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1 Barbara C. Pence Updated 10/28/2008 CURRICULUM VITAE NAME: Barbara C. Pence ADDRESS: TTUHSC Office of Research, Room 2B106 Texas Tech University Health Sciences Center Lubbock, Texas 79430 Phone: (806) 743-2556 FAX: (806) 743-2656 e-mail: [email protected] PERSONAL: Place of Birth: Citizenship: Plainfield, NJ United States Citizen EDUCATION: B.A. 1977 Microbiology, Chemistry (minor) Texas Tech University, Lubbock, Texas M.S. 1979 Microbiology (Genetic Toxicology) Texas Tech University Thesis Title: "A Mutagenesis Assay for the Colon Carcinogen 1,2dimethylhydrazine" Ph.D. 1984 Experimental Pathology, Nutrition Texas Tech University Lubbock, Texas Dissertation Title: "A Multivariate Analysis of Dietary and Microbial Interactions in the Etiology of Colorectal Cancer" Health Organization Management (Certificate MBA Program) 1993 Texas Tech University Lubbock, Texas Certificate in Health Organization Management 2 Barbara C. Pence Updated 10/28/2008 PROFESSIONAL CERTIFICATION: CCRP (Certified Clinical Research Professional), SoCRA, 2005-present Postdoctoral Training 1986-87 Carcinogenesis U.T. M.D. Anderson Cancer Center Science Park-Research Division, Smithville, Texas National Cancer Institute Training Workshop "Histopathobiology of Neoplasia", June 21-28, 1986, Keystone, Colorado Armed Forces Institute of Pathology Training course: "Comparative Pathology", April 4-26, 1989, Washington, DC New England Biolabs Molecular Biology and Biotechnology Summer Workshop, July 17-30, 1994, Smith College, Northampton, MA POSITIONS HELD: 1977-1978 Teaching Assistant in Microbiology: Department of Biological Sciences, Texas Tech University, Lubbock, Texas 1978-79 Research Assistant: Environmental Protection Agency Screening Program, Texas Epidemiological Studies, Department of Biological Sciences, Texas Tech University, Lubbock, Texas 1979-1982 Laboratory Technician III: Division of Comparative Pathology, Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 1983-1985 Medical Research Technician III: Division of Vivarium Services, Texas Tech University Health Sciences Center, Lubbock, Texas 1985-1986 Postdoctoral Research Associate: Departments of Pathology and Vivarium Services, Texas Tech University Health Sciences Center, Lubbock, Texas 1985-present 3 Barbara C. Pence Updated 10/28/2008 Assistant - Professor (Adjunct), Division of Food and Nutrition, Texas Tech University; Member of Graduate Faculty, 1987-present 1986-1987 Postdoctoral Fellow: Department of Experimental Carcinogenesis, U.T. M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 1987-1992 Assistant Professor: Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas (TTUHSC) 1987-1992 Assistant Professor (Joint): Department of Biochemistry and Molecular Biology, TTUHSC 1989-2008 Member of Graduate Faculty, Department of Cell Biology and Biochemistry, TTUHSC 1992 - tenure awarded 1992-1996 Associate Professor, Department of Pathology, TTUHSC 1992-present Director of Research, Department of Pathology, TTUHSC 1993-present Adjunct Associate Professor of Animal Science and Food Technology, Texas Tech University 1995-present Joint Associate Professor of Radiology, TTUHSC 1996-1999 Assistant Director, Texas Tech University Institute for Biotechnology 1996-present Professor of Pathology, TTUHSC 1998-2008 Associate Vice President for Research; Associate Dean for Research and the Graduate School 4 Barbara C. Pence Updated 10/28/2008 SCIENTIFIC AND PROFESSIONAL SOCIETIES: American Association for Cancer Research American Society for Preventive Oncology American Association for Cancer Education American Institute of Nutrition Women in Cancer Research The Oxygen Society HONORS: Travel Grant: to attend XIII International Congress of Nutrition in Brighton, England, American Institute of Nutrition, 1985, $850 Postdoctoral Fellowship: National Research Service Award, Training Grant # CA09480 (T32), National Cancer Institute, 1986-88 Award for Outstanding Publication, Denver Wildlife Research Center, 1983 Soroptimist Club Mentor/Mentee Program: Mentor, 1991 Cited in Who's Who in Science and Engineering 1st Edition, 1992 - present. Cited in World Who's Who of Women, 12th Edition, 1993 - present. “Scientist of the Year”, ARCS, Lubbock, Texas Chapter, 1998. Member, Metabolic Pathology Study Section, National Cancer Institute, 19931997. Member, Board of Directors, Texas Society for Biomedical Research, 1998present Member, Nutritional Implementation Committee, Division of Cancer Prevention, National Cancer Institute, NIH, 1998-2000. Member, National Cancer Institute Subcommittee E, 2002-present. Member, National Toxicology Program Board of Scientific Counselors, 20022005 Distinguished Alumna, College of Human Sciences, Texas Tech University, 2002 5 Barbara C. Pence Updated 10/28/2008 Recipient: Marsha Sharp “Making a Difference for Women Award‟, from Soroptimist International, April 21, 2004. Member, Physicians Oncology Education Program Steering Committee, Texas Medical Association, 2005-present COMMITTEES: Texas Tech University Health Sciences Center: Founding Member, TTUHSC Institutional Biohazards Committee, 1988-1998; Chair, 1988-90 Member, TTUHSC Faculty Appointments Committee, 1988-1991, 1995-1998 Member, TTUHSC Admissions Committee, 1988-present Member, Research Strategic Planning Committee, TTUHSC, 1989 Member, TTUHSC Educational Policy Committee, 1989-1992; 1993-present; Chair, 1990-91 Member, TTUHSC Faculty Development Leave Committee, 1989 Member, TTUHSC Grading and Promotions Committee, 1990-1993; Chair, 1991-92 Member, TTUHSC Faculty Executive Council, 1991-1994 Member, TTUHSC Faculty Research Council, 1991-1994, 1995-1996 Member, TTUHSC Biochemistry Chair Search Committee, 1991 University Medical Center: Member, University Medical Center Cancer Committee, 1996-1998; member Cancer Audit Sub-Committee, 1991-1994 Member, Joint Strategic Planning Task Force, 2000 National Organizations: Vice-Chairperson, Planning Committee for 1991 FASEB Conference "Molecular Nutrition, Gene Expression and Carcinogenesis" Member, Membership Committee, American Association for Cancer Research, 1992-93, 1995-1996 Member, Program Committee, American Association for Cancer Research, 1994-95 Member, Program Committee, Women in Cancer Research, 1995-1996 Co-Chair, American Institute for Cancer Research Workshop “Diet, Nutrition and Cancer Prevention: Research Opportunities, Approaches and Pitfalls”, 1995 Co-Chair, American Association for Cancer Research Workshop “Nutrition and Cancer Prevention”, annual meeting, 1996 RESEARCH GRANTS AND SUPPORT: 6 Barbara C. Pence Updated 10/28/2008 Research Assistantship: Texas Epidemiologic Studies Project, Cooperative Agreement CR806904-01, Environmental Protection Agency, 1978-79 Grant: "Multiple Dietary Factors in the Promotion or Inhibition of Colorectal Cancer", Institute for Nutritional Sciences, Texas Tech University, 1983-84, $7,450 Grant: "Interactions of Dietary Factors as Modifiers of Colon Carcinogenesis", College of Home Economics Research Institute, Texas Tech University, 198384, $4000 Grant: "Effects of Calcium/Vitamin D Supplementation on Colon Carcinogenesis in Rats", Institute for Nutritional Sciences, Texas Tech University, 1985-86, $4780 Grant: "Development of a Colon Multistage Carcinogenesis Model", Texas Tech University Health Sciences Center Seed Research Grant Program, 1987-88, $5865 Grant: "Reactive Oxygen Species and Selenium Deficiency: Effects on Metabolism of 1,2-Dimethylhydrazine", Institute for Nutritional Sciences, Texas Tech University and Health Sciences Center, 1987-88, $5000 Grant: "Colon Multistage Model: Validation", Texas Tech University Health Sciences Center Seed Research Grant Program, 1988-89, $4000 Grant: "Beef Tallow and Oxidative Stress in Colon Carcinogenesis", National Livestock and Meat Board, 1988-89, $19,150 Grant: "Modulation of Murine Multistage Skin Carcinogenesis by Vitamin D 3", Institute for Nutritional Sciences, Texas Tech University and Health Sciences Center, 1988-89, $5600 Medical Student Summer Research Fellowship, TTUHSC, Summer, 1989 for R. Stephen Lawlis, $1500 Grant: Dietary Calcium and Multistage Skin Carcinogenesis", TTUHSC Seed Research Grant, 1989-90, $6000 Grant: Beef Tallow and Oxidative Stress in Colon Carcinogenesis", Institute for 7 Barbara C. Pence Updated 10/28/2008 Nutritional Sciences, Texas Tech University and Health Sciences Center, Student fellowship, 1990, $6000. Grant: Visiting Professor in Nutrition Program, National Dairy Council, March 1-2, 1990, $1500. Grant: "Beef Tallow versus Polyunsaturates: Production of Oxidant Damage Related to Colon Carcinogenesis", 1990, National Livestock and Meat Board, $22,909 Grant: "Antioxidant Status: Relevance to Colon Carcinogenesis and Tumor Promotion by Type of Dietary Fat", summer 1990, Institute for Nutritional Sciences, Texas Tech University and Health Sciences Center, $2500 Grant: "Beef Tallow and Oxidative Stress in Colon Carcinogenesis", summer 1990, Institute for Nutritional Sciences, Texas Tech University and Health Sciences Center, $600 Grant: "Antioxidant Status: Relevance to Colon Carcinogenesis and Tumor Promotion by Type of Dietary Fat", Institute for Nutritional Sciences, Texas Tech University and Health Sciences Center, 1990-91, $7500 Grant: "Calcium Inhibition of Colon Cancer Progression", National Institutes of Health # CA52006-01A1, 1/1/91 - 12/31/93, $267,517 Grant: "Antioxidant Defenses During Colon Carcinogenesis: Effects of Beef Tallow Versus Polyunsaturates", National Live Stock and Meat Board, 1/1/91 12/31/91, $33,424 Grant: "Elemental Versus Dairy Product Calcium: Implications for Colon Cancer Prevention", National Dairy Council, 1/1/91 - 12/31/93, $133,080 Grant: "Colon, Prostate and Cervical Cancer Control Program for Rural West Texas", Texas Cancer Council, 3/1/92 - 8/31/92, $25,000. Grant: "Participating Institution: Texas Community Oncology Network", UT MD Anderson Cancer Center, Co-Investigator, 7/1/92 - 3/31/94, $248,235. Grant: "West Texas Coalition for Cancer Control, Public Health Region 3", Texas Cancer Council, 9/1/92 - 8/31/93, $100,000. Grant: "West Texas Coalition for Cancer Control, Public Health Region 2", Texas Cancer Council, Co-Investigator, 9/1/92 - 8/31/93, $60,000. 8 Barbara C. Pence Updated 10/28/2008 Grant: "Lean Beef versus Total Fat in Colon Carcinogenesis", American Institute for Cancer Research, 1/1/93 - 12/31/94, $110,000. Grant: "HealthNet", Physicians's Oncology Education Program of the Texas Medical Association, 4/1/93 - 8/31/93, $15,000. Grant: "West Texas Coalition for Cancer Control, Public Health Region 3", Texas Cancer Council, 9/1/93 - 8/31/94, $89,000. Grant: “CATCHUM Project”, University of Texas Medical Branch at Galveston”, 4/1/93 -8/31/95, $15,000. Grant: “West Texas Coalition for Cancer Control, Public Health Regions 9 and 10”, Texas Cancer Council, 9/1/94 - 8/31/95, $101,689. Travel grant: To attend the 16th International Cancer Congress in New Delhi, India, October 30 - November 5, 1994, $3,000. Grant: “Meat Cooking Methods and Colon Carcinogenesis”, American Institute for Cancer Research, 1/1/95 - 12/31/96, $110,000. Grant: “Heme Iron from Beef and its Role in Colon Carcinogenesis”, Texas Tech University Institute for Nutritional Sciences, 9/1/94 - 8/31/95, $10,000, PI: Dr. Mark Miller. Grant: West Texas Coalition Against Cancer”, Texas Cancer Council, 6/1/95 8/31/95, $300,000, PI: Dr. Glen Roberson. Grant:Mentor, Summer Medical Student Research Fellowship, 1995, $1500. Grant: “West Texas Mammography Program”, Texas Cancer Council, 9/1/95 8/31/96, $184,846. Grant: “The CATCHUM Project”, National Cancer Institute 1 R25 CA65618-01, 4/1/95 3/31/98, subcontractee, PI: Billy U. Philips, $21,500 Grant: “Evaluation of the Roles of Antioxidant Nutrients in the Protection of Macromolecules, and Regulation of Apoptosis Following UVB Irradiation of Keratinocytes in Culture”, Institute for Nutritional Sciences, TTU, 9/1/95 8/31/96, $10,000 9 Barbara C. Pence Updated 10/28/2008 Grant: “Inhibition of Skin Cancer Growth by Selenium Compounds, E”.A. Franklin Endowment Fund, 1/1/96 - 12/31/97, $50,000 Grant: “Cooked Meat Mutagens and Increased Risk for Mammary Cancer”, Texas Tech University Institute for Nutritional Sciences, 9/1/96 - 8/31/97, $10,000 Grant: “West Texas Mammography Program”, Texas Cancer Council, 9/1/96 8/31/97, $194,539. Grant: “West Texas Mammography Program”, Texas Cancer Council, 9/1/97 8/31/98, $194,991. Grant: “Selenium: Antioxidant or Prooxidant Mechanism”, National Cancer Institute, R01 CA76675, 1/1/98 - 11/30/03, $739,785. Grant: “Development of a Genetic Counseling Service for Genetic Testing for Breast Cancer”, Lubbock Area Chapter of the Susan G. Komen Breast Cancer Foundation, 1/1/98 – 12/31/98, $10,000. Grant: “The CATCHUM Project”, National Cancer Institute 2 R25 CA65618-05, 4/1/98-3/31/03, B. Pence, subcontractee, PI: Billy U. Philips, $75,000. Grant: “Genetic Effects of Pesticide Exposure in the Aral Sea Region”, NATO, 5/1/00 – 4/30/02, B. Pence, collaborator, PI: Spencer Wells, $14,200. Grant: Neely Treadwell Cancer Investigator Award, Southwest Cancer Center, 11/1/03 –5/31/04, $15,000 Grant: “The CATCHUM Project”, National Cancer Institute 2 R25 CA6561809/26/03-10/1/08, B. Pence, subcontractee, PI: Billy U. Philips, $15,000. Grant: “West Texas Rural EXPORT Center”, (National Center for Minority Health and Health Disparities (NIH) 1 R24 MD0001097-01, 08/31/05-08/31/08. B. Pence, Director of Administrative and Research Cores, PI: Patti Patterson, $1, 225,125. Grant: “Bridging the Gap: A Patient-Centered Curriculum for Cultural Competence”, National Heart, Lung, and Blood Institute, 1 K07 HL81467-01A1, 09/30/06-08/31/11. B. Pence, Co-Investigator, PI: Lynn Bickley, $640,725. 10 Barbara C. Pence Updated 10/28/2008 Grant: “GTP and Tai Chi for Bone Health: A Pilot Study”, National Center for Complementary and Alternative Medicine (NIH), 1 R21 AT003735-01A1, 06/01/07–05/31/09. B. Pence, consultant, PI: Chwan-Li Shen, $445,500. RESEARCH INTERESTS: Cancer Chemoprevention Chemical Carcinogenesis Nutrition/Disease Interactions Toxicology Oxygen Radical Pathogenesis Heterocyclic Amine Carcinogenesis Selenium JOURNAL REVIEWER: Gastroenterology Cancer Research Carcinogenesis Nutrition and Cancer Cancer Letters Journal of Investigative Dermatology Journal of the National Cancer Institute Lipids Journal of Nutritional Biochemistry The Cancer Journal Archives of Biochemistry and Biophysics Journal of Wildlife Diseases Academic Medicine GRANT REVIEWER: *March of Dimes Grants Program: 1989, 1991 *AdHoc Member, Scientific Advisory Board, National Live Stock and Meat Board, 1991 *NIH, National Cancer Institute, special outside reviewer, Metabolic Pathology Study Section: 1991, 1992 *NSF, ASEND grant program - North Dakota, 1991, 1992 *Dept. of Veterans Affairs, Veterans Health Services and Research Administration: 1992 *NIH, National Cancer Institute, Ad Hoc Member, Metabolic Pathology Study Section: 1992-1993 *NIH, National Institute of General Medical Sciences, outside reviewer, 1992 11 Barbara C. Pence Updated 10/28/2008 *USDA Special Grants Program for Tropical and Subtropical Agriculture, 1993 *USDA Human Nutrition Grants Program, 