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Kavinace Flash-Ease Supports nervous and endocrine messengers that regulate sleep and internal temperature* Item number Dosage form Available size Serving size 20018 Capsules 30 Capsules 1 Capsule Benefits may include Patient symptoms Supports neurotransmitters important for sleep and calm1* You may recommend Kavinace Flash-Ease for: Promotes healthy vasomotor and thermoregulatory function2-5* Sleep difficulties* Hot flashes and night sweats* Encourages healthy HPA axis and stress response6,7* Stress* Low mood* Supports healthy sexual function8* Why Kavinace Flash-Ease? 4-amino-3-phenylbutyric acid and 5-HTP support sleep, mood, and calm* Black cohosh, 5-HTP, and 4-amino-3-phenylbutyric acid promote temperature regulation that may reduce hot flashes* Ashwagandha supports a healthy stress response and sexual function* Key ingredients 4-amino-3-phenylbutyric acid: GABA derivative that crosses the blood-brain barrier and acts as a GABA-B agonist1 5-HTP: Precursor to serotonin and melatonin Black cohosh: Herbal with serotonergic, gabaminergic, and potentially selective estrogenic activity4,15 Ashwagandha: Herbal adrenal adaptogen that modulates hormonal stress responses6 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. How Kavinace Flash-Ease works Designed to enhance communication between the nervous and endocrine systems to support multiple sleep and thermoregulation mechanisms that are disrupted by hormonal imbalances. Figure 1. Hot Flash Circadian Rhythm Figure 2. Thermoregulatory Range Average Hot Flash Frequency 11 Shivering 10 9 Sweating Reproductive Age 8 7 6 5 Menopause 4 3 2 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 0 1 2 Comfort Range Time (24 hours) Hot flashes are more likely between early evening and bedtime. Measured objectively via skin conductance.14 The Menopausal Transition Neuro-Endocrine Temperature Regulation As high as 60% of women report sleep issues9 Decreased estrogens and elevated norepinephrine narrow the temperature comfort range of the body13 (Figure 2) Hot flashes reported in 84% of women 11 Vasomotor symptoms last a median of 7.4 years12 Histories of somatic anxiety, perceived stress, mood imbalances, and sleeplessness correlate with longer symptoms12 Low estradiol levels and/or receptor activity produce dysregulated release of serotonin, GABA, and catecholamines4 Activates cardio and thermoregulatory neurons4 Thermoregulatory connections Hot flashes are an objective sleep disturbance Likelihood of hot flashes increase as the comfort range narrows. Accounted for 27% of sleep study-defined waking 11 Supplement Facts Amount Per Serving Proprietary Blend 550 mg 4-amino-3-phenylbutyric acid HCI, Ashwagandha root extract (4.5% withanolides), 5-hydroxytryptophan (from Griffonia simplicifolia seed extract), and Black cohosh root extract (2.5% triterpene glycosides) Black cohosh and serotonin modulate estrogen receptor activity4,5 GABA compensates for norepinephrine elevations14 Ashwagandha and serotonin support healthy HPA axis6,7 Need focused cortisol balance? Learn about Calm CP at www.neuroscienceinc.com/CalmCP Other Ingredients: Microcrystalline cellulose, Vegetable capsule (Hypromellose, water), and Magnesium stearate (vegetable source). Suggested Use: Take 1 capsule at bedtime as needed or as directed by your health care practitioner. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. CNS Drug Reviews. 2001;7(4):471-481 Integr Cancer Ther. 2014;13(1):12-29 Clin Nutr Insights. 1998;6(15):7-10. J. Steroid. Biochem. Mol. Biol. 2014;142:115-120 J. Steroid. Biochem. Mol. Biol. 2014;139:302-310 BMC Womens Health. 2005;5(12) Indian J Psychol Med. 2012;34(3):255-262 J Neuroendocrinol. 2014;26(9):573-586 Biomed Res Int. 2015;2015:284154 Psychoneuroendocrinology. 2015;60:96-104 Fertil Steril. 2014;102(6):1708-1715 JAMA Intern Med. 2015;175(4):531-539 J. Steroid. Biochem. Mol. Biol. 2014;142:115-120 Brain Research. 2004;1021:286-291 J. Clin. Endocrinol. Metab. 1995;80(8):2354-2358 Gynecol Endocrinol. 2011;27(10):844-848 Copyright © 2017 NeuroScience, Inc 022417-Z4034 Phone: (888) 342-7272 www.neuroscienceinc.com *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.