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CURRICULUM VITAE I. BIOGRAPHICAL DATA Name: Robert Anderson Citizenship: Canada Address: Department of Microbiology & Immunology Dalhousie University Tupper Medical Building Halifax, Nova Scotia B3H 1X5, Canada Tel: (902) 494-1063 Fax: (902)-494-5125 E-mail: [email protected] Present Rank: Professor Department of Microbiology and Immunology Faculty of Medicine Dalhousie University II. ACADEMIC RECORD (i) B.Sc. with Honours (Biochemistry) 1970 McGill University Montreal, Canada (ii) Dr.rer.nat. (Physiological Chemistry) 1973 University of Cologne Cologne, West Germany Post-doctoral Experience (i) 1973 - 1974 Institute for Physiological Chemistry University of Cologne (ii) 1974 - 1976 Department of Biochemistry University of Ottawa III. AWARDS AND DISTINCTIONS 1970 Commonwealth Scholarship (declined) 1970 - 1973 Deutscher Akademischer Austauschdienst Scholarship 1984 - 1993 Alberta Heritage Foundation for Medical Research Scholarship 1993 - 2003 Dalhousie Medical Research Foundation Associateship 2007 National Science Council of Taiwan Visiting Professorship IV. ACADEMIC APPOINTMENTS 1976 - 1982 Assistant Professor Department of Microbiology and Immunology, U. Western Ontario 1982 - 1984 Associate Professor (with tenure) Department of Microbiology and Immunology, U. Western Ontario 1984 - 1989 Associate Professor/AHFMR Scholar Department of Microbiology and Infectious Diseases, U. Calgary 1989 - 1993 Professor/AHFMR Scholar Department of Microbiology and Infectious Diseases, U. Calgary 1993 - pres Professor (DMRF Associate 1993-2003) Department of Microbiology & Immunology, Dalhousie Univ. 2007 - 2008 Visiting Professor, Department of Microbiology & Immunology, National Cheng Kung University, Tainan, Taiwan V. EDUCATIONAL ACTIVITIES a) Teaching (i) Undergraduate Courses 1978 - 1984 Microbiology and Immunology 480, Supervision of Research and Project Course for Honours students in Microbiology and Immunology, Univ. of Western Ontario 1978 - 1984 Microbiology and Immunology 462b, Supervision of an Advanced Virology Course (Fourth Year Honours), University of Western Ontario 1985 - 1993 Biology 521 (2 - 4 lectures), University of Calgary 1986 - 1993 Medicine 440, Infectious Disease Elective (2 -3 lectures), University of Calgary 1989 - 1993 Medicine 302 (2 lectures), University of Calgary 1989 - 1993 Medical Microbiology (2 lectures), University of Calgary 1990 - 1993 Preceptor for Medicine 340/440, University of Calgary 1993 - 1994 Tutor, COPS Program, Dalhousie University 1993 - 2000 Medical PIM Unit lectures, Dalhousie University 1993 - pres Microbiology 3114 lectures, Dalhousie University 1993 - pres Microbiology 4114 lectures, Dalhousie University 2000 – pres Microbiobiology 4116 2 lectures alt yrs. Dalhousie U 2004 - 2006 Tropical Diseases BM671 lectures, Thammasat University (ii) Graduate Courses 1976 - 1984 Microbiology and Immunology 563a, Supervision of Current Topics in Virology Course, University of Western Ontario (10 lectures) 1984 - 1993 1986 - 1993 1993 - pres b) VI. Medical Microbiology MDSC 612 lectures, University of Calgary Advanced Virology MDSC 613.04 10 lectures, University of Calgary Microbiology 5114 Advanced Virology lectures and cosupervision, Dalhousie University Graduate student Supervisory Experience 1978 - pres Supervision of fourteen graduate students and twenty-plus honours/ summer students ADMINISTRATIVE RESPONSIBILITIES (i) Departmental 1979 - 1982 Chair, External Seminars Committee Department of Microbiology and Immunology University of Western Ontario 1979 - 1984 Chair, Undergraduate Curriculum Committee Department of Microbiology and Immunology University of Western Ontario 1985 - 1988 Chair, Search Committee for Program in Molecular Biology of Infectious Diseases Department of Microbiology and Infectious Diseases University of Calgary 1989 - 1992 Chair, Adjunct Appointments Committee Department of Microbiology and Infectious Diseases University of Calgary 1989 - 1993 Member, Executive Committee Department of Microbiology and Infectious Diseases University of Calgary 1990 - 1991 Chair, Physicians Evaluation Committee Department of Microbiology and Infectious Diseases University of Calgary 1992 - 1993 Chair, Graduate Education Committee Department of Microbiology and Infectious Diseases University of Calgary 1994 - 1999 Chair, Graduate Studies Committee Department of Microbiology and Immunology