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Ensuring Access to Data and Information
Capacity Building for Tropical Diseases
Lester Chitsulo
Special Programme for Research and Training in Tropical Diseases (TDR)
World Health Organization, Geneva, Switzerland
Permanent Access to Scientific Information in Southern Africa
An International Workshop
5-7 September 2005, Pretoria, South Africa
Purpose of this presentation
• To give an overview of Tropical Diseases
Research (TDR) programme
• To discuss capacity building efforts for ensuring
that data and information from research are
accurate, reproducible, robust and are
disseminated
TDR Objectives
• To support research to improve and/or
develop new tools for preventing,
diagnosing, treating, and controlling
neglected infectious diseases
• To strengthen the capacity of disease
endemic countries to undertake the
research required for disease control
TDR Disease Portfolio
•
•
•
•
•
•
•
•
•
African trypanosomiasis
Chagas disease
Dengue
Leishmaniasis
Leprosy
Lymphatic filariasis
Malaria
Onchocerciasis
Schistosomiasis
• Tuberculosis.
TDR Structure
Director
SSK
PPM
SDR
PDE
IRM
RCS
Disease Coordinator 1
Disease Coordinator 2
Disease Coordinator 3
LDCs
Disease Coordinator n
“RCS-Plus”
TDR Disease Strategic Emphases Matrix
TDR works through Committee
Structures with External Advisors
Secretariat @ 20+ persons
DIR
Advisors @ 200+ persons
SDR
SEB
BCV
PDE
PAG
GDR
PDT 1
CPR
PDT 2
PDT 3
IRM
RCS
MIM
IR
RSG
MIM
DRD
PDT 4
PDT 1
PDT 2
PDT 1
PDT 2
R&D
R&D
Project Project
1
2
Course
1
TDR Support
• Collaborative research grants – tenable globally
• Research capacity strengthening grants for
disease endemic countries
• Research training grants, including career
development fellowships
•
•
•
•
Re-entry grants
Project specific training, good practices
Establishment of networks
Access to scientific literature and
communications – hardware, software and training
• www.who.int/tdr
Capacity building approaches
Global
`
networks
N-S & S-S
partnerhips
Regional
approaches
Institution
Individual
MIM/TDR
Partnership grants
Regional networks
Small grants
R&D-driven projects
Programme-based
Degree training
Group training
Re-entry
Capacity Building Support
A
p
p
r
o
a
c
h
Training in project planning and management
Protocol
development
Characteristics and dynamics of antibodies to MSP-1 of
Plasmodium falciparum in humans naturally exposed to
malaria
Jun – Jul ’0 2
Ethical
Clearance
Aug Sep t
‘02
Local
2002-2005 PERT CHART
Recruitment
Field Staff
training
Aug-Sep
02
Jul ‘02
WHO
Crosssectional
Study
Preparation
Visits by
N. Partner
Workshops
Data
Analysis
Field study
Grant 1st year
Approval funding
Jun 02 Aug 02 Capacity building
&
Collaboration
Oct ’02-Oct
‘04
Sample
Collection
Aug 0 2
PostDoc,PhD
& M.Sc
Training
Report
Longitudinal
Aug 0 2–Nov ‘05
Recruitment
Dec ‘05
Sample
Collection
Nov ‘0 3–Jan ‘05
Laboratory
Work
Aug 0 2- Jan 04
Hb Genotype
MSP1 ELISAs
Sep t ’02-Oct ‘05
Oct 02 –Dec 0 4
MSP1 Alleles
PCR
T cell
work
Epitope
mapping
MSP1 PI
Oct ’04-Ju n ‘05
&comp.ELISA
Mar 03-M ay 05
Nov 0 3-Aug 04
Contribution
to
MSP-1
Vaccine
Development
Capacity building in Research Ethics
SIDCER
is a global network for developing ethical review and
promote ethical and scientific values in biomedical research
FECCIS
FOCUS
FLACEIS
FERCAP
PABIN
http://www.sidcer.org
Quality Practice in basic
biomedical research
• Data from basic research must be
reliable in order to ensure a solid basis for
decision making
• Fully described experimental conditions
and properly collected and recorded data
will ensure reproducibility and avoid
controversies
• QPBBR is concerned with the way the
research work is organised, performed,
reported and supervised
• It is a non-regulatory quality guidance for
researchers in basic biomedical research
Good Laboratory Practices
Good Clinical Practices
Laboratory Assessment
SOPs Training
CLINICAL DATA MANAGEMENT
• Training in clinical data management
• 8 Clinical data management centres
– China, Colombia, Ethiopia, India (2), Japan (2), and Thailand
– To ensure production of high quality databases that
meet clinical and regulatory requirements
• WHO/TDR Annual Meeting on Clinical Data
Management, Second Military Medical University,
Shanghai, September 26-28, 2005.
• http://www.cdmtdr.org/
Strengthening of DEC medical journals
FAME - [email protected]
Improving access to scientific information
Disease Watch
Multilateral Initiative on Malaria (MIM).
Communication
Research grants
Coordination
Reagents
 Biggest global
malaria conference
 Major participation of
African scientists (>
1500)
 Strong interface with
malaria control
 Important malaria
advocacy event
 TDR sponsored
symposia on R & D
innovation in Africa
Partnerships for MSc programmes
L'Universite
D'Abomey-CalaviI
Centers of excellence for applied genomics
Latin American Course
on Bioinformatics
for Tropical Disease Research
FIOCRUZ
South African National
Bioinformatics Institute
Conclusion
• We should build capacity that insures that data
and information from tropical diseases research
are accurate, reproducible and accessible.
• Thank you for the opportunity to share ideas
with you.