1993, 1994-present *National Live Stock and Meat Board, grants review panel, 1993 *NIH, regular member, Metabolic Pathology Study Section, 1993-1997 *NCI, Special Review Committees for numerous RFA's, SEP‟s and site visits, 1993- present *U.S. Army Medical Research and Development Command, Special Reviewer for breast cancer research program, 1994. *Ad Hoc Reviewer, American Institute for Cancer Research grants program, 1995 *Member, scientific review panel, Susan G. Komen Foundation research grants program, 1995 *Member, American Institute for Cancer Research Review Panel I, 1996-present *Member, National Dairy Council Review Team, Dartmouth College Dairy Research Institute for Colon Cancer, 1995 *Member, US Army Medical Research and Development Command review panel for prostate cancer research program, 1998-2001 *Ad-hoc Member, National Cancer Institute Subcommittee E, 2001 (reviews Center Grants and Program Project grants) *Member, NIH National Cancer Institute Subcommittee E, 2002-present; Chair 2006-present *Member, Board of Scientific Counselors, National Toxicology Program, 20022005 INVITED SEMINARS: U.T. M.D. Anderson Cancer Center, Houston, Texas, Sept. 12, 1985, "Multiple Dietary Factors and Etiology of Colon Cancer" University of Arizona Cancer Center, Tucson, Arizona, Oct. 8, 1985, "Multiple Dietary Factors in the Etiology of Colorectal Cancer" Oklahoma State University, Stillwater, Oklahoma, Satellite Teleconference, "Calcium, Osteoporosis and Beyond" aired in February 1986, and "The Diet and Cancer Link" aired in December 1986 University of Texas at Austin, Austin, Texas, February 23, 1987, "Chemoprevention of Cancer: Role of Diet" as part of seminar series, "Nutrition, Immunology and Cancer" Fourth Texas Carcinogenesis Meeting, Smithville, Texas, October 3, 1987, "Calcium or Vitamin D Inhibition of Colon Carcinogenesis Promoted with Dietary Fat" 12 Barbara C. Pence Updated 10/28/2008 Panel Discussion, National Dairy Council, Chicago, Illinois, April 13, 1988, Nutrition Research Conference, "Update on Dietary Calcium and Cancer" Symposium speaker, Federation of American Societies for Experimental Biology Summer Research Conference: "Nutrients and Gene Expression in Carcinogenesis", July 30-August 4, 1989, Copper Mountain, Colorado Invited Seminar Speaker, University of Texas at El Paso, Department of Biology, "Oxygen Radicals in Tumor Promotion", October 20, 1989 Symposium speaker, "Nutrition and Cancer Prevention Conference", November 9, 1989, Austin, Texas, sponsored by the Austin Dietetic Association and the Texas Department of Health. Invited participant and speaker, National Cancer Institute-sponsored workshop on "Calcium, Vitamin D and Colon Cancer", Vail, CO, July 8-10, 1990. Invited speaker, "Partners in Prevention", American Cancer Society-sponsored symposium, October 11, 1990, Houston, Texas. Invited speaker, "Micronutrients and Colorectal Cancer Risk: Implications for Chemoprevention", 5th International Symposium on Colorectal Cancer, Turin, Italy, September 24-26, 1991. Invited speaker, "Calcium and Gastrointestinal Cancer", Dairy Council of Arizona Nutrition Conference "Targeting Trends in Nutrition and Cancer", Tempe, AZ, October 4, 1991. Invited seminar speaker, "Nutritional Modulation of Detoxification Systems", to Faculty of Toxicology, Texas A & M University, October 28, 1991. Invited speaker, "PKC: Implications for Colon Carcinogenesis", to Department of Gastrointestinal Oncology, Univ. of Texas M.D. Anderson Cancer Center, January 15, 1992. Invited speaker, "Role of Calcium in Colon Cancer Prevention: Experimental and Clinical Studies", at conference "Towards Reducing the Incidence of Colorectal Cancer: The Role of Inheritance and Diet", February 18, 1993, Aukland, New Zealand. Invited speaker, "National Dairy Board Annual Research Conference", Ashland, New Hampshire, May 4-5, 1993. 13 Barbara C. Pence Updated 10/28/2008 Panel Discussant, "Diet and Cancer Prevention", Rutgers University, June 11, 1993. Invited speaker, "Dietary Effects in Animal Models for Colon Cancer", M.D. Anderson Annual Clinical Conference on the Advances in the Biology and Therapy of Colorectal Cancer, November 6, 1993. Invited seminar, “Chemoprevention of Colon Cancer with Dietary Calcium: Animal Studies”, University of Texas Southwestern Medical School, December 2, 1993. Invited seminar, “UV-Induced Damage in Murine Epidermis: Role of Antioxidant Enzymes”, Oklahoma Medical Research Foundation, December 9, 1993. Symposium speaker, “Prevention of Colorectal Cancer: Dietary Recommendations and Clinical Trials”, POEP conference, Colorectal Cancer: Detection, Prevention, Treatment, Lubbock, Texas, June 18, 1994. Invited speaker: “Local Health Services Research using Tumor Registry Data”, Texas Tumor Registrars State Meeting, Lubbock, Texas, October 27, 1994. Symposium speaker, “Modulation of Oxidative Damage to DNA by Sodium Selenite via the Mechanism of Apoptosis”, Sixth International Symposium on Selenium in Biology and Medicine, Beijing, China, August 20, 1996. Invited speaker, “Is Well-cooked Meat a Cause of Human Cancer?”, Friday Seminar Series, University of Texas M.D. Anderson Cancer Center, September 20, 1996. Invited speaker, “West Texas Cancer Prevention Partnership”, University of Texas System Texas-Mexican Border Health Symposium, South Padre Island, Texas, October 25, 1996. Invited speaker, “Red Meat, Heterocyclic Amines, and Human Cancer”, University of South Carolina Cancer Center, October 23, 1998. Invited speaker, “Nutrition: The Forgotten Ingredient in Cancer Care”, TaylorJones-Haskell County Medical Society, sponsored by POEP, Abilene, TX, May 18, 2000. 14 Barbara C. Pence Updated 10/28/2008 Invited speaker: “Nutrition and Cancer Therapy: The Good, the Bad and the Ugly”, presented at POEP symposium at TMA Annual Meeting, San Antonio, TX, May 27, 2000. Invited speaker:, “Is well-cooked meat a cause of human cancer?”, presented at workshop “What‟s new in Diet and Cancer Prevention?”, presented at Annual Meeting of American Dietetic Association, Denver, CO, Oct. 16, 2000. Invited speaker: “Nutrition and the Cancer Patient”, presented at Texas Oncology Nurses Association, Dallas, TX, April 27, 2001. Keynote speaker: “Nutrition and Cancer: From Prevention to Survivorship”, 45th Annual Nutrition and Food Service Seminar, University of Texas, Austin, TX, March 21, 2002. Invited speaker: “Cancer – What Primary Care Physicians Need to Know”, presented at POEP symposium at TMA Annual meeting, Dallas, TX, April 20, 2002. Invited speaker: “Nutrition and Cancer: From Prevention to Survivorship”, presented at the Lubbock, Crosby, Garza County Medical Society meeting, May 8, 2004. Invited speaker: “Nutrition and Cancer: From Prevention to Survivorship”, presented at the Lubbock chapter of the Susan G. Komen Foundation, May 8, 2004. Invited speaker: “Nutrition and Cancer”, UMC Southwest Cancer Research and Treatment Center „Well-Informed‟ public lecture, presented August 24, 2004. Invited speaker: “Symposium 2005: IRB Best Practices”, UT Southwestern, May 11-12, 2005. Presenter: “Obesity and Cancer”, CNNT Cancer Survivors‟ Workshop, ACS, Lubbock, TX, August 28, 2006. Invited Participant: “Eliminating Disparities in Clinical Trials (EDICT): Formulating Policies” Roundtable, Houston, TX, September 6-8, 2006. Invited speaker: “Clinical Research: What comes after the guinea pigs?” Southwest Cancer Center Public Lecture, Lubbock, TX, November 2, 2006. 