Dalhousie University 1994 - 2000 Member, Planning Committee Department of Microbiology and Immunology Dalhousie University 2002 Member, Promotion & Tenure Committee Department of Microbiology and Immunology Dalhousie University (ii) VII. Faculty/University 1986 - 1988 Faculty of Medicine Representative for Faculty of Science Council, University of Calgary 1987 - 1990 Member, Biosafety Committee University of Calgary 1989 - 1990 Member, AHFMR Awards Committee University of Calgary 1997 - 2000 Faculty of Medicine Representative on IWK-Grace Scientific Review Committee, Dalhousie University 1999 - 2000 Member, Physiology and Biophysics Departmental Survey Committee 2002 - pres Member, Biochemistry and Molecular Biology Departmental Survey/Search Committee 2003 - pres Member, International Medical Directors Group, Dalhousie University (2003) PROFESSIONAL ACTIVITIES (i) Membership in Professional and Learned Societies Member of American Society for Virology (ii) Professional Service a) Grant Panels 2003-2006 Member CIHR Virology and viral pathogenesis grants panel 2000Member US Military Infectious Disease Grants Panel of the American Institute for Biological Sciences 1999 Invited member, MRC Grants Committee for Virology and Viral Pathogenesis. 1986 - 1990 Member, MRC Grants Committee for Microbiology and Infectious Diseases 1987 - 1990 Member, AHFMR Fellowship Committee b) Grant Review (Agencies) CIHR, MRC, NSERC, NHRDP and Alberta Agricultural Research Institute VIII. INTERNATIONAL ACTIVITIES 1990 & 2001 Sabbaticals at the US Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand 2003 negotiation of Memorandum of Understanding between Dalhousie and Thammasat Universities for cooperation in teaching and research; development of 10 lectures in Tropical Diseases and presentation at Thammasat University; establishment of collaborative research program. 2004 Sabbatical at Thammasat University, Bangkok, Thailand; research, 2004 IX. teaching and medical student exchange awarded CIHR-funded Global Health Research grant for vaccine research for respiratory viruses including SARS (Principal applicant: R. Anderson, Dalhousie; co-applicants: W. Chaicumpa, Thammasat University, K. Lin and C.H. Chang, Kaohsiung University, Taiwan). This grant establishes a network of three universities (Dalhousie, Thammasat and Kaohsiung) for the purpose of vaccine development against respiratory viruses. RESEARCH SUPPORT (held) 1977 - 1978 MRC Grant ($15,000/yr) - "Host Cell Functions Involved in Persistent Measles Virus Infections" 1979 - 1981 MRC Grant ($36,542/yr) - "Cell Membrane Involvement in Persistent and Productive Virus Infections" 1982 - 1984 MRC Grant ($51,568/yr) - "Cell Control of Synthesis and Assembly of Membrane Macromolecules" 1984 - 1986 MRC Grant ($56,000/yr) - "Cell Control of Macromolecular Synthesis and Assembly: Relationship to Viral Permissiveness" 1986 - 1989 MRC Grant ($57,000/yr) - "Viral Cell-killing Functions" 1987 - 1987 AHFMR Technology Transfer Grant ($25,000/yr) - "Lipid Product Development for Skin-Care" 1988 - 1989 AHFMR Technology Transfer Grant ($71,000/yr) - "Lipid Product Development for Skin-Care" 1989 - 1992 MRC Grant ($69,000/yr) - "Host Control of Viral Cell-killing Functions" 1990 - 1993 NSERC ($20,000/yr) - "Membrane Lipid Structure and Function in Deinococcus radiodurans" 1992 - 1995 MRC Grant ($71,000/yr) - "Membrane and RNA targets of cytopathic viral proteins" 1995 - 1996 IWK-Grace ($15,000/yr) - "Role of the alveolar macrophage in RSV infection of BALB/c mice" (co-applicant with A. Stadnyk) 1993 - 1997 NSERC ($20,000/yr) - "Radiation resistance functions in Deinococcus radiodurans" 1997 - 1999 MRC ($61,000/yr) "Immunopathology of RSV infection" (coapplicants: A. Issekutz, G. Johnston, A. Stadnyk) 1998 - 2002 NSERC ($27,000/yr) "Monocyte, cytokine and endothelial cell activation by dengue virus" 1999 - 2002 MRC ($61,000/yr) "Immunopathology of RSV infection" (coapplicants: A. Issekutz, A. Stadnyk) 2001-2003 CIHR ($86,000/yr) “Pathogenesis of dengue virus” 2002-2007 CIHR ($400,000/yr) co-applicant "Mucosal vaccines" (PI: Lorne Babiuk) 2004-2005 CIHR ($90,000/yr) "A collaborative proposal to produce effective vaccines against respiratory viruses, including SARS" 2004-2008 CFI ($2,176,726 total) "Establishment of the Canadian Centre for 2003-2005 2005- 2005- X. Vaccinology (Halifax) with laboratories for basic, translational and multidisciplinary research