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Case Presentations Case 1: Lymphoma in remission • 23 yo patient with hx of depression, suicide attempts, and T lymphoblastic lymphoma in remission on maintenance treatment. • She developed severe wide-spread joint pain during her treatment and was prescribed up to 10-12mg hydromorphone Q4 H PRN. She has been unable to taper her medication and frequently asks for early refills. • She is also needing stimulant medication to help with profound fatigue. • Her mother and her provider are worried about her. • What do you do? Case 1: • Her pain treatment is transferred to Internal Medicine • She is dissatisfied that she is now asked to do the following – Opioid agreement – Urine drug test – 28 day refills • After lengthy discussions, she complies with taper and considers buprenorphine as an alternative • She continues to struggle with depression Case 1: Opportunities • Emphasize non-opioid pain management – Focus on functional gains/progress – Engage in mental health care • • • • Consider limiting opioid dose* Establish opioid risk assessment and explain risks Establish opioid agreements Carefully monitor prescription use – 28 day prescriptions, eRx – Consider urine drug tests • Refer prior to problems developing Use a Risk-Benefit Framework NOT… • Is the patient good or bad? • Does the patient deserve opioids? • Should this patient be punished or rewarded? • Should I trust the patient? RATHER… Do the benefits of opioid treatment outweigh the untoward effects and risks for this patient (or society)? Judge the opioid treatment – NOT the patient Nicolaidis C. Pain Med. 2011 Jun;12(6):890-7. Case • 35 yo female with chronic daily migraine and diffuse myofascial pain who has been prescribed opioids for 5 years after the birth of her daughter. The patient has severe depression and anxiety, chronic nausea, history of adverse childhood experience (neglect as a child), and obesity. She is a stay at home mother to her 2 children, but frequently has to put the children in daycare because she can not care for them when she has severe migraines. She is also prescribed chronic high dose benzodiazepines by a psychiatrist. • The patient has a history of losing her opioid prescription, obtaining opioids from another provider, being allergic to most other pain medication options, missing appointments, and frequently asking for opioid dose increases. 6 Case: Thought Questions • Does this patient have pain? • Does this patient have an opioid use disorder? • What factors place this patient at risk for an opioid use disorder? • What can you do to help this patient? 7 DSM-V criteria 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. Unable to fulfill major role obligations Social or interpersonal problems due to use Use in hazardous situations Tolerance* Withdrawal/physical dependence* Taken in larger amounts or over longer period than wanted Unsuccessful efforts to cut down or control use Great deal of time spent to obtain substance Important activities given up or reduced Continued use despite harm (physical and psychological) Craving *If opioids are prescribed and taken as prescribed, these criterion do not apply.