Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
CURRICULUM VITAE Name: Marco Ciotti Date and place of birth: 30 November, 1963 Roccagorga (LT), Italy Citizenship: Italian Marital Status: Married, 2 children. Address: (home) (offfice) Via Castro dei Volsci, 10 00179 Rome, Italy Tel.: + 39 067801828 Cell phone:+39 338-3715759 University Hospital Tor Vergata Clinical Microbiology and Virology Viale Oxford 81, 00133 Rome, Italy Tel.: +39 0620902088; +39 0620902070 E-mail:[email protected] or [email protected] Professional history: March, 1999 to present Virologist, Laboratory of molecular virology University Hospital Tor Vergata Rome, Italy 25 August,1997-27 February,1999 Visiting Associate Heritable Disorders Branch Section on Genetic Disorders of Drug Metabolism National Institue of Child Health and Human Development National Institutes of Health Bethesda,Maryland,U.S.A. 8 August,1992-7 August,1997 Visiting Fellow Heritable Disorders Branch Section on Genetic Disorders of Drug Metabolism 1 National Institute of Child Health And Human Development National Institutes of Health Bethesda,Maryland,U.S.A. Fellow, Oncology School 1989-1992 Department of Experimental Medicine and Biochemical Science University of Rome Tor Vergata Rome, Italy Fellow, Laboratory of Microbiology 1986-1989 Department of Experimental Medicine and Biochemical Science University of Rome Tor Vergata Rome, Italy Other positions: Medical officer Italian Army Education: High School Degree 1982 Liceo Classico “Dante Alighieri”, Italy Medicine Degree 1989 University of Rome “La Sapienza”, Italy Italian Board 1989 University of Rome “La Sapienza”, Italy Oncology Degree 1994 University of Rome Tor Vergata, Italy Microbiology and Virology Degree 2001 University of Rome Tor Vergata, Italy Scientific Societies: 2 Member of the Pediatrics Italian Society Member of the American Society for Biochemistry and Molecular Biology Member of the European Society Microbiology and Infectious Deseases of Clinical Awards: Award of Bruno Maria Zaini Foundation for: “Critical contribution to the understanting of the molecular basis of Crigler-Najjar disease and bilirubin metabolism” Foreign languages: English ; Spanish Invited Lectures: Workshop on Crigler-Najjar disease Riccione, Italy,1996. Workshop on Crigler-Najjar disease Rockefeller University, New York, NY,1996. UGT1 locus mutations: pharmacologic and metabolic implications. University of Rome “La Sapienza”, Italy,1997. Role of the glucuronidation in the detoxification of exogenous and endogenous substances. University of Rome Tor Vergata, Italy,1998. Phisical state and expression of HPV in SIL and Cervical cancer. Meeting on genital infections and human papilloma viruses (HPV). NIH (ISS), Rome, Italy,2003. Phisical state and expression of HPV in SIL and Cervical cancer. Italian Society of Microbiology, Rome,Italy,2003 3 Role of HPV testing in the managementof minor cervical lesions. 8th World Congress for infectious and immunological diseases in obstetrics and gynecology,Venice,Italy,2003. Clinical applications of drug-resistance tests Workshop Clinical Immunology, Saint John Hospital, Rome, Italy,2004 Clinical role of the HPV test. Department of Gynecology and Obstetrics. Rome, 27/28 May, 2004 and 14/15 October, 2004. Expression of p16INK4a as prognostic marker of cervical cancer. Milan,Italian Society of Microbiology, 26/29 September, 2004. Detection and expression of E6 and E7 oncogenes in non-small lung cancer. Italian Society of Medical Virology, Rome, 16/18 May, 2005. HPV typing: Comparison between sequencing and Linear array HPV genotyping assay. Italian Society of Microbiology , Naples, 16-19 October, 2005. Biology of HPV infection. San Gallicano Hospital, 20, October, 2005, Rome. Markers of tumor progression in HPV related lesions. Workshop HPV infections: from diagnosis to prevention. National Institute of Health (ISS), Rome, 9 –10 November, 2005. Virological molecular diagnosis. Hep-B free meeting. 7 December, 2005. University of Rome Tor Vergata. Monitoring HIV1 infection. Italian Society of Clinical Microbiology (AMCLI) 2006, 19-22 September, 2006. Turin. Markers of tumor progression in cervical lesions HPV related. Creta, Greece, 12 October, 2006. 