and facilities for human challenge studies" (PI: Scott Halperin) ID Biomedical Corp Contract ($150,000) "Evaluation of IDB Proteosome adjuvant/delivery systems formulated with recombinant Trx-RSV G proteins as vaccine candidates" Gates Foundation Grand Challenges in Global Health ($5.6M for 5 years) “Linking innate and specific immunity to develop single dose vaccines for neonates.” (PI: Lorne Babiuk) CIHR ($147,000/yr) "Viral triggers of inflammation and vascular perturbation" PUBLICATIONS (Peer Reviewed Manuscripts) 1. Stoffel, W., Anderson, R. and Stahl, J. (1975) Studies on the asymmetric arrangement of membrane-lipid-enveloped virions as a model system. Hoppe-Seyler's Z. Physiol. Chem. 356, 1123-1129. 2. Anderson, R., Livermore, B.P., Volcani, B.E. and Kates, M. (1975) A novel sulfonolipid in diatoms. Biochim. Biophys. Acta 409, 259-263. 3. Anderson, R., Kates, M. and Volcani, B.E. (1976) Sulfonium analogue of lecithin in diatoms. Nature 263, 51-53. 4. Anderson, R., Kates, M., Baedecker, M.J., Kaplan, I.R. and Ackman, R.G. (1977) The stereoisomeric composition of phytanyl chains in lipids of Dead Sea sediments. Geochim. Cosmochim. Acta 41, 1381-1390. 5. Lucas, A., Flintoff, W., Anderson, R., Percy, D., Coulter, M. and Dales, S. (1977) In vivo and in vitro models of demyelinating diseases: tropism of the JHM strain of murine hepatitis virus for cells of glial origin. Cell 12, 553-560. 6. Anderson, R., Livermore, B.P., Kates, M. and Volcani, B.E. (1978) The lipid composition of the non-photosynthetic diatom, Nitzschia alba. Biochim. Biophys. Acta 528, 77-88. 7. Anderson, R., Kates, M. and Volcani, B.E. (1978) Identification of the sulfolipids in the non-photosynthetic diatom, Nitzschia alba. Biochim. Biophys. Acta 528, 89-106. 8. Lucas, A., Coulter, M., Anderson, R., Dales, S. and Flintoff, W. (1978) In vivo and in vitro models of demyelinating diseases: II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses. Virology 88, 325-337. 9. Anderson, R. and Dales, S. (1978) Biogenesis of poxviruses: glycolipid metabolism in vaccinia-infected cells. Virology 84, 108-117. 10. Kates, M., Tremblay, P., Anderson, R. and Volcani, B.E. (1978) Identification of the free and conjugated sterol in a non-photosynthetic diatom, Nitzschia alba, as 24-methylene cholesterol. Lipids 13, 34-41. 11. Anderson, R., Kates, M. and Volcani, B.E. (1979) Studies on the biosynthesis of sulfolipids in the diatom, Nitzschia alba. Biochim. Biophys. Acta 573, 557-561. 12. Anderson, R. (1979) Regulation of glycolipid biosynthesis: effects of virus infection and drug-induced translational inhibition on glycolipid metobolism. Biochemistry 18, 2395-2400. 13. Anderson, R., Cheley, S. and Haworth-Hatherell, E. (1979) Comparison of the polypeptides of two strains of murine hepatitis virus. Virology 97, 492-494. 14. Thompson, B.G., Anderson, R. and Murray, R.G.E. (1980) Unusual polar lipids of Micrococcus radiodurans strain Sark. Can. J. Microbiology 26, 1408-1411. 15. Anderson, R. and Bilan, P. (1981) Replacement of mouse LM fibroblast choline by a sulfonium analog. Effects on membrane properties as determined by virus probes. Biochim. Biophys. Acta 640, 91-99. 16. Cheley, S. and Anderson, R. (1981) Cellular synthesis and modification of murine hepatitis virus polypeptides. J. Gen. Virol. 54, 301-311. 17. Cheley, S., Anderson, R., Cupples, M.J., Lee Chan, E.C.M. and Morris, V.L. (1981) Intracellular murine hepatitis virus-specific RNAs contain common sequences. Virology 112, 596-604. 18. Cheley, S., Morris, V.L., Cupples, M.J. and Anderson, R. (1981) RNA and polypeptide homology among murine coronaviruses. Virology 115, 310-321. 19. Auer, R.N., Del Maestro, R.F. and Anderson, R. (1981) A simple and reproducible experimental in vivo glioma model. Can. J. Neurol. Sci. 8, 325-331. 20. McGarry, R.C., Anderson, R. and Singhal, S.K. (1982) Regulation of humoral immune responses by a bone-marrow-derived glycolipid-like molecule. Cell. Immunol. 71, 293-302. 21. Mizzen, L., Cheley, S., Rao, M., Wolf, R. and Anderson, R. (1983) Fusion resistance and decreased infectability as major determinants of coronavirus persistence. Virology 128, 407-417. 22. Anderson, R. (1983) Alkylamines: novel lipid constituents in Deinococcus radiodurans. Biochim. Biophys. Acta 753, 266-268. 23. Siddell, S.G., Anderson, R., Cavanagh, D., Fujiwara, K., Klenk, H.D., Laporte, J., MacNaughton, M.R., Pensaert, M.A., Stohlman, S.A., Sturman, L. and van der Zeijst, B.A.M. (1983) Coronaviridae. Intervirology 20, 181-189. 