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CURRICULUM VITAE Louise Elizabeth Jane Thomson, MB.ChB., FRACP 8700 Beverly Blvd, Los Angeles, CA 90048. Californian medical board license number A91738 Board certification American Board of Nuclear Medicine Authorized user radiopharmaceuticals license CSMC EDUCATION: 1991 MB.ChB. Otago University, Dunedin, New Zealand 1999 F.R.A.C.P . Fellow of the Royal Australasian College of Physicians Cardiology and Nuclear Medicine 2001 E.C.F.M.G. Permanent status with ECFMG granted March 2004 2002-2003 Cardiac MRI experience commensurate with level 3 COCATS requirement 2003-2005 ABNM certification. Re-certified 2010 valid 2006-2022 2007- 2008 Cardiac CT 2010 SCCT Level 3 Certification in cardiac CT. experience commensurate with level 3 COCATS requirement Professional Experience: Housesurgeon (Residency internal medicine): 1992 1993 General medicine, General Surgery, Paediatric Surgery and Psychiatry Auckland Hospital, New Zealand. Rheumatology and Emergency Medicine, Middlemore hospital Cardiology, Green Lane Hospital General Medicine, North Shore Hospital, Auckland New Zealand. Registrar (Fellowship internal medicine): 1994 1995 1996 Confidential General Medicine, Middlemore Hospital, Auckland. Professor Sir John Scott, Dr Robert Eason General Medicine and Aged Care, Auckland Hospital Dr John Mercer, Professor Richmond General Medicine, North Shore Hospital, Auckland. Page 1 23-Jun-15 1 Fellowship (cardiology followed by nuclear medicine): 1997-1999 Cardiology fellow Green Lane Hospital Auckland, New Zealand Supervisors: Dr Warren Smith, Dr Harvey White, Dr John Neutze 2000- Oct 2001 General Nuclear Medicine fellow Concord Repatriation and General Hospital Sydney, Australia Supervisors: Drs Hans Van der Wall and Dr Kevin Allman Oct 2001-Jan 2002 General Nuclear Medicine and PET fellow Austin Repatriation and Medical Centre Melbourne, Australia Supervisor: Dr Christopher Rowe February 2002 Locum Cardiologist Green Lane Hospital Auckland, New Zealand US Research Fellowship (cardiac MRI): 2002 - 2003 Research Associate in Cardiovascular Magnetic Resonance Imaging Duke Cardiovascular Magnetic Resonance Center Duke University Medical Center Supervisors: Dr Robert Judd, Dr Raymond Kim US Residency (nuclear medicine): June 2003-2005 Nuclear Medicine Resident and Cardiac Imaging fellow. Cedars Sinai Medical Center, Los Angeles, California Supervisor: Dr Alan Waxman Employment and appointments: July 2005- present Nuclear medicine physician and cardiac imaging specialist Director of fellowship program in cardiovascular imaging Director of adult cardiac magnetic resonance imaging Cedars Sinai Medical Center. 2008- July 2010 Assistant Clinical Professor Step 3, Clinician-Investigator track Department of Medicine, David Geffen School of Medicine, UCLA. 2010 – July 2012 Assistant Clinical Professor Step 4. Clinician-Investigator Track Department of Medicine, David Geffen School of Medicine, UCLA. 2012 – July 2014 Associate Clinical Professor. Clinician-Investigator Track Department of Medicine, David Geffen School of Medicine, UCLA 2014- Associate Clinical Professor Step 2 Clinician-Investigator track. Confidential Page 2 23-Jun-15 2 Professional Activities : Diplomate, American Board of Nuclear Medicine Member Society of Nuclear Medicine and Molecular Imaging Fellow of the Royal Australasian College of Physicians Member New Zealand Medical Association. Member Cardiac Society Australia and New Zealand Unconditional Registration New Zealand Medical Board November 1992 Committee/ Academic Service (National): ABNM Board of Directors Jan 2011- current chair of the ABNM. The ABNM is the credentialing body for nuclear medicine, for initial certification and maintenance of certification. ABNM/ABR taskforce co-chair. This taskforce proposes significant re structuring of the relationship between the ABNM and the ABR, with changes to training, and creation of a primary discipline in nuclear medicine under ABR, with eventual dissolution of the ABNM. Input from stakeholders including ABMS, ACGME, NMRRC, Societies, diplomates and trainees is currently being requested. Correlative Imaging Council member SNMMI 2014-18 Elected committee membership within the society of nuclear medicine and molecular imaging. National Acadamies of Science Mo-99 Study panelist advisor June 2015: National Research Council committee study of the State of Molybdenum-99 Production and Utilization and Progress toward Eliminating use of Highly Enriched Uranium. SCCT Cardiac CT guidelines committee member for acquisition guideline. Published May/June 2009. ASNC representative for ACC Carrier Advisory Committee for local coverage determination for cardiac magnetic resonance. Abstract reviewer for ACC-08 cardiac CT abstract submissions Abstract reviewed for ACC 2011 Abstract reviewer for SNMMI 2013 Previous reviewer for JACC, JACC cardiovascular imaging Circulation American Heart Journal Committee/ Academic Service (Local): MD-RN collaborative committee ALARA committee for reduction of radiation dose exposure in imaging Program director for advanced cardiovascular imaging fellowship Confidential Page 3 23-Jun-15 3 Honors and special awards: Medical school: Royal New Zealand College of General Practice prize 1991, Dawn Short prize in Psychiatry 1991, Distinction awarded in internal medicine, surgery, psychiatry and general practice, at medical school graduation 1991. Awarded NZ cardiac society grant for attendance, Annual scientific meeting, Cardiac Society of Australia and New Zealand Wellington, New Zealand, August 1999 Co-author, Affiliates poster prize, Australia and New Zealand Cardiac Society Meeting. Melbourne, Australia, August 2000. Cedars Sinai Medical Center Leo Rigler award for outstanding resident academic achievement June 2005 Best MD/scientist abstract award for the 38th Annual Western Regional meeting of the society of nuclear medicine, October 2013. Research Grants and Fellowships: Cardiology Department Summer studentship Dunedin Hospital 1989-1990 New Zealand National Heart Foundation overseas training grant 2002-2003 Cedars Sinai Medical Center General Clinical Research Center, Grant # MO1-RR00425 CReFF funding award November 2008 U54 HL081028 (PI: Marbán, E) 09/30/2005 – 08/31/2010 NIH, NHLBI Cellular Cardiomyoplasty for Acute and Chronic Ischemic Heart Disease The goal of this proposal is to develop stem cell-based myocardial regeneration therapies to reverse cardiac failure in patients with coronary artery disease. Role: Co-Investigator R01 HL090957-01A1 (PI: Bairey Merz,N) 09/17/2008 – 06/30/2012 NIH, NHLBI Title: Women’s Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction The major goals of this project are to investigate the approaches to the noninvasive detection and assessment of ischemic heart disease. Role: Role: Co-Investigator PUBLICATIONS: Research Papers (peer reviewed journals): 1. Oh Y S, Thomson LEJ, Fishbein MC, Berman DS, Sharifi B, Chen PS. Scar Formation after Ischemic Myocardial Injury in MRL Mice. Cardiovasc Pathol. 