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Download Derivation of Human Embryonic Stem Cells
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In Vitro Fertilization (IVF) Fertilization and early embryonic development occurs in the laboratory Derivation of Human Embryonic Stem Cells Derivation from Donated IVF Embryos Somatic Cell Nuclear Transfer (SCNT – also known as Therapeutic Cloning) Donor cell Egg (oocyte) Donor nucleus Sperm Fertilised egg Egg Nucleus removed Egg’s nucleus is removed and is replaced by the nucleus from the donor cell. Donated IVF embryo (no longer required for infertility treatment) Early SCNT embryo is formed Early stage embryo Blastocyst stage embryo (5-7 days development) Blastocyst stage embryo (5-7 days in development) Stem cells isolated from embryo which is destroyed in the process Stem cells isolated from embryo which is destroyed in the process Blastocyst stage embryo (5-7 days after fertilization) Transfer to uterus Stem cells are cultured in the laboratory Stem cells are cultured in the laboratory The nuclear transfer stem cells would be genetically identical to the donor Full term baby Stem cell line would then be distributed to scientists Research © Australian Stem Cell Centre 2011 Normal development & understanding disease Development of Therapies Drug discovery Note: Human embryonic stem cells are yet to be derived from SCNT embryos
