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1 To: Medical students interested in research From: Sally Ozonoff, Ph.D., Vice Chair for Research in Psychiatry Re: Research opportunities in the Department of Psychiatry & Behavioral Science We are pleased that you are exploring the field of Psychiatry. One of the best ways to learn about this field is to get involved in research. In our department, we have a wide variety of research projects that students can join, including basic neuroscience, neuroimaging, psychopharmacology, and clinical studies of patients with autism, schizophrenia, mood disorders, and other forms of psychopathology. Participation in projects will provide training in many aspects of research conduct, including literature review, data collection, psychiatric interviews and assessments, data analysis, and publication. The goal is to help medical students develop a theoretical and practical understanding of research questions, design, methodology, data collection and analysis. The ultimate goals of our program are to help physicians in training learn to use research to inform clinical care and to attract more future physicians into exciting research careers. The projects in our department that you can get involved with are of two types: 1. Short Projects: These can be completed in a relatively short time frame, such as during the 6-week summer break, over a 2-3 month period during school, or during a rotation. The type of projects that might be appropriate include, but are not limited to, case studies, literature reviews, or chart reviews asking specific, circumscribed questions. 2. Longer-term Projects: Students desiring more exposure to research can consider longer-term projects requiring 6 months to a year of time commitment. The student would likely take time off from school to work on the project. There is flexibility in when this can be done; some students choose to take off a year between the second and third years of medical school or to add a fifth year. Longerterm projects provide opportunities for hypothesis generation, data collection and interaction with participants, data analysis, and writing. Longer-term projects are more likely to result in co-authored publications. Both short and longer-term projects can be used to fulfill the Scholarly Project option for the Fourth Year Special Study Modules requirement. If the work of a faculty member listed below is of interest, you may contact them directly by email. We hope that you will choose to become involved in research in the Department of Psychiatry and find it an exciting part of your career development. Thank you for your interest. Please don't hesitate to contact me if you have questions or would like further information. Best wishes, Sally Ozonoff, Ph.D. Professor and Vice Chair for Research Department of Psychiatry and Behavioral Sciences [email protected] 916-703-0259 PSYCHIATRY FACULTY RESEARCH INTERESTS 1. David G. Amaral, Ph.D, [email protected] Dr. Amaral's multidisciplinary studies exmaine the neuroanatomical, behavioral and electrophysiological organization and functions of brain systems that are involved in learning, memory, emotion and social behavior carried out on the human brain and on animal models. He also conducts research on neurobiological correlates of autism. 2. Melissa Bauman, Ph.D., [email protected] 2 Dr. Bauman’s research interests focus on the neural systems that mediate species-typical social behavior. She utilizes animal models to study autism. Her current research examines how changes in the prenatal environment, in particular activation and/or abnormalities in the mother’s immune system, may alter the brain/behavior development of offspring. 3. Cameron S. Carter, M.D., [email protected] Director, UC Davis Imaging Research Center Dr. Carter's research focuses on the pathophysiology of disturbances in cognition in mental disorders such as schizophrenia and OCD, with the goal of developing more effective therapies which can improve patients' chances of rehabilitation. Dr. Carter is also involved in the development of new treatments for cognitive disability in schizophrenia and other brain disorders. A key element of the philosophy of his laboratory is that good clinical research can only proceed if it is being constantly informed by ongoing theoretical and methodological progress in basic cognitive neuroscience, and that the experiments of nature provided by clinical brain disorders may provide us with powerful additional insights into the neural basis of normal cognition. 4. Prabhakara V. Choudary, Ph.D., [email protected] Dr. Choudary's primary research interest is regulation of disease gene expression. His current research focuses on identifying genes showing abnormal patterns of expression in postmortem brains of neuropsychiatric patients. Genome-wide approaches including microarray, differential display, and single nucleotide polymorphism (SNP) genotyping technologies are some of the contemporary biomedical research tools used in this work. The goals of this effort are to advance our understanding of the molecular basis of psychiatric diseases and to discover biomarkers and/or novel drug-targets for one or more of the behavioral disorders under study, i.e., mood disorders and schizophrenia. 