2004; 13(4):203-6. 2. Slomka PJ, Fieno D, Thomson L, Friedman JD, Hayes SW, Germano G, Berman DS. Automatic detection and size quantification of infarcts by myocardial perfusion SPECT: clinical validation by delayed-enhancement MRI. Journal of Nuclear Medicine 2006; 46(5):728-35 3. Wagner A, Mahrholdt H, Thomson L, Hager S, Meinhardt G, Rehwald W, Parker M, Shah D, Sechtem U, Kim R, Judd R. Effects of Time, Dose and Inversion Time for Confidential Page 4 23-Jun-15 4 Acute Myocardial Infarct Size Measurements Based on MRI Delayed Contrast Enhancement. J Am Coll Cardiol. 2006; 16;47(10):2027-33. Epub 2006 Apr 27. 4. Van den Bos EJ, Thompson RB, Wagner A, Mahrholdt H, Morimoto Y, Thomson LE, Wang LH, Duncker DJ, Judd RM, Taylor DA. Functional assessment of myoblast transplantation for cardiac repair with magnetic resonance imaging. Eur J Heart Fail. 2005; 7(4):435-43 5. Fieno DS, Thomson LEJ, Slomka PJ, Abidov A, Nishina H, Chien D, Hayes SW, Saouaf R, Germano G, Friedman JD, Berman DS. Rapid assessment of left ventricular segmental wall motion, ejection fraction and volumes with single breath-hold, multislice TrueFISP MR imaging. J Cardiovasc Magn Reson. 2006; 8(3):435-44. 6. Shellock FG, Fieno DS, Thomson LJ, Talavage TM, Berman DS. Cardiac pacemaker: In vitro assessment at 1.5T Am Heart J 2006; 151:436-43 7. Kang X, Shaw LJ, Hayes SW, Hachamovitch R, Abidov A, Cohen I, Friedman JD, Thomson LE, Polk D, Germano G, Berman DS. Impact of body mass index on cardiac mortality in patient with known or suspected coronary artery disease undergoing myocardial perfusion single photron emission computed tomography. J Am Coll Cardiol. 2006; 47(7):1418-26. Epub 2006 Mar 20. 8. Dey D, Slomka P, Chien D, Fieno D, Abidov A, Saouaf R, Thomson L, Friedman JD, Berman DS. Direct quantitative in vivo comparison of calcified atherosclerotic plaque on vascular MRI and CT by multimodality image registration. J Magn Reson Imaging. 2006; 23(3):345-54. 9. Hachamovitch R, Rozanski A, Hayes SW, Thomson LE, Germano G, Friedman JD, Cohen I, Berman DS. Predicting therapeutic benefit from myocardial revascularization procedure: are measurements of both resting left ventricular ejection fraction and stress-induced myocardial ischemia necessary? J Nucl Cardiol. 2006; 13(6): 768-78. 10. Fieno DS, Thomson LEJ, Slomka P, Abidov A, Friedman J, Germano G, Berman DS. Quantitation of infarct size in patients with chronic coronary artery disease using rest redistribution Tl-201 myocardial perfusion SPECT: Correlation with contrastenhanced cardiac magnetic resonance. J Nucl Cardiol 2007; 14:59-67 11. Slomka PJ, Fieno D, Ramesh A, Goyal V, Nishina H, Thomson LE, Saouaf R, Berman DS. Germano G. Patient motion correction for multiplanar multi breath hold cardiac cine MR imaging. J. Magn Reson Imaging 2007 25(5) 965-73 12. Berman DS, Kang X, Slomka PJ, Gerlach J, Yang L, Hayes SW, Friedman JD, Thomson LEJ, Germano G. Underestimation of Extent of Ischemia by Gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease. J Nucl Cardiol. 2007 Jul;14(4):521-8. 13. Thomson LEJ, Fieno DS, Abidov A, Slomka PJ, Hachamovitch R, Saouaf R, Friedman JD, Berman DS. Added value of rest to stress study for recognition of artifacts in perfusion cardiovascular magnetic resonance. J. Cardiovascular Magnetic Resonance 2007, 9, 1-8. 14. Thomson LEJ, Crowley A, Heitner JF, Crawley PJ, Weinsaft J, Kim HW, Parker M, Judd RM, Harrison JK, Kim RJ. Direct En Face Imaging of Secundum Atrial Septal Defects by Velocity Encoded Cardiovascular Magnetic Resonance in Patients Evaluated for Possible Transcatheter Closure. Circulation Cardiovascular Imaging 2008; 1:31-40. 15. Cheng V, Gutstein A, Wolak A, Suzuki Y, Dey D, Gransar H, Thomson LEJ, Hayes SW, Friedman JD, Berman DS. Moving beyond binary grading of coronary arterial Confidential Page 5 23-Jun-15 5 stenosis on coronary computed tomographic angiography. JACC Cardiovascular Imaging 2008; 1(4): 460-471. 16. Gutstein A, Dey D, Cheng V, Wolak A, Gransar H, Suzuki Y, Friedman J, Thomson LE, Hayes S, Pimentel R, Paz W, Slomka P, Le Meunier L, Germano G, Berman DS. Algorithm for radiation dose reduction with helical dual source coronary computed tomography angiography in clinical practice. J Cardiovasc Comput Tomogr. 2008; 2(5):311-22 17. Wolak A, Gutstein A, Cheng VY, Suzuki Y, Thomson LE, Friedman J, Dey D, Hayes SW, Slomka PJ, Germano G, Berman DS. Dual-source coronary computed tomography angiography in patients with atrial fibrillation: initial experience. J Cardiovasc Comput Tomogr. 2008 May-Jun;2(3):172-80 18. Dey D, Lee CJ, Ohba M, Gutstein A, Slomka PJ, Cheng V, Suzuki Y, Suzuki S, Wolak A, Le Meunier L, Thomson LE, Cohen I, Friedman JD, Germano G, Berman DS. Image quality and artifacts in coronary CT angiography with dual-source CT: initial clinical experience. J Cardiovasc Comput Tomogr. 2008 Mar-Apr;2(2):105-14 19. Wolak A, Gransar H, Thomson LE, Friedman JD, Hachamovitch R, Gutstein A, Shaw LJ, Polk D, Wong ND, Saouaf R, Hayes SW, Rozanski A, Slomka PJ, Germano G, Berman DS. Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area. JACC Cardiovasc Imaging. 2008 Mar;1(2):200-9 PMID: 19356429 20. Gutstein A, Wolak A, Lee C, Dey D, Ohba M, Suzuki Y, Cheng V, Gransar H, Suzuki S, Friedman J, Thomson LE, Hayes S, Pimentel R, Paz W, Slomka P, Berman DS. Predicting success of prospective and retrospective gating with dual-source coronary computed tomography angiography: development of selection criteria and initial experience. J Cardiovasc Comput Tomogr. 2008 Mar-Apr;2(2):81-90 PMID: 19083926 21. Wong ND, Gransar H, Shaw L, Polk D, Moon JH, Miranda-Peats R, Hayes SW, Thomson LEJ, Rozanski A, Friedman JD, Berman DS. Thoracic aortic calcium versus coronary artery calcium for the prediction of coronary heart disease and cardiovascular disease events. JACC Cardiovasc Imaging 2009;2;319-326 PMID: 19356578 22. Berman DS, Kang Xingping, Tamarappoo B, Wolak A, Hayes SW, Nakazato R, Thomson LEJ, Kite F, Cohen I, Slomka PJ, Einstein AJ, Friedman JD. Stress thallium-201/ rest technetium 99m sequential dual isotope high speed myocardial perfusion imaging. JACC Cardiovasc Imaging 2009;2;273-282. PMID: 19356571 23. Abbara S, Arbab-Zadeh A, Callister TQ, Desai MY, Mamuya W, Thomson L, Weigold WG. SCCT guidelines for performance of coronary computed tomographic angiography: A report of the Society of Cardiovascular Computed Tomography Guidelines Committee. Journal of Cardiovascular Computed Tomography 2009. 