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Kavinace Flash-Ease
Supports nervous and endocrine messengers
that regulate sleep and internal temperature*
Item number
Dosage form
Available size
Serving size
20018
Capsules
30 Capsules
1 Capsule
Benefits may include
Patient symptoms
„„
Supports neurotransmitters important for sleep and calm1*
You may recommend Kavinace Flash-Ease for:
„„
Promotes healthy vasomotor and thermoregulatory function2-5*
„„
Sleep difficulties*
„„
Hot flashes and night sweats*
„„
Encourages healthy HPA axis and stress response6,7*
„„
Stress*
„„
Low mood*
„„
Supports healthy sexual function8*
Why Kavinace Flash-Ease?
„„
4-amino-3-phenylbutyric acid and 5-HTP support sleep, mood, and calm*
„„
Black cohosh, 5-HTP, and 4-amino-3-phenylbutyric acid promote
temperature regulation that may reduce hot flashes*
„„
Ashwagandha supports a healthy stress response and sexual function*
Key ingredients
4-amino-3-phenylbutyric acid: GABA derivative that
crosses the blood-brain barrier and acts as a GABA-B
agonist1
5-HTP: Precursor to serotonin and melatonin
Black cohosh: Herbal with serotonergic, gabaminergic,
and potentially selective estrogenic activity4,15
Ashwagandha: Herbal adrenal adaptogen that
modulates hormonal stress responses6
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
How Kavinace Flash-Ease works
Designed to enhance communication between the nervous and endocrine systems to support multiple sleep and
thermoregulation mechanisms that are disrupted by hormonal imbalances.
Figure 1. Hot Flash Circadian Rhythm
Figure 2. Thermoregulatory Range
Average Hot Flash Frequency
11
Shivering
10
9
Sweating
Reproductive Age
8
7
6
5
Menopause
4
3
2
1
3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 0 1 2
Comfort Range
Time (24 hours)
Hot flashes are more likely between early evening and bedtime.
Measured objectively via skin conductance.14
The Menopausal Transition
Neuro-Endocrine Temperature Regulation
As high as 60% of women report sleep issues9
Decreased estrogens and elevated norepinephrine narrow the
temperature comfort range of the body13 (Figure 2)
Hot flashes reported in 84% of women
11
Vasomotor symptoms last a median of 7.4 years12
„„
Histories of somatic anxiety, perceived stress, mood imbalances,
and sleeplessness correlate with longer symptoms12
Low estradiol levels and/or receptor activity produce
dysregulated release of serotonin, GABA, and catecholamines4
„„
Activates cardio and thermoregulatory neurons4
Thermoregulatory connections
Hot flashes are an objective sleep disturbance
„„
Likelihood of hot flashes increase as the comfort range narrows.
Accounted for 27% of sleep study-defined waking
11
Supplement Facts
Amount Per Serving
Proprietary Blend
550 mg
4-amino-3-phenylbutyric acid HCI, Ashwagandha root extract (4.5% withanolides), 5-hydroxytryptophan (from Griffonia simplicifolia seed extract), and Black cohosh root extract (2.5% triterpene
glycosides)
„„
Black cohosh and serotonin modulate estrogen receptor activity4,5
„„
GABA compensates for norepinephrine elevations14
„„
Ashwagandha and serotonin support healthy HPA axis6,7
Need focused cortisol balance?
Learn about Calm CP at
www.neuroscienceinc.com/CalmCP
Other Ingredients: Microcrystalline cellulose, Vegetable capsule (Hypromellose, water), and
Magnesium stearate (vegetable source).
Suggested Use: Take 1 capsule at bedtime as needed or as directed by your health care
practitioner.
References
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15.
CNS Drug Reviews. 2001;7(4):471-481
Integr Cancer Ther. 2014;13(1):12-29
Clin Nutr Insights. 1998;6(15):7-10. J. Steroid. Biochem. Mol. Biol. 2014;142:115-120
J. Steroid. Biochem. Mol. Biol. 2014;139:302-310
BMC Womens Health. 2005;5(12)
Indian J Psychol Med. 2012;34(3):255-262
J Neuroendocrinol. 2014;26(9):573-586
Biomed Res Int. 2015;2015:284154
Psychoneuroendocrinology. 2015;60:96-104
Fertil Steril. 2014;102(6):1708-1715
JAMA Intern Med. 2015;175(4):531-539
J. Steroid. Biochem. Mol. Biol. 2014;142:115-120
Brain Research. 2004;1021:286-291
J. Clin. Endocrinol. Metab. 1995;80(8):2354-2358
Gynecol Endocrinol. 2011;27(10):844-848
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Phone: (888) 342-7272 www.neuroscienceinc.com
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.