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K A L A M A Z O O C O U N T Y H E A LT H A N D C O M M U N I T Y SERVICES NICOLE WILSON, RN WHAT IS HEPATITIS C? Hepatitis C virus is a bloodborne pathogen that affects the liver. It ranges in severity from a mild illness lasting a few weeks to a serious, lifelong illness that attacks the liver. Hepatitis C is classified as either “acute” or “chronic.” ACUTE HEPATITIS VS. CHRONIC HEPATITIS Acute Hepatitis C virus infection is a short-term illness that occurs within the first 6 months after someone is exposed to the Hepatitis C virus. For most people, acute infection leads to chronic infection. Chronic Hepatitis C virus infection is a long-term illness that occurs when the Hepatitis C virus remains in a person’s body. Hepatitis C virus infection can last a lifetime and lead to serious liver problems, including cirrhosis (scarring of the liver) or liver cancer. SYMPTOMS OF ACUTE HEPATITIS C If symptoms occur, the average time is 6–7 weeks after exposure, but this can range from 2 weeks to 6 months. Approximately 70%–80% of people with acute Hepatitis C do not have any symptoms. Those that do have symptoms, they may experience: Fever Fatigue Loss of appetite Nausea Vomiting Abdominal pain Dark urine Clay-colored bowel movements Joint pain Jaundice (yellow color in the skin or eyes) SYMPTOMS OF CHRONIC HEPATITIS C Most people with Chronic Hepatitis C do not have any symptoms. REPORTED CASES OF ACUTE HEPATITIS C Increased 44.3% from 2011 to 2012 Increased 20.3% to 2,138 cases in 2013 Increased 2.6% to 2,194 cases in 2014 Increased 11% to 2,436 cases in 2015. The increase in acute HCV case reports reflects new infections associated with rising rates of injection-drug use, and, to a much lesser extent, improved case detection PERSONS WHO SHOULD BE TESTED FOR HCV INFECTION Born from 1945 through 1965 Current or former injection drug user, even if you injected only one time or many years ago. Ever treated for a blood clotting problem before 1987. Received a blood transfusion or organ transplant before July 1992. On long-term hemodialysis treatment. Have abnormal liver tests or liver disease. Work in health care or public safety and were exposed to blood through a needle stick or other sharp object injury. Infected with HIV. Children born to HCV-positive mothers (to avoid detecting maternal antibody, these children should not be tested before age 18 months) HEALTH COMPLICATIONS OF CHRONIC HCV INFECTION Chronic Hepatitis C results in long-term health problems, including: liver damage, liver failure, liver cancer, or even death. It is the leading cause of cirrhosis and liver cancer and the most common reason for liver transplantation in the United States. Approximately 19,000 people die every year from Hepatitis C related liver disease. TREATMENT FOR HCV INFECTION Can acute Hepatitis C be treated? Yes, acute hepatitis C can be treated. Acute infection can clear on its own without treatment in about 25% of people. If acute hepatitis C is diagnosed, treatment does reduce the risk that acute hepatitis C will become a chronic infection. Acute hepatitis C is treated with the same medications used to treat chronic Hepatitis C. However, the optimal treatment and when it should be started remains uncertain. Can chronic Hepatitis C be treated? Yes. There are several medications available to treat chronic Hepatitis C, including new treatments that appear to be more effective and have fewer side effects than previous options. The Food and Drug Administration (FDA) maintains a complete list of approved treatments. There are six different genotypes of hepatitis C. The figure shows the global distribution of these genotypes and their subtypes. In the United States, genotypes 1, 2, and 3, are the most common. In Michigan genotypes 1a and 1b account for 89% of reported genotypes. The Good and The Bad…. HCV TREATMENT INSURANCE COVERAGE On Tuesday March 1st, the Michigan Department of Health and Human Services (MDHHS) announced that Michigan Medicaid would provide coverage for new medications to treat hepatitis C virus (HCV) for patients that meet pre-approval criteria. “Baby Boomers,” those born between 1945 and 1965, are five times more likely than other adults to be infected with hepatitis C according to national statistics. CDC now recommends one-time hepatitis C testing of everyone born between 1945 and 1965. MDHHS data shows that the number of new chronic hepatitis C diagnoses in persons born between 1945 and 1965 is greater than any other birth cohort. KALAMAZOO COUNTY HCV 2016 Young Adults Ever injected: Yes (57.1%), No (4.8%), UNK (35.7) HCV INFECTIONS INCREASE IN MICHIGAN AMONG YOUNG ADULTS An emerging epidemic of HCV in young adults ages 18-29 has been identified in areas across the US. The increase in HCV cases in this age group is due to sharing of injection drug equipment and works related to the concurrent opiate and heroin epidemics. A vast majority of chronic HCV cases aged 18-29 years old who were diagnosed in 2015 were white, non-Hispanic, and non-Arab with an approximately 50/50 split between males and females. 86.7% reported a history of IVDU. REFERENCES CDC.Gov https://www.cdc.gov/hepatitis/hcv/ MDHHS.gov http://www.michigan.gov/documents/mdhhs/Hepatitis_B_and_C_Annual_Report_2015_530584_ 7.pdf