3, 190-204. 24. Berman DS, Kang X, Gransar H, Gerlach J, Friedman JD, Hayes SW, Thomson LE, Hachamovitch R, Shaw LJ, Slomka P, De Yang L, Germano G. Quantitative assessment of myocardial perfusion abnormality on SPECT myocardial perfusion imaging is more reproducible than expert visual analysis. J Nucl Cardiol. 2009; 16(1):45-53 PMID: 19152128 25. Abidov A, Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Kang X, De Yang L, Thomson L, Germano G, Slomka P, Berman DS. Are shades of gray prognostically useful in reporting myocardial perfusion single-photon emission computed Confidential Page 6 23-Jun-15 6 tomography? Circ Cardiovasc Imaging 2009 Jul;2(4):290-8 Epub 2009 May 11 PMID: 19808609 26. Shaw LJ, Polk DM, Kahute TA, Wong ND, Moon J, Miranda-Peats R, Rozanski A, Friedman JD, Hayes S, Thomson L, Berman DS. Prognostic accuracy of B-natriuretic peptide measurements and coronary artery calcium in asymptomatic subjects (from the Early Identification of Subclinical Atherosclerosis by Non invasive Imaging Research (EISNER) study. Am J Cardiol. 2009 Nov 1;104(9):1245-50 PMID: 19840570. 27. Karlsberg RP, Budoff MJ, Thomson LEJ, Friedman JD, Berman DS. Reduction in downstream test utilization following introduction of coronary computed tomography in a cardiology practice. Int J Cardiovasc. Imaging. 2009 Dec 9. PMID: 19967562 28. Cheng VY, Slomka PJ, Ahlen M, Thomson LEJ, Waxman AD, Berman DS. Impact of carbohydrate restriction with and without fatty acid loading on myocardial 18FFDG uptake during PET: A randomized controlled trial. Accepted for publication JNC 2009. PMID: 20013165 29. Nakazato R, Dey D, Gutstein A, Le Meunier L, Cheng VY, Pimentel R, Paz W, Hayes SW, Thomson LE, Friedman JD, Berman DS. Coronary artery calcium score using a reduced tube voltage and radiation dose protocol with dual source computed tomography. J Cardiovasc. Comput. Tomogr. 2009 Nov-Dec;36(6):394-400. PMID: 20083060 30. Karlsberg RP, Budoff MJ, Thomson LE, Friedman JD, Berman DS. Integrated coronary computed tomographic angiography in an office-based cardiology practice. Rev Cardiovasc Med 2009 Fall;10(4):194-201. PMID: 20065929 31. Hachamovitch R, Kang X, Amanullah AM, Abidov A, Hayes SW, Friedman JD, Cohen I, Thomson LE, Germano G, Berman DS. Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly. Circulation 2009 Dec 1;120(22):2197-206 PMID: 19917890 32. Karlsberg RP, Budoff MJ, Berman DS, Thomson LE, Friedman JD. 64-slice multidetector computed tomography (MDCT) reduces other diagnostic studies for coronary artery disease. Am J Med. 2009 Nov;122(11):e13 PMID: 19854311 33. Wong ND, Gransar H, Narula J, Shaw L, Moon JH, Miranda-Peats R, Rozanski A, Hayes SW, Thomson LE, Friedman JD, Berman DS. Myeloperoxidase, subclinical atherosclerosis and cardiovascular disease events. JACC Cardiovasc Imaging. 2009 Sep;2(9): 1093-9. PMID: 19761988 34. Le Meunier L, Smlomka PJ, Dey D, Ramesh A, Thomson LE, Hayes SW, Friedman JD, Cheng V, Germano G, Berman DS. Enhanced definition PET for cardiac imaging. J Nucl Cardiol. 2010 Feb 12. PMID: 20151238 35. Cheng VY, Wolak A, Gutstein A, Gransar H, Wong ND, Dey D, Thomson LE, Hayes SW, Friedman JD, Slomka PJ, Berman DS. Low-density lipoprotein and noncalcified coronary plaque composition in patients with newly diagnosed coronary artery disease on computed tomographic angiography. Am J Cardiol. 2010 Mar 15;105(6):761-6. PMID: 20211316. 36. Prasad M, Ramesh A, Kavanagh P, Tamarappoo BK, Nakazato R, Gerlach J, Cheng V, Thomson LE, Berman DS, Germano G, Slomka PJ. Quantification of 3D regional myocardial wall thickening from gated magnetic resonance images. J Magn Reson Imaging. 2010 Feb;31(2):317-27. PMID: 20099344. 37. Tamarappoo BK, Gutstein A, Cheng VY, Nakazato R, Gransar H, Dey D, Thomson LE, Hayes SW, Friedman JD, Germano G, Slomka PJ, Berman DS. Assessment of the relationship between stenosis severity and distribution of coronary artery stenoses on Confidential Page 7 23-Jun-15 7 multislice computed tomographic angiography and myocardial ischemia detected by single photon emission computed tomography. J Nucl Cardiol. 2010 Apr 28 PMID: 20425027 38. Tamarappoo BK, Dey D, Nakazato R, Shmilovich H, Smith T, Cheng VY, Thomson LE, Hayes SW, Friedman JD, Germano G, Slomka PJ, Berman DS. Comparison of the Extent and Severity of Myocardial Perfusion Defects Measured by CT Coronary Angiography and SPECT Myocardial Perfusion Imaging. JACC Cardiovasc Imaging. 2010 Oct;3(10):1010-9. PMID: 20947046 39. Tamarappoo BK, Dey D, Shmilovich H, Nakazato R, Gransar H, Cheng VY, Friedman JD, Hayes SW, Thomson LEJ, Slomka PJ, Rozanski A, Berman DS. Increased Pericardial Fat Volume Measured from Non contrast CT Predicts Myocardial Ischemia by SPECT. JACC Cardiovasc. Imaging. 2010 November: 110412. 40. Nakazato R, Tamarappoo BK, Kang X, Wolak A, Kite F, Hayes SW, Thomson LE, Friedman JD, Berman DS, Slomka PJ. Quantitative upright-supine high-speed SPECT myocardial perfusion imaging for detection of coronary artery disease: correlation with invasive coronary angiography. J Nucl Med. 2010 Nov;51(11):1724-31. PMID: 20956478 41. Le Meunier L, Slomka PJ, Dey D, Ramesh A, Thomson LE, Hayes SW, Friedman JD, Cheng V, Germano G, Berman DS. Motion frozen (18)F-FDG cardiac PET. J Nucl Cardiol J Nucl Cardiol. 2011 Apr;18(2):259-66. Epub 2010 Dec 16. PMID: 21161704 42. Rozanski A, Gransar H, Kubzansky LD, Wong N, Shaw L, Miranda-Peats R, Thomson LE, Hayes SW, Friedman JD, Berman DS. Do physchological risk factors predict the presence of coronary atherosclerosis? Psychosom Med. 2011 Jan;73(1):715. PMID: 20978226 43. Ishimori ML, Martin R, Berman DS, Goykhman P, Shaw LJ, Shufelt C, Slomka PJ, Thomson LE, Schapira J, Yang Y, Wallace DJ, Weisman MH, Bairey Merz CN. Myocardial ischemia in the absence of obstructive coronary artery disease in systemic lupus erythematosus. JACC Cardiovasc Imaging 2011 Jan;4(1):27-33. PMID: 21232700 44. Hachamovitch R, Rozanski A, Shaw LJ, Stone GW, Thomson LE, Friedman JD, Hayes SW, Cohen I, Germano G, Berman DS. Impact of ischaemia and scar on the therapeutic benefit derived from myocardial revascularization vs medical therapy among patients undergoing stress- rest myocardial perfusion scintigraphy. Eur Heart J. 2011 Jan 21. 45. Rozanski A, Gransar J, Shaw LJ, Kim J, Miranda-Peats L, Wong ND, Rana JS, Orakzai R, Hayes SW, Friedman JD, Thomson LE, Polk D, Min J, Budoff M, Berman DS. Impact of coronary artery calcium scanning on coronary risk factors and downstream testing: a prospective randomized trial. J Am Coll Cardiol. 