4 Performance evaluation of the Abbott PCR RealTime Assay for HCV and HBV: the prospective of a Virology laboratory. 3° National Virology Congress, Turkey-Uludag, 9-13 December, 2007. Referee for peer-review journals Proceedings of the American Thoracic Society Teaching activity School of Clinical Microbiology and Virology : Molecular biology and techniques of molecular virological diagnosis (2002 to date) School for Technicians of Biomedical Laboratory : Microbiology and Virology (2006 to date). School of Oncology : Viral Oncogenesis (2007) Books and Chapters of Books Co-author of the Chapter: HPV and low-grade cervical lesions. In: Cervicovaginal pathology. From laboratory to clinic, pp. 109-114. Masson Edition, 2002. Co-author “Clinical Microbiology” textbook (Favalli C e Brunello O) EMSI, Rome,2006. Co-author “Priciples of Clinical Immunology” textbook (Favalli C e Perricone R) EMSI, Rome,2007. Co-author “Medical Microbiology” textbook (Fadda G, Favalli C, Palu’ G) EMSI, Rome,2007. 5 Publications: 1. Ciotti,M., Yeatman, M.T., Sokol, R.J., and I.S. Owens. Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a CriglerNajjar type I patient. J. Biol. Chem. 270(7):3284-3291,1995. 2. Silvestri, I., Albonici, L., Ciotti, M., Lombardi, M.P., Sinibaldi, P., Manzari, V., Orlando, P., Carretta, F., Strazzollo, G., and P., Grippo. Antimitotic and antiviral activities of Kelletinin A in the HTLV-I infected MT2 cells. Experentia 51(11):1076-1080,1995. 3. Ciotti, M., and I.S. Owens. Evidence for overlapping active sites for 17Ethynylestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase. Biochemistry 35(31):10119-10124,1996. 4. Ciotti, M., Obaray, R., Martin, M.G., and I.S. Owens. Genetic defects at the UGT 1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis. Am.J.Med.Genetics 68:173-178,1997. 5. Ciotti, M., Marrone, A., Potter, C., and I.S. Owens. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: Pharmacological implications. Pharmacogenetics 7(6):485-495,1997. 6. Ciotti, M., Chen, F., Rubaltelli, F.F., and I.S. Owens. Coding defect and a TATA Box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease. BBA-Molecular Basis of Disease 1407(1): 40-50,1998. 7. Ciotti, M., Cho, J.W., George, J., and I.S Owens. Required buried -helical structure in the bilirubin UDP-glucuronosyltransferase, UGT1A1, contains a nonreplaceable phenylalanine. Biochemistry 37(31):11018-11025,1998. 8. Ciotti, M., Werlin, S.L., and I.S. Owens. Delayed response to phenobarbital Treatment of a Crigler-Najjar type II patient with partially inactivating missense mutations in the bilirubin UDP-glucuronosyltransferase gene. J. Pediatr. Gastroenterol. Nutr. 28(2):210213,1999. 9. Ciotti, M., Basu, N., Brangi, M., and I.S. Owens. Glucuronidation of 7-Ethyl-10Hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus. Biochem. Biophys. Res. Commun. 260(1):199-202,1999. 10. Ciotti, M., Lakshmi, V. M., Basu, N., Davis, B.B., Owens, I.S., and T.V Zenser,.. 6 Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides. Carcinogenesis 20(10):1963-1969,1999. 11. Brangi, M., Litman, T., Ciotti, M., Nishiyama, K., Kohlhagen, G., Takimoto, C., Robeyl, R., Pommier, Y., Fojol, T., Bates, S.E.. Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Res 59(23):5938-5946, 1999. 12. Giuliani, L., Magnanti, M., Gandini, O., Gazzaniga, P., Santiemma, V., Ciotti, M., Saccani, G., Frati, L., Aglianò, A.M.. Follicle-stimulating hormone testosterone and hypoxia differentially regulate UDP-glucuronosyltransferase 1 isoforms expression in rat and peritubalar myoid cells. J. Steroid Biochem. Mol. Biol. 74:149-155,2000. 13. Giuliani, L., Gazzaniga, P., Caporuscio, F., Ciotti, M., Frati, L., and Aglianò, A.M.. Can down-regulation of UDP-glucuronosyltransferases in human bladder tissue impact the risk of chemical carcinogenesis? Int. J. Cancer 91(1):141-143,2001. 14. Fontana, C., Ciotti, M., Favaro, M., Pistoia, E.S., Pietroiusti, A., Galante, A., Favalli, C.. Diagnosi molecolare di Helicobacter Pylori a confronto con tecniche tradizionali. Bollettino di Microbiologia e Indagini di Laboratorio news 7(2):5-19,2001. 15. Medici, M.A., Sciortino, M.T., Perri, D., Amici, C., Avitabile, E., Ciotti, M., Balestrieri, E., De Smaele, E., Franzoso, G., and Mastino, A.. Protection by herpes simplex virus Glycoprotein D against Fas-mediated Apoptosis: ROLE OF NUCLEAR FACTORκB.J Biol Chem 278(38):36059-36067,2003. 