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UNIT 2 PART 2: CELL DIVISION • All cells come from other cells. • Each round of cell growth and division is called the cell cycle. • For unicellular organisms, this is reproduction because it results in a new individual. 1 In a cell with a nucleus two processes take place: • Mitosis – The division of the nucleus – It has four stages • • • • Prophase Metaphase Anaphase Telophase • Cytokinesis – The division of the cytoplasm – Forms two separate cells – These cells are genetically identical Before mitosis the cell must grow and prepare. This happens during Interphase, where the cell spends most of its time. 2 Interphase • From the end of one division to the beginning of the next: G1, S, and G2. • This is when the cell grows, makes more organelles and proteins, and replicates the chromosomes so they become doubled. • Centrioles in animal cells also replicate. • During Interphase, the chromosomes are uncoiled, not visible, and called chromatin. 3 • Doubled chromosomes become visible. Prophase – Each strand is called a chromatid. – The chromatids are connected by a centromere. • Centrioles move to the poles. • Microtubules form asters and the spindle apparatus that stretches from pole to pole. • Nuclear membrane and nucleolus disappear. chromatids 4 Metaphase • Centromeres, which are connected to spindle fibers, line up in the middle of the cell on the metaphase, or equatorial, plane. • By the end of metaphase the centromeres divide and the chromatids become separate chromosomes. 5 Anaphase • The chromosomes are pulled to opposite poles by the spindle fibers so that there is one complete set at each end of the cell. 6 Telophase • The chromosomes reach the poles and will uncoil again into chromatin. • The spindles and asters disappear. • A nuclear membrane forms around each set of chromosomes forming two daughter nuclei. • Nucleoli reappear. 7 Cytokinesis: The formation of two separate identical cells • In animal cells the cell membrane pinches in until opposite sides touch and two new cells are formed. • In plant cells a cell plate forms between the two daughter nuclei and forms a new cell wall. 8 MITOSIS REVIEW - IPMAT • Interphase – chromatin and replication of DNA • Prophase – chromosomes visible • Metaphase – lined up in the middle • Anaphase – chromosomes move • Telophase – two new nuclei form 9 Mitosis Animation 10 Some Mitosis Facts • The two daughter cells made from mitosis are identical to each other and the parent cell. • Mitosis happens most often in least specialized cells like early embryos. 11 Some Mitosis Facts • Specialized cells like xylem, muscle, and nerve cells rarely, if ever, divide. • Places of growth like root tips, bone marrow, and skin have cells that divide rapidly. • A protein called cyclin regulates the cell cycle. 12