24. Cheley, S. and Anderson, R. (1984) A reproducible method for the detection of specific RNA sequences by dot-blot hybridization. Anal. Biochem. 137, 15-19. 25. Vreeland, R.H., Anderson, R. and Murray, R.G.E. (1984) Cell wall and phospholipid composition and their contribution to the salt tolerance of Halomonas elongata. J. Bacteriol. 160, 879-883. 26. Sorensen, O., Beushausen, S., Puchalski, S., Cheley, S., Anderson, R., Coulter-Mackie, M. and Dales, S. (1984) In vivo and in vitro models of demyelinating diseases. VIII. Genetic, immunologic and cellular influences on JHM virus infection of rats. Adv. Exp. Med. Biol. 173, 279-297. 27. Mizzen, L., Hilton, A., Cheley, S. and Anderson, R. (1985) Attenuation of murine coronavirus infection by ammonium chloride. Virology 142, 378-388. 28. Anderson, R. and Hansen, K. (1985) Structure of a novel phosphoglycolipid from Deinococcus radiodurans. J. Biol. Chem. 260, 12219-12223. 29. Hilton, A., Mizzen, L., Macintyre, G., Cheley, S. and Anderson, R. (1986) Translational control in murine hepatitis virus infection. J. Gen. Virol. 67, 923-932. 30. Anderson, R. and Bhatti, A.R. (1986) Fatty acid distribution in the phospholipids of Francisella tularensis. Lipids 21, 669-671. 31. Anderson, R., Daya, M. and Reeve, J. (1987) An evaluation of the contribution of membrane lipids to protection against ultraviolet radiation. Biochim. Biophys. Acta 905, 227-230. 32. Lin, W.S., Wong, F. and Anderson, R. (1987) Role of superoxide in radiation-killing of Escherichia coli and in thymine release from thymidine. Biochem. Biophys. Res. Commun. 147, 778-786. 33. Mizzen, L., Macintyre, G., Wong, F. and Anderson, R. (1987) Translational regulation in mouse hepatitis virus infection is not mediated by altered intracellular ion concentrations. J. Gen. Virol. 68, 2143-2151. 34. Mizzen, L., Daya, M. and Anderson, R. (1987) The role of protease-dependent membrane fusion in persistent and lytic infections of murine hepatitis virus. Adv. Exp. Med. Biol. 218, 175-186. 35. Daya, M., Cervin, M. and Anderson, R. (1988) Cholesterol enhances mouse hepatitis virus-mediated cell fusion. Virology 163, 276-283. 36. Kooi, C., Mizzen, L., Alderson, C., Daya, M. and Anderson, R. (1988) Early events of importance in determining host cell permissiveness to mouse hepatitis virus infection. J. Gen. Virol., 69, 1125-1135. 37. Macintyre, G. and Anderson, R. (1989) A model for persistent murine coronavirus infection involving maintenance via cytopathically infected cell centres. J. Gen. Virol., 70, 763-768. 38. Daya, M., Wong, F., Cervin, M., Evans, G., Vennema, H., Spaan, W. and Anderson, R. (1989) Mutation of host cell determinants which discriminate between lytic and persistent mouse hepatitis virus infection results in a fusion-resistant phenotype. J. Gen. Virol. 70, 3335-3346. 39. Huang, Y. and Anderson, R. (1989) Structure of a novel glucosamine- containing phosphoglycolipid from Deinococcus radiodurans. J. Biol. Chem. 264, 18667-18672. 40. Anderson, R. (1989) Molecular considerations for the laboratory diagnosis of Japanese Encephalitis Virus. S.E. Asian J. Trop. Med. Pub. Hlth. 20, 605-610. 41. Reeve, J., Kligman, L.H. and Anderson, R. (1990) Are natural lipids UVscreening agents? Appl. Microbiol. Biotechnol. 33, 161-166. 42. Daya, M., Wong, F., Cervin, M., Evans, G., Vennema, H., Spaan, W. and Anderson, R. (1990) Mouse fibroblast mutants selected for survival against mouse hepatitis virus infection show increased resistance to infection and virus-induced cell fusion. Adv. Exp. Med. Biol. 276:59-66. 43. Macintyre, G., Kooi, C., Wong, F. and Anderson, R. (1990) On the membrane cytopathology of mouse hepatitis virus infection as probed by a semi-permeable translation inhibiting drug. Adv. Exp. Med. Biol. 276:67-72. 44. Kooi, C., Cervin, M. and Anderson, R. (1991) Differentiation of acid pHdependent and -nondependent entry pathways for mouse hepatitis virus. Virology 180, 108-119. 45. Huang, Y. and Anderson, R. (1991) Phosphatidylglyceroylalkylamine: A novel phosphoglycolipid precursor in Deinococcus radiodurans. J. Bacteriol. 173, 457-462. 46. Macintyre, G., Curry, B., Wong, F. and Anderson, R. (1991) Hygromycin B therapy of a murine coronaviral hepatitis. Antimicrob. Agents Chemother. 35:2125-2127. 47. Cervin, M. and Anderson, R. (1991) Modulation of coronavirus-mediated cell fusion by homeostatic control of cholesterol and fatty acid metabolism. J. Med. Virol 35:142-149. 