5. Irwin Feinberg M.D., [email protected] Dr. Feinberg conducts quantitative studies of the relation of sleep EEG to age over the human life span and the implications of these relations for the function of sleep and the nature of brain aging. 6. David Hessl, Ph.D., [email protected] Dr. Hessl has focused his research on genetic, brain, environmental and neuroendocrine factors affecting cognition and behavior in children and adults with fragile X syndrome. He also studies premutation carriers of fragile X who as children are at increased risk for attention deficit hyperactivity disorder and autism, and who as older adults are at risk for a neurodegenerative disease involving tremor, ataxia, and dementia. He conducts collaborative studies with researchers from several disciplines, including neuroscience, molecular genetics, and neuropathology in an effort to understand links between genetics, brain function and behavior. 7. Donald M. Hilty, M.D., [email protected] Dr. Hilty helped launch psychiatry telecommunication services through the UC Davis Telemedicine Program, allowing him to treat patients in remote areas. He is investigating the use of pharmacological agents to treat bipolar disorders and conducting studies to assess outcomes for patients with depression and measure patient/provider satisfaction with telemedicine services. 8. W. Ladson Hinton, M.D., [email protected] Dr. Hinton’s principal interests are culture and psychopathology in older adults, gender influences, ethnicity, access and quality of care, and qualitative methods. His current research includes a mixed method qualitative study examining barriers and facilitators of depression care for ethnically diverse older men in primary care settings and community based research to develop innovative culturally tailored interventions for Asian American and Latino family caregivers. He is also examining how the DSM cultural formulation can be adapted to improve cross-cultural psychiatric diagnosis in older adults 3 Richard J. Maddock, M.D., [email protected] Dr. Maddock conducts research on the pathophysiology and treatment of anxiety and mood disorders. He studies neurobiological models of panic disorder and depression using neuroimaging methods, particularly magnetic resonance spectroscopy (MRS) for measuring glutamate, GABA, lactate and other brain metabolites. Current studies include investigations of the effects of exercise on brain metabolism in healthy volunteers and in patients with anxiety and mood disorders. 9. 10. Barbara E. McDermott, Ph.D., [email protected] Dr. McDermott is a forensic psychologist prospectively evaluating patients using a variety of standardized assessments to evaluate factors associated with institutional aggression and outcome in the community. Her lab conducts violence risk assessments, diagnostic assessments, assessments of symptoms and readiness for release. The primary goal of this research is to evaluate whether, by employing structured assessments of mental illness, dangerousness and readiness for release, differences between patients who succeed versus patients who do not can be identified. 11. Michael Minzenberg, M.D., [email protected] Dr. Minzenberg studies the neurochemical systems in the brain that modulate cognitive function in healthy individuals, and which may be related to cognitive dysfunction in persons with schizophrenia. These systems may serve as targets for novel medications to treat this illness. In addition, Dr. Minzenberg is interested in the processing of social and emotional information and its basis in corticolimbic circuitry, and how dysfunction of this circuitry may relate to emotional and interpersonal disturbances in both schizophrenia and personality disorders. Tara Niendam, Ph.D., [email protected] Dr. Niendam is a clinical psychologist with research and clinical interests in adolescent populations who are at high risk for severe mental illness, specifically schizophrenia and bipolar disorder. She is interested in understanding how cognitive impairments associated with the onset of mental illness can negatively impact an adolescent’s ability to maintain friendships and succeed in school. Dr. Niendam uses cognitive neuroscience methods, including functional magnetic resonance imaging (fMRI), to understand the neurobiological bases for clinical symptoms and psychosocial functioning in at risk youth. 12. 13. Stephen Noctor, Ph.D., [email protected] Dr. Noctor studies development of cortical structures in the central nervous system. He investigates factors that control proliferation of the precursor cells that produce cortical neurons and glia, and how cortical cells migrate over long distances to reach their appropriate position in the developing brain. Sally Ozonoff, Ph.D., [email protected] Vice Chair for Research Dr. Ozonoff’s current research focuses on very young children with autism. She is studying the onset of autism in a prospective investigation that follows high-risk infants from birth through age 3. She is also studying autistic regression. Dr. Ozonoff’s clinical interests are in the diagnosis and assessment of autism spectrum disorders, with specializations in infant and adult diagnosis and Asperger syndrome. 