15 Barbara C. Pence Updated 10/28/2008 Roundtable presentation at AAMC GREAT meeting on training graduate students for translational and clinical research, April 27, 2007 Invited Presentation to SACHRP (Secretary‟s Advisory Committee on Human Research Protections): “Eliminating Disparities in Clinical Trials” on July 31, 2007, Washington, DC Panel discussion/presentation: “Eliminating Disparities: The Scientific Perspective” at PRIM&R meeting, December 4, 2007 National Press Conference: “EDICT Recommendations for Clinical Trials”, National Press Club, Washington DC, April 1, 2008. ABSTRACTS: 1. Felkner, I.C., M.J. Wargovich and B.C. Wells. 1981. Colon cancer induced in rats by 1,2-dimethylhydrazine: parallel mutagenesis and enzymology monitored by a Bacillus subtilis detector system. In: Abstracts of the January 1981 Workshop, "The Large Bowel Cancer Program: Its Achievements and Future Investigation". 2. Wells, B.C., M.J. Wargovich and I.C. Felkner. 1981. Characterization of interactions affecting mutagenic activity of the colon carcinogen, 1,2-dimethylhydrazine. Annual Meeting of the American Society for Microbiology, Dallas, Texas. 3. Pence, D.B., B.C. Wells and L. Windberg. 1981. Sarcoptic mange in south Texas coyotes. Annual Meeting of the Wildlife Disease Association, Laramie, Wyoming. 4. Pence, D.B. and B.C. Wells. 1982. Epizootiology of sarcoptic mange in south Texas coyotes. Fifth International Congress of Parasitology, Toronto, Canada (Abstracts, In: Mol. Biochem. Parasitol. Suppl., p. 570). 5. Pence, B.C. and F. Buddingh. 1984. Dietary selenium deficiency and 1,2dimethylhydrazine-induced colon cancer. Fed. Proc. 43: 794. 6. Pence, B.C. and F. Buddingh. 1984. Effects of selenium deficiency on 1,2dimethylhydrazine-induced colon cancer in rats. Third International Symposium on Selenium in Biology and Medicine, Beijing, China. 7. Pence, B.C. 1985. Dietary cholesterol effects on fecal levels of Bacteroides fragilis group organisms. Annual Meeting of the American Society for Microbiology, Las Vegas, Nevada. 16 Barbara C. Pence Updated 10/28/2008 8. Pence, B.C., S.P. Yang and F. Buddingh. 1985. Multiple dietary interactions in the promotion of colon cancer in rats. Fed. Proc. 44: 1499. 9. Pence, B.C., F. Buddingh and S.P. Yang. 1985. Enhancement of 1,2dimethylhydrazine tumorigenesis by dietary cholesterol, beef fat and indole-3carbinol. Proc. American Association for Cancer Research 26: 124. 10. Pence, B.C., S.P. Yang and F. Buddingh. 1985. A model for the study of the effects of complex dietary interactions on carcinogenesis. Abstracts, XIII International Congress of Nutrition, Brighton, England 11. Buddingh, F. and B.C. Pence. 1985. Enhancement of 1,2-dimethylhydrazine tumorigenesis by dietary cholesterol, beef fat and indole-3-carbinol. Annual Meeting of the Texas Branch of the American Association for Laboratory Animal Science, Arlington, Texas. 12. Pence, B.C. and F. Buddingh. 1986. Dietary effects on lipid peroxides and uric acid in rat serum. Fed. Proc. 45: 1076. 13. Pence, B.C., S.C. Buessow, M.T. Yang, S.P. Yang and F. Buddingh. 1986. Effect of selenium and molybdenum supplementation on K562 erythroleukemia cells in culture. Fifth Joint Meeting of the American Institute of Nutrition, American Society for Clinical Nutrition and the Canadian Society for Nutritional Sciences, Davis, California. J. Nutr. 116: xxxi. 14. Pence, B.C. and F. Buddingh. 1987. Inhibition of dietary fat promotion of colon carcinogenesis by supplemental calcium or vitamin D. Proc. American Association for Cancer Research 28: 154. 15. Reiners, J.J.Jr. and B.C. Pence. 1987. 12-O-Tetradecanoylphorbol-13-acetatedependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis. Proc. American Association for Cancer Research 28: 160. 16. Pence, B.C. 1989. Reactive oxygen species and selenium deficiency: toxic effects of 1,2-dimethylhydrazine. FASEB J. 3: A779. 17. Pence, B.C. and M.F. Naylor. 1989. Effects of single-dose ultraviolet light on superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase in Skh:HR-1 mouse epidermis. Proc. American Association for Cancer Research 30: 200. 17 Barbara C. Pence Updated 10/28/2008 18. Pence, B.C., Demick, D.S. and F. Buddingh. 1989. Effective control of Myobia spp. in laboratory mice with chlorpyrifos (DursbanTM). Annual Meeting of Texas Branch of the American Association for Laboratory Animal Science, Fort Worth, Texas. 19. Kuratko, C.N. and B.C. Pence. 1989. The effect of different dietary fats on oxygen radical detoxication in rat colon. Annual Meeting of the American Dietetic Association, Kansas City, Missouri. J. Amer. Dietetic Assoc. 89: A-59, 1989. 20. Kuratko, C.N. and B.C. Pence. 1990. Effect of different dietary fats and 1,2dimethylhydrazine on oxygen radical detoxification in rat colon. FASEB J. 4: A666. 21. Pence, B.C., Lawlis, R.S. and C.N. Kuratko. 1990. Effect of dietary vitamin D3 on mouse skin tumor promotion. Proc. Amer. Assoc. for Cancer Res. 31: 143 (A850). 22. Pence, B.C., Kuratko, C.N. and S.-Y. Tsai. 1990. Dietary fat effects on antioxidant status of rat colon: implications for carcinogenesis. To be presented at "Oxidative Damage and Repair", November 14-20, Pasadena, CA. Free. Rad. Biol. Med. 9 Suppl.: 164. 23. Tsai, S.-Y., Richard, B.C. and B.C. Pence. 1991. Effects of dietary fat on hepatic microsomal metabolism of 1,2-dimethylhydrazine. FASEB J. 5: A926. 24. Kuratko, C.N., Tsai, S.-Y. and B.C. Pence. 1991. Effects of dietary fat and 1,2dimethylhydrazine on hepatic microsomal lipid peroxidation. FASEB J. 5: A1281. 25. Pence, B.C. and G.S. Cameron. 1991. Effects of multiple applications of tumor promoters and ultraviolet radiation on epidermal proliferation and antioxidant status. Proc. Amer. Assoc. for Cancer Res. 32: 150 . 26. Pence. B.C. 1991. Do dietary fats promote colon cancer by inducing oxidative stress? NIH Workshop: Cellular and Molecular Targets for Chemoprevention, March 16-19, 1991, Charleston, SC. 27. Pence, B.C. 1991. Micronutrients and colorectal cancer risk: implications for chemoprevention. Proc. 5th International Symposium on Colorectal Cancer. Torino, Italy, p. 54. 28. L.S. Binder, J. Brown III, E.J. Wheeler, J.A. Chappell, T. McMahon, P. Doris, B. Pence, R. Rolfe, P. Castiglia, R. Elizondo, R. Brands, A. Reynolds, D. Mahr, S. 18 Barbara C. Pence Updated 10/28/2008 Reding, J. Barber, and P. Duarte. 1991. The W.K. Kellogg Foundation's community partnership with health professions education (CP/HPE): The Texas Tech model emerges. Proc. Assoc. American Medical Colleges Annual Meeting. 29. Pence, B.C., Zhao, C. and S. Hunter. 1992. Elemental versus dairy calcium: effects on colonic protein kinase C and ornithine decarboxylase. FASEB J. 6: A1494. 30. Tsai, S.-Y., Dunn, D.M. and B.C. Pence. 1992. Colonic antioxidant status during dimethylhydrazine carcinogenesis: effects of type and amount of dietary fat. FASEB J. 6: A1395. 31. Pence, B.C., Dunn, D.M., Zhao, C. Hunter, S. and M.J. Wargovich. 1992. Modulation of rat colonic protein kinase C and ornithine decarboxylase by dietary calcium. Proc. Amer. Assoc. for Cancer Res. 33: 130 (779). 32. Pence, B.C. 1993. Role of calcium in colon cancer prevention: experimental and clinical studies. Presented at conference, "Towards Reducing the Incidence of Colorectal Cancer: The Role of Inheritance and Diet", Aukland, New Zealand, Feb. 15-19, 1993. 33. Tsai, S.-Y. and B.C. Pence. 1993. Effect of type and amount of dietary lipid on colonic nuclear aberrations during colon carcinogenesis. FASEB J. 7:A174. 34. Delver, E. and B.C. Pence. 1993. Effects of dietary selenium level on UV-induced skin cancer and epidermal antioxidant status. FASEB J. 7:A290. 35. Pence, B.C., Zhao, C., Hunter, S. and M.J. Wargovich. 1993. Compartmentalization of calcium, free fatty acids and bile acids in rats fed cholic acid and CaCO3. Gastroenterology 104:A440. 