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TB Assessment for Refugees and Immigrants
Obtain medical history, including
any current TB signs/symptoms
Administer Mantoux Tuberculin Skin Test (TST) or Interferon Gamma
Release Assay (IGRA) (unless documented previous positive or history of
previous treatment for TB disease)
TST or IGRA Negative
TST or IGRA Positive
Yes
Signs/symptoms consistent
with active pulmonary or
extrapulmonary TB?
Perform a Chest x-ray (CXR)
Chest x-ray abnormalities?
No
No
Yes - stable, consistent
with old, healed TB, or
non-TB abnormality
Signs/symptoms consistent
with active pulmonary or
extrapulmonary TB?
No – and
TST/IGRA
negative
Yes - consistent
with TB disease
Sputum specimens on 3 consecutive days for AFB
smear & mycobacterial cultures OR extrapulmonary
evaluation, as indicated by ATS/CDC diagnostic
guidelines: www.cdc.gov/nchstp/tb
Yes
No – and
TST/IGRA
positive
Candidate for
LTBI treatment
Yes
Active TB disease ruled out?
No
Contact MDH to order TB
medications, if needed:
(651) 201-5414
Contact MDH to report suspected TB
disease and order medications, if needed:
(651) 201-5414
Complete Minnesota Refugee Health Assessment form and return to:
Local Public Health or MDH per county protocol
Additional considerations:
 For most refugees and immigrants, TST is positive if >10 mm induration. Use 5 mm cutoff for: HIV+, recent close contact to
infectious TB case, arrivals with TB Class conditions (A, B1, B2), CXR with fibrotic changes, organ transplant, or otherwise
significantly immunocompromised.
 CDC recommendations published in 2010 state that although a TST is acceptable, the IGRA is preferred for BCG-vaccinated
persons age 5 years or older.
 For Refugee and Immigrant arrivals with a “TB Class Condition”:
 Follow the “TB follow-up recommendations for arrivals with a TB Class condition”.
 Complete a TB Class Follow-up Worksheet (instructions accompany the worksheet) and return to MDH.
Tuberculosis Program
P.O. Box 64975
St. Paul, MN 55164-0975
651-201-5414 or 1-877-676-5414
www.health.state.mn.us/tb
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