48. Macintyre, G., Woods, D.E. and Anderson, R. (1991) Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob. Agents Chemother. 35:2630-2633. 49. Anderson, R., King, A.D. and Innis, B. (1992) Correlation of E protein binding with cell susceptibility to dengue 4 virus infection. J. Gen. Virol. 73, 2155-2159. 50. Anderson, R. and Huang, Y. (1992) Fatty acids are precursors of alkylamines in Deinococcus radiodurans. J. Bacteriol. 174:7168-7173. 51. Daniel, C., Anderson, R., Buchmeier, M.J., Fleming, J.O., Spaan, W.J.M., Wege, H. and Talbot, P.J. (1993) Identification of an immunodominant linear neutralization domain on the S2 portion of the murine coronavirus spike glycoprotein and evidence that it forms part of a complex tridimensional structure involving both S1 and S2. J. Virol. 67:1185-1194. 52. Anderson, R. and Wong, F. (1993) Membrane and phospholipid binding by murine coronaviral nucleocapsid N protein. Virology 194, 224-232. 53. Wong, F. and Anderson, R. (1993) Involvement of lipids in membrane binding of MHV nucleocapsid protein. Adv. Exp. Med. Biol. 342, 203-208. 54. Osiowy, C., Horne, D. and Anderson, R. (1994) Antibody dependent enhancement of Respiratory Syncytial Virus infection by sera from young infants. Clin. Diag. Lab. Immunol. 1, 670-677 55. He, R.T., Innis, B.L., Nisalak, A., Usawattanakul, W., Kalayanarooj, S., Wang, S. and Anderson, R. (1995) Antibodies which block virus attachment to Vero cells are a major component of the human neutralizing antibody response against dengue virus-2. J. Med. Virol. 45, 451-461. 56. Osiowy, C. and Anderson, R. (1995) Neutralization of respiratory syncytial virus after cell attachment. J. Virol. 69, 1271-1274. 57. Huang, Y. and Anderson, R. (1995) Glucosyldiglyceride structures in Deinococcus radiodurans J. Bacteriol. 177, 2567-2571. 58. Wang, S., He, R.T., Patarapotikul, J., Innis, B.L. and Anderson, R. (1995) Antibody-enhanced binding of dengue virus to human platelets Virology 213, 254-257. 59. Tantivanich, S., Suphanaranonda, K., Balachandra, K. and Anderson, R. (1995) Detection of respiratory syncytial virus from clinical specimens: comparison between reverse transcription polymerase chain reaction and tissue culture. S.E. Asian J. Trop. Med. Publ. Hlth. 26, 684-688. 60. Stadnyk, A., Gillan, T. and Anderson, R. (1997) Respiratory syncytial virus triggers IL-6 in BALB/c mouse alveolar macrophages in the absence of virus replication. Cell. Immunol. 176, 122-126. 61. Anderson, R., Wang, S., Osiowy, C. and Issekutz, A.C. (1997) Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. J. Virol. 71, 4226-4232. 62. Wang, S., He, R. and Anderson, R. (1999) PrM- and cell-binding domains of the dengue viral E protein. J. Virol. 73, 2547-2551 63. Mader, D., Huang, Y., Wang, C., Fraser, R., Issekutz, A., Stadnyk, A. and Anderson, R. (2000) Liposome encapsulation of a soluble recombinant fragment of the respiratory syncytial (RSV) G protein enhances immune protection and reduces pulmonary eosinophilia associated with virus challenge. Vaccine 18, 1110-1117. 64. King, C., Marshall, J.S., Alshurafa, H. and Anderson, R. (2000) Release of vasoactive cytokines by antibody enhanced dengue virus infection of a human mast cell/basophil line. J. Virol. 74, 7146-7150. 65. King, C., Anderson, R. and Marshall, J.S. (2002) Dengue virus selectively induces human mast cell chemokine production. J. Virol. 76, 8408-8419. 66. Chang, C.-H., Huang, Y., Issekutz, A,C., Griffith, M., Lin, K.H. and Anderson, R. (2002) IL-1 released from epithelial cells after adenovirus type 37 infection activates ICAM-1 expression on human vascular endothelial cells. J. Virol. 76, 427-431. 67. Huang, Y. and Anderson, R. (2002) Enhanced immune protection of a liposomeencapsulated recombinant respiratory syncytial virus (RSV) vaccine using immunogenic lipids from Deinococcus radiodurans. Vaccine 20, 1586-1592. 68. Huang, Y. and Anderson (2003) A single amino acid substitution in a recombinant G protein vaccine drastically impairs protective immunity against respiratory syncytial virus (RSV). Vaccine 21, 2500-2505. 69. Chang, C.-H., Huang, Y. and Anderson, R. (2003) Activation of vascular endothelial cells by IL-1 released by epithelial cells infected with respiratory syncytial virus. Cell. Immunol. 221, 37-41. 70. Anderson, R. (2003) Manipulation of cell surface molecules by flaviviruses. Adv. Virus. Res. 59, 229-274. 