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OMB No. 0925-0001 and 0925-0002 (Rev. 10/15 Approved Through 10/31/2018) BIOGRAPHICAL SKETCH NAME: Van Ness, Peter H. eRA COMMONS USER NAME (agency login): PVANNESS POSITION TITLE: Senior Research Scientist, Department of Internal Medicine, Geriatrics Section, Yale School of Medicine; Co-Director of Biostatistics Core, Yale Program on Aging EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE Completion FIELD OF STUDY (if applicable) Date MM/YYYY Columbia College of Columbia University, New BA 05/1975 Religious Studies York, NY University of Chicago Divinity School, Chicago, MA 12/1977 Religious Studies IL University of Chicago Divinity School, Chicago, PHD 08/1983 Theology (and philosophy) IL Yale School of Medicine, New Haven, CT MPH 05/2000 Chronic Disease Epidemiology Yale School of Medicine, New Haven, CT Postdoctoral 04/2002 Epidemiology Fellow A. Personal Statement Dr. Van Ness is a senior biostatistician at the Program on Aging in the Geriatrics Section of the Department of Internal Medicine of the Yale University School of Medicine. He is also the Co-Director of the Biostatistics Core of Yale’s Claude D. Pepper Older Americans Independence Center and its Program on Aging. He has worked productively for over 13 years with geriatricians, gerontologists, and other researchers, providing statistical expertise to numerous Yale collaborators. During this time Dr. Van Ness has become knowledgeable of diverse study designs and proficient at many types of statistical analysis. He has special expertise regarding the distinctive statistical challenges of conducting biomedical research on aging and/or with older study participants that Dr. Van Ness and colleagues have addressed under the rubric of Gerontologic Biostatistics. Thus, Dr. Van Ness’s record of collaborative clinical and basic research and first-author methodological publications make him very well suited to contribute to the research activities proposed in the renewal of Dr. Sherwin’s award entitled “Yale University Clinical and Translational Science Award.” 1. Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A cluster-randomized controlled trial of a multicomponent intervention protocol for pneumonia prevention among nursing home elders. Clin Infect Dis. 2015 Mar 15;60(6):849-57. PubMed PMID: 25520333; PubMed Central PMCID: PMC4415071. 2. Lipska KJ, Inzucchi SE, Van Ness PH, Gill TM, Kanaya A, Strotmeyer ES, Koster A, Johnson KC, Goodpaster BH, Harris T, De Rekeneire N. Elevated HbA1c and fasting plasma glucose in predicting diabetes incidence among older adults: are two better than one?. Diabetes Care. 2013 Dec;36(12):3923-9. PubMed PMID: 24135387; PubMed Central PMCID: PMC3836095. 3. Lipska KJ, De Rekeneire N, Van Ness PH, Johnson KC, Kanaya A, Koster A, Strotmeyer ES, Goodpaster BH, Harris T, Gill TM, Inzucchi SE. Identifying dysglycemic states in older adults: implications of the emerging use of hemoglobin A1c. J Clin Endocrinol Metab. 2010 Dec;95(12):528995. PubMed PMID: 20861123; PubMed Central PMCID: PMC2999974. 4. Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic biostatistics: the statistical challenges of clinical research with older study participants. J Am Geriatr Soc. 2010 Jul;58(7):1386-92. PubMed PMID: 20533963; PubMed Central PMCID: PMC2918405. B. Positions and Honors Positions and Employment 1981 - 1985 1986 - 1996 1992 - 1995 1997 - 1998 2001 2002 2005 - Instructor, then Assistant Professor, of Philosophy, College of St. Francis, Joliet, IL Assistant, then Associate, Professor of Philosophy of Religion, Union Theological Seminary, New York, NY Dean of Academic Affairs, Union Theological Seminary, New York, NY Visiting Associate Professor of Religion, Columbia University, New York, NY Lecturer in Epidemiology, Yale School of Public Health, New Haven, CT Associate Research Scientist, Research Scientist, and now, Senior Research Scientist, Yale School of Medicine, Department of Internal Medicine, Geriatrics Section, New Haven, CT Associate Director, now Co-Director of Biostatistics, Yale Program on Aging, New Haven, CT Other Experience and Professional Memberships 2002 2003 2005 2005 2008 - 2010 2008 - 2010 2011 - Member, American Statistical Association Member, Editorial Advisory Board, Journal of Religion and Health Member, Gerontological Society of America Member, Society of the Scientific Study of Religion Ad hoc Member, Aging Systems and Geriatrics Study Section of the National Institutes of Health Convener, Gerontological Society of American Measurement, Statistics, and Research Design Interest Group DSMB Biostatistician, Intensive versus Standard Blood Pressure Lowering to Prevent Functional Decline in Older People Honors 1971 1975 1983 2000 Regents Scholarship, New York State BA, Cum Laude, Columbia College of Columbia University Ph, D., with distinction, University of Chicago Epidemiology and Public Health Representative to Student Research Day, Yale School of Medicine C. Contribution to Science 1. With biostatistical colleagues at the Yale Program on