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Transcript
Host Defense Against Bacterial Toxins: Mechanisms and Therapies Pore-forming toxins are the largest single class of proteinaceous bacterial toxins produced by both Gram-positive and Gram-negative bacterial species. Many pore-forming toxins have been proven to be key virulence factors in major pathogenic bacteria. The first part of the presentation will cover our multi-pronged genome-wide approaches dissecting the host defense mechanisms against poreforming toxin attack in a genetic model organism, Caenorhabditis elegans. With this, more than 100 novel genes and one key MAPK pathway were found involved in the innate immune responses against the pore-forming toxins. The second part of talk further extends the host defense mechanisms from a model organism to one human primary target of bacterial infection, respiratory airway epithelium. By discovering a potential prophylactic drug to prevent the poreforming toxin-related infections, the novel cellular protection mechanisms against pore-forming toxins are further dissected.