71. Chang, C.-H., Lin, K.-H. and Anderson, R. (2004) Towards an in vitro model for acute hemorrhagic conjunctivitis: cytokine-mediated vascular endothelial cell activation triggered by enterovirus type 70 infection. J. Clin. Virol. 30, 19-23. 72. Hirsch, P., Gallikowski, C.A., Siebert, J., Peissl, K., Kroppenstedt, R., Schumann, P., Stackebrandt, E. and Anderson, R. (2004) Deinococcus frigens sp. nov., Deinococcus saxicola sp. nov., and Deinococcus marmoris sp. nov., low temperature and droughttolerating, UV-resistant bacteria from continental antarctica. System. Appl. Microbiol. 27, 636-645. 73. Huang, Y. and Anderson, R. (2005) Modulation of protective immunity, eosinophilia and cytokine responses by selective mutagenesis of a recombinant G protein vaccine against Respiratory Syncytial Virus (RSV). J. Virol. 79, 4527-4532. 74. Benoit, A., Huang, Y., Proctor, J., Rowden, G. and Anderson, R. (2006) Effects of alveolar macrophage depletion on liposomal vaccine protection against respiratory syncytial virus (RSV). Clin. Exp. Immunol. 145, 147-154. 75. Knight, J.B., Huang, Y.Y., Halperin, S.A., Anderson, R., Morris, A., MacMillan, A., Jones, T., Burt, D.S., Van Nest, G. and Lee, S.F. (2006) Immunogenicity and protective efficacy of a recombinant filamentous hemagglutinin from Bordetella pertussis. Clin. Exp. Immunol. 144, 543-551. 76. Brown, M.G., King, C.A., Sherren, C., Marshall, J.S. and Anderson, R. (2006) A dominant role for FcRII in antibody-enhanced dengue virus infection of human mast cells and associated CCL5 release. J. Leuk. Biol. 80, 1242-1250. 77. Chan, S.Y.V., Hilchie, A.L., Brown, M.G., Anderson, R. and Hoskin, D.W. (2007) Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species. Exp. Mol. Pathol. 82, 1-11 78. Benoit, A.C., Huang, Y., Maneewatchararangsri, S., Tapchaisri, P. and Anderson, R. (2007) Regulation of airway eosinophil and neutrophil infiltration by galactosylceramide in a mouse model for respiratory syncytial virus (RSV) vaccineaugmented disease. Vaccine 25, 7754-7762. 79. Lin, C.-F., Lei, H.-Y, Lin, Y.-S., Liu, C.-C. and Anderson, R.. Patient and Mouse Antibodies against Dengue Virus Nonstructural Protein 1 Cross-React with Platelets and Cause Their Dysfunction or Depletion. American Journal of Infectious Diseases 4: 68-74, 2008 Abstracts (International Meetings) 1. Kates, M., Anderson, R. and Volcani, B., E. Novel sulfolipids in diatoms. IUPAC Meeting, August 1976, Dunedin, New Zealand. 2. Kates, M., Tremblay, P., Anderson, R. and Volcani, B.E. Identification of the free and bound sterol of a non-photosynthetic diatom, Nitzschia alba. Meeting of the American Oil Chemists' Society. May 1977, New York. 3. Cheley, S. and Anderson, R. Polypeptide homology between tropism-contrasting strains of murine hepatitis virus. ICN-UCLA Symposium. March 1978, Keystone, Colorado, U.S.A. (J. Supramol. Struct. Suppl 4, Abstract 766). 4. Cheley, S., Anderson, R. and Morris, V.L. Intracellular murine hepatitis virus-specific RNAs contain common sequences. 5th International Congress of Virology. August 1981, Strasbourg, France. 5. Anderson, R., Cheley, S. and Morris, V.L. Interrelatedness of murine coronaviruses. American Society for Microbiology Meeting. March 1982, Atlanta, Georgia, U.S.A. 6. Mizzen, L., Cheley, S., Rao, M., Wolf, R., Hilton, A. and Anderson, R. Host cell-mediated persistence of murine coronavirus. American Society for Virology Meeting, July 1983, East Lansing, Michigan, U.S.A. 7. Sorensen, O., Coulter-Mackie, M.B., Cheley, S., Anderson, R. and Dales, S. An in vivo model for demyelinating disease. Coronavirus infection of rats. American Society for Virology Meeting, July 1983, East Lansing, Michigan, U.S.A. 8. Coulter-Mackie, M.B., Sorensen, O., Cheley, S., Anderson, R. and Dales, S. In vitro model for demyelinating diseases: persistent infection of rat Schwannoma cells by coronaviruses or measles virus. American Society for Virology Meeting, July 1983, Ea st Lansing, Michigan, U.S.A. 9. Del Maestro, R.F., McDonald, W. and Anderson, R. Superoxide dismutases, catalase and glutathione peroxidase in experimental and human brain tumors. 3rd International Conference on superoxide and superoxide dismutase, 1983. 10. Mizzen, L. and Anderson, R. Role of the plasma membrane in determining host permissiveness to mouse hepatitis virus infection. 13th International Congress of Biochemistry, Amsterdam, August 1985. 