2011 Apr 12;57(15):1622-32. PMID:21439754 46. Nakazato R, Tamarappoo BK, Smith TW, Cheng VY, Dey D, Shmilovich H, Gutstein A, Gurudevan S, Hayes SW, Thomson LE, Friedman JD, Berman DS. Assessment of left ventricular regional wall motion and ejection fraction with lowradiation dose helical dual source CT: Comparison to two-dimensional echocardiography. J Cardiovasc Comput Tomogr. 2011 Jan28. PMID: 21367686 47. Nakazato R, Berman DS, Dey D, Le Meunier L, Hayes SW, Fermin JS, Cheng VY, Thomson LE, Friedman JD, Germano G, Slomka PJ. Automated quantitative Rb-82 3D PET/CT myocardial perfusion imaging: Normal limits and correlation with invasive coronary angiography. J Nucl Cardiol 2011 Dec 28. PMID:22203445 Confidential Page 8 23-Jun-15 8 48. Nakazato R, Rajani R, Cheng VY, Shmilovich H, Nakanishi R, Otaki Y, Gransar H, Slomka PJ, Hayes SW, Thomson LE, Friedman JD, Wong ND, Shaw LJ, Budoff M, Rozanski A, Berman DS, Dey D. Weight change modulates epicardial fat burden: A 4 year serial study with non-contrast computed tomography. Atherosclerosis 2012 Jan;220(1): 139-44 Epub 2011 Oct 20. PMID: 22056214 49. Shmilovich H, Dey D, Cheng VY, Rajani R, Nakazato R, Otaki Y, Nakanishi R, Slomka PJ, Thomson LE, Hayes SW, Friedman JD, Gransar H, Wong ND, Shaw LJ, Budoff M, Rozanski A, Berman DS Threshold for the upper normal limit of indexed epicardial fat volume: derivation in a healthy population and validation in an outcome-based study. Am J Cardiol 2011 Dec 1;108(11): 1680-5 Epub 2011 Aug 30. PMID: 21880291 50. Shmilovich H, Cheng VY, Tamarappoo BK, Dey D, Nakazato R, Gransar H, Thomson LE, Hayes SW, Friedman JD, Germano G, Slomka PJ, Berman DS. Vulnerable plaque featyres on coronary CT angiography as markers of inducible regional myocardial hypoperfusion from severe coronary artery stenosis. Atherosclerosis 2011 Dec;219(2):588-95. Epub 2011 Aug 4 PMID: 21862017 51. Nakanishi R, Rajani R, Cheng VY, Gransar H, Nakazato R, Shmilovich H, Otaki Y, Hayes SW, Thomson LE, Friedman JD, Slomka PJ, Berman DS, Dey D. Increase in epicardial fat volume is associatated with greater coronary artery calcification progression in subjects at intermediate risk by coronary calcium score: a serial study using non-contrast cardiac CT. Atherosclerosis 2011 Oct;218(2):363-8. Epub 2011 July 23 PMID:21835407 52. Otaki Y, Rajani R, Cheng VY, Gransar H, Nakanishi R, Shmilovich H, Nakazato R, Hayes SW, Thomson LE, Friedman JD, Slomka PJ, Wong ND, Rozanski A, Shaw L, Budoff M, Berman DS, Dey D. The relationship between epicardial fat volume and incident coronary artery calcium. J Cardiovasc Comput Tomogr. 2011 SepOct;5(5):310-6. Epub 2011 Jun 13. PMID 21783453 53. Mehta PK, Goykhman P, Thomson LE, Shufelt C, Wei J, Yang Y, Gill E, Minissian M, Shaw LJ, Slomka PJ, Slivka M, Berman DS, Bairey Merz CN. Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease. JACC Cardiovasc Imaging. 2011 Mat;4(5):514-22. PMID: 21565740. 54. Rana JS, Gransar H, Wong ND, Shaw L, Pencina M, Nasir K, Rozanski A, Hayes SW, Thomson LE, Friedman JD, Min JK, Berman DS. Comparitive value of coronary artery calcium and multiple blood biomarkers for prognostication of cardiovascular events. Am J Cardiol 2012 Mar 15 (Epub ahead of print). May 15; 109(10): 1449-53. PMID: 22425333 55. Dey D, Nakazato R, Pimentel R, Paz W, Hayes SW, Friedman JD, Cheng VY, Thomson LE, Slomka PJ, Berman DS. Low radiation coronary calcium scoring by dual-source CT with tube current optimization based on patient body size. J Cardiovasc Comput Tomogr. 2012 Mar;6(2):113-20. PMID: 22381663 56. Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marban L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marban E. Intracoronary cardiosphere derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective randomized phase 1 trial. Lancet 2012 Mar 10;379(9819):895-904. Epub 2012 Feb 14. PMID: 22336189 57. Shmilovich H, Cheng VY, Rajani R, Dey D, Tamarappoo BK, Nakazato R, Smith RW, Otaki Y, Nakanishi R, Gransar H, Paz W, Pimentel RT, Hayes SW, Friedman JD, Thomson LE, Berman DS. Relation of diagonal earl lobe crease to the preence, extent and severity of coronary artery disease determined by coronary computed Confidential Page 9 23-Jun-15 9 tomography angiography. Am J Cardiol. 2012 May 1; 109(9): 1283-7. Epub 2012 Feb 13. PMID: 22335855 58. Nakazato R, Dey D, Cheng VY, Gransar H, Slomka PJ, Hayes SW, Thomson LE, Friedman JD, Min JK, Berman DS. Epicardial fat volume and concurrent presence of both myocardial ischemia and obstructive coronary artery disease. Atherosclerosis. 1012 Apr;221(2):422-6. PMID: 22305262 59. Goykhman P, Mehta PK, Minissian M, Thomson LE, Berman DS, Ishimori ML, Wallace DJ, Weisman MH, Shufelt CL, Bairey Merz CN. Subendocardial ischenmia and myocarditis in systemic lupus erythematosus detected by cardiac magnetic resonance imaging. J Rheumatol. 2012 Feb;39(2):448-50. PMID: 22298279 60. Hachamovitch R, Nutter B, Hlatky MA, Shaw LJ, Ridner ML, Dorbala S, Beanlands RS, Chow BJ, Branscomb E, Chareonthaitawee P, Weigold WG, Voros S, Abbara S, Yasuda T, Jacobs JE, Lesser J, Berman DS, Thomson LE, Raman S, Heller GV, Schussheim A, Brunken R, Williams KA, Farkas S, Delbeke D, Schoepf UJ, Reichek N, Rabinowitz S, Sigman SR, Patterson R, Corn CR, White R, Kazerooni E, Corbett J, Bokhari S, Machac J, Guarneri E, Borges-Neto S, Millstine JW, Caldwell J, Arrighi J, Hoffmann U, Budoff M, Lima J, Johnson JR, Johnson B, Gaber M, Williams JA, Foster C, Hainer J, Di Carli MF; SPARC Investigators. Patient management after noninvasive cardiac imaging results from SPARC (Study of myocardial perfusionand coronary anatomy imaging roles in coronary artery disease). J Am Coll Cardiol. 2012 Jan 31; 59(5):462-74. PMID 22281249 61. Nakazato R, Rajani R, Cheng VY, Shmilovich H, Nakanishi R, Otaki Y, Gransar H, Slomka PJ, Hayes SW, Thomson LE, Friedman JD, Wong ND, Shaw LJ, Budoff M, Rozanski A, Berman DS, Dey D. Weight change modulates epicardial fat burden: a 4 year serial study with non contrast computed tomography. Atherosclerosis 2012 Jan;220(1):139-44. PMID: 22056214 62. Nakazato R, Berman DS, Gransar H, Hyun M, Miranda-Peats R, Kite FC, Hayes SW, Thomson LE, Friedman JD, Rozanski A, Slomka PJ. Prognostic value of quantitative high-speed myocardial perfusion imaging. J Nucl Cardiol. 2012 Dec 19(6):1113-23. PMID:23065414 63. Smith T, Gurudevan S, Cheng V, Trento A, Derobertis M, Thomson L, Friedman J, Hayes S, Siegel RJ, Berman DS. Assessment of the morphological features of degenerative mitral valve disease using 64-slice mult detector computed tomography. J Cardiovasc Comput Tomogr 2012 Nov-Dec; 6(6): 415-21. PMID 23146347. 