16. Ciotti, M., Basu, N.K., Hwang, M.S., Kole, L., Mitra, P.S., Cho, J.W., and Owens, I.S. Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem , 279(2):1429-1441,2004. 17. Ciotti, M.,Sesti, F., Paba, P., Benedetto, A., Patrizi, L., Criscuolo, A., Piccione, E., Branca, M., Syrjänen K., Favalli, C. Human papillomavirus (HPV) testing in the management of women with abnormal pap smear. Experience from colposcopy referral clinic. Eur J Gynaecol Oncol 25(5):577-584,2004. 18. Basu, N.K., Kubota, S., Meselhy, M.R., Ciotti, M., Chowdhury, B., Hartori, M., and Owens, I.S.. Gastrointestinally-distributed UDP-glucuronosyltransferase1A10 which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon pphosphorylation. J Biol Chem, 279(27):28320-28329,2004. 7 19. Splendiani, G., Cipriani, S., Condò, S., Paba, P., Ciotti, M., Favalli, C., Vega, A., Dominijanni, S., and Casciani, C.U.. Polyoma virus BK and renal dysfunction in a transplanted population. Transplant Proc, 36(3):713-715,2004. 20. Branca, M., Ciotti, M., Santini, D., Di Bonito, L., Giorgi, C., Benedetto, A., Paba, P., Favalli, C., Costa, S., Agarossi, A., Alderisio, M., and Syrjänen, K. p16INK4a expression is related to grade of CIN and high-risk human papillomavirus but does not predict virus clearence after conization or disease outcome. Int J Gynecol Pathol, 23(4):354-365, 2004. 21. Branca, M, Ciotti, M, Santini, D, Di Bonito, L, Benedetto, A, Giorni, C, Paba, P, Favalli, C, Costa, S, Agarossi, A, Alderisio, M, and Syrjanen, K. Activation of the ERK/MAP kinase patway in cervical intraepithelial neoplasia is related to grade of the lesion but not to high-risk human papillomavirus, virus clearence, or prognosis in cervical cancer. Am J Clin Pathol, 122:902-911,2004. 22. Branca, M.., Costa, S., Mariani, L., Sesti, F., Agarossi, A., Di Carlo, A., Galati, M., Benedetto, A., Ciotti, M., Giorgi, C., Criscuolo, A., Valieri, M., Favalli, C., Paba, P., Santini, D., Piccione, E., Alderisio, M., De Nuzzo, M., Di Bonito, L., and Syrjanen,K.. Assessment of risk factors and Human Papillomavirus (HPV) related pathogenic mechanisms of CIN in HIV-positive and HIVnegative women .Study Design and Baseline Data of the HPV-PathogenISS Study. European Journal of Gynaecological Oncology , 25(6):689-698,2004. 23. Giuliani, L., Ciotti, M., Stoppacciaro, A., Pasquini, A., Silvestri, I., De Matteis, A.,Frati, L., and Aglianò, A.M..UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. Oncol Rep., 13(2):185-191,2005. 24. Branca, M, Giorgi, C, Santini, D, Di Bonito, L, Ciotti, M, Costa, S, Benedetto, A, Casolati, EA, Favalli, C, Paba, P, Di Bonito, P, Mariani, L, Syrjanen, S, Bonifacio, D, Accardi, L, Zanconati, F, Syrjanen,K. Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer. Am J Clin Pathol, 124(1):1-9,2005. 25. Branca, M, Giorgi, C, Santini, D, Di Bonito, L, Ciotti, M, Benedetto, A, Paba, P, Costa, S, , Bonifacio, D, Di Bonito, P, Accardi, L, Favalli, C, Syrjanen,K. Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high-risk HPV, but does not predict virus clearence after treatment of CIN or prognosis of cervical cancer. J Clin Pathol, 59:40-47, 2006. 26. Ciotti, M, Paba, P, Bonifacio, D, Di Bonito, L, Benedetto, A, Favalli, C. Single or multiple HPV types in cervical cancer and associated metastases. Oncol Rep, 15(1):143-148, 2006. 8 27. Branca, M, Ciotti, M, Giorgi, C, Santini, D, Di Bonito, L, Costa, S, , Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Syrjanen, S, Favalli, C, Syrjanen, K. Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIPM-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Anticancer Res 26:1543-1556, 2006. 28. Branca, M, Giorgi, C, Ciotti, M, Santini, D, Di Bonito, L, Costa, S, , Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Syrjanen, S, Favalli, C, Syrjanen, K. Relationship of up-regulation of 67 –kd laminin receptor to grade of cervical intraepithelial neoplasia and to high-risk HPV types and prognosis in cervical cancer. Acta Cytol ,50 (1):6-15,2006. 29. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, , Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Ruutu, M, Favalli, C, Syrjanen, K. Down-regulated nucleoside diphosphate NDP kinase nm23-H1 expression is unrelated to high-risk human papillomavirus but associated with progression of CIN and unfavourable prognosis in cervical cancer. J Clin Pathol, 59:1044-1051, 2006. 