11. Anderson, R. and Hansen, K. Structure of a novel phosphoglycolipid from Deinococcus radiodurans. 13th International Congress of Biochemistry, Amsterdam, August 1985. 12. Macintyre, G., Hilton, A., Mizzen, L. and Anderson, R. Inhibition of host protein synthesis in mouse hepatitis virus infection. 3rd International Coronavirus Symposium, Asilomar, California, September 1986. 13. Mizzen, L., Daya, M. and Anderson, R. The role of protease-dependent membrane fusion in determining the severity of mouse hepatitis virus infection. 3rd International Coronavirus Symposium, Asilomar, California, September 1986. 14. Anderson, R., Mizzen, L., Macintyre, G. Wong, F. Translational control in mouse hepatitis virus infection - evidence against a role for altered sodium ion concentrations. 4th Federation of Asian and Oceanic Biochemists Congress, Singapore, December 1986. 15. Kooi, C., Alderson, C., Daya, M. and Anderson, R. Uptake of mouse hepatitis virus by cells of varying permissiveness. Annual Meeting of the American Society for Virology, Chapel Hill, North Carolina, May 1987. 16. Daya, M., Cervin, M. and Anderson, R. Cholesterol-modulated expression of mouse hepatitis virus-induced cell fusion. Conference on Regulation of Viral Gene Expression, Washington, D.C., November 1987. 17. Kooi, C., Daya, M., Alderson, C. and Anderson, R. Cellular permissiveness to murine hepatitis virus infection. 7th International Congress of Virology, Edmonton, Alberta, August 1987. 18. Macintyre, G., Mizzen, L., Wong, F. and Anderson, R. The effect of altered sodium ion concentrations on translational regulation during mouse hepatitis virus infection. 7th International Congress of Virology, Edmonton, Alberta, August 1987. 19. Daya, M., Padda, J., Kooi, C. and Anderson, R. Inhibition of mouse hepatitis virus infection by cyclosporine A. 1st Asia-Pacific Congress of Medical Virology, Singapore, November 1988. 20. Anderson, R. Molecular considerations for the laboratory diagnosis of Japanese Encephalitis virus. SEAMEO-TROPMED Technical Meeting, Bangkok, Thailand, June, 1989. 21. Anderson, R., Kooi, C. and Cervin, M. A cell surface fusion-dependent mechanism for mouse hepatitis virus entry. American Society for Virology 8th Annual Meeting, London, Ontario, July, 9-13, 1989. 22. Anderson, R., Wong, F., Cervin, M., Daya, M. and Evans, G. Mouse fibroblast mutants selected for survival against mouse hepatitis virus infection show increased resistance to infection and virus-induced cell fusion. 4th International Symposium on Co ronaviruses, Cambridge, England, July 16-21, 1989. 23. Macintyre, G., Kooi, C., Wong, F. and Anderson, R. Virus-cell membrane interactions in an in vitro model for MHV persistence. 4th International Symposium on Coronaviruses, Cambridge, England, July 16-21, 1989. 24. Huang, Y. and Anderson, R. Structural aspects of novel phosphoglycolipids from Deinococcus radiodurans. International Glycobiology Symposium, Bethesda, Maryland, U.S.A., April 29 - May 1, 1990. 25. Macintyre, G., Wong, F., Curry, B. and Anderson, R. Inhibition of mouse hepatitis virus infection by hygromycin B. 8th International Congress of Virology, Berlin, West Germany, August 26-31, 1990. 26. Daniel, C., Anderson, R., Buchmeier, M.J., Fleming, J.O., Spaan, W.J.M., Wege, H. and Talbot, P.J. Identification of an immunodominant neutralization domain on the murine coronavirus spike glycoprotein. ASV Meeting, Fort Collins, Colorado, U.S.A., July 7-11, 1991. 27. Anderson, R. and Wong, F. Involvement of lipids in membrane binding of MHV nucleocapsid protein. 5th Coronavirus Symposium, Chantilly, France, September 13-18, 1992. 28. Osiowy, C., Horne, D. and Anderson, R. Enhancing antibodies in young infants infected with Respiratory Syncytial Virus. 12th Annual Meeting of the American Society for Virology, Davis, California, July 10-14, 1993 29. Anderson, R., Wang, S., Osiowy, C. and Issekutz, A. Dengue virus infection of blood monocytes triggers activation of endothelial cells. 16th Annual Meeting of the American Society for Virology, Bozeman, Montana, July 19-23, 1997 30. King, C.A., Marshall, J., Alshurafa, H. and Anderson, R. Dengue 2 virus infection of human basophils/mast cells. 18th Annual Meeting of the American Society for Virology, Amherst, Massachusetts, July 10-14, 1999. 31. Mader, D., Wang, C., Huang, Y., Fraser, R., Stadnyk, A.W., Issekutz, A.C. and Anderson, R. Protection against RSV infection with an intranasal, liposome-encapsulated vaccine. 