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Ashish R. Parekh, MD Urologic Surgery Kaiser Permanente, WLA * Men>Women (4:1 ratio) * Age 20-50 * Prior stone former 10x more likely to get another stone in his lifetime * Hereditary * Medullary sponge kidney, hyperoxaluria, cystinuria, renal tubular acidosis (RTA) * Dehydration * Excessive salt * Excessive oxalates * Medications * Indinavir, Guifenesin, topirimate, diuretics * Medical problems * Hyperparathyroidism, gout, intestinal malabsorption, laxative abuse, obesity, diabetes, recurrent urinary tract infections * Fad diets * * Normal urine pH is 5.5-6.5 * The kidneys filter EXCESS minerals (potassium, calcium, phosphorus, etc) and metabolites (oxalates, uric acid) from the blood * When the pH is TOO HIGH (alkaline) or TOO LOW (acidic) AND there is TOO MUCH mineral/metabolite, STONES FORM IN THE KIDNEY, just like in a test tube in chemistry class; it’s a concentration/crystallization problem! * * Earliest stone: Egyptian mummy, 4500-5000 BC * Earliest stone surgery (literary documentation): Sushruta performed a perineal lithotomy, India, ~6th century BC * Documented in Sushruta Samhita * Modern day surgery: * 1800s: perineal lithotomy (bladder stone removal) * 1900s: percutaneous stone removal, ESWL, ureteroscopy * * Pain in the upper back (SEVERE), either the LEFT or RIGHT side * Blood in urine * Fevers, nausea, vomiting DO NOT IGNORE THESE SYMPTOMS!! * * Proper history FROM THE PATIENT * Hydration, control of pain, nausea, vomiting * Urine and blood tests * Imaging test (plain Xray, CT scan or ultrasound) * Antibiotics are OPTIONAL, but life-saving if there is sign of infection * Urology referral * * Pain medication * NSAIDs are best * Narcotics in case of severe pain * Medication to help pass the stone * Tamsulosin * FOLLOWUP IMAGING TO PROVE STONE HAS PASSED! * Instructions on how to PREVENT future stones * Hydration, less salt, less animal protein, add lemon juice to your water * * * EXTRACORPOREAL SHOCKWAVE LITHOTRIPSY * Least invasive * German-engineering at its finest! * URETEROSCOPY WITH LASER LITHOTRIPSY * Endoscopic (no “cutting”) * PERCUTANEOUS NEPHROLITHOTOMY * Small hole in your back * URETEOSCOPY, LASER LITHOTRIPSY PERCUTANEOUS NEPHROLITHOTOMY * MOST stones pass (especially if <7mm) without surgery * ONLY uric acid stones can be dissolved * Stones can cause kidney failure, if causing a blockage * Stones are possible even if you have NO PAIN * Kidney stones are COMPLETELY different than gallstones * Catch your stone, so we can analyze and give recommendations * * Calcium Oxalate Stone types Calcium Phosphate (60-70%) Uric Acid (10-15%) Struvite (10-15%)