64. Nasseri Y, Ourian AJ, Waxman A, D’Agnolo, Thomson LE, Margulies RD. Fluorodeoxyglucose positron emission tomography-computed tomography: a novel approach for the diagnosis of cholecystitis for equivocal diagnoses after ultrasouhnd imaging. Am Surg. 2012 Oct; 78(10): 1109-13. PMID 23025952 65. Goykhman P, Mehta PK, Agarwal M, Shufelt C, Slomka PJ, Yang Y, Xu Yuan, Shaw LJ, Berman DS, Bairey Merz CN, Thomson LEJ. Reproducibility of myocardial perfusion reserve – variations in measurements made form post processing using commercially available software. Cardiovascular Diagnosis and Therapy, Vol 2 (4) 2012. (online publication) 66. Rozanski A, Gransar H, Hayes SW, Min J, Friedman JD, Thomson LEJ, Berman DS. Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing (1991-2009). J Am Coll Cardiol 2013 Mar 12;61(10):1054-65. PMID 23473411. 67. Rajani R, Shmilovich H, Nakazato R, Nakanishi R, Otaki Y, Cheng VY, Hayes SW, Thomson LE, Friedman JD, Slomka PJ, Min JK, Berman DS, Dey D. Relationship of epicardial fat volume to coronary plaque , severe coronary stenosis and high risk coronary plaque features assessed by coronary CT angiography. J Cardiovasc Comput Tomogr 2013 Mar-Apr, 7(2):125-32. PMID 23622507 Confidential Page 10 23-Jun-15 10 68. Nakashini R, Rana JS, Shalev A, Gransar H, Hayes SW, Labounty TM, Dey D, Miranda-Peats R, Thomson LE, Friedman JD, Abidov A, Min JK, Berman DS. Mortality risk as a function of the ratio of pulmonary trunk to ascending aorta diameter in patients with suspected coronary artery disease. Am J Cardiol 2013 May 1; 111(9):1259-63. PMID 23415638 69. Pang J Bhat H, Sharif B, Fan Z, Thomson LE, Labounty T, Friedman JD, Min J, Berman DS, Li D. Whole heart coronary MRA with 100% respiratory gating efficiency: Self –navigated three – dimensional retrospective image-based motion correction(TRIM). Magn Reson med. 2013 Feb 7. PMID 23401157 70. Sharif B, Dharmakumar R, Labounty T, Arsnjani R, Shufelt C, Thomson L, Bairey Merz CN, Berman DS, Li D. Towards elimination of the dark rim artifact in first pass myocardial perfusion MRI: removing gibbs rining effects using radial acquisition: Magn Reson Med 2013 Sept 12. Epub ahead of print. PMID 24030840 71. Nakashini R, Rana JS, Rozanski A, Cheng VY, Gransar H, Thomson LE, MirandaPeats R, Hayes SW, Friedman JD, Berman DS, Min JK. Relationship of dyspnea versus typical angina to coronary artery disease severity, burden, composition and location on coronary CT angiography. Atherosclerosis. Atherosclerosis 2013 Sep; 230(1): 61-6 PMID 23958253. 72. Chen D, Sharif B, Dharmakumar R, Thomson LE, Bairey Merz CN, Berman DS, Li D. Improved quantification of myocardial blood flow using highly constrained back projection reconstruction. Magn Reson Med. 2013 Oct 1. PMID: 24122950 73. Agarwal M, Shufelt C, Mehta PK, Gill E, Berman DS, Li D, Sharif B, Li N, Bairey Merz CN, Thomson LEJ. Cardiac risk factors and myocardial perfusion reserve in women with microvascular coronary dysfunction. Cardiovascular Diagnosis and Therapy. 2013 (9) 3(3) p 146-152 74. Shufelt CL, Thomson LEJ, Goykhman P, Agarwal M, Mehta PK, Sedlak T, Li N, Gill E, Samuels B, Azabal B, Kar S, Kothwade K, Minissian M, Slomka P, Berman DS, Bairey Merz CN. Cardac magnetic resonance imaging myocardial perfusion reserve index assessment in women with microvascular coronary dysfunction and reference controls. Cardiovascular Diagnosis and Therapy. 2013 (9) 3(3) p 153-160 75. Sharif B, Dharmakumar R, Arsanjani R, Thomson L, Bairey Merz CN, Berman DS, Li D. Non-ECG-gated myocardial perfusion MRI using continuous magnetizationdriven radial sampling. Magn Reson Med. Jan 2014.[Epub ahead of print] doi: 10.1002/mrm.25074 PubMed PubMed PMID: 24443160 76. Nelson MD, Szczepaniak LS, Wei J, Haftabaradaren A, Bharadwaj M, Sharif B, Mehta PK, Zhang X, Thomson LE, Berman DS, Li D, Bairey Merz N.Diastolic dysfunction in women with signs and symptoms of ischemia in the absence of obstructive coronary artery disease. A hypothesis generating study. Circ Cardiovasc. Imaging 2014 Mar 14 (Epub ahead of print). PMID: 24633782 77. Rozanski A, Gransar H, Min JK, Hayes SW, Friedman JD, Thomson LE, Berman DS. Long-term mortality following normal exercise myocardial perfusion SPECT according to coronary disease risk factors. J Nucl Cardiol. 2014 April 21 (2): 341-50. PMID: 24379127 78. Arsanjani R, Hayes SW, Fish M, Shalev A, Nakanishi R, Thomson LE, Friedman JD, Germano G, Berman DS, Slomka P. Two position supine/prone myocardial perfusion SPECT (MPS) imaging improves visual inter-observed correlation and agreement. J Nucl Cardiol. 2014 Aug 21 (4):703-11 PMID: 24807622 79. Chen D, Sharif B, Dharmakumar R, Thomson LE, Bairey Merz CN, Berman DS, Li D. Quantification of myocardial blood flow using non ECG triggered MR imaging. Magn Reson Med 2014 Sep 16 E Pub PMID: 25227935 80. Thomson LE, Wei J, Agarwal M, Haft-Baradaran A, Shufelt C, Mehta PK, Gill EB, Johnson BD, Kenkre T, Handberg M, Li D, Sharif B, Berman DS, Petersen JW, Pepine CJ, Bairey Merz CN. Cardiac magnetic resonance myocardial perfusion Confidential Page 11 23-Jun-15 11 reserve index is reduced in women with coronary microvascular dysfunction: A national Heart Lung and Blood institute sponsored study from the Women’s Ischemia Syndrome Evaluation. Circ. Cardiovasc. Imaging 2015 Apr; 8(4). Pii: e002481. PMID: 25801710 81. Brodov Y, Gransar H, Rozanski A, Hayes SW, Friedman JD, Thomson LE, Dey D, Slomka PJ, Min JK, Shaw LJ, Shah PK, Germano G, Berman DS. Extensive thoracic aortic calcification is an independent predictor of development of coronary artery calcium among individuals with coronary artery calcium score of zero. Atherosclerosis 2015 Jan; 238(1): 4-8. PMID: 25461732 82. Nakazato R, Slomka PJ, Fish M, Schwartz RG, Hayes SW, Thomson LE, Friedman JD, Lemley M Jr, Mackin ML, Peterson B, Schwartz AM, Doran JA, Germano G, Berman DS. Quantitative high-efficiency cadmium-zinc-telluride SPECT with dedicated parallel hole collimation system in obese patients: results of a multicenter study. J Nucl Cardiol. 