Download BT 6302

DOC/LP/01/28.02.02
LESSON PLAN
LP- BT 6302
LP Rev. No: 00
Sub Code & Name: BT 6302
BIOORGANIC CHEMISTRY
Unit: I
Branch: BT
Semester : V
Date: 03/06/2014
Page 1 of 6
AIM: To enable the students
 To know in detail about the elements of atom, charges and their bonding rule.
 To understand the various kinetic properties and types of reaction mechanisms
 To understand the possible bio-organic reactions involved in biosynthesis
UNIT-I: BONDING AND STEREOCHEMISTRY
9
Atoms Electrons and orbitals - Covalent Bonds - Octet rule - Polar covalant Bonds –
Electronegativity formal charge - Resonance Acids and Bases - Arrhenius and Bronsted
Lowry Theories - Acid Base equilbria - SP3 hybridization - Conformations analysis
ethane, butane and cyclohexane - Cis- trans isomerism. Stereochem activity around the
tetrahedral carbon – optical activity - Conformation of the peptide bond.
OBJECTIVE: The objective of this unit is to impart the students the knowledge on
bonds, Resonance, hybridization, isomerism and Stereochem activity.
Session
No
Topics to be covered
Time
(min)
1)
Atoms Electrons and orbitals
50
2)
Covalent Bonds
50
Ref
TB3(01-07)
TB1(59-64)
TB4(004-005, 007-008)
TB3(008)
Teaching
Method
Smart
class & BB
Smart
class & BB
TB3(007)
Octet rule
Polar covalant Bonds
3)
Electronegativity
50
TB1(015-018)
TB1(015-018)
50
TB4(006)
TB4(015-019)
TB1(009-013)
formal charge
4)
Resonance Acids and Bases
Smart
class & BB
Smart
class & BB
TB4(031-032)
Arrhenius and Bronsted Lowry
Theories
5)
Acid Base equilbria
50
SP3 hybridization
6)
Conformations analysis ethane,
50
7)
Cis- trans isomerism
50
8)
Stereochem activity around the
50
50
Conformation of the peptide
bond
TB4(070,090-096)
TB1(129-146)
TB4(087-088)
TB1(247-248)
tetrahedral carbon
optical activity
Smart
class & BB
TB4(008-010)
butane and cyclohexane
9)
TB4(031-032)
TB1(076),
RF1(41, 52,68, 180, 210,
628)
RF1(039, 046-047, 025026)
Smart
class & BB
Smart
class & BB
Smart
class & BB
Smart
class & BB
DOC/LP/01/28.02.02
LESSON PLAN
LP- BT 6302
LP Rev. No: 00
Sub Code & Name: BT 6302
Date: 03/06/2014
BIOORGANIC CHEMISTRY
Unit: II
Branch: BT
Semester : V
Page 2 of 6
UNIT II: MECHANISMS OF SUBSTITUTION AND ADDITION REACTIONS 9
SN1 and SN2 reactions on tetrahedral carbon- nucleophiles- mechanism steric effects –
nucleophilic addition on Acetals and ketals -Aldehyde and ketone groups – reactions of
carbonyl group with amines- acid catalyzed ester hydrolysis – Saponification of an
esterhydrolysis of amides. Ester enolates – claisen .condensation – Michael condensation.
Objective: The objective of this unit is to give deeper knowledge on nucleophiles,
Saponification and condensation reactions.
Session
No
1)
Topics to be covered
SN1 and SN2 reactions on
tetrahedral carbon
Time
(min)
50
Ref
TB4(365-373)
TB4(129,370)
nucleophiles
2)
4)
5)
6)
7)
8)
nucleophilic addition on Acetals
and ketals
Aldehyde and ketone groups
reactions of carbonyl group
with amines
acid catalyzed ester hydrolysis
Saponification of an
esterhydrolysis of amides
Ester enolates
Method
Smart class &
BB
Smart class &
BB
50
TB1(586, 419-420, 298300)
TB4(36, 597, 750)
50
TB3(489-490)
50
TB3(485)
50
TB4(637)
50
Class notes
50
TB1(398-406)
Smart class &
BB
Smart class &
BB
50
TB1(436-437)
Smart class &
mechanism steric effects
3)
Teaching
Smart class &
BB
Smart class &
BB
Smart class &
BB
TB4(680)
claisen .condensation
9)
50
Michael condensation
TB3(600)
BB
Smart class &
BB
DOC/LP/01/28.02.02
LESSON PLAN
LP- BT 6302
Sub Code & Name: BT 6302
BIOORGANIC CHEMISTRY
Unit: III
Branch: BT
Semester : V
LP Rev. No: 00
Date: 03/06/2014
Page 3 of 6
UNIT III: KINETICS AND MECHANISM
9
Kinetic method – Rate law and mechanism – Transition states- Intermediates – Trapping
of intermediates – Microscopic reversibility – Kinetic and thermodynamic reversibility –
Isotopes for detecting intermediates. Primary and secondary isotopes – the Arrhenius
equation Eyring equation - ΔG, ΔS, ΔH, Thermodynamics of coupled reactions.