Aging I have established the subdiscipline of Gerontologic Biostatistics. It addresses the distinctive methodological challenges of conducting clinical research with older study participants and the special pedagogical requirements of training biostatisticians for work in this field. It also provides valuable resources for methodological and pedagogical issues involved in basic aging research. My original contributions have concerned the application of new missing data techniques to gerontologic research, the generation of explanatory hypotheses from data limited by the high rates of morbidity and mortality in older study samples, and the integration of qualitative research results with quantitative results when studying persons with chronic conditions that may never be entirely remediated. a. Van Ness PH, Murphy TE, Araujo KL, Pisani MA, Allore HG. The use of missingness screens in clinical epidemiologic research has implications for regression modeling. J Clin Epidemiol. 2007 Dec;60(12):1239-45. PubMed PMID: 17998078; PubMed Central PMCID: PMC2443713. b. Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic biostatistics: the statistical challenges of clinical research with older study participants. J Am Geriatr Soc. 2010 Jul;58(7):1386-92. PubMed PMID: 20533963; PubMed Central PMCID: PMC2918405. c. Van Ness PH, Fried TR, Gill TM. Mixed Methods for the interpretation of longitudinal gerontologic data: insights from philosophical hermeneutics. J Mix Methods Res. 2011 Oct;5(4):293-308. PubMed PMID: 22582035; PubMed Central PMCID: PMC3347468. d. Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Multivariate graphical methods provide an insightful way to formulate explanatory hypotheses from limited categorical data. J Clin Epidemiol. 2012 Feb;65(2):179-88. PubMed PMID: 21889310; PubMed Central PMCID: PMC3250573. 2. With my longstanding geriatrician colleague Carlos A. Vaz Fragoso, M.D., I have contributed to the application and interpretation of clinically valid methods of measuring pulmonary function in older persons. These methods more adequately identify older persons whose changes in lung function are diseaserelated rather than aging-related, thereby preventing clinicians from inappropriately treating older adults with unnecessary and costly medications having potentially harmful side effects. a. Vaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM. The ratio of FEV1 to FVC as a basis for establishing chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 Mar 1;181(5):446-51. PubMed PMID: 20019341; PubMed Central PMCID: PMC3159085. b. Vaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Gill TM. Respiratory impairment and COPD hospitalisation in older persons: a competing risk analysis. Eur Respir J. 2012 Jul;40(1):37-44. PubMed PMID: 22267770; PubMed Central PMCID: PMC3773173. c. Vaz Fragoso CA, Gill TM, McAvay G, Quanjer PH, Van Ness PH, Concato J. Respiratory impairment in older persons: when less means more. Am J Med. 2013 Jan;126(1):49-57. PubMed PMID: 23177541; PubMed Central PMCID: PMC3529831. d. Vaz Fragoso CA, McAvay G, Gill TM, Concato J, Quanjer PH, Van Ness PH. Ethnic differences in respiratory impairment. Thorax. 2014 Jan;69(1):55-62. PubMed PMID: 23939399; PubMed Central PMCID: PMC3925402. 3. With longstanding infectious disease colleagues Manisha Juthani-Mehta, M.D., and Vincent J. Quagliarello, M.D., I have developed models to identify risk factors for urinary tract infection and pneumonia. Furthermore, I have designed and analyzed randomized clinical trials whose interventions, informed by our previous observational research, sought to improve infectious disease outcomes for older adults. a. Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Interobserver variability in the assessment of clinical criteria for suspected urinary tract infection in nursing home residents. Infect Control Hosp Epidemiol. 2008 May;29(5):446-9. PubMed PMID: 18419369; PubMed Central PMCID: PMC2671070. b. Juthani-Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical features to identify urinary tract infection in nursing home residents: a cohort study. J Am Geriatr Soc. 2009 Jun;57(6):963-70. PubMed PMID: 19490243; PubMed Central PMCID: PMC2692075. c. Van Ness PH, Peduzzi PN, Quagliarello VJ. Efficacy and effectiveness as aspects of cluster randomized trials with nursing home residents: methodological insights from a pneumonia prevention trial. Contemp Clin Trials. 2012 Nov;33(6):1124-31. PubMed PMID: 22917599; PubMed Central PMCID: PMC3468687. d. Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A cluster-randomized controlled trial of a multicomponent intervention protocol for pneumonia prevention among nursing home elders. Clin Infect Dis. 2015 Mar 15;60(6):849-57. PubMed PMID: 25520333; PubMed Central PMCID: PMC4415071. 