30. Ciotti, M, Giuliani, L, Ambrogi, V, Ronci, C, Benedetto, A, Mineo, CT, Syrjanen, K, Favalli, C. Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer. Oncol Rep , 16(1):183-189, 2006. 31. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, , Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Syrjanen, S, Favalli, C, Syrjanen, K. Down-regulation of E-cadherin is closely associated with progression of cervical intraepithelial neoplasia (CIN), but not with high-risk human papillomavirus (HPV) or disease outcome in cervical cancer. Eur J Gynaecol Oncol., 27(3):215-223, 2006. 32. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, , Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Ruutu M, Syrjanen S, Favalli, C, Syrjanen, K. Upregulation of nuclear factor-kB (NF-kB) is related to the grade of cervical intraepithelial neoplasia, but is not an indipendent predictor of high-risk human papillomavirus or disease outcome in cervical cancer. Diagn Cytopathol, 34(8):555-563, 2006. 33. Natoli, S, Ciotti, M, Paba, P, Testore, GP, Palmieri, G, Orlandi, A, Sabato, AF, Leonardis, F. A novel mutation of varicella-zoster virus associated to fatal hepatitis. J Clin Virol, 37:72-74, 2006. 34. Rezza, G, Valdarchi, C, Puzelli, S, Ciotti, M, Farchi, F, Fabiani, C, Calzoletti, L, Donatelli, I, Perno, CF.Respiratory viruses and influenza-like illness: a survey in the area of Rome, winter 2004-2005. Eur Surveill, 11 (10), 2006. 35. Ciotti, M, Coletti, A, Giuliani, L, Cappiello, G, Syrjanen, K, Favalli, C. The p53 codon 72 arg/arg homozygous women in Central Italy are at 9 increased risk for HPV infections. Anticancer Res, 26:3745-3748, 2006. 36. Giuliani, L, Coletti, A, Syrjanen, K, Favalli, C, and Ciotti, M. Comparision of DNA sequencing and Roche linear array in human papillomavirus (HPV) genotyping. Anticancer Res, 26:3939-3941, 2006. 37. Branca, M, Ciotti, M, Giorgi, C, Santini, D, Di Bonito, L, Costa, S, Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Syrjanen, S, Favalli, C, Syrjanen, K. Up-regulation of proliferatine cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancer. Eur J Obstet Gynecol Reprod Biol , 2006 [Epub ahead of print] 38. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Ruutu M, Syrjanen SM, Favalli, C, Syrjanen, K. Over-expression of Topoisomerase II α is related to the grade of cervical intraepithelial Neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment. Int J Gynecol Pathol, 25(4):383-392, 2006. 39. Branca, M, Giorgi, C, Ciotti, M, ,Santini, D, Di Bonito, L, Costa, S, Benedetto, A, Bonifacio, D, Di Bonito, P, Paba, P, Accardi, L, Mariani, L, Ruutu, M, Syrjanen, S, Favalli, C, Syrjanen, K. Upregulation of telomerase (hTERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papilllomavirus, virus persistence, or disease outcome in cervical cancer. Diagn Cytopathol 34:739-748, 2006. 40. Gentile, G, Picardi, A, Capobianchi, A, Spagnoli, A, Cudillo, L, Dentamaro, T, Tendas, A, Cupelli, L, Ciotti, M, Volpi, A, Amadori, S, Martino, P, de Fabritiis, P. A prospective study comparino quantitative cytomegalovirus (CMV) polymerase chain reaction in plasma and pp65 antigenemia in Monitoring patients after allogenic stem cell transplantation. BMC Infect Dis, 6:167, 2006. 41. Di Bonito, P, Grasso, F, Mochi, S, Accardi, L, Dona’, MG, Branca, M, Costa, S, Mariani, L, Agarossi, A, Ciotti, M, Syrjanen, K, and Giorgi, C. Serum antibody response to Human papillomavirus (HPV) infections detected by a novel ELISA technique based on denatured recombinant HPV16 L1, L2, E4, E6 and E7 proteins.Infect Agent Cancer , 1:6, 2006. 42. Orlandi, A, Francescani, A, Angeloni, C, Palmieri, G, Fulvia, G, Ciotti, M, Criscuolo, A, Sesti, F, Czernobilsky, B, and Spagnoli, L.G. Human papilloma virus infection of the vulva: comparision between clinical and pathological findings in relation to genotyping. Acta Obstet Gynecol Scand, 86:1003-10,2007. 10 43. Marchetti, S, Graffeo, R, Siddu, A, Santangelo, R, Ciotti, M, Picardi, A, Favalli, C, Fadda, G, Cattani, P. BK virus DNA detection by real-time polymerase chain reaction in clinical specimens. New Microbiologica, 30:119-26,2007. 