36. Pence, B.C., Dunn, D.M., Zhao, C., Landers, M. and M.J. Wargovich. 1994. Experimental chemoprevention of colon carcinogenesis by combined calcium and aspirin. Proc. Amer. Assoc. Cancer Res. 35: 624. 37. Pence, B.C., Dunn, D.M., Zhao, C. and M. Landers. 1994. Elemental vs. dairy product calcium in experimental colon cancer prevention. FASEB J. 8:A426. 38. Zhao, C., Landers, M., Butler, M., Miller, M. and B.C. Pence. 1994. Effects of beef protein and fat source on serum iron status in rats. FASEB J. 8:A721. 19 Barbara C. Pence Updated 10/28/2008 39. Pence, B.C., Zhao, C., Landers, M. and M.J. Wargovich. 1994. Modulation of colonic protein kinase C by dietary bile acids, calcium carbonate, and aspirin. Proc. XVI Internatl.Cancer Congress, Delhi, India. 40. Ronaghan, C.A. and B.C. Pence. 1994. Strategies for cancer control program implementation in rural regions. Proc. XVI Internatl. Cancer Congress, Delhi, India. 41. Pence, B.C., Dunn, D.M., Zhao, C., Landers, M. and M.J. Wargovich. 1994. Validation of intermediate biomarkers during experimental colon carcinogenesis in rats. Gastroenterology, 106, A427. 42. Landers, M., Dunn, D.M., Zhao, C., B.C. Pence and M.J. Wargovich. 1994. Promotional effects of lactose feeding on small bowel tumorigenesis in an experimental animal model of colon carcinogenesis, Gastroenterology, 106, A407. 43. Butler, M.J., Miller, M.F. and B.C. Pence. 1994. Lack of colon promoting carcinogenesis by beef in the rat model. Annual Meeting of the American Meat Science Association. 44. Kuratko, C.N. and B.C. Pence. 1994. Dietary lipid and iron modify normal colonic mucosa without affecting phospholipase A2 activity. American Institute for Cancer Research meeting, Washington, D.C. 45. Pence, B.C., Butler, M.J., Dunn, D.M. and M.F. Miller. 1994. Non-promoting effects of lean beef in the rat colon carcinogenesis model. American Institute for Cancer Research meeting, Washington, D.C. 46. Kuratko, C.N. and B.C. Pence. 1995. Fatty acid composition of colon mucosa is altered by dietary lipid and iron without affecting phospholipase A 2 activity. Proc. Amer. Assoc. Cancer Res. 36, 115 (#682). 47. Stewart, M.S., Cameron, G.S., Harris, B.D. and B.C. Pence. 1995. Modulation of UVB-induced oxidative damage to DNA in murine keratinocytes by sodium selenite. Proc. Amer. Assoc. Cancer Res., 36, 113 (# 669). 48. Stewart, M.S., Cameron, G.S. and B.C. Pence. 1995. Modulation of ultraviolet B light-induced oxidative damage by vitamins C and E. FASEB J. 9: A988 (#5736). 49. Walsh, L.P. and B.C. Pence. 1995. Induction of apoptosis by sodium selenite in human colonic carcinoma cells. Gastroenterology 108, A550. 20 Barbara C. Pence Updated 10/28/2008 50. Philips, B.U. Jr., M. Becker, J.R. Bowling, E. Buck, C.O. Freytes, J.B. Green, L. Kirk, B.C. Pence, J. Shores and A. Weinberg. 1995. Impact evaluation drives strategic planning in cancer education: The Texas consortium. Annual meeting, American Association for Cancer Education. 51. Philips, B.U. Jr., J.B. Battles, M. Becker, J.R. Bowling, C. Browne, E. Buck, M. Calloway, C.O. Freytes, J.B. Green, L. Kirk, B.C. Pence, J. Shores, J. Sprankell and A. Weinberg. 1995. OSCE‟s: A teaching tool in cancer prevention, detection and control. Annual meeting, American Association for Cancer Education. 52. Becker, M., Battles, J.B., Bowling, J.R., Brown, C., Buck, E., Callaway, M., Freytes, C.O., Green, J.B., Kirk, L., Pence, B.C., Philips, B.U., Shores, J., Sprankell, J., and Weinberg, A. 1995. A template for longitudinal clinical performance assessment. Annual meeting of Generalists in Medical Education, Washington DC. 53. Battles, J.B., Becker, M., Bowling, J.R., Brown, C., Buck, E., Callaway, M., Freytes, C.O., Green, J.B., Kirk, L., Pence, B.C., Philips, B.U., Shores, J., Sprankell, J., and Weinberg, A. 1996. Intra-institutional multi-level OSCE stations for screening and detection of cancer. Presented at international OSCE meeting at Maastricht, the Netherlands. 54. Stewart. M.S. and Pence, B.C. 1996. Modulation of UVB-induced oxidative damage to DNA of murine keratinocytes by sodium selenite: lack of effect on repair. Proc. Amer. Assoc. Cancer Res. 37: 143 (#988). 55. Stewart, M., Dixon, M. and Pence, B.C. 1996. Changes in activity of antioxidant enzymes in mouse keratinocytes following UVB irradiation. FASEB J.10: A740 (#4281). 56. Pence, B.C., Landers, M. and Walsh, L.P. 1996. Induction of heterocyclic amine metabolism in rats by diets containing well-browned beef and a high fat content. Gastroenterology 109, A575. 57. Pence, B.C., Stewart, M., Walsh, L. and Cameron, G. 1996. Modulation of oxidative damage to DNA by sodium selenite via the mechanism of apoptosis. Proceedings of the Sixth International Symposium on Selenium in Biology and Medicine, Beijing, China, August 18-23. 58. Pence, B.C., Shen, C.-L., Landers, M. and Walsh, L.P. 1996. Induction of heterocyclic amine metabolism in rats by diets containing well-browned beef and a high fat content. Proceedings of the Annual Research Conference of the American Institute for Cancer Research, Washington, D.C., August 29-30. 21 Barbara C. Pence Updated 10/28/2008 59. Morell, S.R., Battles, J.B., Becker, M., Bowling, J.R., Buck, E., Freytes, C.O., Green, J.B., Laufman, L., Pence, B.C., Shores, J., Weinberg, A. and Philips, B.U. 1996. A template for the creation of an educational Internet Site. J. Cancer Educ. 1996, 11:26 (#64). 60. Stewart, M., Spallholz, J., Neldner, K., and Pence, B.C. Disparate protective effects of selenite, selenocystamine, and selenomethionine in keratinocytes. Experimental Skin Carcinogenesis Conference, Bastrop, Texas, October 28-31, 1996. 61. Stewart, M.S. and Pence, B.C. 1997. Selenium compounds differ in their abilities to exert prooxidant effects and induce apoptosis in UVB-exposed keratinocytes. Proc. Amer. Assoc. Cancer Res.38: 79 (#529). 62. Davis, R.L., Spallholz, J.E., and Pence, B.C. 1997. Copper inhibits seleniteinduced cytotoxicity in human colonic carcinoma cells (HT29). FASEB J. 11: A403 (#2333). 63. Shen, C.-L., Purewal, M., San Francisco, S. and Pence, B.C. 1997. Absence of PhIP adducts and p53 mutations in rats fed a cooked beef diet containing high levels of heterocyclic amines. FASEB J. 11: A572 (#3328). 64. Stewart, M.S., Spallholz, J.E., Neldner, K. and Pence, B.C. 1997. Cytotoxicity of selenium compounds to cultured normal primary human keratinocytes and squamous cell carcinoma cells. FASEB J. 11: A403 (#2332). 65. Kuratko, C., Brinlee, R. and Pence, B.C. 1997. N-acetyl transferase activity is decreased in rats fed high fat diets containing menhaden oil. FASEB J. 11: A578 (#3345). 66. Pence, B.C., Landers, M., Dunn, D.M., Shen, C.L., and Miller, M.F. 1997. Enhancement of colon and stomach carcinogenesis in rats fed a diet containing well-cooked meat with a high heterocyclic amine content. Gastroenterology 112: A638. 67. Stewart, M., Grimson, M., Pence, B., and Bornhop, D., 1998. Polyazamacrocyclic Tb chelates: Investigations using a new biomarker for early detection of colon cancer. Proc. Am. Assoc. Cancer Res. 39: 337 (#2296). 68. Shen, C.-L., Cowden, K.D., and Pence, B.C. 1998. Increasing levels of PhIP in the diet alter the activity of heterocyclic amine metabolizing enzymes in liver, stomach, 22 Barbara C. Pence Updated 10/28/2008 and colon of female Sprague-Dawley rats. Proc. Am. Assoc. Cancer Res.39:16 (#106). 69. Davis, R.L., Spallholz, J.E., and Pence, B.C. 1998. Copper inhibits seleniteinduced apoptosis and DNA fragmentation in human colonic carcinoma cells. FASEB J. 12: A564 (#3273). 