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EVERYTHING A MEDICAL STUDENT SHOULD KNOW ABOUT A CT SCAN OF THE HEAD By Thanh Binh Nguyen Neuroradiologist Ottawa Hospital Last updated July 2007 What is a CAT scan?  CAT scan stands for Computed Assisted Tomography  Cross sectional images are obtained by multiple measurements of the x-rays attenuation from several projections. What are we measuring?  The attenuation coefficient reflects the reduction in the x-ray intensity by the material relative to water.  The Hounsfield Unit is the scale used. (HUwater=0, HUbone >500, HUlung=-500) CT and radiation  Effective dose takes into account which tissue has absorbed what radiation dose (expressed in Sievert)  We can decrease the effective dose in CT by reducing the tube current but image noise will be increased Radiation and risk of cancer   1. 2. 3. Lifetime risk of developing fatal cancer from radiation exposure in a population is 0.005% per milliSievert(mSv) Exposure from mSV Natural background 3 /yr CT head 2 CT spine 10 STROKE Canadian Stroke Facts*  40,000-50,000 new stroke’s /year  65% of survivors have disability  4th leading cause of death  Longest length-ofstay for any diagnosis (37 d)  Leading cause of     transfer to long term care Leading cause of neuro disability in adults Cost >$2.7 billion/year $27,500 / acute stroke $46,000-$122,000 / patient for chronic care *Canadian Heart and Stroke Foundation Stroke  denotes a persistent loss of neurologic function with sudden onset  diverse etiologies... Ischaemic Cerebrovascular Stroke Venous Congestion / Stroke Hemorrhagic Stroke Anatomy Arterial Territories  Anterior Cerebral  Middle Cerebral  Posterior Cerebral  Basilar  Superior Cerebellar  Anterior Inferior Cerebellar  Posterior Inferior Cerebellar Supratentorial Territories From Osborne, A: Neuroradiology Left PCA MCA ACA Anterior choroidal infarct Watershed (between ACA and MCA) Ischaemic CV Stroke  Thromboembolic most common  Hemodynamic  Atherosclerotic  Dissection  Vasospasm  Hypotensive /asphyxia (watershed)  Migraine  Vasculitis  Thrombotic: hypercoagulable states Hemorrhagic Stroke  Primary Intracerebral bleed Hypertensive  Amyloid angiopathy  Arteriovenous malformations  Neoplasms  Trauma   Subarachnoid hemorrhage Aneurysm  AVM’s  Trauma  Hypertensive Hemorrhage Classically involves the deep nucleii Amyloid angiopathy Hyperdense vessel sign Hyperdense vessel sign & loss of gray/white junction... Left insular ribbon sign & effacement of sulci NEOPLASM APPROACH TO BRAIN TUMOR  Intra-axial(from the brain) versus Extra-axial     (from the meninges or skull) Location (supratentorial vs infratentorial) Age of patient Imaging characteristics Could you this be something other than neoplasm (infarction, abscess, etc…)? CT with contrast or MRI is often needed. EDEMA  Vasogenic edema:  Involves white matter primarily with sparing of gray matter  Seen with brain tumors, abscess  Cytotoxic edema  Involves both white matter and gray matter  Seen with infarction BRAIN TUMORS  Extraaxial: meningioma  Intraaxial:  Primary Glial tumors: low grade to high grade astrocytoma (glioblastoma multiforme)  Non glial tumor (lymphoma, hemangioblastoma, etc…)   Metastasis (lung, breast, colon, etc…) Unenhanced CT of the head shows a mass in the left frontal lobe with vasogenic edema Ring enhancing lesion (GBM) Vasogenic edema GLIOMAS  Astrocytomas  85% of cerebral gliomas  Young to middle-aged adults (20-50 years)  Varying degree of malignancy. Highest grade is glioblastoma multiforme which presents as a mass with ill-defined margins, variable enhancement and extensive vasogenic edema.  Oligodendrogliomas  Young, middle-aged adult  Solid, well-defined mass with calcification  70 year old gentleman complaining of dizziness and off balance for one week with associated nausea and vomiting. He also had attack of left facial numbness and left arm numbness for a week. Cerebellar exam showed nystagmus of lateral gaze and left-sided incoordination C- C+ Left tonsillar herniation C- C+ C- C+ Hyperdense cerebellar mass seen on plain CT scan which enhances homogeneously and causes compression of the 4th ventricle and hydrocephalus C- C+ DIAGNOSIS  BURKITT LYMPHOMA Ct scan of the head with contrast in patient with renal cell carcinoma Enhancing nodule at corticomedullary junction Vasogenic edema: involves whiter matter more than gray matter DIAGNOSIS  METASTASES  Hematogenous seeding to corticomedullary junction  Usually in MCA territory  Usually the degree of edema is out of proportion to the size of the lesion Ct scan of the head without contrast Hyperdense mass Enhances homgeneously and appears extraaxial Thickening of the adjacent bone (hyperostosis) DIAGNOSIS  MENINGIOMA INFECTION INTRACRANIAL INFECTION  Intraaxial:  Encephalitis  Cerebritis  Abscess  Extraaxial:  Subdural empyema  Epidural abscess  Meningitis CEREBRAL INFECTION  Encephalitis: generalized and difuse infection of the brain. Often of viral origin (ex.herpes simplex)  Cerebritis: localized but poorly demarcated area of parenchymal softening.  Abscess: follows cerebritis. Occurs when a central zone of necrosis becomes encapsulated. MODE OF SPREAD  Hematogenous spread: could reach the corticomedullary junction or leptomeninges.  Direct extension: ex.sinusitis leading to epidural abscess or subdural empyemas  Spread along the nerves (ex.herpes encephalitis along the trigeminal nerve) ABSCESS (could look similar to metastatic lesion on CT) Ring enhancing lesion Vasogenic edema SUBDURAL EMPYEMA (C-) SUBDURAL EMPYEMA (C+) TUBERCULOSIS Basal leptomeningitis (seeding of the subarachnoid space) TUBERCULOSIS Multiple tuberculomas seen on MRI exam with contrast THE END