Objective: The objective of this unit is to educate the students on Kinetics, Transition
states, Microscopic reversibility, Arrhenius and Eyring equation.
Session
Topics to be covered
Time
Ref
(min)
No
Teaching
Method
1)
Kinetic method
50
Class notes
Smart class & BB
2)
Rate law and mechanism
50
TB1(192-197)
Smart class & BB
3)
Transition states
50
TB1(200-204)
Smart class & BB
4)
Intermediates – Trapping of
50
TB1 (197-200)
Smart class & BB
intermediates
5)
Microscopic reversibility
50
TB1(200-203)
Smart class & BB
6)
Kinetic and thermodynamic
50
TB1(215-217)
Smart class & BB
50
TB1(225-228)
Smart class & BB
50
TB1(222-225)
Smart class & BB
the Arrhenius equation Eyring 50
TB1(187-192)
Smart class & BB
reversibility
7)
Isotopes for detecting
intermediates
8)
Primary and secondary
isotopes
9)
equation - ΔG, ΔS, ΔH,
Thermodynamics of coupled
reactions
DOC/LP/01/28.02.02
LESSON PLAN
LP- BT 6302
Sub Code & Name: BT 6302
BIOORGANIC CHEMISTRY
Unit: IV
Branch: BT
Semester : V
UNIT IV: CATALYSIS
LP Rev. No: 00
Date: 03/06/2014
Page 4 of 6
9
Reactivity – Coenzymes – Proton transfer – metal ions – Intra molecular reactions –
Covalent catalysis – Catalysis by organized aggregates and phases. Inclusion
Complexation
Objective: The objective of this unit is to enrich the students on catalysis of metal ion,
covalent and Inclusion Complexation.
Session
Topics to be covered
No
Time
Ref
Teaching Method
(min)
1)
Reactivity
50
Class notes
Smart class & BB
2)
Coenzymes
50
RF1(482-485)
Smart class & BB
3)
Proton transfer
50
RF1(290-291)
Smart class & BB
4)
metal ions
50
RF1(388-390)
Smart class & BB
5)
Intra molecular reactions
50
Smart class & BB
6)
Covalent catalysis
50
RF1 (166167,177)
RF1(163-166)
7)
Catalysis by organized aggregates
50
Class notes
Smart class & BB
8)
Catalysis by organized phases
50
Class notes
Smart class & BB
9)
Inclusion Complexation
50
RF1(345,443)
Smart class & BB
Smart class & BB
DOC/LP/01/28.02.02
LESSON PLAN
LP- BT 6302
Sub Code & Name: BT 6302
BIOORGANIC CHEMISTRY
Unit: V
Branch: BT
Semester : V
UNIT V: BIOORGANIC REACTIONS
LP Rev. No: 00
Date: 03/06/2014
Page 5 of 6
9
Timing of Bond formation and fission – Acyl group transfer – C-C bond formation and
fission – Catalysis of proton transfer reactions – Transfer of hydride ion – Alkyl group.
Transfer – Terpene biosynthesis Murrlfield state peptide synthesis – Sanger method for
peptide and DNA sequencing.
Objective: The objective of this unit is to saturate the students with various bioorganic
reactions and sequencing methods.
Session
No
1)
2)
3)
4)
Topics to be covered
Timing of Bond formation
and fission
Acyl group transfer
C-C bond formation and
fission
Catalysis of proton transfer
reactions
Time
(min)
Ref
Teaching Method
50
Class notes,
RF1(126-127)
Smart class & BB
50
Class notes
Smart class & BB
50
50
RF1(126-127)
Class notes
Smart class & BB
Smart class & BB
5)
Transfer of hydride ion
50
RF1(174,176)
Smart class & BB
6)
Alkyl group Transfer
50
Class notes
Smart class & BB
Terpene biosynthesis
7)
TB3(608-612)
50
TB3(599-600)
Murrlfield state peptide
TB4(979-980)
synthesis
RF1(033)
Smart class & BB
8)
9)
Sanger method for peptide
sequencing
Sanger method for DNA
sequencing
50
50
TB4(981)
Class notes
Smart class & BB
Smart class & BB
DOC/LP/01/28.02.02
Course delivery plan:
WEEK
1
2
3
4
1
UNITS
5
6
7
2
8
3
9
10
11
12
13
4
14
15
5
Prepared by
Approved by
Sathish. N
Prof. Sulochana somasundaram
Asst. Professor
Professor
03/06/2014
03/06/2014
Signature
Name
Designation
Date
Text Books:
1. Carey, Francis A.” Organic Chemistry”. 7th Edition, Tata MCGraw Hill, 2009.
2. Page, M.I. and Andrew Williams “Organic and Bio-organic Mechanisms”. Pearson,
2010.
3. A text book of organic chemistry Bansal, Raj k. Wiley eastern chemistry(organic),
1986
4. Organic Chemistry Mehta, Bhupinder; Mehta, Manju Prentice-Hall of India, 2005
REFERENCES
1. Dugas, Hermann “ Bioorganic Chemistry : A Chemical Approach to Enzyme Action”
3rd Edition, Springer, 2003.