44. Giuliani, L, Jaxmar, T, Casadio, C, Gariglio, M, Manna, A, D’Antonio, D,Syrjanen, K, Favalli, C, and Marco Ciotti. Detection of oncogenic viruses (SV40, BKV, JCV, HCMV, HPV) and p53 codon 72 polymorphism in lung carcinoma. Lung Cancer, 57:273-281, 2007. 45. Giuliani, L, Favalli, C, Syrjanen, K, and Ciotti, M. Human Papillomavirus Infections in Lung Cancer. Detection of E6 and E7 Transcripts and Review of the Literature. Anticancer Res, 27(40):2697-704,2007. 46. Marchetti, S, Graffeo, R, Siddu, A, Santangelo, R, Ciotti, M, Picardi, A, Favalli, C, Fadda, G, Cattani, P. BK virus DNA detection by real-time polymerase chain reaction in clinical specimens. New Microbiologica, 30:119-26,2007. 47. Mazibrada, J, Ritta’, M, Mondini, M, De Andrea, M, Azzimonti, B, Borgogna, C, Ciotti, M, Orlandi, A, Surico, N, Chiusa, L, Landolfo, S, Gariglio, M. Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis. Gynecol Oncol 2007 [Epub ahead of print]. 48. Benedetto, A, Giuliani, L, Paba, P, Favalli, C, and Ciotti, M.Evaluation of viral and cellular factors to assess the risk of oncogenesis by human papillomavirus. Res Adv Virol, 2, 2007 (Invited review). 49. Gravina, P, Ciotti, M, Masini, S, Valentini, A, Marcuccilli, F, Crocetta, N, Federici, G, Perno, CF, and Bernardini, S. Impact of storage conditions on genetic analysis or viral load determination in clinical specimens. Clin Chem Lab Med 2008. (In press) 11 Abstracts 1. Ciotti, M., Ritter, J:K., Yeatman, M.T., Kaiser, C., and I.S Owens. Bilirubin UDPglucuronosyltransferase specific mutations in the UGT1 gene complex. The FASEB Journal 7(7):A1022,1993. 2. Owens, I.S., Ritter, J.K., Chen, F., Ciotti, M. and M.T. Yeatman. Organization and alteration at the human UGT1 locus encoding multiple Phenol UGT isozymes. Glucuronidation Workshop-Pitlochry 22, 1993. 3. Ciotti, M., Huang, T., and I. S. Owens. Characterization of two micro-regions in the human major bilirubin UDP-glucuronosyltransferase isozyme. The FASEB Journal 8(7):A1062, 1994. 4. Owens , I.S., Ciotti ,M., and Huang, T. Structure-function relationship as defined by the characterization of the two conserved micro-regions in the human major bilirubin UDPglucuronosyltransferase isozyme. 10th International Symposium on Microsomes and Drug Oxidation 8, 1994. 5. Ciotti, M., Obaray, R., Martin, M. G., and I.S., Owens. Identification of a two-base mutation in the bilirubin UDP-glucuronosyltransferase at the UGT1 gene complex locus in two unrelated Crigler Najjar type I patients. The FASEB Journal 9(6): A63, 1995. 6. Rubaltelli, D., Ciotti, M., Rubaltelli, F.F., and I.S., Owens. Two differente missense mutations at the UGT1 gene complex locus that generate pH-sensitive activity of the major bilirubin UDP-glucuronosyltransferase in Crigler Najjar type II patients. . The FASEB Journal 9 (6):A64, 1995. 7. Ciotti, M, Chen, F., Ritter J.K., and I.S., Owens. Genetic-basis of impaired detoxification of bilirubin. The Second International Symposium on Fertility Regulation, Beijing, China, 1995. 8. Ciotti, M, Marrone, A., and I.S., Owens. Genetic polymorphism in HLUG-P1 gene. XIth International Symposium on Microsomes and Drug Oxidation L 100, 1996. 9. Ciotti, M, Rubaltelli, F.F., and I.S., Owens. Two missense mutations in the major bilirubin UDP-glucuronosyltransferase at the UGT1 gene complex locus that cause Crigler Najjar type II syndrome. International Perinatology Collegium 19, 1996. 10. Ciotti, M. and I.S. Owens. Comparison of bilirubin and 17Ethynylstradiol glucuronidation by HUG-Br1 and some of its mutants. The FASEB Journal 10 (6):A2212, 1996. 11. Cho, J.W., Huang T., Gholami, N., Potter C., Ciotti, M., and I.S., Owens. Extension of 12 the human UGT1 gene complex locus and characterization of some encoded isoforms. VIIth Glucuronidation Workshop on Glucuronidation, Iowa City, Iowa, 1996. 12. Ciotti, M., and I.S., Owens. Genetic polymorphism in Crigler-Najjar type I and II Syndrome and its relationship to hyperbilirubinemia. International Workshop, Riccione, Italy, 1996. 13. Ciotti, M., Rubaltelli, D., Rubaltelli, F.F., and I.S., Owens. Two different mutations in the TATA box element of the UGT1A gene are responsible for its reduced expression. Conference on treatment of Crigler Najjar syndrome. Rockefeller University, New York, N.Y., 1996. 