4. With almost twenty years of experience as a philosopher of religion before expanding my education and expertise to include epidemiology and public health, I bring to my work as a social epidemiologist and gerontologic biostatistician an exceptionally great knowledge about, and sensitivity to, some of the religious and spiritual issues that influence the health behaviors and medical decision-making of older persons. My contributions to understanding the multiform relationships between various aspects of health and religion have especially focused on the concept of risk and issues in geriatric psychiatry. a. Van Ness PH, Larson DB. Religion, senescence, and mental health: the end of life is not the end of hope. Am J Geriatr Psychiatry. 2002 Jul-Aug;10(4):386-97. PubMed PMID: 12095898; PubMed Central PMCID: PMC4357420. b. Van Ness PH, Kasl SV. Religion and cognitive dysfunction in an elderly cohort. J Gerontol B Psychol Sci Soc Sci. 2003 Jan;58(1):S21-9. PubMed PMID: 12496305; PubMed Central PMCID: PMC4353608. c. Van Ness PH, Towle VR, O'Leary JR, Fried TR. Religion, risk, and medical decision making at the end of life. J Aging Health. 2008 Aug;20(5):545-59. PubMed PMID: 18443144; PubMed Central PMCID: PMC2526227. Complete List of Published Work in My Bibliography: http://1.usa.gov/1jBchIN D. Research Support Ongoing Research Support 2P30AG021342-11 Gill (PI) 09/30/02 - 05/31/18 NIH/NIA Claude D. Pepper Older Americans Independence Center at Yale The goal of the Center is to train clinicians, biostatisticians and other scientists in the skills necessary to conduct interventions and studies of multi-factorial geriatric health conditions. Role: Co-Director of the Biostatistics Core 5R01MH085740 Lee, Hochang (PI) 07/01/10 – 08/28/16 NIMH Intracranial Atherosclerosis and Predictors of Post CABG Depression We predict that pre-operative burden of ICA, as assessed by TCD, will be a strong independent risk factor for post-CABG depression, and that features and symptomatology (e.g. late age of onset, executive dysfunction, functional impairment, apathy and anhedonia) will be consistent with the "Vascular Depression" Hypothesis. Confirming these predictions will support the hypothesis that post-CABG depression is a form of Vascular Depression, thus laying the foundation for risk stratification with a mobile, bedside tool and development of etiologically-based prevention strategies to reduce morbidity and mortality associated with post-CABG depression. Role: Biostatistician 8 UL1 TR000142-07 (Sherwin) 07/01/11 – 6/30/16 NIH/NCATS Yale University Clinical and Translational Science Award Goal: This is a grant that is funding the Yale Center for Clinical Investigation that provides a “home” for training the next generation of clinical investigators. This would include providing expanded biostatistical resources. Role: Biostatistician 1R01AG041153 Juthani-Mehta (PI) 05/01/12 – 04/30/16 NIH/NIA Cranberry Capsules for Prevention of UTI in Nursing Home Residents The major goal of this project is to derive an empiric definition of UTI in nursing home residents. Role: Biostatistician 1 P30 HS023554-01 Chaudhry (PI) 09/30/14 – 09/29/18 AHRQ Yale Center for Healthcare Innovation, Redesign and Learning (CHIRAL) The Yale Center for Healthcare Innovation, Redesign, and Learning (CHIRAL) is a joint venture of Yale School of Medicine (YSM) and Yale-New Haven Hospital (YNHH) that brings together an expert group of physicians, nurses, industrial engineers, communication experts, informatics specialists, sociologists, simulation researchers, clinical researchers and administrators, creating a dynamic learning environment to improve patient safety. CHIRAL will focus on some of the most perilous moments in healthcare: transitions of care Role: Biostatistician 1I01CX000927-01A1 VA Merit Award Vaz Fragoso (PI) 10/01/14 – 09/30/17 Veterans Affairs (VA) Health Administration Respiratory Impairment in Aging Populations The main aim of this project is to assess associations of LMS (Lambda-Mu-Sigma) and GOLD (Global Initiative for Obstructive Lung Disease) defined respiratory impairment with health outcomes like respiratory symptoms, healthcare utilization, and death. Role: Biostatistician Completed Research Support N/A Tinetti (PI) 01/01/98 – 06/30/14 The John A. Hartford Foundation Center of Excellence The goal of this project was to increase the number of physicians pursuing academic careers in geriatrics. Role: Biostatistician DF#06-205 Fried & Fraenkel) (PI) 03/01/07 - 02/28/11 Donaghue Foundation Improving the Quality of Care for Atrial Fibrillation by Promoting Patient-Centered Decision-Making The major goal of this randomized controlled trial was to examine the effectiveness of a novel, interactive, computer-based decision support tool on improving the concordance between patients’ preferences and treatment decisions regarding anticoagulation for non-valvular atrial fibrillation. Role: Biostatistician R01 AG030575 Quagliarello (PI) 01/01/09 – 12/31/14 NIH/NIA A Randomized Controlled Trial to Reduce Pneumonia in Nursing Home Residents The goal of this project was to test a multi-component intervention for its effectiveness in reducing the rate of documented pneumonia in nursing home residents with impaired oral hygiene or swallowing difficulty compared to usual care. Role: Biostatistician