70. Philips, B.U., Battles, J.B., Bowling, J.R., Bramson, R., Camp, M., Chang, H.M., Freytes, C.O., Kuratko, C., Laufman, L.E., Pence, B.C., Shores, J.H., Weinberg, A., and Burt, T.M. 1998. The Implementation of technology-based information into the Texas Medical School Consortium. J. Cancer Educ. 13S: 28 (#116). 71. Shen, C.-L., Song, W., and Pence, B.C. 1999. Comparative abilities of selenium compounds in protection against UVB damage in normal human keratinocytes. Proc. Am. Assoc. Cancer Res. 40:360 (#2384). 72. Shen, C.-L., Song, W., and Pence, B.C. 1999. Differential antioxidant and apoptotic effects of selenium compounds on human skin cells. FASEB J. 13: A247 (218.2). 73. Kuratko, C.N., Jones, B.G., Chauncey, K.B., Kirby, R.K., and Pence, B.C. 1999. Assessment of nutrition knowledge and attitudes of medical students graduating from a four-year traditional curriculum. FASEB J. 13: A550 (440.17). 74. Chauncey, K., Kirby, R.K., Jones, B.G., Kuratko, C.N., and Pence, B.C. 1999. Nutrition knowledge scores: Graduating family practice residents vs. graduating medical students. Annual meeting, Society for Teachers of Family Medicine. 75. Shen, C.-L., Song, W., and Pence, B.C. 2000. Effects of selenium compounds plus other antioxidants on cytotoxicity and DNA oxidative damage in normal human keratinocytes. FASEB J. 14: A537 #372.7. 76. Shen, C.-L., Song, W., and Pence, B.C. 2000. Effects of selenium compounds plus esterified glutathione on cytotoxicity, cellular glutathione level, and DNA oxidative damage in normal human keratinocytes. Proc. Am. Assoc. Cancer Res. 41: 340 (#2160). 77. Chauncey, K., Kuratko, C., Jones, B.G., Homan, R.V., and Pence, B.C. 2000. Charting a course for integrating nutrition training into medical education. Annual Meeting, AAMC, October 28-November 3, 2000, Chicago, IL. 23 Barbara C. Pence Updated 10/28/2008 78. Shen, C.-L., Song, W., and Pence, B.C. 2001. Effects of selenium compounds plus ultraviolet B on glutathione peroxidase and DNA oxidative damage in skin of Skh:HR-1 hairless mice. Proc. Am. Assoc. Cancer Res. 42: 464 (#2496). 79. Shen, C.-L., Song, W., and Pence, B.C. 2001. Differential apoptotic effects of selenium compounds on human colonic carcinoma cells. FASEB J. 15: A967 (#744.6). 80. Liu, Z., Shen, C.-L., Pence, B.C., and Kuratko, C.N. 2001 Production of inflammatory mediators during early colon carcinogenesis is increased by N-6 fatty acids. American J. Clin. Path. 116:611. 81. Shen, C.-L., Song, W., and Pence, B.C. 2002. Effects of dietary selenium compounds and glutathione modifiers on epidermal reduced glutathione in the ultraviolet light-exposed Skh: HR-1 mouse model. Proc. Am. Assoc. Cancer Res. 43: 1143-44 (#5667). 82. Pence, B.C., Shen, C.-L., and Song, W. 2002. Effects of dietary selenium compounds plus ultraviolet light on epidermal glutathione in the Skh: HR-1 hairless mouse model. Proc. Am. Assoc. Cancer Res. 43: 1144 (#5668). 83. Pence, B.C., Shen, C.-L., and Song, W. 2002. Effects of dietary selenium compounds and glutathione modifiers on epidermal glutathione peroxidase in the ultraviolet light-exposed Skh: HR-1 mouse model. FASEB J. 16: (A 605). 84. Shen, C.-L., Oetama, B., Henry, J., and Pence, B. 2002. Differential effects of selenium compounds on nitric oxide production in an induced oxidative stress human osteoarthritic chondrocyte model. FASEB J. 16: (LB 286). 85. Shen, C.-L., Graham, S., Morgan, D.L., Oetama, B., Brewton, L., and Pence, B. 2002. Differential effects of selenium compounds on glutathione peroxidase and reduced glutathione in oxidative stress-induced human osteoarthritic synoviocyte model. FASEB J. 16: (LB 287). 86. Pence, B. and Chaffin, W.L. 2002. First experience with a required RCR Course: Summary of responses to a student survey. AAMC GREAT meeting, Denver, CO. 87. K.-J. Hong, D. M. Dunn, D.-F. Lo, C.-L. Shen, and B. C. Pence. 2003. Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells. Proc. Am. Assoc. Cancer Res.44: 425 (#1872). 24 Barbara C. Pence Updated 10/28/2008 88. K.-J. Hong, C.-L. Shen, and B. C. Pence. 2003. Apoptotic effects and antiinflammatory function of different selenium compounds in HT-29 colonic carcinoma cells. Proc. Am. Assoc. Cancer Res. 44: 893.(#3903). 89. K-J. Hong, C.N. Hostrup, C-L. Shen and B.C. Pence. 2003. Inhibitory effects of Ling Zhi (Ganoderma lucidum) extract on inflammation and cytokine expression in human colonic carcinoma cells. FASEB J. 17:178 (#457.8). 90. C.N. Hostrup, K-J. Hong, D.M. Dunn, C-L. Shen and B.C. Pence. 2003. Antioxidant and anti-inflammatory effects of herbal treatment Ling Zhi (Ganoderma lucidum), on human colonic carcinoma (HT-29) cells. FASEB J.17:178 (#457.9). 91. K-J. Hong, C-L. Shen and B.C. Pence. 2003. Differential effects of selenium compounds on inflammation and cytokine expression in human colonic carcinoma cells. FASEB J.17:263 (#692.8). 92. C.L. Shen, J. Huang, B. Oetama, M. Zumwalt and B.C. Pence. 2004. Effects of selenium compounds on the production of inflammatory mediators in human osteoarthritic chondrocytes. FASEB J. 18: A917 (#604.18). 93. C.-L. Shen, D.D. Lo and B.C. Pence. 2004. Dietary n-3 polyunsaturated fatty acids modulate the production of inflammatory mediators in tissues of middle-age rats. FASEB J. 18: A7 (#36.5). 94. K.-J. Hong, E. Cobos, and B.C. Pence. 2004. Anti-inflammatory and inhibitory effects of AHCC in A549 human lung cancer cells and HT-29 human colon cancer cells. http://www.faseb.org/eb2004/cite. 95. B.C. Pence, D. Bustillos and A. Weinberg. 2007. Eliminating health disparities in cancer clinical trials: The EDICT Project. AACR “Science of Cancer Health Disparities Meeting”, Atlanta, GA. PUBLICATIONS: 1. Felkner, I.C., K.M. Hoffman and B.C. Wells. 1979. DNA-damaging and mutagenic effects of 1,2-dimethylhydrazine on Bacillus subtilis repair-deficient mutants. Mutation Res. 68: 31-40. 2. Shiau, S.Y., R.A. Huff, B.C. Wells and I.C. Felkner. 1980. Mutagenicity and DNAdamaging activity for several pesticides tested with Bacillus subtilis mutants. Mutation Res. 71: 169-179. 25 Barbara C. Pence Updated 10/28/2008 3. Buddingh, F., M.J. Bailey, B.C. Wells and J. Haesemeyer. 1981. Physiological significance of benzo(a)pyrene adsorbed to carbon blacks: elution studies, AHH determinations. J. Amer. Ind. Hygiene Assn. 42: 503-509. 4. Wells, B.C., M.J. Wargovich and I.C. Felkner. 1981. Parameters for detection of mutagenesis of 1,2-dimethylhydrazine using an in vitro Bacillus subtilis system. Cancer Lett. 12: 287-294. 5. Pence, D.B., L.A. Windberg, B.C. Pence and R. Sprowls. 1983. The epizootiology and pathology of sarcoptic mange in coyotes, Canis latrans from south Texas. J. Parasitol. 69: 1100-1115. 6. Pence, B.C. and F. Buddingh. 1985. Effect of dietary selenium deficiency on incidence and size of 1,2-dimethylhydrazine-induced colon tumors in rats. J. Nutr. 115: 1196-1202. 7. Pence, B.C. and F. Buddingh. 1985. The effect of carbon black ingestion on 1,2dimethylhydrazine-induced colon carcinogenesis in rats and mice. Toxicol. Lett. 25: 273-277. 8. Pence, B.C. 1985. Fecal mutagens and Bacteroides fragilis levels in the feces of dimethylhydrazine-treated rats: influence of diet. Mutation Res. 158: 53-60. 9. Pence, B.C., F. Buddingh and S.P. Yang. 1986. Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3carbinol. J. Natl. Cancer Inst. 77: 269-276. 10. Pence, B.C. and F. Buddingh. 1987. Dietary effects on serum uric acid and lipid peroxides in 1,2-dimethylhydrazine-induced colon cancer in rats. Nutrition Res. 7: 1093-1097. 11. Reiners, J.J.Jr., B.C. Pence, M.C.S. Barcus and A.R. Cantu. 1987. 12-OTetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis. Cancer Res. 47: 17751779. 12. Pence, B.C. and F. Buddingh. 