18th Annual Meeting of the American Society for Virology, Amherst, Massachusetts, July 10-14, 1999. 32. King, C.A., Marshall, J.S. and Anderson, R. Selective production of RANTES and IL-1 in dengue virus infected human basophils/mast cells. 19th Annual Meeting of the American Society for Virology, Fort Collins, Colorado, July 8-12, 2000. 33. King, C.A., Anderson, R. and Marshall, J.S. Human mast cells produce RANTES, MIP-1 and MIP-1 in response to dengue virus infection. Experimental Biology 2001 Meeting, Orlando, Florida, March 31-April 4, 2001. 34. King, C.A., Sherren, C., Marshall, J.S., and Anderson, R. FcRII-dependent dengue virus infection of human mast cells selectively induces T cell chemoattractants. 50th annual meeting - American Society for Tropical Medicine and Hygiene, Atlanta, Georgia, Nov. 1115, 2001 35. Anderson, R., Chang, C., and Huang, Y. Vascular endothelial cell activation by respiratory syncytial virus (RSV) infection of pulmonary epithelium. 12th Meeting of the International Congress of Virology, Paris, France, July 27-Aug 1, 2002 36. Anderson, R. Identification of crucial amino acids in a recombinant G protein vaccine required for protective immunity against respiratory syncytial virus (RSV). Viral Vaccines 2003 Conference, Edinburgh, UK, July 14-16, 2003. 37. Huang, Y. and Anderson, R. Mutational analysis of a recombinant G protein vaccine for respiratory syncytial virus. Meeting of the American Society for Virology, Montreal, Canada July 7-11, 2004. 38. Brown, M., King, C., Sherren, C., Marshall, J. and R. Anderson, R. Requirement of FcRII in antibody-enhanced dengue virus infection of mast cells. Meeting of the American Society for Virology, Montreal, Canada July 7-11, 2004. 39. Benoit, A., Huang, Y. and Anderson, R. Liposome-based vaccine against respiratory syncytial virus (RSV): protective efficacy in BALB/c mice and differential reduction of inflammatory cells by lipid adjuvants. Meeting of the American Society for Virology, Montreal, Canada, July 7-11, 2004. 40. Brown, M.G., King, C.A., Huang, Y.Y., Marshall, J.S. and Anderson R. Antibody-dependent dengue virus-induced apoptosis of a human basophil/mast cell line. Meeting of the American Society for Virology, Pennsylvania State University, June 1822, 2005. 41. Burke, SM, Brown, MG, Zinn, S, Anderson, R, Issekutz, TB, Marshall, JS. (2006) Virus associated stimuli induce CXCR3 ligand production by human mast cells. Oral Presentation. American Association of Immunology Annual Conference (Boston, MA). XI. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. Graduated MSc and Ph.D. theses Stephen Cheley, PhD - 1984 "MHV replication - a molecular study" Lee Mizzen, PhD - 1986 "Host cell mediation of MHV persistence" Anne Hilton, MSc - 1986 "Translational control in MHV infection" Maleki Daya, PhD - 1989 "MHV Infections and the Host Cell Membrane" Marguerite Cervin, PhD - 1990 "MHV - Lipid Interaction" Cora Kooi, PhD - 1990 "Early Events of MHV Infection" Georgina Macintyre, PhD - 1990 "Translational Regulation by MHV Infection" Yan Huang, PhD - 1996 "Membrane lipids and recA of Deinococcus radiodurans" Carla Osiowy, PhD - 1996 "Cellular and antibody interactions with respiratory syncytial virus" Runtao He, PhD - 1997 "Characterization of dengue virus envelope protein" Cheng Wang, MSc - 1998 "Cloning and expression of a respiratory syncytial virus G protein fragment and investigation of its vaccine potential" David Mader, MSc – 2000 “Vacine potential of prokaryotically expressed fragments of the respiratory syncytial virus (RSV) F and G proteins” Christine King, PhD - 2002 "Antibody-enhanced dengue virus infection of mast cells" Anita Benoit, MSc - 2004 "Liposomal RSV vaccine: roles of lipid adjuvants and alveolar macrophages" Michael Brown, PhD (expected 2008) "Apoptosis in dengue virus pathogenesis" XII. CONTRIBUTIONS TO THE TRAINING OF HIGHLY QUALIFIED PERSONNEL (last 10 years) Student Level Period Present Position Yan Huang Ph.D. 1988 - 1995 Postdoctoral Fellow Dalhousie University Carla Osiowy Ph.D. 1991 - 1995 Scientist Health Canada Runtao He Ph.D. 1992 - 1997 Scientist Health Canada Cheng Wang MSc 1995 - 1998 Technician Dalhousie University David Mader MSc 1998-2000 Technician Dalhousie University Christine King PhD 1999-2002 Postdoc Cambridge University Anita Benoit MSc 2001-2004 PhD student, University of Ottawa Chenghsien Chang Postdoc 2000-2002 Associate Prof Kaohsiung Medical University, Taiwan