2015 Apr; 22(2):266-75 PMID: 25388380 83. Nakanishi R, Gransar H, Slomka P, Arsanjani R, Shalev A, Otaki Y, Friedman JD, Hayes SW, Thomson LE, Fish M, Germano G, Abidov A, Shaw L, Rozanski A, Berman DS. Predictors of high risk coronary artery disease in subjects with normal SPECT myocardial perfusion imaging. Accepted for publication J Nucl Cardiol 2015 84. Otaki Y, Hell M, Slomka P, Schuhback A, Gransar H, Huber B, Nakazato R, Guido G, Hayes SW, Thomson LE, Friedman JD, Achenbach S, Berman DS. Relationship of Epicardial Fat Volume from non-contrast CT with Impaired Myocardial Flow Reserve by Positron Emission Tomography. Accepted for publication JCCT 2015. Editorial: Thomson LEJ Cardiovascular Magnetic Resonance in Clinically Suspected Cardiac Amyloidosis: Diagnostic Value of a Typical Pattern of Late Gadolinium Enhancement. J. Am Coll. Cardiol invited editorial comment. J Am Coll Cardiol 2008; 51(10):1031-2. Reviews: 1. Thomson LEJ, Allman KC. Prognostic value of myocardial perfusion imaging in patients with known or suspected coronary artery disease. Eur Heart J 2001; 3(supplement F) :F5F7. 2. Thomson LEJ, White HD. The Role of Ultrafast Computed Tomography in the Assessment of Suspected or Known Coronary Artery Disease. Invited review. J HK Coll Cardiol. 2003; 11(1):16-21. 3. Thomson LE, Hachamovitch R. Coronary Artery Calcium Scoring Using Electron-Beam Computed Tomography: Where Does This Test Fit into a Clinical Practice? Rev Cardiovasc Med. 2002; 3:121-128. 4. Thomson LEJ, Kim RJ, Judd RM. Magnetic Resonance Imaging Assessment of Myocardial Viability. J Magn Reson Imaging. 2004;19(6):771-88. 5. Berman DS, Hachamovitch R, Shaw LJ, Friedman JD, Hayes SW, Thomson LE, Fieno DS, Germano G, Slomka P, Wong ND, Kang X, Rozanski A. Roles of Nuclear Cardiology, Cardiac Computed Tomography and Cardiac Magnetic Resonance: Assessment of Patietns with Suspected Coronary Artery Disease. J Nucl Med. 2006; 47(1):74-82 6. Berman DS, Hachamovitch R, Shaw LJ, Friedman JD, Hayes SW, Thomson LE, Fieno DS, Germano G, Slomka P, Wong ND, Kang X, Rozanski A. Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: Noninvasive Confidential Page 12 23-Jun-15 12 risk stratification and a conceptual framework for the selection of noninvasive imaging tests in patients with known or suspected coronary artery disease. J Nucl Med. 2006; 47(7):1107-18 7. Fieno DS, Saouaf R, Thomson LEJ, Abidov A, Friedman JD, Berman DS. Cardiovascular Magnetic Resonance of Primary Tumors of the Heart: A Review. J Cardiovasc Magn Reson. 2006; 8, 839-853 8. Berman DS, Shaw LJ, Hachamovitch R, Friedman JD, Polk DM, Hayes SW, Thomson LE, Germano G, Wong ND, Kang X, Rozanski A. Comparative use of radionuclide stress testing, coronary artery calcium scanning and non invasive coronary angiography for diagnostic and prognostic cardiac assessment. Semin Nucl Med. 2007; 37(1): 2-16 9. Berman DS, Shaw LJ, Min JK, Hachamovitch R, Abidov A, Germano G, Hayes SW, Friedman JD, Thomson LE, Kang X, Slomka P, Rozanski A. SPECT/PET myocardial perfusion imaging versus coronary CT angiography in patients with known or suspected CAD. Q J Nucl Med Mol Imaging. 2010 Apr;54(2):177-200 PMID: 20592682 10. Daneshvar D, Wei J, Tolstrup K, Thomson LE, Shufelt C, Merz CN. Diastolic dysfunction: improved understanding using emerging techniques. Am Heart J. 2010 Sep; 160(3): 394-404 11. Rostamian A, Narayan SM, Thomson L, Fishbein M, Siegel RJ. The incidence, diagnosis, and management of pulmonary vein stenosis as a complication of atrial fibrillation ablation. J Interv Card Electrophysiol. 2014 Mar 14 (Epub ahead of print). Book Chapters: 1. Wagner A, Mahroldt H, Thomson L, Sechtem U, Judd RM, Kim RJ. Assessment of myocardial viability using cardiovascular MR imaging. In: Lardo AC , Fayad ZA, Chronos N, Fuster V, eds. MRI of the cardiovascular system. Established and Emerging Applications. London, UK: Martin Dunitz; 2003 2. Hachamovitch R, Thomson LEJ. Understanding Statistical Analysis and Data Interpretation in Studies of Noninvasive Cardiovascular Testing. In: Heller GV, Cerqueira MD. Nuclear Cardiology for the Internist. McGraw-Hill, 2004. 3. Thomson LEJ, Fieno D. Comparison of function, viability and perfusion assessed by MPS and cardiac magnetic resonance imaging. In Clinical Gated Cardiac SPECT. 2nd Edition. Editors: Germano and Berman. Blackwell. ISBN-13: 978-1405131551 4. Thomson LEJ, Karlsberg RP, Friedman JD, Hayes SW, Saouaf R, Berman DS. Adult Congenital Heart Disease. In Handbook of Cardiovascular CT; Essentials for Clinical Practice. MJ Budoff and JS Shinbane. 2008 Springer Verlag Inc. ISBN-13: 9781848000919 5. Berman DS, Shaw L, Rozanski A, Friedman J, Hayes S, Thomson LEJ, Slomka P, Germano G. Cardiac SPECT and PET, complementary roles with cardiac CT. In Clinical Cardiac CT. Budoff and Shinbane. 2008 Springer Verlag Inc. ISBN: 978-1-84800-091-9 6. Thomson LEJ “Nuclear Based Techniques” in Cardiovascular Imaging for Clinical Practice. Editors Stephen J Nicholls and Stephen G Worthley. 2010 Jones and Bartlett Publishers ISBN-13: 9780763756222. Confidential Page 13 23-Jun-15 13 7. Thomson LEJ “The role of cardiac MRI” in Chest Pain with Normal Coronary Arteries: A multidisciplinary approach. Editors Juan Carlos Kaski, Guy D Eslick, C.Noel Bairey Merz. 2013 Springer ISBN-13: 978-1447148371 Case reports: 1. Thomson LE, Stewart JT. Ticlopidine induced agranulocytosis managed with granulocyte colony stimulating factor. N Z Med J. 1998;111:81-2. 2. Thomson L, Webster M, Wilson N. Transcatheter closure of a large coronary artery fistula with the Amplatzer duct occluder. Catheter Cardiovasc Interv. 1999; 48:188-90. 3. Thomson LE, Breit R, Allman KC, Van der Wall H. Shoulder anatomy defined by a Tc99m leukocyte study. Clin Nucl Med. 2001; 26:444-5. 4. Thomson LE, Allman KC. Erythema multiforme reaction to sestamibi. J Nucl Med. 2001; 42:534. 5. Thomson LE, Chen X, Greaves SC. Entrapment of mitral chordal apparatus causing early postoperative dysfunction of a St. Jude mitral prosthesis. J Am Soc Echocardiogr. 2002;15:843-4. 6. Patel MR, Thomson LEJ, Meine TJ, Burfeind WR, Messier RH, Robinson EN, Corey R, Kim R. An intracardiac mass in a young man with congenitally acquired HIV. Cardiol Rev. 2004; 12(3):126-30. 7. Thomson LEJ, Goodman MP, Naqvi TZ, Feldman R, Buchbinder NA, Waxman A, D’Agnolo A. Aortic root infection in a prosthetic valve demonstrated by Gallium 67 Citrate SPECT Clin Nucl Med. 2005; 30(4):265-8. 8. Heitner JF, Klem I, Alexander K, Thomson L, Meine TJ, Patel MR, Haq SA, Shah DJ, Kim RJ. The case of the disappearing myxoma. J Cardiovasc Magn Reson. 2005; 7(5):841-3. 9. Lee CJ, Ramirez CA, Thomson LEJ. A Stone Heart. A case of fatal cardiac microcalcification. European Heart Journal. electronic advance publication May 4 2007; 2007:28(19):2312 10. Rajani R, Friedman J, Cheng VY, Thomson L, Hayes SW, Tomizawa T, Berman DS. A tale of two coronaries. Int. J. Cardiol. 2011. January. Published online. 