14. Askari, F.K., Turcotte, J.K., Bromberg, J. G., Dickinson, C.J., Ciotti, M., and W. M., McDonnel. Infra-hepatic auxiliary liver transplantation with preservation of the entire native liver in the treatment of Crigler Najjar syndrome type I. Gastroenterology 9:A 1216, 1997. 15. Owens, I.S., Ciotti, M., Chen, F., and F.F., Rubaltelli. A common genetic defect between the Crigler Najjar type I and II diseases in the transcriptional TATA box promoter element of the bilirubin UDP-glucuronosyltransferase gene. 7th International Congress of Inborn Errors Metabolism: O65, 1997. 16. Ciotti, M, Marrone, A., and I.S., Owens. Genetic polymorphism in the human UGT1A6 gene : Pharmacological implications. The American Journal of Human Genetics 61(4): A1449, 1997. 17. Ciotti,M., Cho J.W., George J., and I.S., Owens. A required buried -helical structure in the human bilirubin UGT1A1 contains a non-replaceable phenylalanine. 12th InternationalSymposium on Microsomes and Drug Oxidation S2-1, 1998. 18. Gong, Q., Cho, J.W., George, J., Potter, C., Gholami, N., Ciotti, M., Hwang, M.S., and I.S.Owens. Completition of the description of the UGT1A locus and the partial characterization of its metabolic function. IXth International Workshop on Glucuronidation and the UDP-Glucuronosyltransferases, Brisbane, Australia, 1998. 19. Magnanti, M., Giuliani, L., Gandini, O., Gazzaniga, P., Ciotti, M., Aglianò, A.M. UDP-glucuronosyltransferase 1 isoform mRNA expression in rat testis. The Endocrine Society’s 81 Annual Meeting : P2-84, 1999. 20. Fontana, C., Ciotti, M., Pietroiusti, A., Luzzi, I., Capalbo, F., Pistoia, E.S., Marino, D., Favalli, C. Diagnosi su feci e diagnosi sierologica di Helicobacter Pylori. 27˚ Congresso Nazionale della Società Italiana di Microbiologia, Vol. III-C&M2:78, 1999. 21. Fontana, F., Ciotti, M., Pietroiusti, A., Giorgetti, G., Pistoia, E.S., Marino, D., Favalli, C. Diagnosi di H. Pylori: fattori interferenti. 27˚ Congresso Nazionale della Società Italiana di Microbiologia, Vol. III-C&M2:79, 1999. 13 22. Fontana, C., Ciotti, M., Pistoia, E.S., Capalbo, F., Favalli, C. Helicobacter Heilmannii: sospetto ruolo nella dispepsia gastrica. . 27˚ Congresso Nazionale della Società Italiana di Microbiologia, Vol. III-C&M2:79, 1999. 23. Basu, N., Ciotti, M., Hsai, N., and I.S. Owens. Detoxification of natural chemicals by a subset of the human family A UDP-glucuronosyltransferase isozymes. The FASEB Journal 633:A636,1999. 24. Fontana, C., Ciotti, M., Ciotti, L., Favaro, M., Pistoia, E.S., Marino, D., Capalbo, F., Favalli, F.. Incerta posizione tassonomica di Helicobacter Heilmannii. 28˚ Congresso Nazionale della Società Italiana di Microbiologia, Anno 2-N. 2:84, 2000. 25. Perri, D., Sciortino, M.T., Medici, M.A., Avitabile, E., Valveri, V., Ciotti, M., Matteucci, C., Amici, C., De Smaele, E., Mastino, A.. HSV-1 inibisce l’apoptosi mediata da Fas in cellule U937 mediante l’attivazione di NF-KB. 29˚ Congresso Nazionale della SocietàItaliana di Microbiologia, Anno 3-N.2:66, 2001. 26. Ciotti, M., Paba, P., Benedetto, A., Sesti, F., Criscuolo, A.A., Piccione, E., and Favalli, C..Correlazione tra citologia cervicale deponente per ASCUS e L-SIL e positività al test HPV alto rischio. Osservazioni preliminari. 30 Congresso Nazionale della Società Italiana di Microbiologia, Anno 4-N.1: 87, 2002. 27. Basu, N.K., Kole, L.A., Ciotti, M., Owens, I.S.. A novel human chemical defense system in the gastrointestinal tract regulated by PKC mediated phosphorylation and dietary constituents. The Faseb Journal 16(4): A150.5, 2002. 28. Sesti, F., Criscuolo, A.A., Ciotti, M., Paba, P., Benedetto, A., Favalli, C., Piccione, E.. HPV e alterazioni cellulari cervicali di basso grado. Osservazioni preliminari. XVII Congresso Nazionale della Società Italiana di Colposcopia e Patologia Cervico Vaginale, Roma 5-7 Dicembre 2002: 109-114,in Patologia Cervicovaginale: Dal laboratorio alla Clinica. Edizione Masson. 29. Sesti,F., Ciotti,M., Paba,P., Benedetto,A., Criscuolo,A., Branca,M., Favalli,C., and Piccione,E.. Use of HPV typing in management of women with ASCUS/LSIL. 5th International Multidisciplinary Congress Eurogin 2003. 