14. 15. Dan Ragland, Ph.D., [email protected] Dr. Ragland’s work investigates the effect of schizophrenia on brain function during episodic memory encoding and retrieval. Of particular interest is the role that organizational abilities play in new learning and subsequent memory retrieval, how schizophrenia disrupts these organizational processes, and how these deficits might be remediated to improve patients’ frontotemporal brain activity and daily function. His research has used a combination of neuropsychological and functional 4 imaging techniques to identify the cognitive functions and brain regions underlying these memory processes. Dr. Ragland is also interested in developing cognitive interventions for individuals with schizophrenia in the early stages of illness. 16. Sally J. Rogers, Ph.D., [email protected] Dr. Rogers specializes in the study of treatments for very young children with autism. Dr. Rogers studies early social, cognitive, and emotional development, development of motor skills, communication, imitation, and language in children with severe disabilities, development of social relationships in people with disabilities, and treatment efficacy in autism. 17. Julie Schweitzer, Ph.D., [email protected] Dr. Schweitzer's interests include the identification and treatment of attention-deficit/ hyperactivity (ADHD) and related disorders in children and adults using behavioral, functional neuroimaging and ERP methods. In addition, her laboratory is currently conducting clinical trials research including assessing the effects of computerized cognitive training versus parent education on school and executive functioning in children with ADHD. Other projects include assessing the effect of prenatal exposure to cocaine on neural and behavioral functioning in adolescents. Dr. Schweitzer's goal is to apply translational research methods using a variety of basic behavioral and physiological techniques to develop novel treatment and preventative approaches to addressing attentional disorders. 18. Andreea L. Seritan, M.D., [email protected] Dr. Seritan is a geriatric psychiatrist with an interest in cognitive disorders, in particular dementias associated with movement disorders. She is a member of Drs. Randi and Paul Hagerman’s interdisciplinary research team, working to advance understanding of psychiatric and cognitive aspects of fragile X-associated tremor/ataxia syndrome (FXTAS). 19. Tony J. Simon, Ph.D., [email protected] Dr. Simon is a pediatric cognitive neuroscientist. His research focuses on the neural basis of cognitive impairments seen in genetic disorders that produce mental retardation, developmental disability and psychopathology. Dr. Simon investigates how dysfunction in specific neurocognitive processing systems, such as attention and spatial or temporal processing, can generate a range of cognitive and behavioral impairments. His goal is to develop remedial intervention programs that will minimize such disability. Dr. Simon's current projects center on studies of children with chromosome 22q11.2 deletion syndrome. He uses neuroimaging methods, such as functional magnetic resonance imaging (fMRI), Voxel Based Morphometrics, and Diffusion Tensor Fiber Imaging in order to study the structure, function and connective patterns in the developing brain. 20. Marjorie Solomon,Ph.D., [email protected] Dr. Solomon’s current research efforts involve studies about social skills, parent-child interaction therapy for children with autism spectrum disorders, and friendship and attachment in high functioning children with autism spectrum disorders. Additional research interests are in: cognitive control and higher cognition, including reinforcement learning in high functioning individuals with autism spectrum disorders, as well as comparative development of pervasive development disorders and psychotic illnesses, using cognitive neuroscience methods and functional magnetic resonance imaging (fMRI). Guohua Xia, M.D., [email protected] Dr. Xia's interests include biopsychosocial aspects of major psychiatric disorders including crosscultrual issues in mental health. Current research projects include Transcranial Magnetic Stimulation (TMS) treatment of depression and other psychiatric disorders. He is also exploring TMS usage in cognitive function studies with or without brain diseases. 21. 22. Peter Yellowlees, M.D., [email protected] 5 Research interests include: telemedicine and eHealth, long distance health and education delivery, internet email and video consultation services, and the use of virtual reality for health education on the internet.. 23. Jong H. Yoon, M.D., [email protected] Dr. Yoon's research focuses on the investigation of the function (or dysfunction) of the prefrontal cortex in the healthy and diseased state. To that end, he has begun a parallel series of visual object working memory studies in healthy and schizophrenic subjects. In these experiments he is studying the relative contribution of the PFC and the visual assocation areas in maintenance functions in the face of external distractors. In another set of studies, he will be examining the impact of affective information on inhibitory control processes in working memory.