11. Orakzai RH, Nalawadi S, Cuk O, Thomson L, Elad Y, Trento A, Siegel RJ, Loghavi S. Multimodality evaluation of a rare intracardiac tumor. Cardiac hemangioma. Am J Med. 2011 Aug;124(8):e3-4 PMID: 21787898 12. Beigel R, Thomson L, Siegel R. An unusual case of saline contrast injected in the anterior cubital vein appearing in the left heart prior to the right heart. J Am Coll Cardiol 2013 Aug 13; 62(7):e13 PMID:23747763 13. Jones E, Greenfield N, Mehta PK, Shufelt C, Thomson L, Bairey Merz CN. Polycythemia vera and microvascular dysfunction in a 26 year old male presenting with chest pain. International Journal of case reports and images. Accepted for publication 2015. Confidential Page 14 23-Jun-15 14 LECTURES / PRESENTATIONS: SNMMI categorical in cardiac imaging Course organizer, moderator and speaker. Know the device – implanted cardiac devices Baltimore June 2015 ACR Annual Pet-CT symposium Cardiac PET/CT: Radiopharmaceuticals, Protocols and interpretations. Chicago March 5-7 2015 9th Annual Cedars Sinai Womens Heart Disease Symposium April 24 2015. Session moderator: Case presentations and discussion. Cedars Sinai 29th Annual Case Review with the Experts Faculty: Role of Cardiac MRI in Clinical Practice: When is it the Procedure of Choice? January 25 2015 8th Annual Cedars Sinai Womens Heart Disease Symposium April 25 2014. Session moderator: Case presentations and discussion. Cedars Sinai 28th Annual Case Review with the Experts Faculty: Role of Cardiac MRI in Clinical Practice: When is it the Procedure of Choice? January 25 2014 Biomedical science graduate program course in Research and clinical imaging. “Cardiac MRI: Clinical applications April 29, 2014 Cardiac Society of Australia and New Zealand, Annual scientific meeting August 2013 Invited lecture: “Imaging in diabetes, the role of nuclear imaging”. 7th Annual Cedars Sinai Womens Heart Disease Symposium April 19 2013. Session moderator: Case presentations and discussion. 17th Annual Heart Failure Meeting April 2013- An update on therapy symposium. Faculty: MRI for the diagnosis and prognosis of cardiomyopathies. Cedars Sinai 27th Annual Case Review with the Experts Faculty: Role of Cardiac MRI in Clinical Practice: When is it the Procedure of Choice? January 20th 2013 Tarzana Hospital Grand Rounds. July 31st 2012. Invited lecture “Cardiac MRI evaluation of cardiomyopathies”. 6th Annual Cedars Sinai Womens Heart Disease Symposium April 27 2012. Session moderator: Case presentations and discussion. Ischemic heart disease in women Cedars Sinai 26th Annual Case Review with the Experts January 2012 Faculty: Role of Cardiac MRI in Clinical Practice: When is it the Procedure of Choice? Classic Pet cases: interpretation and reporting. 5th Annual Cedars Sinai Womens Heart Disease Symposium April 29 2011 Faculty: Ischemic heart disease in women – diagnostic approaches for chest pain, palpitations and shortness of breath. Confidential Page 15 23-Jun-15 15 Cedars Sinai 25th Annual Case Review with the Experts January 21st 2011 Faculty: Role of Cardiac MRI in Clinical Practice: When is it the Procedure of Choice? Classic Pet cases: interpretation and reporting. 4th Annual Cedars Sinai Womens Heart Disease Symposium May 12 2010 Faculty:Non invasive testing for Microvascular angina in women. Case review. Cedars Sinai 24th Annual Case Review with the Experts January 30th 2010 Faculty: Does Cardiac MRI have a role in clinical practice?. Imaging Grand Rounds September 2009 Cedars Sinai Medical Center Cardiac CT and MR: Applications in known coronary artery disease. Cardiac Imaging Board review mock examination for senior CSMC radiology residents. May 2009 3rd Annual Cedars Sinai Womens Heart Disease Symposium Faculty:. Non invasive testing for Microvascular angina in women. Case review. May 2009 Cedars Sinai 23rd Annual Case Review with the Experts Faculty: Cardiac CT and CMR: When is CMR the test of choice? Diagnostic CTA case presentation utilizing Terra Recon workstation January 30th 2009 Sierra Heart Institute’s nineteenth annual “Trends in Cardiovascular Medicine: Cardiology for the Primary Physician” conference. Approach to Diagnosis of Ischemia Including GenderSpecific Imaging Issues. October 17-19, 2008 2nd Annual Cedars Sinai Womens Heart Disease Symposium Faculty: Women and heart disease. Approach to diagnosis including gender specific imaging issues. May 2008 Cardiac Imaging Board review mock examination for senior CSMC radiology residents. May 8th 2008. Core curriculum lecture in Current applications of cardiac MRI Division of Cardiology. UCLA-VA Greater Los Angeles/San Fernando Valley Program May 7th 2008 Society of Nuclear Medicine Mid-Winter symposium February 16th 2008 The future role of cardiac MRI and cardiac CT. Cedars Sinai 22nd Annual Case Review with the Experts January 27th 2008 Faculty: Cardiac CT and CMR: When is CMR the test of choice. Diagnostic CTA case presentation utilizing Terra Recon workstation Cardiology at the Frontier Sydney Australia December 1st 2007 St Vincents Hospital Sesquincentenary Conference Faculty: Combined MR and Nuclear- a better view? Cardiology Rounds Cedars Sinai Medical Center July 2007 ACC abstracts review and cardiac imaging update Confidential Page 16 23-Jun-15 16 Cardiology Rounds Tarzana and Encino Hospital July 2007. Invited lecture: Cardiovascular MRI Cedars Sinai Womens Heart Disease Symposium April 2007 Faculty: Women and heart disease. Approach to diagnosis including gender specific imaging issues. Cedars Sinai Womens Health Conference Faculty: Angina with normal coronary arteries: microvascular disease is a women’s issue. UCLA medical student lectures on cardiac imaging. Jan 12th, March 9th and May 18 2007. Cardiac Imaging Board review lectures and examination for senior CSMC radiology residents. April 30th, May 17th and 23rd. 2007. ACC/ ASNC 29th Annual Recent Advances in Clinical Nuclear Cardiology and Cardiac CT Featuring Case Review with the Experts.Washington DC May 2007. Faculty: Myocardial Viability: When is CMR the Test of Choice? : Non ischemic cardiomyopathy and CHF: What is the optimal non invasive work up with CT, CMR, SPECT or PET? Cedars Sinai 21st Annual Case Review with the Experts, January 2007 Faculty: Cardiac CT and CMR: When is CMR the test of choice. : Diagnostic CTA case presentation utilizing Vitrea workstation ACC/ ASNC 28th Annual Recent Advances in Clinical Nuclear Cardiology and Cardiac CT Featuring Case Review with the Experts.Washington DC May 2006. Faculty: Myocardial Viability: Integrating the Use of Nuclear, Echo and MRI Methods Cardiac CT vs. CMR: When is CMR the Test of Choice? Saint Agnes Medical Center's 2006 Heart and Vascular Symposium on Saturday, April 29, 2006 Current Applications of CT Angiography and MRI in Cardiovascular Imaging Cedars Sinai 20th Annual Case Review with the Experts January 2006 