30. Branca,M.,Giorgi,C.,Benedetto,A.,Favalli,C.,Ciotti,M.,Piccione,E.,Sesti,F.,Sbiroli,C., Mariani,L.,Vecchione,A.,Costa,S.,Santini,D.,Agarossi,A.,Di Carlo,A.,Di Bonito,L., Syrjanen.K.. Assessment of the risk factors,pathogenetic mechanisms and cervical cancer in HIV-positive and HIV-negative women with implications in screening and management (HPV-pathogenesis study). 5th International Multidisciplinary Congress Eurogin 2003. 31. Splendiani, G., Cipriani, S., Condò, S., Paba, P., Ciotti, M., Favalli, C., Vega, A., Muraca, F., Casciani, C.U.. Epidemiologia del polioma virus BKV in una popolazione di pazienti trapiantati. XXVII Congresso Nazionale S.I.T.O. 2003. 32. Ciotti, M., Paba, P., Ambrogi, V., Benedetto, A., Mineo, T.C., Favalli, C.. Cancro del 14 Polmone ed infezione da HPV. XXXIII Congresso Nazionale AMCLI, Firenze 14-17 Ottobre, Microbiologia Medica, 18(2): 161, 2003. 33. Ciotti, M., Paba, P., Ambrogi, V., Benedetto, A., Mineo, T.C., Syrjanen, K., Favalli, C.. Rilevazione di multipli genotipi di HPV nel cancro del polmone mediante ibridazione inversa. 31° Congresso Nazionale SIM, Bollettino SIM, Anno 5 (1): 82, 2003. 34. Paba, P., Ciotti, M., Benedetto, A., Syrjanen, K., Branca, M., Favalli, C.. Stato fisico ed Espressione di HPV nei carcinomi cervicali. 31° Congresso Nazionale SIM, Bollettino SIM, Anno 5 (1): 89, 2003. 35. Sciortino, M.T., Medici, M.A., Perri, D., Valveri, V., Ciotti, M., Camuti, A. P., Grelli, S., Mastino, A... Herpes simplex tipo 1 induce l’espressione di geni pro-sopravvivenza NF-KBdipendenti nelle fasi precocissime dell’infezione. 31° Congresso Nazionale SIM, Bollettino SIM, Anno 5 (1): 48, 2003. 36. Marchetti, S., Ciotti, M., Graffeo, R., Santangelo, R., Manzara, S., Siddu, A.., Della Monica, L., Splendiani, G., Cattani, P., Favalli, C., Fadda, G.. Diagnosi molecolare dell’infezione da polyomavirus umano BKV. 31° Congresso Nazionale SIM, Bollettino SIM, Anno 5 (1): 39, 2003. 37. Sesti, F., Ciotti, M., Paba, P., Benedetto, A., Altieri, A., Calugi, G., Criscuolo, A., Favalli, C., Piccione, E.. Role of HPV testing in the management of women with minor cervical lesions. 8th World Congress for Infectious and Immunological Diseases in Obstetrics and Gynaecology : 84, Venezia, 8-11 November, 2003. 38. Branca,M., Giorgi, C., Benedetto, A., Favalli, C., Ciotti, M., Piccione, E., Sesti, F., Sbiroli, C., Mariani. L., Costa, S., Santini, D., Agarossi, A., Di Carlo, A., Di Bonito, L., Syrjanen, K.. Assessment of risk factors and HPV-related pathogenetic mechanisms of CIN in HIVpositive and HIV-negative women. Implications in screening and patient managment. 21st International Papillomavirus Conference, Mexico City, Mexico, February 20-26,2004: A125. 39. Ciotti, M., Paba, P., Benedetto, A., Branca, M., Syrjanen, K., Favalli, C.. Expression of p16INK4a is a prognostic factor in cervical cancer, related to grade of CIN and high-risk human papillomavirus (HPV) but does not predict virus clearence after cone treatment. XXXIII Congresso Nazionale AMCLI, Padova, 8-11 Giugno, 2004, Vol. 19 (2): P170. 40. Ciotti, M., Paba, P., Benedetto, A., Branca, M., Syrjanen, K., Favalli, C.. L’espressione di p16INK4a è un fattore prognostico nel cancro della cervice, correlato al grado CIN e al papillomavirus ad alto rischio, ma non predice la clearence virale dopo conizzazione. 32° Congresso SIM, 26-29 Settembre,2004:A13. 41. Giuliani, L., Ciotti, M., Paba, P., Benedetto, A., Favalli, C.. Presenza di papillomavirus umano (HPV) in tumori polmonari non a piccole cellule. 2° Congresso Nazionale Società Italiana di Virologia Medica, 16-18 Maggio,2005:A36. 15 42. Ciotti, M., Paba, P., Benedetto, A., Bonifacio, D., Di Bonito, L., Favalli, C. HPV types in cervical carcinoma and associated metastases: can single cancer cells harbor multiple HPV genotypes? ESGO 14 meeting, 25-29 September, 2005, Instambul. 43. Coletti, A., Giuliani, L., Cappiello, T., Calugi, G., Ciotti, M., e Favalli, C. Polimorfismo al codone 72 della p53 e lesioni cervicali associate ad infezioni HPV ad alto rischio. 33° Congresso SIM, 16-19 Ottobre, 2005: 7. 44. Giuliani, L., Ciotti, M., Benedetto, A., Favalli, C. Presenza di papillomavirus umano (HPV) in tumori polmonari non a piccole cellule. Congresso SIM, 16-19 Ottobre, 2005: 70. 