1987. Co-carcinogenic effect of carbon black ingestion with dietary fat on the development of colon tumors in rats. Toxicol. Lett. 37: 177-182. 26 Barbara C. Pence Updated 10/28/2008 13. Pence, B.C. and J.J. Reiners, Jr. 1987. Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters. Cancer Res. 47: 6388-6392. 14. Pence, B.C. and F. Buddingh. 1988. Inhibition of dietary fat promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3. Carcinogenesis 9: 187-190. 15. R.S. Riley and B.C. Pence. 1988. Letter to Q & A Editor: Answer to question: "Could you provide information on perspectives and supplier of in situ hybridization techniques in diagnostic pathology?". CAP Today, 2: 26. 16. B.C. Pence. 1988. Book Review: Comparative Genetic Toxicology. J. Wildl. Dis. 24: 725. 17. B.C. Pence. 1989. Letter to the Editor, Re: Response to critique of Robertson and Koval. Toxicology Lett. 48: 319-320. 18. Pence, B.C. and M.F. Naylor. 1990. Effects of single-dose ultraviolet radiation on skin superoxide dismutase, catalase, and xanthine oxidase in hairless mice. J. Invest. Dermatol. 95: 213-216. 19. Pence, B.C., D.S. Demick, B.C. Richard and F. Buddingh. 1991. Effective nontoxic use of DursbanTM granules for the control of Myobia spp. in laboratory mice. Lab. Animal Sci. 41: 139-142. 20. Pence, B.C. 1991. Dietary selenium and antioxidant status: toxic effects of 1,2dimethylhydrazine. J. Nutr. 121: 138-144. 21. Kuratko, C.N. and B.C. Pence. 1991. Changes in colonic antioxidant status in rats during long-term feeding of different high fat diets. J. Nutr. 121: 1562-1569. 22. Pence, B.C., S.-Y. Tsai and B.C. Richard. 1991. Effects of dietary fat on the hepatic microsomal metabolism of 1,2-dimethylhydrazine. Cancer Lett. 59: 225229. 23. Pence, B.C., B.C. Richard, R.S. Lawlis and C.N. Kuratko. 1991. Effects of dietary calcium and vitamin D3 on murine skin tumor promotion. Nutr. Cancer 16: 171181. 24. B.C. Pence. 1991. Book Review: Antioxidant Nutrients and Immune Functions. J. Nutr. Immunol. 1: 109-110. 27 Barbara C. Pence Updated 10/28/2008 25. Kuratko, C.N. and B.C. Pence. 1992. Effects of dietary fat source on rat colonic antioxidant status during challenge with 1,2-dimethylhydrazine. J. Nutr. 122: 278282. 26. Cameron, G.S. and B.C. Pence. 1992. Effects of multiple applications of tumor promoters and ultraviolet radiation on murine epidermal antioxidant status and hyperplasia. J. Invest. Dermatol. 99: 189-192. 27. Tsai, S.-Y. and B.C. Pence. 1992. Effects of dietary fat on hepatic microsomal and cytosolic activation of 2-aminofluorene. Cancer Lett. 67: 87-92. 28. Pence, B.C. and D.M. Dunn. 1993. Vitamin D, cancer and immunity. J. Nutr. Immunol. 2: 109-125. 29. Pence, B.C. 1993. Role of calcium in colon cancer prevention: experimental and clinical studies. Mutation Res. 290: 87-95. 30. Kuratko, C.N., S.-Y. Tsai, and B.C. Pence. 1994. Effects of dietary fat and 1,2dimethylhydrazine on liver microsomal lipid peroxidation. J. Nutr. Biochem. 5: 7883. 31. Pence, B.C., E. Delver and D.M. Dunn. 1994. Effects of dietary selenium on UVBinduced skin carcinogenesis and epidermal antioxidant status. J. Invest. Dermatol. 102: 759-761. 32. Pence, B.C.. 1995. Dietary selenium, skin cancer and antioxidant enzymes. Guest Editorial, The Nutrition Report, vol. 13. 33. Pence, B.C., D.M. Dunn, C. Zhao, M. Landers, and M.J. Wargovich. 1995. Chemopreventive effects of calcium and aspirin supplementation in cholic acidpromoted colon carcinogenesis: correlation with intermediate endpoints. Carcinogenesis 16: 757-765. 34. Pence, B.C., M.J. Butler, D.M. Dunn, M.F. Miller, C. Zhao and M. Landers. 1995. Non-promoting effects of lean beef in the rat colon carcinogenesis model. Carcinogenesis 16:1157-1160. 35. Kuratko, C.N. and Pence, B.C. 1995. Dietary and tumor effects on colonic phospholipase A2. 1995. Cancer Lett. 95: 181-187. 28 Barbara C. Pence Updated 10/28/2008 36. Pence, B.C., D.M. Dunn, C. Zhao, M. Landers and S. Hunter. 1996. Elemental versus dairy calcium: effects on colon carcinogenesis and calcium compartmentalization. Nutr. Cancer 25: 35-45. 37. Stewart, M.S., Cameron, G.S. and Pence, B.C. 1996. Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture. J. Invest. Dermatol. 106: 1086-1089. 38. Aukema, H.M., Davidson, L.A., Pence, B.C., Jiang, Y.-H., Lupton, J.R., and Chapkin, R.S. 1997. Butyrate alters activity of specific cAMP-receptor proteins in a transgenic mouse colonic cell line. J. Nutr.127: 18-24. 39. Lai, C., Dunn, D.M., Miller, M.F., and Pence, B.C. 1997. Non-promoting effects of iron from beef in the rat colon carcinogenesis model. Cancer Lett. 112: 87-91. 40. Stewart, M.S., Davis, R.L., Walsh, L.P. and B.C. Pence. 1997. Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29). Cancer Lett. 117: 35-40. 41. Pence, B.C., Landers, M., Dunn, D.M., Shen, C.-L., and Miller, M.F. 1998. Feeding of a well-cooked beef diet containing a high heterocyclic amine content enhances colon and stomach carcinogenesis in rats. Nutr. Cancer 30: 220-226. 42. Shen, C.-L., Purewal, San Francisco, S., and Pence, B.C. 1998. Absence of PhIP adducts, p53 and Apc mutations in rats fed a cooked beef diet containing a high level of heterocyclic amines. Nutr. Cancer 30: 227-231. 43. Pence, B.C., Shen, C.-L., Dunn, D.M., Landers, M., Purewal, M., and San Francisco, S. 1998. Enhancement of colon and stomach carcinogenesis in 1, 2dimethylhydrazine-treated rats fed a diet high in heterocyclic amines. Zeit. Lebensmittel-untersuchung und-Forschung A. 207: 455-458. 44. Davis, R.L., Spallholz, J.E. and Pence, B.C. 1998. Copper inhibition of seleniteinduced apoptosis in HT29 cells. Nutr. Cancer 32: 181-189. 45. Stewart, M.S., Neldner, K.H., Spallholz, J.E. and Pence, B.C. 1999. Selenite, selenocystamine, and selenomethionine have disparate abilities to impose oxidative stress and induce apoptosis in mouse keratinocytes. Free Rad. Biol. Med.26: 42-48. 29 Barbara C. Pence Updated 10/28/2008 46. Bornhop, D.J., Hubbard, D.S., Houlne, M.P., Adair, C., Kiefer, G.E., Pence, B.C., and Morgan, D.L. 1999. Fluorescent tissue site-selective lanthanide chelate, TbPCTMB for enhanced imaging of cancer. Anal. Chem. 71:14: 2607-2615. 47. Shen, C.-L., Song, W., and Pence, B.C. 2001. Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes. Cancer Epidemiol. Biomarkers Prev., 10: 385-390. 48. K.-J. Hong, D. M. Dunn, C.-L. Shen, and B. C. Pence. 2004. Effects of Ganoderma lucidum on apoptotic function in HT-29 human colonic carcinoma cells. Phytotherapy Res. 18:768-770. 49. M.C. Esperat, D. Feng, Y. Zhang, Y. Masten, S. Allcorn, L. Velten, L. Billings, B. Pence, and M. Boylan. 2008. Transformation for Health: A framework for conceptualizing health behaviors in vulnerable populations. Nursing Clinics of North America 43: 381-395. 50. Wells, R.S., Ruzabakiev, R., Kabulov, M., Yuldasheva, N. Khegai, T., Shen, C.-L. and Pence, B.C. High levels of oxidative damage in an Aral Sea population. In preparation. 51. Pence, B.C. and C.-L. Shen. Why selenium is not an effective skin cancer chemoprevention agent. J. Invest. Dermatol. In revision. 52. Pence, B.C. and C.-L. Shen. Effects of different selenium compounds on UVBinduced skin tumorigenesis. In preparation. BOOK CHAPTERS: 1. Pence, B.C. and F. Buddingh. 1987. Effect of selenium deficiency on 1,2dimethylhydrazine-induced colon cancer in rats. In: G.F. Combs, Jr., J.E. Spallholz, O.A. Levander and J.E. Oldfield (eds.), Third International Symposium on Selenium in Biology and Medicine. AVI Publishing Co., Inc., Westport, CT. pp. 1053-1059. 2. Fischer, S.M., J.J. Reiners, Jr., B.C. Pence, C.M. Aldaz, C.J. Conti, R.J. Morris, J.F. O'Connell, J.B. Rotstein and T.J. Slaga. 