor or staff member at the Academic Advising Center (107 Liberal Arts Building) to initiate the withdrawal process. All other students must meet with a staff member or advisor at the Office of Academic Resources in the Pope Student Center to initiate the withdrawal process. After meeting with the staff member or advisor, all students will then finalize the withdrawal process in the Financial Aid Office. Students who fail to complete the official drop/withdrawal procedure will receive the grade of F. Withdrawal from class is a student responsibility. The grade of W counts as hours attempted for the purposes of financial aid. Disability Statement Students with disabilities or special needs are encouraged to contact Disability Support Services in Academic Resources. In order to make an appointment to obtain information on the process for qualifying for accommodations, the student must contact the Coordinator of Disability Support Services. Contact information: Andrea Roberson Pope Student Center, lower level 706/272-2524 [email protected] Workforce Development If a student receiving aid administered by the DSC Workforce Development Department drops this class or completely withdraws from the College, the Schedule Adjustment Form must be taken to the Workforce Development Office located in Room 112 of the Technical Education Building. The Office is open on the following schedule: Monday/Tuesday/Thursday: 9:00 a.m.-12:15 p.m. and 1:30 p.m. - 5:00 p.m. Friday: 8:00 a.m.- 12:00 p.m. The office phone number is 272-2635. Tentative Schedule for CHEM 3500 Spring 2010 Week of Tuesday January 4 January 11 January 18 Chapter 2: Water, Weak Bonds, and the Generation of Order Out of Chaos Chapter 3: Amino Acids Chapter 5: Basic Concepts of Enzyme Action Thursday Chapter 1: Biochemistry and the Unity of Life Chapter 3: Amino Acids Chapter 4: Protein Three-Dimensional Structure Chapter 6: Kinetics and Regulation January 25 Exam 1 (Ch. 1-6) Chapter 7: Mechanisms and Inhibitors February 1 Chapter 8: Hemoglobin, an Allosteric Protein Chapter 9: Carbohydrates February 8 Chapter 10: Lipids Ch. 11: Membrane Structure and Function February 15 Chapter 12: Signal-Transduction Pathways Exam 2 (Ch. 7-12) February 22 Chapter 14: Metabolism: Basic Concepts and Design Chapter 15: Glycolysis March 1 Spring Break Spring Break March 8 Chapter 16: Gluconeogenesis Chapter 17: Citric Acid Cycle March 15 Chapter 18: Citric Acid Cycle Chapter 19: Oxidative Phosphorylation March 22 Chapter 20: Oxidative Phosphorylation Chapter 21: Photosynthesis March 29 Exam 3 (Ch. 14-21) Chapter 23: Glycogen Degradation April 5 Chapter 24: Glycogen Synthesis Chapter 26: Fatty Acid Degradation April 12 Chapter 27: Fatty Acid Synthesis April 19 Chapter 33: DNA Replication Chapter 34: DNA Repair April 26 Exam 4 (23-24, 26-27, 32-34, 38-39) May 3 Final Exam Tuesday, May 4 8:00-10:00 AM Chapter 32: The Structure of Informational Macromolecules: DNA and RNA Chapter 33: DNA Replication Chapter 38: The Genetic Code Chapter 39: The Mechanism of Protein Synthesis