45. Calugi, G., Ciotti, M., Benedetto, A., D’Agostini, C., Grelli, S., Favalli, C. HIV menome and long term non progressor. Congresso SIM, 16-19 Ottobre, 2005: 5 46. Marchetti, S., Graffeo, R., Siddu, A., Ciotti, M., Santangelo, R., Manzara, S., favalli, C., e Fadda, G. Determinazione di poilomavirus BK mediante real-time PCR nel sangue di pazienti trapiantati di midollo. Congresso SIM, 16-19 Ottobre, 2005: 43. 47. Calugi, G., Ciotti, M., Benedetto, A., D’Agostini, C., Grelli, S., Favalli, C. HIV menome and long term non progressor. XXII Coferenza Nazionale di Citometria, 4-8 Ottobre, 2005: 28. 48. Grelli, S., D’Agostini, C., Ombres, D., Calugi, G., Ciotti, M., Montella, F., Vullo, V., Favalli, C., Vella, S., Macchi, B., and Mastino, A. Contribution of CD8+ cells to decreased levels of lymphocyte apoptosis in response to highly active antiretroviral therapy in HIV patients. . XXII Coferenza Nazionale di Citometria, 4-8 Ottobre, 2005: 32. 49. Marzano, V, Nuccetelli, M, Ciotti, M, Giuliani, L, Plachino, G, Urbani, A, Favalli, C, and Federici, G. Proteomic expression patterns in HPV-16 transfected human cell line: P6. Perspective of metabonomics and proteomics investigations in clinical science, 29-30 March, 2006, Fondazione Santa Lucia, Rome. 50. Parruti, G, Manna, A, Di Girolamo, A, Ciotti, M, Racciati, D, D’Amico, G, Favalli, C, Pizzigallo, E, D’Antonio, A. Diagnostic relevance of screening clinical specimens from patients attending infectious diseases and haematology units for HHV6 DNA: a two-year experience. 16th European Congress of Clinical Microbiology and Infectious Diseases, Nice 1-4, April 2006, France. 51. Ciotti, M, Marcuccilli, F, Guenci, T, Perno, CF. Confronto tra due dosaggiin Real-time per la determinazione quantitativa di HCV-RNA. XXXV Congresso AMCLI, Torino 19-22, Settembre, 2006: A87. 52. Lenci, I, Di Paolo, D, Tisone, G, Marcuccilli, F, Ciotti, M, Guerci, T, Perno, CF, Angelico, M. Covalently closet circular DNA (cccDNA) in post-transplant liver biopsies: a new tool to assess the need of continous prophylaxis against HBV recurrence. J Hepatol 46:S72, 2007. 16 53. Giuliani, L, Jaxmar, T, Casadio, C, Gariglio, M, Manna, A, D’Antonio, D,Syrjanen, K, Favalli, C, and Marco Ciotti. Detection of oncogenic viruses (SV40, BKV, JCV, HCMV, HPV) and p53 codon 72 polymorphism in lung carcinoma.7th National Congress of the Italian Society of Virology, Orvieto, 24-26 June, 2007:46. 54. Giorgi, C, Di Bonito, P, Grasso, F, Mochi, S, Accardi, L, Dona’ MG, Branca, M, Costa,S, Mariani, L, Agarossi, A, Ciotti, M, Syrjanen, K. Clinical and epidemiological correlates of antibody response to denatured recombinant human papillomavirus (HPV16) L and E antigens as measured by a novel ELISA. 7th National Congress of the Italian Society of Virology, Orvieto, 24-26 June, 2007:33. 55. Ciotti, M, Marcuccilli, F, Guenci, T, Belladonna, S, Pulvirenti, FR, Perno, FC. Evaluation of the new Abbott Realtime HBV assay. Third European Congress of Virology, 1-5 September, 2007:95. 56. Giorni, C, Di Bonito, P, Grasso, F, Mochi, S, Accardi, L, Dona’, MG, Branca, M, Costa, S, Mariani, L, Agarossi, A, Ciotti, M, Syrjanen, K. Clinical and epidemiological correlates of antibody response to denatured recombinant HPV16L and E antigens. Third European Congress of Virology, 1-5 September, 2007:95. 57. Giuliani, L, Casciani, S, Ronci, C, Massarelli, R, Federici, G, Favalli, C, Ciotti, M, and Dessi’, M. Detection of HPV, BKV, JCV and SV40 in urine of healthy individuals. Biochimica Clinica 31(5):414, 2007. 58. Dessi’, M, Giuliani, L, Casciani, S, Ronci, C, Federici, G, Favalli, C, Perno, CF, Ciotti, M. Ricerca di HPV, BKV, JCV e SV40 nell’urina di individui sani. Italian J Lab Med 3 (Sup):177,2007. 59. Ciotti, M, Marcuccilli, F, Guenci, T, Belladonna, S, Pulvirenti, FR, Perno, FC. Confronto tra due dosaggi in Real-time per la determinazione quantitativa di HBV-DNA. Microbiologia Medica 22(3):236, 2007. 60. Perno, CF, Marcuccilli, F, Bertoli, A, Ciotti, M, Lenci, I, Di Paolo, D, Angelico, M. HBV, cccDNA e resistenze. 35º Congresso Nazionale della Societa’ Italiana di Microbiologia, catania, 30 Sett-3 Ottobre, 2007:17. 61. Svicher, V, Giuliani, L, Coletti, A, Calugi, G, Perno, CF, Ciotti, M. Prevalence of human papillomavirus genotypes in a cohort from central Italy. 35º Congresso Nazionale della Societa’ Italiana di Microbiologia, catania, 30 Sett-3 Ottobre, 2007:45. 62. 17 18