1988. Mechanisms of carcinogenesis using mouse skin: the multistage assay revisited. In: R. Langenbach, J.C. Barrett and E. Elmore (eds.), Tumor Promoters: Biological Approaches for Mechanistic Studies and Assay Systems. Raven Press, New York, pp. 11-30. 30 Barbara C. Pence Updated 10/28/2008 3. Pence, B.C. 1991. Calcium and vitamin D effects on tumor promotion in rat colon and mouse skin. In: M. Lipkin, H. Newmark, and G. Kelloff (eds.), Calcium, Vitamin D and Prevention of Colon Cancer, CRC Press, Boca Raton, FL, pp. 191208. 4. Pence, B.C. 1992. Micronutrients and colorectal cancer risk: implications for chemoprevention. In: F.P. Rossini, H.T. Lynch and S.J. Winawer (eds.), Fifth International Symposium on Colorectal Cancer: Biology and Management of High Risk Groups, Elsevier, Amsterdam, pp. 171-174. 5. Pence, B.C., C. Zhao, M. Landers and M.J. Wargovich. 1994. Modulation of colonic protein kinase C by dietary bile acids, calcium carbonate, and aspirin. Proc. of the XVI International Cancer Congress, New Delhi, India, Monduzzi Editore, Bologna,pp. 577-581. 6. Pence, B.C. 1996. Nutrition and women‟s cancers: breast, cervical, endometrial and ovarian. In: I. Wolinsky and Klimas-Tavantzis, (eds.), Nutrition Concerns of Women, CRC Press, Boca Raton, FL. pp. 193-211. 7. Yang, C.S., Pence, B.C., Wargovich, M.J. and Landau, J.M. 1996. Diet, Nutrition, and Cancer: Research Opportunities, Approaches, and Pitfalls”, In Dietary Phytochemicals in Cancer Prevention and Treatment. (Edited under the auspices of the American Institute for Cancer Research, Vol. 401, pp. 231-238, Plenum Press, New York. 8. Pence, B.C. and Yang, T.C. 1999. Antioxidants: radiation and stress, In, H. Lane and D.A. Schoeller, (eds.), Nutrition in Space Flight and Weightlessness Models, CRC Press, pp. 233-251. 9. Pence, B.C. 2003. Nutrition and women‟s cancers: breast, cervical, endometrial and ovarian. In: I. Wolinsky and Klimas-Tavantzis, (eds.), Nutrition Concerns of Women, 2nd Ed., CRC Press, Boca Raton, FL., pp. 341-363 . 10. Pence, B.C. 2007. Metabolic Abnormalities. In: Quattromani, F., ed. Pediatric Q & A. New York, NY. Thieme Publishers; pp. 232-239 BOOKS: 1. Pence, B.C. and Dunn, D.M., 1998. Nutrition and Women‟s Cancers, CRC Press, Boca Raton, FL, 179 pp. 31 Barbara C. Pence Updated 10/28/2008 TEACHING EXPERIENCE: Attendee, Workshop "Options in Medical Education", University of New Mexico School of Medicine, Feb. 3-7, 1992 (problem-based learning) TTUHSC School of Medicine: Coordinator for Nutrition in the Medical Curriculum, 19902000 Member, CATCHUM Project Steering Committee to develop cancer prevention and early detection modules and standardized patient scenarios for the undergraduate medical curriculum, 1992-present Lecturer, MPA 61745 Pathology/ Pathophysiology Course, on Cell Injury and Adaptation, Molecular Biology, Neoplasia, and Nutritional Diseases, for sophomore medical students (16-22 lecture hours), 1987-present Course Director: F & N 5350, Nutritional Pathophysiology, for graduate students and Registered Dietitian interns (3 semester hours), 1988-1993 Course Director: BCH 6335/F & N 5311, Nutritional Biochemistry, for graduate students (3 semester hours), 1990 Guest Lecturer: PHM 5335, Cellular and Molecular Toxicology, for graduate students, lectures on carcinogenesis and tumor promotion, 1989 Lecturer, Medical Biochemistry, for freshman medical students (5 lecture hours), on nutritional aspects of biochemistry, 1990-1993 Course Director, MPA 50101, Clinical Nutrition Elective for freshman medical students, 1990-1994 Guest Lecturer, AHMT Clinical Chemistry course for medical technology students on tumor markers and laboratory diagnosis of nutritional status, 1991 Lecturer, Physical Therapy Pathology, PT 5203, lectures on neoplasia and diseases of the skin, 1993-present Guest Lecturer, Medical Aspects of Health Organization Management for MBA students, on cancer epidemiology and management of cancer issues, 1994-present Guest Lecturer, F & N 5350, Nutritional Pathophysiology, for graduate students and dietetic interns, on immunology and cancer, 1994 32 Barbara C. Pence Updated 10/28/2008 Lecturer, Introduction to Medicine, for sophomore medical students, on gastrointestinal function and nutrition topics, 1995 – 97 Course Director, GSBS 5101, Responsible Conduct of Research, required of all graduate students and clinical research fellows, 2001-present Course Director, Clinical Research Fellowship, 2001 Facilitator, 3 PBL cases in geriatrics curriculum, 2001-2002 MSI Lectures on Cancer Genetics and Nutrition (4 lecture hours), 2005-2006 STUDENTS SUPERVISED: Connye Kuratko, Ph.D. student, Division of Food and Nutrition, Texas Tech University, Chairperson, Graduate Advisory Committee, graduation date: August 1991. Richard Stephen Lawlis, Medical Student II, 1989 Summer Research Fellowship, Faculty Mentor Shwu-Yar Tsai, Ph.D. student, Division of Food and Nutrition, Texas Tech University, Chairperson, Graduate Advisory Committee, graduation date: May 1993. Marjory Stewart, Ph.D. student, Division of Food and Nutrition, Texas Tech University, Chairperson, Graduate Advisory Committee, graduation date: May 1996. Erica Delver, M.S. student, Division of Food and Nutrition, Texas Tech University, Chairperson, Graduate Advisory Committee, graduation date: August 1993. Vijay Patel, Medical Student II, 1992 Summer Research Fellowship, Faculty Mentor Bing Shi, Ph.D. student, Division of Food and Nutrition, Texas Tech University, Member, Graduate Advisory Committee, graduation date: May, 1994 Micah Butler, M.S. student, Department of Animal Science and Food Technology, Texas Tech University, Member, Graduate Advisory Committee, graduation date: August 1995. 33 Barbara C. Pence Updated 10/28/2008 Jau-Jiin Chen, Ph.D. student, Division of Food and Nutrition, Texas Tech University, Member, Graduate Advisory Committee, graduation date: December 1996. Lugen Chen, Ph.D. student, Division of Food and Nutrition, Texas Tech University, Member, Graduate Advisory Committee, graduation date: May 1997. Melanie Landers, M.S. student, Division of Food and Nutrition, Texas Tech University, Chairperson, Graduate Advisory Committee, left program Michael Dixon, Medical Student I, summer research fellow, Texas Tech Health Sciences Center, Faculty Mentor, 1995 Chris Lai, M.S. student, Department of Animal Science and Food Technology, Texas Tech University, Member, Graduate Advisory Committee, graduation date: August 1996 Randy Davis, Ph.D. student, Division of Food and Nutrition, Texas Tech University, Member, Graduate Advisory Committee, graduation date May 1998. Amit Kumar, undergraduate student, Department of Biological Sciences, Texas Tech University, Faculty Mentor, 1995-1997. Karen Cowden, undergraduate student, Howard Hughes Medical Institute Fellow, Texas Tech University, Faculty Mentor, 1997-1999. Cecily Hostrup, undergraduate student, Texas Tech University, 2001-2002. Haitao Luo, PhD student, TIEHH and Dept. of Environmental Toxicology, Member, Graduate Advisory Committee, graduation date August 2005. Madhavi Billam, PhD student, TIEHH and Dept. of Environmental Toxicology, Member, Graduate Advisory Committee, graduation date May 2006. Zemin Wang, PhD student, TIEHH and Dept. of Environmental Toxicology, Member, Graduate Advisory Committee, graduation date August, 2007. Li Xu, PhD student, TIEHH and Dept. of Environmental Toxicology, Member, Graduate Advisory Committee, graduation date December 2009. POSTDOCTORAL FELLOWS TRAINED: 34 Barbara C. Pence Updated 10/28/2008 Marjory Stewart, 1996-97 Leslie Shen, 1996-1998 Kevin Hong, 2002-2004