Faculty: Cardiac CT and CMR: Where is CMR the test of choice. Los Angeles Radiologic Society Midwinter Conference January 2006 Faculty: Basic cardiac and coronary anatomy and anomalies. Systolic heart Failure. Diastolic Heart Failure. CSMC Radiology and nuclear medicine residents lecture HIDA scans September 1st 2005 Cardiac MR board review for senior CSMC and UCLA radiology residents August 2005 and 2006. Los Angeles Radiologic Society Meeting May 2005. Invited speaker Nuclear cardiology case challenges – correlative imaging presentation Nuclear Cardiology for the Technologist. Baltimore April 2005 Invited speaker Cardiology Beyond Perfusion and SPECT – cardiac MRI SNM 2004: Cardiac viability defined by magnetic resonance imaging Confidential Page 17 23-Jun-15 17 Invited speaker for continuing education special session on viability imaging. Cardiac MR board review for senior CSMC and UCLA radiology residents Feb 16th 2004 Adenosine stress testing:In service education for cardiac MR technologists, CSMC Jan 23, 2004. Cardiac MR case review CSMC Cardiology fellows weekly meeting Jan 19th 2004. Cardiac MR abstracts summary of AHA Cardiology rounds CSMC November 2003 Cardiac MR assessment of viability Cardiology Rounds CSMC June 2004 Magnetic resonance Imaging techniques for Non invasive hemodynamic Evaluation. Lecture at the Inaugural DCMRC Cardiovascular MR Practicum, December 2002. Magnetic Resonance Imaging of Atrial Septal Defects Cardiology Grand Rounds, Duke University Medical Center, November 2002. Myocardial Viability Imaging by single photon emission computed tomography . Internal Medcine Grand Rounds Concord repatriation and general hospital, April 2000, Sydney, Australia. Adenosine use in myocardial perfusion stress testingImproved image quality and patient tolerability with exercise Australasian College of physicians nuclear medicine continuing education program March 2001, Sydney, Australia. The role of nuclear medicine in detection of myocardial viability NZ cardiology registrars training weekend May 2001, Auckland, New Zealand Adenosine- Safety and efficacy of treadmill exercise during pharmacologic stress testing Australia and New Zealand Society of Nuclear Medicine branch meeting September 2001, Sydney, Australia TEACHING/ MENTORSHIP: Research Internship – Created and supervised research intern, Michael Pedram, from October 2014- July 2015. Research project: Quantitative Bone SPECT-CT. I am the Cardiovascular Imaging Fellowship program director and have responsibility for supervision and teaching of the following advanced cardiac imaging fellows and research scientists: Manish Motwani 2014- visiting post doc Richard Stoebner MD, Commander Medical Corps United States Navy current clinical cardiovascular imaging fellow 2013 – 2015. Ankit Rathod MD - Clinical cardiovascular imaging fellow 2014 - 2015 Confidential Page 18 23-Jun-15 18 Prior visiting MD scientists and fellows in this program: Ankit Rathod - fellow 2014 - 2015 Andreas Kumar 2014 visiting post doc Yafim Brodov: Save a Heart Foundation fellow 2013- 2014 Mariana Diaz: visiting radiologist from Mexico 2013- 2014 William Psei Chin: visiting cardiologists 2013- 2014 Reza Arsanjani: clinical cardiovascular imaging fellow 2011-2012. Now cardiologist on staff at CSMC Jamal Rana: clinical cardiovascular imaging fellow 2011-2012 Aryeh Shalev: Save a Heart Foundation fellow 2011-2013 Yuka Otaki: Japanese visiting scientist. 2010- 2013 Rine Nakanishi: Japanese visiting scientist. 2010- 2012 Thomas Smith: Cardiologist from Sacramento, for 6 month experience in advanced cardiac imaging. 2010 Haim Shmilovich; Save-a-Heart Foundation fellow 2009-2011 Ryo Nakazato; July 2008 – present, Japanese visiting scientist in CT, MR) Balaji Tamarappoo; July 2008- 2010. Cardiovascular imaging clinical fellow. Victor Cheng; July 2007-2008 clinical fellow, currently cardiologist at CSMC. Arik Wolak; Save-a-Heart Foundation fellow, in practice in Israel. Ariel Gutstein Save-a-Heart Foundation fellow, in practice in Israel. Yasu Suzuki: Japanese research fellow in CT, CMR and Nuclear cardiology Muneo Oba: Japanese research fellow in MPS,CT and CMR July 2007 Shoji Suzuki: Japanese research fellow in MPS, CT and CMR July 2007 Aiden Abidov: Save-a-Heart Foundation fellow 2003, in clinical practice in USA. Women’s Heart Center collaboration: I have mentored the following physicians in the cardiac MRI core lab operations and research activities involving the womens heart center May Bakir 2014-2015 (cardiology fellow in NY) Janet Wei 2013- 2014 (staff cardiologist with WHC). Afsaneh Haftbaradaran 2012-2013 Megha Agarwal 2011-2012 (cardiology fellow UC Davis) Pavel Goykhman 2010-2011 (cardiology fellow in NY) Cardiac imaging case conference: I run this conference held Thursday mornings 8-9am This weekly conference is attended by radiology residents and cardiology fellows as well as cardiovascular imaging fellows. Reviews cases in MR, CT and nuclear cardiac imaging. I schedule this meeting and teach approx 12-14 sessions each year. Basic science course (imaging): I have re-designed and implemented this course 2014This weekly conference is attended by radiology residents and cardiology fellows and covers basic science requirement for the radiology residency program in nuclear medicine as well as for the cardiology fellowship eligibility for nuclear cardiology certification. Radiology residents board review sessions in cardiac MR and nuclear cardiology. 2005-2014. Nuclear cardiology for the technologist, ACC sponsored course, Cedars Sinai 2004 Duke Cardiovascular Magnetic Resonance Center Cardiovascular Practicum MRI for the non-invasive assessment of cardiovascular hemodynamics. Dec 2002. Cardiovascular clinical skills training for FRACP candidates 1997-2001. Lecturer for Green Lane hospital nursing advanced cardiac course, 1997-1999. Medical student clinical tutorials in cardiology, Green Lane Hospital 1997- 1999 Confidential Page 19 23-Jun-15 19 RESEARCH: Current research interests span nuclear medicine, cardiac MRI, cardiac CT and nuclear cardiology and include in-house, inter-departmental and multicenter collaborative research. My primary interest is in the study of cardiac MRI utility in the evaluation of women with angina and open coronary arteries, for which I am director of the cardiac MRI core laboratory for the NHLBI sponsored WISE study. I am additionally involved in clinical nuclear medicine research activities and have worked with radiology residents and medical residents in producing abstracts and publications based upon general nuclear and cardiac imaging cases. Confidential Page 20 23-Jun-15 20